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The evolutionary argument against eating seed oils | Layne Norton, Ph.D. (Layne Norton, PhD) This clip is from episode # 380 of The Drive which was released on 1/19/26. In the full episode, we cover: -The core arguments against seed oils: the four main claims underlying the idea that... seed oils are uniquely harmful, and how well they hold up once major confounders are addressed -The historical trials that shaped the debate: the Minnesota Coronary Experiment, Sydney Diet Heart Study, Rose Corn Oil trial, and later studies replacing saturated fat with polyunsaturated fat -Mechanisms and causality: LDL cholesterol, oxidized LDL, linoleic acid (omega-6), inflammation, -Mendelian randomization, and why lifetime LDL exposure matters more than per-particle oxidation risk -Practical takeaways: industrial processing concerns, cooking oils, real-world dietary fat choices, and how to prioritize nutrition relative to calories, activity, and overall lifestyle factors Listen (Ep. # 380) to the full episode on my website ( or your favorite podcast player.show more

Peter Attia

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Why ingredient changes don’t always mean healthier food | Layne Norton, Ph.D. (Layne Norton, PhD) This clip is from episode # 380 of The Drive which was released on 1/19/26. In the full episode, we cover: -The core arguments against seed oils: the four main claims underlying the idea that seed oils are uniquely harmful, and how well they hold up once major confounders are addressed -The historical trials that shaped the debate: the Minnesota Coronary Experiment, Sydney Diet Heart Study, Rose Corn Oil trial, and later studies replacing saturated fat with polyunsaturated fat -Mechanisms and causality: LDL cholesterol, oxidized LDL, linoleic acid (omega-6), inflammation, -Mendelian randomization, and why lifetime LDL exposure matters more than per-particle oxidation risk -Practical takeaways: industrial processing concerns, cooking oils, real-world dietary fat choices, and how to prioritize nutrition relative to calories, activity, and overall lifestyle factors Listen (Ep. # 380) to the full episode on my website ( or your favorite podcast player.

Why ingredient changes don’t always mean healthier food | Layne Norton, Ph.D. (Layne Norton, PhD) This clip is from episode # 380 of The Drive which was released on 1/19/26. In the full episode, we cover: -The core arguments against seed oils: the four main claims underlying the idea that seed oils are uniquely harmful, and how well they hold up once major confounders are addressed -The historical trials that shaped the debate: the Minnesota Coronary Experiment, Sydney Diet Heart Study, Rose Corn Oil trial, and later studies replacing saturated fat with polyunsaturated fat -Mechanisms and causality: LDL cholesterol, oxidized LDL, linoleic acid (omega-6), inflammation, -Mendelian randomization, and why lifetime LDL exposure matters more than per-particle oxidation risk -Practical takeaways: industrial processing concerns, cooking oils, real-world dietary fat choices, and how to prioritize nutrition relative to calories, activity, and overall lifestyle factors Listen (Ep. # 380) to the full episode on my website ( or your favorite podcast player.

Peter Attia

87,211 views • 6 months ago

There are a variety of ways that seed oils either contribute detrimentally to health directly or, at least, serve as a marker for unhealthy dietary patterns. But is it for the reasons that some claim? In my recent episode with Dr. Layne Norton (Layne Norton, PhD), he points out that if we're going to claim that seed oils are uniquely harmful, we need to apply that same logic symmetrically to saturated fat. Because the evidence against saturated fat is stronger. Since there are pretty strong feelings about seed oils, let's take a step back. As a champion powerlifter who eats a very high protein diet (by all reports), Layne is neither anti-meat nor likely a high consumer of seed oils. In fact, given his track record during his Ph.D. (including meat industry funding), his biases lean the other way. Good science, though, demands that we follow the facts, even if they tarnish an otherwise elegant mechanistic explanation. And the problem is that the view of seed oils as a primary culprit of modern chronic disease actually oversimplifies its complex, multi-factorial origin... and may even be a type of blame shifting. In the following clip: We also get into why it is probably still prudent to be careful about seed oils when it comes to situations where there is high heat and reheating. And even why a healthy diet ultimately does limit the intake of seed oils overall [e.g. fewer processed hyper-palatable foods, fried foods], but this is mostly a result of adhering to other, more useful dietary frameworks. Find the longer conversation with Dr. Layne Norton, including more of the nuance on seed oils, on Apple Podcasts, Spotify, and YouTube as Episode 94. Show notes here:

There are a variety of ways that seed oils either contribute detrimentally to health directly or, at least, serve as a marker for unhealthy dietary patterns. But is it for the reasons that some claim? In my recent episode with Dr. Layne Norton (Layne Norton, PhD), he points out that if we're going to claim that seed oils are uniquely harmful, we need to apply that same logic symmetrically to saturated fat. Because the evidence against saturated fat is stronger. Since there are pretty strong feelings about seed oils, let's take a step back. As a champion powerlifter who eats a very high protein diet (by all reports), Layne is neither anti-meat nor likely a high consumer of seed oils. In fact, given his track record during his Ph.D. (including meat industry funding), his biases lean the other way. Good science, though, demands that we follow the facts, even if they tarnish an otherwise elegant mechanistic explanation. And the problem is that the view of seed oils as a primary culprit of modern chronic disease actually oversimplifies its complex, multi-factorial origin... and may even be a type of blame shifting. In the following clip: We also get into why it is probably still prudent to be careful about seed oils when it comes to situations where there is high heat and reheating. And even why a healthy diet ultimately does limit the intake of seed oils overall [e.g. fewer processed hyper-palatable foods, fried foods], but this is mostly a result of adhering to other, more useful dietary frameworks. Find the longer conversation with Dr. Layne Norton, including more of the nuance on seed oils, on Apple Podcasts, Spotify, and YouTube as Episode 94. Show notes here:

