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Scientists stopped muscle aging in mice. Blocking Hmgb1 in middle-aged mice with antibodies had remarkable results: senescent markers dropped, muscle regeneration improved, physical performance increased, and inflammation decreased.

Longevity Science News

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At 500–1,000 mg daily, urolithin A is showing early human evidence of benefits for mitochondrial markers and muscle performance It targets mitophagy, the process cells use to remove damaged mitochondria, the structures that produce energy In middle-aged adults with low fitness, 500 mg daily for four months increased muscle markers involved in mitochondrial cleanup and energy production In a small trial of resistance-trained men, 1,000 mg daily for eight weeks improved static strength and repetitions before fatigue compared with placebo, but did not significantly improve the maximum weight they could lift

At 500–1,000 mg daily, urolithin A is showing early human evidence of benefits for mitochondrial markers and muscle performance It targets mitophagy, the process cells use to remove damaged mitochondria, the structures that produce energy In middle-aged adults with low fitness, 500 mg daily for four months increased muscle markers involved in mitochondrial cleanup and energy production In a small trial of resistance-trained men, 1,000 mg daily for eight weeks improved static strength and repetitions before fatigue compared with placebo, but did not significantly improve the maximum weight they could lift

FoundMyFitness Clips

15,208 görüntüleme • 24 gün önce

Urolithin A may be one of the most interesting supplements for mitochondrial aging It activates mitophagy, the cellular cleanup process that removes damaged mitochondria before they drag down energy production, muscle function, and immune resilience In older adults, 1,000 mg/day improved markers of immune aging, increasing CD8+ T cells and natural killer cells while lowering markers of cellular senescence In untrained athletes, the same dose boosted VO2 max by 10% beyond exercise alone, and improved hamstring strength in older adults by 10–12% versus exercise alone

Urolithin A may be one of the most interesting supplements for mitochondrial aging It activates mitophagy, the cellular cleanup process that removes damaged mitochondria before they drag down energy production, muscle function, and immune resilience In older adults, 1,000 mg/day improved markers of immune aging, increasing CD8+ T cells and natural killer cells while lowering markers of cellular senescence In untrained athletes, the same dose boosted VO2 max by 10% beyond exercise alone, and improved hamstring strength in older adults by 10–12% versus exercise alone

FoundMyFitness Clips

49,353 görüntüleme • 4 ay önce

Scientists found a surprising weapon against cancer - a bacteria naturally found in the gut of Japanese tree frogs. When researchers tested Ewingella americana in mice with colorectal tumors, a single injection led to complete tumor elimination in the tested mice. But the craziest part came next... When cancer cells were injected again, the mice rejected the new tumors - suggesting their immune systems had learned to recognize that cancer. Could bacteria one day help teach our immune system how to fight cancer? This research is still preclinical and has only been demonstrated in mice, but the idea could open a fascinating new direction for cancer treatment. #cancer #science #biology #medicine #research

Scientists found a surprising weapon against cancer - a bacteria naturally found in the gut of Japanese tree frogs. When researchers tested Ewingella americana in mice with colorectal tumors, a single injection led to complete tumor elimination in the tested mice. But the craziest part came next... When cancer cells were injected again, the mice rejected the new tumors - suggesting their immune systems had learned to recognize that cancer. Could bacteria one day help teach our immune system how to fight cancer? This research is still preclinical and has only been demonstrated in mice, but the idea could open a fascinating new direction for cancer treatment. #cancer #science #biology #medicine #research

Bharat Indians

48,021 görüntüleme • 12 gün önce

Russell Crowe went from 126 kg (278 lbs) down to 100.9 kg (222 lbs), and he looks fantastic. He credits Joe Rogan for introducing him to Brigham Buhler at Ways2Well. After targeted injections in his shoulders and knees plus IVs, his chronic arthritis and old injuries have improved dramatically, some areas by 70-90%. At 61, he’s finally training without constant pain and building muscle sustainably for the long haul. Chronic inflammation (inflammaging) is a major driver of muscle loss, arthritis progression, and reduced recovery as we age. Lowering systemic inflammation has been shown in multiple studies to improve muscle function, joint health, and physical performance even in older adults.

Russell Crowe went from 126 kg (278 lbs) down to 100.9 kg (222 lbs), and he looks fantastic. He credits Joe Rogan for introducing him to Brigham Buhler at Ways2Well. After targeted injections in his shoulders and knees plus IVs, his chronic arthritis and old injuries have improved dramatically, some areas by 70-90%. At 61, he’s finally training without constant pain and building muscle sustainably for the long haul. Chronic inflammation (inflammaging) is a major driver of muscle loss, arthritis progression, and reduced recovery as we age. Lowering systemic inflammation has been shown in multiple studies to improve muscle function, joint health, and physical performance even in older adults.

