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Select your cell: I'm prototyping an interactive sc RNA-seq portal where the UMAP is dynamically linked to morphing 3D artistic renders of each cell type. You can play with the initial build below.

51,281 Aufrufe • vor 1 Jahr •via X (Twitter)

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Evolution says you can turn anything into anything if you tweak it long enough. But that house of cards collapses immediately when you realize what it takes to make even a single cell. They say new cell types arise one mutation at a time. Is that plausible? Here is the issue: Different cell types are created through a massive coordinated stack of genetic information, and it's not all just about DNA sequences. First you need a whole suite of new genetic systems related to the cell: new genes for the cell’s internal systems, instructions for its specific functional role in the body, the regulators that coordinate everything, markers to tell them where to go and when, and the controls that keep the wrong programs off. But the DNA structure itself must also be manipulated. You see, every cell in your body contains the DNA instructions to make any other cell. So how does a bone cell become a bone cell instead of a skin cell? Because of how the DNA is folded. DNA is folded in certain ways for different cell types, so that only the "bone cell instructions" are able to be read by the "cell construction program." The DNA fold decides which programs are open for each cell type. This is critical. If DNA is not folded properly so that specific cell-type information can be read, catastrophe ensues. Then you need placement blueprints, so the cells form in the right place, in the right number, and lock together to form a functional tissue. These developmental instructions are passed from parent to offspring - but research shows that tweaking these master developmental programs ends badly for the child. One mutation at a time cannot invent that entire programming stack and keep it coordinated. Research has confirmed this. To convert one cell type into another in the lab, researchers have to force many changes to happen at the same time in coordination. And even when directed by the researcher, cell conversion almost always fails. Change the sequence without the fold and you cannot get a new cell type. Fold the DNA without the new systems and you can only rearrange old programs. Make the cell without the map and it shows up in the wrong place. Break one layer in the stack and the others do not patiently wait - they fail. So creating a new cell type is not simply "tweak a gene one at a time." It requires a coordinated stack of entirely new programmed instructions: > New suite of internal systems, programmed into the DNA > New functional DNA fold so only the right systems are activated > New mapping blueprints so everything goes where it's needed Step-by-step mutation does not coordinate those layers. It produces broken cells before it produces new ones. Coordination of this level of complexity has only ever been known to come from one place: Intelligence.

Divinely Designed

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