Dr. Rhonda Patrick

58,819 views • 1 year ago

GOVERNMENT BURIED THE TRUTH: SATURATED FAT DOESN'T KILL "The government actually funded massive trials that proved saturated fats & cholesterol DON'T cause heart disease—but they BURIED the results!" ~Nina Teicholz, PhD The Minnesota Coronary Experiment proved that lowering cholesterol RAISED death in men. For every 30 mg/dL drop in cholesterol, all-cause mortality risk increased by 22%. Sydney Diet Heart Study showed replacing saturated fats with vegetable oils increased death from heart disease by 62% & all-cause mortality by 70%. Unpublished raw data revealed the dangers of seed oils. Kailuan Study Low LDL & Stroke Risk revealed LDL <70 mg/dL linked to 2.69X higher risk of hemorrhagic stroke. High LDL & Longevity (Systematic Review, 19 studies, 6.3M+ participants) proved High LDL-C associated with greater longevity. Inverse relationship with mortality in elderly; no link to reduced lifespan. Contradicts statin-driven myths. Saturated fats & cholesterol are essential for health: - Absorb vitamins A, D, E, K - Support digestion & bile acids - Boost immunity against infections, bacteria, viruses - Lower cancer, depression, suicide risks - Optimal for brain (60% fat, 30% cholesterol) - Prevent osteoporosis, stroke, dementia - Protect against toxins & all-cause mortality Avoid seed oils like soybean, corn, canola—they cause oxidation & inflammation. Embrace heart-healthy fats: butter, ghee, tallow, lard, duck fat, & extra virgin 100% coconut, avocado & olive oil.

GOVERNMENT BURIED THE TRUTH: SATURATED FAT DOESN'T KILL "The government actually funded massive trials that proved saturated fats & cholesterol DON'T cause heart disease—but they BURIED the results!" ~Nina Teicholz, PhD The Minnesota Coronary Experiment proved that lowering cholesterol RAISED death in men. For every 30 mg/dL drop in cholesterol, all-cause mortality risk increased by 22%. Sydney Diet Heart Study showed replacing saturated fats with vegetable oils increased death from heart disease by 62% & all-cause mortality by 70%. Unpublished raw data revealed the dangers of seed oils. Kailuan Study Low LDL & Stroke Risk revealed LDL <70 mg/dL linked to 2.69X higher risk of hemorrhagic stroke. High LDL & Longevity (Systematic Review, 19 studies, 6.3M+ participants) proved High LDL-C associated with greater longevity. Inverse relationship with mortality in elderly; no link to reduced lifespan. Contradicts statin-driven myths. Saturated fats & cholesterol are essential for health: - Absorb vitamins A, D, E, K - Support digestion & bile acids - Boost immunity against infections, bacteria, viruses - Lower cancer, depression, suicide risks - Optimal for brain (60% fat, 30% cholesterol) - Prevent osteoporosis, stroke, dementia - Protect against toxins & all-cause mortality Avoid seed oils like soybean, corn, canola—they cause oxidation & inflammation. Embrace heart-healthy fats: butter, ghee, tallow, lard, duck fat, & extra virgin 100% coconut, avocado & olive oil.

Valerie Anne Smith

52,828 views • 2 months ago

There's One Un-Natural Ingredient That Causes Inflammation, Metabolic Dysfunction, Heart Disease, Diabetes, Cancer & Even Macular Degeneration...It's Vegetable Seed Oils. In The Los Angeles Veterans Administration Study, those consuming vegetable oils had 82% more cancer. In The Rose Corn Oil Study, those who ate corn oil had 92% increase in heart attacks & 364% increase in death. In the Sydney Diet-Heart Study, The Group Consuming Vegetable Oil Had A 62% Higher Death Rate. In The Minnesota Coronary Experiment, Participants Who Ate Corn Oil & Margarine Had 86% More Heart Attacks. In The MARGARIN Study, the number of strokes, heart attacks & cardiovascular deaths was seven times higher in the group eating vegetable oil margarine. Industrial Oils Like Canola, Sunflower, Soybean, Corn, Rice Bran, Safflower, Grape Seed, Cottonseed, Rape Seed, Peanut & Walnut Are All Harmful. ⏩There are many other Industrial Seed & Nut Oils not listed. Any oil that goes thru industrial processing, Hexane solvents, high heat oxidation, bleaching & Sodium Hydroxide deodorizing is toxic to health & wellbeing. Hexane is a neurotoxin & Sodium Hydroxide is a carcinogen. Seed oils are filled with heavy metals like lead, cadmium & antimony. Seed oils also contain high levels of Phthalates which are endocrine hormone disruptors. Vegetable Seed Oils are in more than 90% of processed foods & used in more than 90% of restaurants. Industrial oils are cheap, but will cost you your health. Vegetable seed oils are very high in damaged Omega-6 fats making them pro-inflammatory. These oils were never meant for human consumption. They were only meant for engine lubricants, lamp oil & soap. Another major reason why seed oils are pernicious to overall health is that they remain in the body for extended periods. The half-life of Linoleic Acid is approximately 680 days. This means that on a cellular level, it takes approximately six years to replace 95% of the Linoleic Acid in the body with healthy fats. Healthy fats provide actual nutrients like Vitamins A, D, E, K & Omega-3. Tallow, Ghee, Butter, Lard, Duck Fat & Cold Pressed Unrefined Virgin Coconut Oil are all nutritious & life affirming fats. 👇Seed Oils Cause Colon Tumors👇 👇Seed Oils Cause Inflammatory Bowel Disease👇 👇Seed Oils Cause Coronary Heart Disease👇 👇Seeds Oils Cause Macular Degeneration👇 Speaker: Dave Asprey