Camus

719,566 görüntüleme • 3 ay önce

Higher deuterium in drinking water correlates with higher rates of major depression. Higher deuterium in drinking water correlates with higher rates of type 2 diabetes. This isn't a fringe hypothesis. It's a University of Utah population study mapping deuterium concentration in US tap water against disease prevalence across the country. Correlation — not proof of causation. But striking enough that Tatyana Strekalova — Clinician Scientist at Maastricht University, Senior Researcher at the University of Oxford, and Professor of Physiology at Sechenov First Moscow State Medical University — decided to test it in mice. The logic is straightforward. Deuterium concentration in drinking water decreases with distance from the ocean — inland, high-altitude water is naturally more deuterium-depleted. If geography determines deuterium load, and deuterium load correlates with disease prevalence, then what happens when you deliberately give animals water at the low end of that natural range? What her lab found is striking. They used 90 ppm deuterium-depleted water throughout — the lowest deuterium concentration found naturally in drinking water on Earth. Not a pharmaceutical dose. Not exotic laboratory depletion. And compared it to control mice drinking 140 ppm water. The difference between antarctic meltwater and coastal tap water. Finding 1: Aged mice. Two weeks. Depressive-like behaviors measurably reduced They took 18-month-old mice — equivalent to very old age, approaching maximum mouse lifespan. These mice displayed measurable depressive behaviors: Anhedonia — loss of sensitivity to reward, measured by reduced preference for sweet water. Increased helplessness behavior. Reduced novelty exploration. Impaired hippocampus-dependent memory. After two weeks on 90 ppm DDW? Sucrose preference increased — anhedonia reversed. Helplessness behavior significantly reduced. Novelty exploration improved. Hippocampal memory improved. Two weeks. Naturally occurring low-deuterium water. Measurable reversal across four independent behavioral markers. Finding 2: DDW matched antidepressant effect in stressed young mice They used a chronic stress model in young mice — predator scent, restraint stress, tail suspension. This reliably induces anhedonia in susceptible mice. Then they divided mice into three groups: normal water at 140 ppm, DDW at 90 ppm, and citalopram — a standard SSRI antidepressant. DDW produced rescue of sucrose preference comparable to citalopram. Helplessness behavior was also rescued comparably. Serotonin transporter expression — one of the key molecular targets of SSRIs — was rescued by both citalopram and DDW. This is mouse data. Direct translation to humans requires clinical trials. But the mechanism convergence is a legitimate finding. Finding 3: DDW normalized REM sleep in stressed mice Depression is the only psychiatric disorder diagnosable by a specific sleep architecture change — increased REM sleep. It's a biological marker, not a subjective report. Stressed mice showed increased REM sleep — the biological depression signature. DDW normalized REM sleep. Slow-wave sleep and wakefulness also improved. Finding 4: DDW protected against western diet-induced cognitive impairment and glucose dysregulation They used 12-month-old female mice on a standardized western diet — high saturated fat, high sugar, high cholesterol. Western diet produced: impaired glucose tolerance, brain inflammation, reduced mitochondrial markers in brain and liver, liver steatosis — fat accumulation in the liver — impaired object recognition memory, and impaired hippocampal memory. DDW at 90 ppm on western diet: Prevented glucose tolerance impairment despite continued western diet. Improved object recognition memory. Improved hippocampal memory in old mice. Did not improve liver steatosis. The liver finding matters. DDW protected the brain and metabolic glucose handling but did not reverse the liver damage. Strekalova’s interpretation: DDW is counteracting brain inflammation driven by damage elsewhere in the body — not fixing the damage itself. Finding 5: Deuterium-enriched water (180 ppm) did the opposite They tested the reverse — 180 ppm water, equivalent to what you would find in evaporative pools in the Sahara. Results on aged mice with western diet: Novelty exploration clearly suppressed. Hippocampus-dependent memory suppressed. Strekalova describes this as a surprise finding. 90 ppm sits at the low end of natural drinking water on Earth. 180 ppm sits at the high end of what occurs in extreme arid environments. The difference between them produced measurable opposing effects on memory and cognition in aged mice. Gene expression — deuterium sits upstream of circadian biology In both the aging model and the stress model, DDW altered gene expression in the hippocampus and prefrontal cortex. Affected categories: DNA repair, oxidative stress response, immune regulation, mitochondrial function, cellular plasticity, aging-related genes. And one finding that connects directly to everything else: Per2. Per2 is a core circadian clock gene. DDW affecting its expression means deuterium content influences circadian biology at the gene level. Deuterium doesn't just affect cancer cells and mitochondrial efficiency. It sits upstream of the circadian system. The implication The deuterium content of your water varies by geography. Antarctic water versus coastal tap water. The difference is measurable. The biological effects in these models are measurable and opposing. Most people optimizing their health are tracking sleep, sunlight, training, and nutrition. Nobody told them deuterium was also on the list.