There's One Un-Natural Ingredient That Causes Inflammation, Metabolic Dysfunction, Heart Disease, Diabetes, Cancer & Even Macular Degeneration...It's Vegetable Seed Oils. In The Los Angeles Veterans Administration Study, those consuming vegetable oils had 82% more cancer. In The Rose Corn Oil Study, those who ate corn oil had 92% increase in heart attacks & 364% increase in death. In the Sydney Diet-Heart Study, The Group Consuming Vegetable Oil Had A 62% Higher Death Rate. In The Minnesota Coronary Experiment, Participants Who Ate Corn Oil & Margarine Had 86% More Heart Attacks. In The MARGARIN Study, the number of strokes, heart attacks & cardiovascular deaths was seven times higher in the group eating vegetable oil margarine. Industrial Oils Like Canola, Sunflower, Soybean, Corn, Rice Bran, Safflower, Grape Seed, Cottonseed, Rape Seed, Peanut & Walnut Are All Harmful. ⏩There are many other Industrial Seed & Nut Oils not listed. Any oil that goes thru industrial processing, Hexane solvents, high heat oxidation, bleaching & Sodium Hydroxide deodorizing is toxic to health & wellbeing. Hexane is a neurotoxin & Sodium Hydroxide is a carcinogen. Seed oils are filled with heavy metals like lead, cadmium & antimony. Seed oils also contain high levels of Phthalates which are endocrine hormone disruptors. Vegetable Seed Oils are in more than 90% of processed foods & used in more than 90% of restaurants. Industrial oils are cheap, but will cost you your health. Vegetable seed oils are very high in damaged Omega-6 fats making them pro-inflammatory. These oils were never meant for human consumption. They were only meant for engine lubricants, lamp oil & soap. Another major reason why seed oils are pernicious to overall health is that they remain in the body for extended periods. The half-life of Linoleic Acid is approximately 680 days. This means that on a cellular level, it takes approximately six years to replace 95% of the Linoleic Acid in the body with healthy fats. Healthy fats provide actual nutrients like Vitamins A, D, E, K & Omega-3. Tallow, Ghee, Butter, Lard, Duck Fat & Cold Pressed Unrefined Virgin Coconut Oil are all nutritious & life affirming fats. 👇Seed Oils Cause Colon Tumors👇 👇Seed Oils Cause Inflammatory Bowel Disease👇 👇Seed Oils Cause Coronary Heart Disease👇 👇Seeds Oils Cause Macular Degeneration👇 Speaker: Dave Asprey

Valerie Anne Smith

30,793 views • 1 year ago

REDUCE OXIDIZED LDL WITH THIS FAT! LDL cholesterol is not the enemy. Your liver produces it on purpose — to transport hormones, nutrients, and building blocks your body needs. The real problem is oxidized LDL, the damaged form that contributes to arterial plaque. And here’s what most people don’t know: Multiple human RCTs show that high-polyphenol, cold-pressed extra-virgin olive oil can significantly reduce oxidized LDL — in some trials by up to 30%. It’s the polyphenols like hydroxytyrosol and oleuropein that protect LDL from oxidative damage and improve your lipid profile. So the goal isn’t to “eliminate LDL.” The goal is to prevent it from oxidizing. And one of the most powerful tools for that, backed by randomized controlled trials, is single-origin, high-polyphenol extra-virgin olive oil. Upgrade your oils, protect your LDL, protect your heart. #cholesterol #longevity #oliveoil

Chris MMHealth

32,415 views • 8 months ago

SEED OILS Are Poison In A Bottle...Industrialized Seed Oils Are The Most Egregious Assault On Health & Nutrition In The Modern World. Shocking Suppressed Research Reveals These Toxic Seed Oils Touted As 'Heart Healthy' Cause Heart Disease, Cancer, Stroke & Early Death. The half-life of Seed Oils is 680 days. This means that on a cellular level, it takes approximately six years to replace 95% of the toxic seed oils in the body with healthy fats. 100 yrs ago, vegetable oils & seed oils were nonexistent in the daily diet. Today they account for 30% of the daily diet & have made their way into almost every packaged food & restaurant meal we eat. “Vegetable oils” in this context refer to oils extracted from seeds, grains & legumes including but not an exhaustive list: soybean oil, corn oil, sunflower oil, safflower oil, canola oil, rapeseed oil, peanut oil, rice bran oil, grape seed oil, palm oil, linseed oil, sesame oil & cottonseed oil. These oils are all commonly referred to as seed oils. As vegetable oil consumption has grown, rates of obesity, cancer & diabetes–among other chronic illnesses–have surged to unprecedented levels. 6 in 10 adults have a chronic disease & 4 in 10 adults have two or more. Research Showing Direct Disease Causation From Seed Oils: Death: In the Sydney Diet Heart Study: Group #1 consumed butter & Group #2 consumed vegetable oil & margarine. The group consuming oil & margarine had 62% higher death rate over a 7yr period. Heart Disease: In the Minnesota Coronary Experiment, participants who increased their consumption of corn oil & margarine had 86% more heart attacks. Stroke: In the MARGARIN Study, after two years, the number of strokes, heart attacks & cardiovascular deaths was seven times higher in the group eating vegetable oil margarine. Heart Attack: In the Rose Corn Oil Trial, tested replacing butter with corn oil. The result was a 92% increase in heart attacks & a 364% increased risk of death in the group consuming corn oil. Cancer: In the Los Angeles Veterans Administration Study, the group of participants who increased fat from vegetable oil–while keeping total fat the same–were 82% higher rates of cancer. The Tortured Journey Of A Seed To Make Industrial Oil: 1. Chemical extraction via petroleum based solvent (or hexane) 2. Acid wash process (heated to 80°C = 176°F) High Heat = oxidation 3. Neutralization process (heated to 95°C = 203°F) High Heat = oxidation 4. Bleaching process (heated to 110°C = 230°F) High Heat = oxidation 5. Deodorants (heated to 260°C = 500°F) = trans fats → need to use chemical to deodorize because they’ve oxidized so much from the above process that they are colorless & smell awful if consumed as is. 6. Color enhancement After the refining process, what remains is toxic sludge. It Is Time To Return To Real 'Heart Healthy Fats' That Carry No Risk Of Metabolic Dysfunction Or Chronic Disease: Animal Sourced Fats: Butter, Ghee, Tallow, Suet, Lard & Duck Fat. Fruit Oil Saturated Fats: Unrefined Cold Pressed Virgin 100% Coconut & Avocado Oils. 👇Sydney Diet Heart Study👇 👇Minnesota Coronary Experiment👇 👇Los Angeles Veterans Administration Study👇 Video: @LongevityXLab