Higher deuterium in drinking water correlates with higher rates of major depression. Higher deuterium in drinking water correlates with higher rates of type 2 diabetes. This isn't a fringe hypothesis. It's a University of Utah population study mapping deuterium concentration in US tap water against disease prevalence across the country. Correlation — not proof of causation. But striking enough that Tatyana Strekalova — Clinician Scientist at Maastricht University, Senior Researcher at the University of Oxford, and Professor of Physiology at Sechenov First Moscow State Medical University — decided to test it in mice. The logic is straightforward. Deuterium concentration in drinking water decreases with distance from the ocean — inland, high-altitude water is naturally more deuterium-depleted. If geography determines deuterium load, and deuterium load correlates with disease prevalence, then what happens when you deliberately give animals water at the low end of that natural range? What her lab found is striking. They used 90 ppm deuterium-depleted water throughout — the lowest deuterium concentration found naturally in drinking water on Earth. Not a pharmaceutical dose. Not exotic laboratory depletion. And compared it to control mice drinking 140 ppm water. The difference between antarctic meltwater and coastal tap water. Finding 1: Aged mice. Two weeks. Depressive-like behaviors measurably reduced They took 18-month-old mice — equivalent to very old age, approaching maximum mouse lifespan. These mice displayed measurable depressive behaviors: Anhedonia — loss of sensitivity to reward, measured by reduced preference for sweet water. Increased helplessness behavior. Reduced novelty exploration. Impaired hippocampus-dependent memory. After two weeks on 90 ppm DDW? Sucrose preference increased — anhedonia reversed. Helplessness behavior significantly reduced. Novelty exploration improved. Hippocampal memory improved. Two weeks. Naturally occurring low-deuterium water. Measurable reversal across four independent behavioral markers. Finding 2: DDW matched antidepressant effect in stressed young mice They used a chronic stress model in young mice — predator scent, restraint stress, tail suspension. This reliably induces anhedonia in susceptible mice. Then they divided mice into three groups: normal water at 140 ppm, DDW at 90 ppm, and citalopram — a standard SSRI antidepressant. DDW produced rescue of sucrose preference comparable to citalopram. Helplessness behavior was also rescued comparably. Serotonin transporter expression — one of the key molecular targets of SSRIs — was rescued by both citalopram and DDW. This is mouse data. Direct translation to humans requires clinical trials. But the mechanism convergence is a legitimate finding. Finding 3: DDW normalized REM sleep in stressed mice Depression is the only psychiatric disorder diagnosable by a specific sleep architecture change — increased REM sleep. It's a biological marker, not a subjective report. Stressed mice showed increased REM sleep — the biological depression signature. DDW normalized REM sleep. Slow-wave sleep and wakefulness also improved. Finding 4: DDW protected against western diet-induced cognitive impairment and glucose dysregulation They used 12-month-old female mice on a standardized western diet — high saturated fat, high sugar, high cholesterol. Western diet produced: impaired glucose tolerance, brain inflammation, reduced mitochondrial markers in brain and liver, liver steatosis — fat accumulation in the liver — impaired object recognition memory, and impaired hippocampal memory. DDW at 90 ppm on western diet: Prevented glucose tolerance impairment despite continued western diet. Improved object recognition memory. Improved hippocampal memory in old mice. Did not improve liver steatosis. The liver finding matters. DDW protected the brain and metabolic glucose handling but did not reverse the liver damage. Strekalova’s interpretation: DDW is counteracting brain inflammation driven by damage elsewhere in the body — not fixing the damage itself. Finding 5: Deuterium-enriched water (180 ppm) did the opposite They tested the reverse — 180 ppm water, equivalent to what you would find in evaporative pools in the Sahara. Results on aged mice with western diet: Novelty exploration clearly suppressed. Hippocampus-dependent memory suppressed. Strekalova describes this as a surprise finding. 90 ppm sits at the low end of natural drinking water on Earth. 180 ppm sits at the high end of what occurs in extreme arid environments. The difference between them produced measurable opposing effects on memory and cognition in aged mice. Gene expression — deuterium sits upstream of circadian biology In both the aging model and the stress model, DDW altered gene expression in the hippocampus and prefrontal cortex. Affected categories: DNA repair, oxidative stress response, immune regulation, mitochondrial function, cellular plasticity, aging-related genes. And one finding that connects directly to everything else: Per2. Per2 is a core circadian clock gene. DDW affecting its expression means deuterium content influences circadian biology at the gene level. Deuterium doesn't just affect cancer cells and mitochondrial efficiency. It sits upstream of the circadian system. The implication The deuterium content of your water varies by geography. Antarctic water versus coastal tap water. The difference is measurable. The biological effects in these models are measurable and opposing. Most people optimizing their health are tracking sleep, sunlight, training, and nutrition. Nobody told them deuterium was also on the list.

no.mind

17,344 görüntüleme • 3 ay önce

Thymulin is a peptide made by the thymus, and it falls to undetectable levels as you age. Fumito Ito's group at USC joined old and young mice in shared circulation, saw inflammation in the old animals drop to young levels, and traced the effect back to thymulin. Giving it back to aged mice slowed tumors and made anti-PD-L1 work in animals that had shown no response at all. Giving it to young mice did almost nothing, which means this is restoration of a signal that was lost rather than a boost on top of a healthy one. We work the same axis in patients by bringing IL-1 and TGF beta down, and thymulin rises when you do that.

Thymulin is a peptide made by the thymus, and it falls to undetectable levels as you age. Fumito Ito's group at USC joined old and young mice in shared circulation, saw inflammation in the old animals drop to young levels, and traced the effect back to thymulin. Giving it back to aged mice slowed tumors and made anti-PD-L1 work in animals that had shown no response at all. Giving it to young mice did almost nothing, which means this is restoration of a signal that was lost rather than a boost on top of a healthy one. We work the same axis in patients by bringing IL-1 and TGF beta down, and thymulin rises when you do that.

Jason R. Williams, MD, DABR

13,274 görüntüleme • 2 ay önce

They studied 81 identical twins. Same DNA. Same childhood. Same parents. Only ONE twin got Multiple Sclerosis. Then they found the difference hiding in their poop. Two completely normal gut bacteria — Eisenbergiella tayi & Lachnoclostridium — were SKY-HIGH in every single twin with MS… and almost absent in their healthy twin. Scientists then took those exact bacteria from the sick twins and transplanted them into mice. Result: • 60–70% of mice developed brain & spinal cord inflammation + paralysis • <10% of control mice got sick • In many cases, the bacteria exploded in numbers DAYS before the first symptoms • Female mice were hit hardest (just like real MS) This is the strongest evidence ever that MS — for a huge number of patients — may actually start in the gut. A second international study with 1,000+ people just confirmed the same two bacteria. Full 1:40 mind-blowing breakdown in the video 👇