SEED OILS Are Poison In A Bottle...Industrialized Seed Oils Are The Most Egregious Assault On Health & Nutrition In The Modern World. Shocking Suppressed Research Reveals These Toxic Seed Oils Touted As 'Heart Healthy' Cause Heart Disease, Cancer, Stroke & Early Death. The half-life of Seed Oils is 680 days. This means that on a cellular level, it takes approximately six years to replace 95% of the toxic seed oils in the body with healthy fats. 100 yrs ago, vegetable oils & seed oils were nonexistent in the daily diet. Today they account for 30% of the daily diet & have made their way into almost every packaged food & restaurant meal we eat. “Vegetable oils” in this context refer to oils extracted from seeds, grains & legumes including but not an exhaustive list: soybean oil, corn oil, sunflower oil, safflower oil, canola oil, rapeseed oil, peanut oil, rice bran oil, grape seed oil, palm oil, linseed oil, sesame oil & cottonseed oil. These oils are all commonly referred to as seed oils. As vegetable oil consumption has grown, rates of obesity, cancer & diabetes–among other chronic illnesses–have surged to unprecedented levels. 6 in 10 adults have a chronic disease & 4 in 10 adults have two or more. Research Showing Direct Disease Causation From Seed Oils: Death: In the Sydney Diet Heart Study: Group #1 consumed butter & Group #2 consumed vegetable oil & margarine. The group consuming oil & margarine had 62% higher death rate over a 7yr period. Heart Disease: In the Minnesota Coronary Experiment, participants who increased their consumption of corn oil & margarine had 86% more heart attacks. Stroke: In the MARGARIN Study, after two years, the number of strokes, heart attacks & cardiovascular deaths was seven times higher in the group eating vegetable oil margarine. Heart Attack: In the Rose Corn Oil Trial, tested replacing butter with corn oil. The result was a 92% increase in heart attacks & a 364% increased risk of death in the group consuming corn oil. Cancer: In the Los Angeles Veterans Administration Study, the group of participants who increased fat from vegetable oil–while keeping total fat the same–were 82% higher rates of cancer. The Tortured Journey Of A Seed To Make Industrial Oil: 1. Chemical extraction via petroleum based solvent (or hexane) 2. Acid wash process (heated to 80°C = 176°F) High Heat = oxidation 3. Neutralization process (heated to 95°C = 203°F) High Heat = oxidation 4. Bleaching process (heated to 110°C = 230°F) High Heat = oxidation 5. Deodorants (heated to 260°C = 500°F) = trans fats → need to use chemical to deodorize because they’ve oxidized so much from the above process that they are colorless & smell awful if consumed as is. 6. Color enhancement After the refining process, what remains is toxic sludge. It Is Time To Return To Real 'Heart Healthy Fats' That Carry No Risk Of Metabolic Dysfunction Or Chronic Disease: Animal Sourced Fats: Butter, Ghee, Tallow, Suet, Lard & Duck Fat. Fruit Oil Saturated Fats: Unrefined Cold Pressed Virgin 100% Coconut & Avocado Oils. 👇Sydney Diet Heart Study👇 👇Minnesota Coronary Experiment👇 👇Los Angeles Veterans Administration Study👇 Video: @LongevityXLab

Valerie Anne Smith

35,051 views • 1 year ago

The #1 food quietly destroying your liver right now… isn’t alcohol, sugar, or cholesterol. It’s industrial seed oils (canola, soybean, corn, sunflower, grapeseed, etc.). They’re hidden in: - mayonnaise - salad dressings - restaurant deep-fryers - protein bars - chips & crackers (even the “zero sugar” ones) These oils: - accumulate in fat cells for up to 18 months (linoleic acid half-life in adipose tissue ~680 days per adipose biopsy studies) - drive non-alcoholic fatty liver disease (NAFLD) via massive omega-6 overload - spike insulin → insulin resistance → more liver fat storage - contain trace hexane (petroleum solvent used in extraction) - are the highest source of inflammatory omega-6 in the modern diet Human trials show that when linoleic acid intake exceeds ~6–8% of calories (common today), it displaces anti-inflammatory omega-3s, increases liver fat accumulation, and worsens NAFLD markers—even when total calories and body weight are controlled (see 2021–2024 reviews in Progress in Lipid Research and Nutrients). Best swaps: tallow, lard, avocado oil, grass-fed butter. Do you still use seed oils daily (cooking, dressings, snacks)? Or have you already switched — and noticed any difference in energy, digestion, or how you feel? Your experience 👇

The #1 food quietly destroying your liver right now… isn’t alcohol, sugar, or cholesterol. It’s industrial seed oils (canola, soybean, corn, sunflower, grapeseed, etc.). They’re hidden in: - mayonnaise - salad dressings - restaurant deep-fryers - protein bars - chips & crackers (even the “zero sugar” ones) These oils: - accumulate in fat cells for up to 18 months (linoleic acid half-life in adipose tissue ~680 days per adipose biopsy studies) - drive non-alcoholic fatty liver disease (NAFLD) via massive omega-6 overload - spike insulin → insulin resistance → more liver fat storage - contain trace hexane (petroleum solvent used in extraction) - are the highest source of inflammatory omega-6 in the modern diet Human trials show that when linoleic acid intake exceeds ~6–8% of calories (common today), it displaces anti-inflammatory omega-3s, increases liver fat accumulation, and worsens NAFLD markers—even when total calories and body weight are controlled (see 2021–2024 reviews in Progress in Lipid Research and Nutrients). Best swaps: tallow, lard, avocado oil, grass-fed butter. Do you still use seed oils daily (cooking, dressings, snacks)? Or have you already switched — and noticed any difference in energy, digestion, or how you feel? Your experience 👇

Camus

52,510 views • 4 months ago

How androgen receptors impact testosterone effect | Carole Hooven, Ph.D. (Carole Hooven ) This clip is from episode # 374 of The Drive which was released on 12/1/25. In the full episode, we cover: -A stark contrast of male social bonding compared to females, and evolutionary parallels in chimpanzees -Why females evolved different behavioral strategies: nurturing, risk aversion, and the cultural norms that override biology -Why males commit disproportionately more violent crime, and how cultural and environmental forces shape aggression -How evolution, health, lifestyle, and androgen receptor biology shape modern testosterone replacement therapy (TRT) Watch or listen (Ep. # 374) to the full episode on my website or your favorite podcast player.

How androgen receptors impact testosterone effect | Carole Hooven, Ph.D. (Carole Hooven ) This clip is from episode # 374 of The Drive which was released on 12/1/25. In the full episode, we cover: -A stark contrast of male social bonding compared to females, and evolutionary parallels in chimpanzees -Why females evolved different behavioral strategies: nurturing, risk aversion, and the cultural norms that override biology -Why males commit disproportionately more violent crime, and how cultural and environmental forces shape aggression -How evolution, health, lifestyle, and androgen receptor biology shape modern testosterone replacement therapy (TRT) Watch or listen (Ep. # 374) to the full episode on my website or your favorite podcast player.

Peter Attia

43,184 views • 7 months ago

Lifestyle factors that shape Alzheimer’s risk | Lisa Mosconi, Ph.D. (Dr. Lisa Mosconi) This clip is from episode # 381 of The Drive which was released on 1/26/26. In the full episode, we cover: -What preclinical Alzheimer’s disease looks like in women: insights from advanced brain imaging into metabolic and structural changes that precede symptoms -How Alzheimer’s compares with other dementias: differences in prevalence, underlying pathology, symptom progression, and the challenges of accurate diagnosis -Hormone therapy and brain health: what the evidence suggests about menopausal hormone therapy, the legacy of the WHI, why timing and formulation matter, and how SERMs may offer a targeted approach -Reducing risk across midlife: genetics (including APOE4), modifiable lifestyle factors, sleep, metabolism, mood, and emerging therapies such as GLP-1 agonists within a long-term brain health framework Listen (Ep. # 380) to the full episode on my website ( or your favorite podcast player.

Lifestyle factors that shape Alzheimer’s risk | Lisa Mosconi, Ph.D. (Dr. Lisa Mosconi) This clip is from episode # 381 of The Drive which was released on 1/26/26. In the full episode, we cover: -What preclinical Alzheimer’s disease looks like in women: insights from advanced brain imaging into metabolic and structural changes that precede symptoms -How Alzheimer’s compares with other dementias: differences in prevalence, underlying pathology, symptom progression, and the challenges of accurate diagnosis -Hormone therapy and brain health: what the evidence suggests about menopausal hormone therapy, the legacy of the WHI, why timing and formulation matter, and how SERMs may offer a targeted approach -Reducing risk across midlife: genetics (including APOE4), modifiable lifestyle factors, sleep, metabolism, mood, and emerging therapies such as GLP-1 agonists within a long-term brain health framework Listen (Ep. # 380) to the full episode on my website ( or your favorite podcast player.

Peter Attia

444,817 views • 5 months ago

Best Age to Freeze Your Eggs | Paula Amato, M.D. (Paula Amato) This clip is from episode # 352 of The Drive which was released on 6/9/25. In the full episode, we discuss: -How infertility is defined and diagnosed, and the broader trends contributing to rising infertility rates -The step-by-step process of IVF -How to choose the right IVF clinic -Optimizing fertility through lifestyle: diet, stress management, sleep, exercise, and supplementation -Much more Watch or listen (Ep. # 352) to the full episode on my website ( or your favorite podcast player.