They studied 81 identical twins. Same DNA. Same childhood. Same parents. Only ONE twin got Multiple Sclerosis. Then they found the difference hiding in their poop. Two completely normal gut bacteria — Eisenbergiella tayi & Lachnoclostridium — were SKY-HIGH in every single twin with MS… and almost absent in their healthy twin. Scientists then took those exact bacteria from the sick twins and transplanted them into mice. Result: • 60–70% of mice developed brain & spinal cord inflammation + paralysis • <10% of control mice got sick • In many cases, the bacteria exploded in numbers DAYS before the first symptoms • Female mice were hit hardest (just like real MS) This is the strongest evidence ever that MS — for a huge number of patients — may actually start in the gut. A second international study with 1,000+ people just confirmed the same two bacteria. Full 1:40 mind-blowing breakdown in the video 👇

Camus

129,234 görüntüleme • 10 ay önce

PL network team World (World) scaled globally in 2025, launching new credentials, expanding to 20+ countries, and operating multiple privacy-preserving compute nodes. Performance improved, costs dropped, and resilience increased, with broader expansion planned through 2026.

PL network team World (World) scaled globally in 2025, launching new credentials, expanding to 20+ countries, and operating multiple privacy-preserving compute nodes. Performance improved, costs dropped, and resilience increased, with broader expansion planned through 2026.

Protocol Labs

367,857 görüntüleme • 8 ay önce

NAD⁺ declines in skeletal muscle with age, and that decline tracks with metabolic and functional deterioration. Studies show that older adults also have lower NAD⁺ levels in key organs including the brain, liver, and skin, even when circulating NAD⁺ appears relatively stable. Aging occurs at different rates in different organs and the NAD⁺ biology reflects that. The encouraging part is that older adults who are physically active maintain muscle NAD⁺ levels comparable to younger individuals. Exercise protects the NAD⁺ system by improving mitochondrial turnover, reducing chronic inflammation, and stimulating NAD⁺ biosynthesis. Charles Brenner, PhD explains that, across many conditions (including aging), inflammation is a common theme. Chronic inflammation increases NAD⁺ consumption, effectively placing the NAD⁺ system “under attack.” Aging and many lifestyle-related diseases may, in part, reflect this persistent metabolic stress, and it's why exercise, weight loss, and a micronutrient-rich diet (all of which reduce chronic inflammation) can support healthy NAD levels.

NAD⁺ declines in skeletal muscle with age, and that decline tracks with metabolic and functional deterioration. Studies show that older adults also have lower NAD⁺ levels in key organs including the brain, liver, and skin, even when circulating NAD⁺ appears relatively stable. Aging occurs at different rates in different organs and the NAD⁺ biology reflects that. The encouraging part is that older adults who are physically active maintain muscle NAD⁺ levels comparable to younger individuals. Exercise protects the NAD⁺ system by improving mitochondrial turnover, reducing chronic inflammation, and stimulating NAD⁺ biosynthesis. Charles Brenner, PhD explains that, across many conditions (including aging), inflammation is a common theme. Chronic inflammation increases NAD⁺ consumption, effectively placing the NAD⁺ system “under attack.” Aging and many lifestyle-related diseases may, in part, reflect this persistent metabolic stress, and it's why exercise, weight loss, and a micronutrient-rich diet (all of which reduce chronic inflammation) can support healthy NAD levels.

Dr. Rhonda Patrick

30,299 görüntüleme • 7 ay önce

There is now converging evidence in animals and humans that omega-3 fatty acids are at the least anti-catabolic and, likely, anabolic. They seem to do this by shifting the balance away from breakdown and more towards muscle building, particularly in the context of anabolic resistance. Animal studies show omega-3 fatty acids augment muscle development: Steers fed omega-3s showed improved amino acid efficiency and activated pathways involved in muscle growth. Similarly, pigs given a high omega-3 diet exhibited larger muscles and markers of improved amino acid absorption and use. But more importantly, we have human evidence: • In one study, young women taking 5 grams of omega-3s per day cut their muscle loss almost in half and increased muscle protein synthesis after two weeks of leg immobilization. • In another study, older adults consuming 3.36 grams of omega-3s daily for two months had an increase in muscle protein synthesis in the presence of amino acids and insulin. • Yet another study found that healthy older adults taking 4 grams of omega-3s daily for half a year increased various measures of muscle size and strength. • Still another study, older adults who consumed 4 grams of krill oil daily for six months improved knee strength, grip strength, thigh muscle thickness, and measures of muscle nerve response. There are still open questions. For example, a consistent theme is that many of the studies are high dose at 4 and 5 grams per day - does that imply that these effects in muscle only happen at high dosages? Another question we might ask is, in what context is omega-3 more anabolic - for example, in old age? During immobilization? When protein intake is sub-optimal for muscle building? (It often is for many of us.) Listen to my recent podcast guest Dr. Chris McGlory for more discussion of this fascinating new emerging field. Show notes and transcript for this episode here:

There is now converging evidence in animals and humans that omega-3 fatty acids are at the least anti-catabolic and, likely, anabolic. They seem to do this by shifting the balance away from breakdown and more towards muscle building, particularly in the context of anabolic resistance. Animal studies show omega-3 fatty acids augment muscle development: Steers fed omega-3s showed improved amino acid efficiency and activated pathways involved in muscle growth. Similarly, pigs given a high omega-3 diet exhibited larger muscles and markers of improved amino acid absorption and use. But more importantly, we have human evidence: • In one study, young women taking 5 grams of omega-3s per day cut their muscle loss almost in half and increased muscle protein synthesis after two weeks of leg immobilization. • In another study, older adults consuming 3.36 grams of omega-3s daily for two months had an increase in muscle protein synthesis in the presence of amino acids and insulin. • Yet another study found that healthy older adults taking 4 grams of omega-3s daily for half a year increased various measures of muscle size and strength. • Still another study, older adults who consumed 4 grams of krill oil daily for six months improved knee strength, grip strength, thigh muscle thickness, and measures of muscle nerve response. There are still open questions. For example, a consistent theme is that many of the studies are high dose at 4 and 5 grams per day - does that imply that these effects in muscle only happen at high dosages? Another question we might ask is, in what context is omega-3 more anabolic - for example, in old age? During immobilization? When protein intake is sub-optimal for muscle building? (It often is for many of us.) Listen to my recent podcast guest Dr. Chris McGlory for more discussion of this fascinating new emerging field. Show notes and transcript for this episode here:

Dr. Rhonda Patrick

190,965 görüntüleme • 3 yıl önce

The first human age-reversal trial is officially happening. But before the FDA cleared it, Harvard professor David Sinclair had to pull off a mice experiment most scientists thought was impossible: "These mice had their optic nerve regenerated. We were able to show that using [the information theory of aging] method we could cure blindness in animal for the first time." Since then, he also discovered you could treat and reverse diseases like Alzheimer's, multiple sclerosis, ALS, kidney disease and liver disease in mice too: “It's not just the eye that can get reversed and cured of diseases. It's seemingly every part of the body.” It's what he calls "a universal reset of the body." He confirmed his method also worked in monkeys. Now humans are next. The FDA just cleared the first age-reversal trial. Life Biosciences raised $80 million to make it happen. As he put it: "The eye is just the beginning. We believe we can treat every tissue—a whole body reset."

The first human age-reversal trial is officially happening. But before the FDA cleared it, Harvard professor David Sinclair had to pull off a mice experiment most scientists thought was impossible: "These mice had their optic nerve regenerated. We were able to show that using [the information theory of aging] method we could cure blindness in animal for the first time." Since then, he also discovered you could treat and reverse diseases like Alzheimer's, multiple sclerosis, ALS, kidney disease and liver disease in mice too: “It's not just the eye that can get reversed and cured of diseases. It's seemingly every part of the body.” It's what he calls "a universal reset of the body." He confirmed his method also worked in monkeys. Now humans are next. The FDA just cleared the first age-reversal trial. Life Biosciences raised $80 million to make it happen. As he put it: "The eye is just the beginning. We believe we can treat every tissue—a whole body reset."

John Cumbers

1,163,043 görüntüleme • 6 ay önce

Jordan Peterson lost 50 pounds (22.7 kg) on carnivore and reversed decades of health issues. In 2018 on Joe Rogan he revealed he eliminated psoriasis, gum disease, snoring, reflux, anxiety, depression, and more, just by eating mostly beef, salt, and water. He now wakes up clear-headed, needs less sleep, and feels better than he has in decades. He has largely stuck with a meat-heavy/low-carb approach since (last detailed public comments were a few years ago), with occasional updates from him and daughter Mikhaila. Chronic inflammation (inflammaging) is a major driver of muscle loss, arthritis progression, and reduced recovery as we age. Lowering systemic inflammation has been shown in multiple studies to improve muscle function, joint health, and physical performance even in older adults.

Jordan Peterson lost 50 pounds (22.7 kg) on carnivore and reversed decades of health issues. In 2018 on Joe Rogan he revealed he eliminated psoriasis, gum disease, snoring, reflux, anxiety, depression, and more, just by eating mostly beef, salt, and water. He now wakes up clear-headed, needs less sleep, and feels better than he has in decades. He has largely stuck with a meat-heavy/low-carb approach since (last detailed public comments were a few years ago), with occasional updates from him and daughter Mikhaila. Chronic inflammation (inflammaging) is a major driver of muscle loss, arthritis progression, and reduced recovery as we age. Lowering systemic inflammation has been shown in multiple studies to improve muscle function, joint health, and physical performance even in older adults.

Camus

109,094 görüntüleme • 3 ay önce

Abdominal wall pain: differential diagnosis A 28-year-old soccer player presented with right periumbilical pain of 2 months' duration. An MRI was performed, which showed no abnormalities in the abdominal wall. He was diagnosed with anterior cutaneous nerve entrapment syndrome (ACNES), and perineural injection was performed, with no improvement in symptoms. He came to the clinic for a second opinion, presenting with tenderness on palpation of the middle third of the rectus abdominis muscle, which increased with trunk resistance flexion. The pain decreased after this test was performed after muscle inhibition. An ultrasound assessment was completed, revealing no abnormalities in the discomfort, but evidence of increased thickness and decreased echogenicity of the tendon at its origin in the pubic ramus, associated with significant pain on sonopalpation, related to tendinosis. An evaluation was completed with a thoracic spine examination, revealing significant pain at the level of the spinous process of T8 (the rectus abdominis muscle is innervated by the T7-T12 thoracoabdominal nerves). It was decided to treat the patient with ultrasound-guided injections around the rectus abdominis tendon with 1 cc of triamcinolone and 1 cc of 2% lidocaine, and periradicular injections of the right T8 muscle with 2 cc of betamethasone and 1 cc of 2% lidocaine. The symptoms resolved immediately, and the patient did not reappear during the following two months of follow-up.