Best Age to Freeze Your Eggs | Paula Amato, M.D. (Paula Amato) This clip is from episode # 352 of The Drive which was released on 6/9/25. In the full episode, we discuss: -How infertility is defined and diagnosed, and the broader trends contributing to rising infertility rates -The step-by-step process of IVF -How to choose the right IVF clinic -Optimizing fertility through lifestyle: diet, stress management, sleep, exercise, and supplementation -Much more Watch or listen (Ep. # 352) to the full episode on my website ( or your favorite podcast player.

Peter Attia

24,677 views • 1 year ago

When to Have Sex for the Highest Chance of Getting Pregnant | Paul Turek, M.D. This clip is from episode # 351 of The Drive which was released on 6/2/25. In the full episode, we discuss: -How to optimize conception through the timing of sex, ejaculation frequency, and understanding the sperm lifecycle -Effects of medication, microplastics, stress, and exercise on fertility -How alcohol, marijuana, and nicotine affect male fertility -Genetic factors that affect fertility -Much more Watch or listen (Ep. # 351) to the full episode on my website ( or your favorite podcast player.

When to Have Sex for the Highest Chance of Getting Pregnant | Paul Turek, M.D. This clip is from episode # 351 of The Drive which was released on 6/2/25. In the full episode, we discuss: -How to optimize conception through the timing of sex, ejaculation frequency, and understanding the sperm lifecycle -Effects of medication, microplastics, stress, and exercise on fertility -How alcohol, marijuana, and nicotine affect male fertility -Genetic factors that affect fertility -Much more Watch or listen (Ep. # 351) to the full episode on my website ( or your favorite podcast player.

Peter Attia

78,838 views • 1 year ago

Microplastics, Stress, and Male Fertility | Paul Turek, M.D. This clip is from episode # 351 of The Drive which was released on 6/2/25. In the full episode, we discuss: -How to optimize conception through the timing of sex, ejaculation frequency, and understanding the sperm lifecycle -Effects of medication, microplastics, stress, and exercise on fertility -How alcohol, marijuana, and nicotine affect male fertility -Genetic factors that affect fertility -Much more Watch or listen (Ep. # 351) to the full episode on my website ( or your favorite podcast player.

Microplastics, Stress, and Male Fertility | Paul Turek, M.D. This clip is from episode # 351 of The Drive which was released on 6/2/25. In the full episode, we discuss: -How to optimize conception through the timing of sex, ejaculation frequency, and understanding the sperm lifecycle -Effects of medication, microplastics, stress, and exercise on fertility -How alcohol, marijuana, and nicotine affect male fertility -Genetic factors that affect fertility -Much more Watch or listen (Ep. # 351) to the full episode on my website ( or your favorite podcast player.

Peter Attia

20,725 views • 1 year ago

How Women Can Balance Strength and Cardio With Limited Time | Abbie Smith-Ryan, Ph.D. (Abbie Smith-Ryan PhD) This clip is from episode # 378 of The Drive which was released on 1/5/26. In the full episode, we cover: -The benefits of creatine supplementation and importance of protein intake across the menstrual cycle -How pregnancy and the postpartum period affect body composition -The biggest open questions about women’s health: combining menopause hormone therapy with exercise, GLP-1 drugs, minimizing injury risk, and more -How the training response differs between men and women, and the importance of type IIa muscle fibers Listen (Ep. # 378) to the full episode on my website ( or your favorite podcast player.

How Women Can Balance Strength and Cardio With Limited Time | Abbie Smith-Ryan, Ph.D. (Abbie Smith-Ryan PhD) This clip is from episode # 378 of The Drive which was released on 1/5/26. In the full episode, we cover: -The benefits of creatine supplementation and importance of protein intake across the menstrual cycle -How pregnancy and the postpartum period affect body composition -The biggest open questions about women’s health: combining menopause hormone therapy with exercise, GLP-1 drugs, minimizing injury risk, and more -How the training response differs between men and women, and the importance of type IIa muscle fibers Listen (Ep. # 378) to the full episode on my website ( or your favorite podcast player.

Peter Attia

41,748 views • 6 months ago

Why building muscle now protects you later in life | Rhonda Patrick, Ph.D. (Dr. Rhonda Patrick) This clip is from episode # 369 of The Drive which was released on 10/20/25. In the full episode, we cover: -How protein requirements evolve with age, activity, and goals, and why building muscle early is critical for long-term health -The connection between protein intake, mTOR, and longevity, and why fears around activation are largely misplaced -Why creatine’s cognitive effects may be as important as its role in physical performance -How regular heat exposure supports recovery, enhances mood, and may help protect against neurodegenerative disease Listen (Ep. # 369) to the full episode on my website ( or your favorite podcast player.

Why building muscle now protects you later in life | Rhonda Patrick, Ph.D. (Dr. Rhonda Patrick) This clip is from episode # 369 of The Drive which was released on 10/20/25. In the full episode, we cover: -How protein requirements evolve with age, activity, and goals, and why building muscle early is critical for long-term health -The connection between protein intake, mTOR, and longevity, and why fears around activation are largely misplaced -Why creatine’s cognitive effects may be as important as its role in physical performance -How regular heat exposure supports recovery, enhances mood, and may help protect against neurodegenerative disease Listen (Ep. # 369) to the full episode on my website ( or your favorite podcast player.