Abdominal wall pain: differential diagnosis A 28-year-old soccer player presented with right periumbilical pain of 2 months' duration. An MRI was performed, which showed no abnormalities in the abdominal wall. He was diagnosed with anterior cutaneous nerve entrapment syndrome (ACNES), and perineural injection was performed, with no improvement in symptoms. He came to the clinic for a second opinion, presenting with tenderness on palpation of the middle third of the rectus abdominis muscle, which increased with trunk resistance flexion. The pain decreased after this test was performed after muscle inhibition. An ultrasound assessment was completed, revealing no abnormalities in the discomfort, but evidence of increased thickness and decreased echogenicity of the tendon at its origin in the pubic ramus, associated with significant pain on sonopalpation, related to tendinosis. An evaluation was completed with a thoracic spine examination, revealing significant pain at the level of the spinous process of T8 (the rectus abdominis muscle is innervated by the T7-T12 thoracoabdominal nerves). It was decided to treat the patient with ultrasound-guided injections around the rectus abdominis tendon with 1 cc of triamcinolone and 1 cc of 2% lidocaine, and periradicular injections of the right T8 muscle with 2 cc of betamethasone and 1 cc of 2% lidocaine. The symptoms resolved immediately, and the patient did not reappear during the following two months of follow-up.

sergio serrano belmar

19,017 görüntüleme • 1 yıl önce

YOU ALL GONNA BE EXCITED WITH THIS ONE, YOU CAN NOW GET A RELIABLE source of PEPTIDES FROM MYSELF FOLLOW SUPREME PEPTIDES AND WATCH THIS GROW, PEOPLE KNOW THEY CAN TRUST ME. BENEFITS BELOW ⬇️ Peptides are short chains of amino acids that act as signaling molecules in the body. Different peptides have very different effects, so the benefits depend entirely on which peptide you’re referring to. Here are some of the most commonly discussed peptide categories and their potential benefits: Healing and Recovery * BPC-157 – Often promoted for tendon, ligament, muscle, and gut healing. * TB-500 (Thymosin Beta-4 fragment) – May support tissue repair and reduce recovery time after injury. * Potential benefits: * Faster recovery from injuries * Improved wound healing * Reduced inflammation (evidence in humans is limited) Muscle Growth and Performance * CJC-1295 and Ipamorelin – Stimulate the body’s release of growth hormone. * Potential benefits: * Increased lean muscle mass * Better recovery after exercise * Improved sleep * Possible reduction in body fat Weight Loss * Tirzepatide and Semaglutide * Potential benefits: * Reduced appetite * Significant weight loss * Improved blood sugar control in people with diabetes Skin and Anti-Ageing * GHK-Cu (Copper Peptide) * Potential benefits: * Improved skin elasticity * Reduced appearance of fine lines * May promote hair growth * Supports wound healing Sexual Health * PT-141 (Bremelanotide) * Potential benefits: * Increased sexual desire in some people * Used for certain forms of low sexual desire Immune Function * Thymosin Alpha-1 * Potential benefits: * Supports immune system function * Studied in certain infections and cancers Are peptides safe? It depends on the peptide and how it’s used.

YOU ALL GONNA BE EXCITED WITH THIS ONE, YOU CAN NOW GET A RELIABLE source of PEPTIDES FROM MYSELF FOLLOW SUPREME PEPTIDES AND WATCH THIS GROW, PEOPLE KNOW THEY CAN TRUST ME. BENEFITS BELOW ⬇️ Peptides are short chains of amino acids that act as signaling molecules in the body. Different peptides have very different effects, so the benefits depend entirely on which peptide you’re referring to. Here are some of the most commonly discussed peptide categories and their potential benefits: Healing and Recovery * BPC-157 – Often promoted for tendon, ligament, muscle, and gut healing. * TB-500 (Thymosin Beta-4 fragment) – May support tissue repair and reduce recovery time after injury. * Potential benefits: * Faster recovery from injuries * Improved wound healing * Reduced inflammation (evidence in humans is limited) Muscle Growth and Performance * CJC-1295 and Ipamorelin – Stimulate the body’s release of growth hormone. * Potential benefits: * Increased lean muscle mass * Better recovery after exercise * Improved sleep * Possible reduction in body fat Weight Loss * Tirzepatide and Semaglutide * Potential benefits: * Reduced appetite * Significant weight loss * Improved blood sugar control in people with diabetes Skin and Anti-Ageing * GHK-Cu (Copper Peptide) * Potential benefits: * Improved skin elasticity * Reduced appearance of fine lines * May promote hair growth * Supports wound healing Sexual Health * PT-141 (Bremelanotide) * Potential benefits: * Increased sexual desire in some people * Used for certain forms of low sexual desire Immune Function * Thymosin Alpha-1 * Potential benefits: * Supports immune system function * Studied in certain infections and cancers Are peptides safe? It depends on the peptide and how it’s used.

Anthony Fowler

28,226 görüntüleme • 3 ay önce

CHECK out YOU ALL GONNA BE EXCITED WITH THIS ONE, YOU CAN NOW GET A RELIABLE source of PEPTIDES FROM MYSELF FOLLOW SUPREME PEPTIDES AND WATCH THIS GROW, PEOPLE KNOW THEY CAN TRUST ME. BENEFITS BELOW ⬇️ all p Peptides are short chains of amino acids that act as signaling molecules in the body. Different peptides have very different effects, so the benefits depend entirely on which peptide you’re referring to. Here are some of the most commonly discussed peptide categories and their potential benefits: Healing and Recovery * BPC-157 – Often promoted for tendon, ligament, muscle, and gut healing. * TB-500 (Thymosin Beta-4 fragment) – May support tissue repair and reduce recovery time after injury. * Potential benefits: * Faster recovery from injuries * Improved wound healing * Reduced inflammation (evidence in humans is limited) Muscle Growth and Performance * CJC-1295 and Ipamorelin – Stimulate the body’s release of growth hormone. * Potential benefits: * Increased lean muscle mass * Better recovery after exercise * Improved sleep * Possible reduction in body fat Weight Loss * Tirzepatide and Semaglutide * Potential benefits: * Reduced appetite * Significant weight loss * Improved blood sugar control in people with diabetes Skin and Anti-Ageing * GHK-Cu (Copper Peptide) * Potential benefits: * Improved skin elasticity * Reduced appearance of fine lines * May promote hair growth * Supports wound healing Sexual Health * PT-141 (Bremelanotide) * Potential benefits: * Increased sexual desire in some people * Used for certain forms of low sexual desire Immune Function * Thymosin Alpha-1 * Potential benefits: * Supports immune system function * Studied in certain infections and cancers All here

CHECK out YOU ALL GONNA BE EXCITED WITH THIS ONE, YOU CAN NOW GET A RELIABLE source of PEPTIDES FROM MYSELF FOLLOW SUPREME PEPTIDES AND WATCH THIS GROW, PEOPLE KNOW THEY CAN TRUST ME. BENEFITS BELOW ⬇️ all p Peptides are short chains of amino acids that act as signaling molecules in the body. Different peptides have very different effects, so the benefits depend entirely on which peptide you’re referring to. Here are some of the most commonly discussed peptide categories and their potential benefits: Healing and Recovery * BPC-157 – Often promoted for tendon, ligament, muscle, and gut healing. * TB-500 (Thymosin Beta-4 fragment) – May support tissue repair and reduce recovery time after injury. * Potential benefits: * Faster recovery from injuries * Improved wound healing * Reduced inflammation (evidence in humans is limited) Muscle Growth and Performance * CJC-1295 and Ipamorelin – Stimulate the body’s release of growth hormone. * Potential benefits: * Increased lean muscle mass * Better recovery after exercise * Improved sleep * Possible reduction in body fat Weight Loss * Tirzepatide and Semaglutide * Potential benefits: * Reduced appetite * Significant weight loss * Improved blood sugar control in people with diabetes Skin and Anti-Ageing * GHK-Cu (Copper Peptide) * Potential benefits: * Improved skin elasticity * Reduced appearance of fine lines * May promote hair growth * Supports wound healing Sexual Health * PT-141 (Bremelanotide) * Potential benefits: * Increased sexual desire in some people * Used for certain forms of low sexual desire Immune Function * Thymosin Alpha-1 * Potential benefits: * Supports immune system function * Studied in certain infections and cancers All here

Anthony Fowler

159,094 görüntüleme • 2 ay önce

Nano-Curcumin ELIMINATES Cyclospora Infection in Mice—the Parasite Behind the “Explosive Diarrhea” Outbreak Across 31 States Just 7 daily doses of nano-curcumin cut Cyclospora shedding by 97.2%, ELIMINATED detectable parasites, RESTORED damaged tissue, AND prevented relapse. A recent animal study experimentally infected mice with Cyclospora, then compared 7-day courses of nano-curcumin, regular curcumin, Bactrim/TMP-SMX, and no treatment. At day 30—more than two weeks after treatment ended—parasite shedding was reduced by: 📉Nano-curcumin: -97.2% 📉Regular curcumin: -93.5% 📉Bactrim: -79.4% ⚠️Untreated control: persistent and increasing shedding Nano-curcumin produced the lowest parasite burden, the greatest restoration of intestinal villi, no detectable parasites in intestinal tissue, and no recurrence after withdrawal. Regular curcumin was also remarkably effective. It reduced shedding by 93.5%, substantially restored damaged intestinal tissue, and left no parasites detectable by H&E staining at day 30—although low-level stool shedding remained. Bactrim improved the infection, but parasite excretion increased again after treatment stopped, indicating relapse. All three treatments significantly reduced shedding compared with untreated mice. Human trials are urgently needed.

Nano-Curcumin ELIMINATES Cyclospora Infection in Mice—the Parasite Behind the “Explosive Diarrhea” Outbreak Across 31 States Just 7 daily doses of nano-curcumin cut Cyclospora shedding by 97.2%, ELIMINATED detectable parasites, RESTORED damaged tissue, AND prevented relapse. A recent animal study experimentally infected mice with Cyclospora, then compared 7-day courses of nano-curcumin, regular curcumin, Bactrim/TMP-SMX, and no treatment. At day 30—more than two weeks after treatment ended—parasite shedding was reduced by: 📉Nano-curcumin: -97.2% 📉Regular curcumin: -93.5% 📉Bactrim: -79.4% ⚠️Untreated control: persistent and increasing shedding Nano-curcumin produced the lowest parasite burden, the greatest restoration of intestinal villi, no detectable parasites in intestinal tissue, and no recurrence after withdrawal. Regular curcumin was also remarkably effective. It reduced shedding by 93.5%, substantially restored damaged intestinal tissue, and left no parasites detectable by H&E staining at day 30—although low-level stool shedding remained. Bactrim improved the infection, but parasite excretion increased again after treatment stopped, indicating relapse. All three treatments significantly reduced shedding compared with untreated mice. Human trials are urgently needed.

Nicolas Hulscher, MPH

121,823 görüntüleme • 2 ay önce

BREAKING: Study finds 10g of creatine per day added 2.4 POUNDS of lean mass in 12 weeks WITHOUT EXERCISE. Creatine ALONE also improved: - Muscular strength - Muscular endurance - Cognitive processing speed - Delayed memory recall - Episodic memory - HbA1c - Triglycerides - HDL cholesterol - VLDL cholesterol Combining creatine WITH EXERCISE produced even greater physical gains and additional improvements in memory and cognitive processing. Some of the increase in lean mass may reflect increased intracellular water from creatine, not solely new muscle tissue. Importantly, this was a gold-standard study design: a randomized, double-blind, placebo-controlled trial.