Peter Attia

45,295 views • 7 months ago

"Our Entire War On Saturated Fat, Which Has Dominated The Healthcare Advice That We Get From Our Doctors, Has Been Wrong." Nicole Shanahan In Fact, The Higher Your Cholesterol, The Longer You Live. There Is Zero Correlation That Saturated Fat & Cholesterol Cause Heart Disease. Researchers have analyzed Ancel Keys data, using all 22 original countries, the "supposed' link between saturated fat & heart disease totally VANISHED. Ancel Keys was a liar & a fraud. Ancel Keys "7 countries study" that made it look like heart disease was associated with fat intake was deceptive & false. He started with 22 countries & just tossed out the ones that didn’t fit his hypothesis! One of the most harmful things that has come from Keys’ studies was what the food industry/large health organizations did with this information & how they utilized it to sell more processed foods. In 1961, Ancel Keys landed a position on the nutrition committee for the American Heart Association. That same year, the AHA advised Americans to replace the saturated fats in their diets with polyunsaturated fats. This prompted Americans to start utilizing PUFAs found in highly processed hydrogenated oils (i.e. corn, canola, soybean, etc.) instead of animal fats such as tallow, butter & ghee. Those guidelines, which were supposed to eradicate cardiovascular disease, only added fuel to the fire as chronic disease skyrocketed. Keys also determined to test his hypothesis in the Minnesota Coronary Experiment which failed miserably & the results of the study were buried until 2016. The MCE was a double blind controlled clinical trial in 6 Minnesota mental hospitals. Replacing butter with corn oil lowered cholesterol as predicted, but it raised cardiovascular disease & death. Ancel Keys knew in 1989 that he was not only not correct, he was also precisely wrong. The National Heart, Lung and Blood Institute funded that study. It's worth speculating how much expensive bad advice they continued to give in the 27 years from the study's conclusion in 1989, until the exposition of the study's actual results by Chris Ramsden in 2016. Industrialized toxic seed oils added onto a high sugar, processed carbohydrate, chemical filled diet has caused 93% of Americans to be metabolically unhealthy. The dramatic rise of the rates of heart disease, cancer, diabetes & chronic autoimmune speak for themselves. 👇Minnesota Coronary Experiment: Released 2016👇 👇Dangers Of 'Heart Healthy' Seed Oils👇 👇The Higher Your LDL, The Longer You Live👇 Speaker: Nicole Shanahan Video: Meat Health

"Our Entire War On Saturated Fat, Which Has Dominated The Healthcare Advice That We Get From Our Doctors, Has Been Wrong." Nicole Shanahan In Fact, The Higher Your Cholesterol, The Longer You Live. There Is Zero Correlation That Saturated Fat & Cholesterol Cause Heart Disease. Researchers have analyzed Ancel Keys data, using all 22 original countries, the "supposed' link between saturated fat & heart disease totally VANISHED. Ancel Keys was a liar & a fraud. Ancel Keys "7 countries study" that made it look like heart disease was associated with fat intake was deceptive & false. He started with 22 countries & just tossed out the ones that didn’t fit his hypothesis! One of the most harmful things that has come from Keys’ studies was what the food industry/large health organizations did with this information & how they utilized it to sell more processed foods. In 1961, Ancel Keys landed a position on the nutrition committee for the American Heart Association. That same year, the AHA advised Americans to replace the saturated fats in their diets with polyunsaturated fats. This prompted Americans to start utilizing PUFAs found in highly processed hydrogenated oils (i.e. corn, canola, soybean, etc.) instead of animal fats such as tallow, butter & ghee. Those guidelines, which were supposed to eradicate cardiovascular disease, only added fuel to the fire as chronic disease skyrocketed. Keys also determined to test his hypothesis in the Minnesota Coronary Experiment which failed miserably & the results of the study were buried until 2016. The MCE was a double blind controlled clinical trial in 6 Minnesota mental hospitals. Replacing butter with corn oil lowered cholesterol as predicted, but it raised cardiovascular disease & death. Ancel Keys knew in 1989 that he was not only not correct, he was also precisely wrong. The National Heart, Lung and Blood Institute funded that study. It's worth speculating how much expensive bad advice they continued to give in the 27 years from the study's conclusion in 1989, until the exposition of the study's actual results by Chris Ramsden in 2016. Industrialized toxic seed oils added onto a high sugar, processed carbohydrate, chemical filled diet has caused 93% of Americans to be metabolically unhealthy. The dramatic rise of the rates of heart disease, cancer, diabetes & chronic autoimmune speak for themselves. 👇Minnesota Coronary Experiment: Released 2016👇 👇Dangers Of 'Heart Healthy' Seed Oils👇 👇The Higher Your LDL, The Longer You Live👇 Speaker: Nicole Shanahan Video: Meat Health

Valerie Anne Smith

221,163 views • 1 year ago

How Busy Moms Can Build Fitness Without Extra Time | Abbie Smith-Ryan, Ph.D. (Abbie Smith-Ryan PhD) This clip is from episode # 378 of The Drive which was released on 1/5/26. In the full episode, we cover: -The benefits of creatine supplementation and importance of protein intake across the menstrual cycle -How pregnancy and the postpartum period affect body composition -The biggest open questions about women’s health: combining menopause hormone therapy with exercise, GLP-1 drugs, minimizing injury risk, and more -How the training response differs between men and women, and the importance of type IIa muscle fibers Listen (Ep. # 378) to the full episode on my website ( or your favorite podcast player.

How Busy Moms Can Build Fitness Without Extra Time | Abbie Smith-Ryan, Ph.D. (Abbie Smith-Ryan PhD) This clip is from episode # 378 of The Drive which was released on 1/5/26. In the full episode, we cover: -The benefits of creatine supplementation and importance of protein intake across the menstrual cycle -How pregnancy and the postpartum period affect body composition -The biggest open questions about women’s health: combining menopause hormone therapy with exercise, GLP-1 drugs, minimizing injury risk, and more -How the training response differs between men and women, and the importance of type IIa muscle fibers Listen (Ep. # 378) to the full episode on my website ( or your favorite podcast player.