BREAKING: Study finds 10g of creatine per day added 2.4 POUNDS of lean mass in 12 weeks WITHOUT EXERCISE. Creatine ALONE also improved: - Muscular strength - Muscular endurance - Cognitive processing speed - Delayed memory recall - Episodic memory - HbA1c - Triglycerides - HDL cholesterol - VLDL cholesterol Combining creatine WITH EXERCISE produced even greater physical gains and additional improvements in memory and cognitive processing. Some of the increase in lean mass may reflect increased intracellular water from creatine, not solely new muscle tissue. Importantly, this was a gold-standard study design: a randomized, double-blind, placebo-controlled trial.

Nicolas Hulscher, MPH

514,741 görüntüleme • 5 gün önce

Supplementing with protein during strength training can increase gains in muscle size by approximately 27%, even when baseline protein intake is already considered adequate. The current RDA for protein, 0.8 grams per kilogram of body weight per day, is meant to prevent deficiency, not to optimize muscle growth or performance. Increasing intake to 1.5x the RDA leads to greater improvements in both muscle size and strength when combined with resistance exercise. Doubling the RDA is even better. Meta-analyses suggest that around 1.6 g/kg/day of protein is sufficient to maximize gains in muscle strength and fat-free mass, with potential (though smaller) benefits observed at higher intakes up to 2.2 g/kg/day for those aiming to fully optimize muscle growth and recovery (like athletes). This highlights how conservative the RDA truly is and why higher protein intakes are important, particularly for individuals engaging in regular strength training or other forms of physical activity.

Supplementing with protein during strength training can increase gains in muscle size by approximately 27%, even when baseline protein intake is already considered adequate. The current RDA for protein, 0.8 grams per kilogram of body weight per day, is meant to prevent deficiency, not to optimize muscle growth or performance. Increasing intake to 1.5x the RDA leads to greater improvements in both muscle size and strength when combined with resistance exercise. Doubling the RDA is even better. Meta-analyses suggest that around 1.6 g/kg/day of protein is sufficient to maximize gains in muscle strength and fat-free mass, with potential (though smaller) benefits observed at higher intakes up to 2.2 g/kg/day for those aiming to fully optimize muscle growth and recovery (like athletes). This highlights how conservative the RDA truly is and why higher protein intakes are important, particularly for individuals engaging in regular strength training or other forms of physical activity.

Dr. Rhonda Patrick

92,581 görüntüleme • 11 ay önce

Congrats to EloShapes.com on their launch! On a similar note, is out of beta and available to the public. A lot of you have been asking me what my plan is now that EloShapes is also doing 3D scans... the answer is: nothing changed! I think that competition is good. I'm a mouse nerd and a LONG TIME EloShapes user, so the more options I get as a user, the better. I really think that my vision and EloShapes, though, is fundamentally different. I've had the domain for FMM for years, I have a much larger platform in mind compared to what I built so far. The 3D scans are the necessary step for my vision, not the end goal: they never were. I am also very proud of the fact that I've been able to scan at least 5 mice in full color EVERY DAY with my own pipeline, and I think I will easily have almost full coverage of the mice people would want on the website within months. Check the video for the mice I've added in just the last few days, all textured. Apart from some of the features I've mentioned before (like the virtual hand/grip), FMM is meant to be kind of a "MyAnimeList" for mice, so that you can share your profile, like this: and then later on leverage this curated list of mice you build for yourself to be shown even more mice you might like. FMM is also a tool for reviewers and anyone that wants to share their opinions on mice. Links like this: allow you to easily share your specific points about a mouse via the annotations, viewpoint sharing and measurements. And of course, as I've said since the beginning, I will use FMM to centralize all my hard testing about sensors, dpi, and such, so that you'll be able to find EVERYTHING about a mouse, including the raw results of my standardized sensor implementation testing. So, with this said, I will keep scanning as many mice as possible and adding as many features as possible until FMM becomes what I envisioned so long ago. Join my discord if you want to keep up! I hope you'll all give it a try! Ciao!

bardOZ (Giovanni Laerte Frongia)

26,159 görüntüleme • 5 ay önce

Dr. David Sinclair, a Harvard aging researcher, tested his own biological age and got a number that terrified him. At 48, his blood test came back reading 58. Ten years older than he actually was. He started metformin first. His age barely moved, down to 56. Then he began taking an NAD-boosting molecule his lab had been testing in mice, the same one that reversed mitochondrial aging in old animals within a week. Months later, he retested. His biological age had dropped to 31.4. He wasn't just younger than before. He was younger than his real age by nearly two decades. His nurse called his latest labs "better than perfect." — Dr. David Sinclair on Dr. Mark Hyman's (@markhymanmd) podcast

Dr. David Sinclair, a Harvard aging researcher, tested his own biological age and got a number that terrified him. At 48, his blood test came back reading 58. Ten years older than he actually was. He started metformin first. His age barely moved, down to 56. Then he began taking an NAD-boosting molecule his lab had been testing in mice, the same one that reversed mitochondrial aging in old animals within a week. Months later, he retested. His biological age had dropped to 31.4. He wasn't just younger than before. He was younger than his real age by nearly two decades. His nurse called his latest labs "better than perfect." — Dr. David Sinclair on Dr. Mark Hyman's (@markhymanmd) podcast

Longevity

45,035 görüntüleme • 1 ay önce