Peter Attia

86,036 views • 6 months ago

How Older Adults Can Stop Muscle Loss | Rhonda Patrick, Ph.D. (Dr. Rhonda Patrick) This clip is from episode # 369 of The Drive which was released today (10/20/25). In the full episode, we cover: -How protein requirements evolve with age, activity, and goals, and why building muscle early is critical for long-term health -The connection between protein intake, mTOR, and longevity, and why fears around activation are largely misplaced -Why creatine’s cognitive effects may be as important as its role in physical performance -How regular heat exposure supports recovery, enhances mood, and may help protect against neurodegenerative disease -More Watch or listen (Ep. # 369) to the full episode on my website or your favorite podcast player.

How Older Adults Can Stop Muscle Loss | Rhonda Patrick, Ph.D. (Dr. Rhonda Patrick) This clip is from episode # 369 of The Drive which was released today (10/20/25). In the full episode, we cover: -How protein requirements evolve with age, activity, and goals, and why building muscle early is critical for long-term health -The connection between protein intake, mTOR, and longevity, and why fears around activation are largely misplaced -Why creatine’s cognitive effects may be as important as its role in physical performance -How regular heat exposure supports recovery, enhances mood, and may help protect against neurodegenerative disease -More Watch or listen (Ep. # 369) to the full episode on my website or your favorite podcast player.

Peter Attia

106,207 views • 9 months ago

Vegetable Oils: The Unknown Story - Nina Techolz If you've ever wondered where all this heart disease, cancer, and diabetes is coming from, listen to this lecture from Nina on the real history of seed/vegetable oils and how they became so pervasive in the American diet thanks to advertising from demons like Edward Bernays and the corporate capture of the regulatory and health agencies. These same corporations also captured scientists and doctors in the early to mid 1900s to manufacture research to tell everyone that vegetable oils are healthier than animal fats (arguing animal fats cause heart disease), and catering mostly to the stay at home mothers who were preparing all the food for families. They would use manipulative campaign tactics where they appealed to the "modern woman" for why they should give up butter and lard in favor of something like cottonseed or canola oil based margarine to cook with. As soon as butter, lard, tallow, and other animal fats were starting to be replaced with the seed oils, we saw an explosion in disease rates. Heart disease, cancer, and diabetes especially, skyrocketed in near perfect unison with the introduction of seed oils, and it has continued ever since. Every single fast food place is still using soybean, canola, peanut, sunflower or corn oil to cook your food. Anything that is fried, is being fried in one of these oils. They're trying to make you fat, sick, inflamed, and stupid, so you're more profitable for the Rockefeller medical system.

Vegetable Oils: The Unknown Story - Nina Techolz If you've ever wondered where all this heart disease, cancer, and diabetes is coming from, listen to this lecture from Nina on the real history of seed/vegetable oils and how they became so pervasive in the American diet thanks to advertising from demons like Edward Bernays and the corporate capture of the regulatory and health agencies. These same corporations also captured scientists and doctors in the early to mid 1900s to manufacture research to tell everyone that vegetable oils are healthier than animal fats (arguing animal fats cause heart disease), and catering mostly to the stay at home mothers who were preparing all the food for families. They would use manipulative campaign tactics where they appealed to the "modern woman" for why they should give up butter and lard in favor of something like cottonseed or canola oil based margarine to cook with. As soon as butter, lard, tallow, and other animal fats were starting to be replaced with the seed oils, we saw an explosion in disease rates. Heart disease, cancer, and diabetes especially, skyrocketed in near perfect unison with the introduction of seed oils, and it has continued ever since. Every single fast food place is still using soybean, canola, peanut, sunflower or corn oil to cook your food. Anything that is fried, is being fried in one of these oils. They're trying to make you fat, sick, inflamed, and stupid, so you're more profitable for the Rockefeller medical system.

Inversionism

160,705 views • 2 years ago

Physical Symptom vs. Medical Issue | Josh Spitalnick, Ph.D., A.B.P.P. This clip is from episode # 362 of The Drive which was released on (8/25/25). In the full episode, we cover: -How avoidance rewires the brain and turns everyday worry into disordered anxiety -Why uncertainty intolerance fuels anxiety and how to build tolerance through exposure -The difference between worrying vs. worry, and thoughts vs. thinking -How wearables, health tracking, and social media can worsen health anxiety -How to use values-based behavior to override fear and build resilience -More Watch or listen (Ep. # 362) to the full episode on my website (https:/peterattiamd.com/joshspitalnick) or your favorite podcast player.

Physical Symptom vs. Medical Issue | Josh Spitalnick, Ph.D., A.B.P.P. This clip is from episode # 362 of The Drive which was released on (8/25/25). In the full episode, we cover: -How avoidance rewires the brain and turns everyday worry into disordered anxiety -Why uncertainty intolerance fuels anxiety and how to build tolerance through exposure -The difference between worrying vs. worry, and thoughts vs. thinking -How wearables, health tracking, and social media can worsen health anxiety -How to use values-based behavior to override fear and build resilience -More Watch or listen (Ep. # 362) to the full episode on my website (https:/peterattiamd.com/joshspitalnick) or your favorite podcast player.

Peter Attia

33,427 views • 11 months ago

How Much Protein Should You Really Eat Daily? | David Allison, Ph.D. This clip is from episode # 368 of The Drive which was released today (10/13/25). In the full episode, we cover: -Why the protein RDA may be inadequate for most people and how to think about optimal intake -What current evidence shows about muscle protein synthesis and high-protein diets -The limitations and biases of nutrition research, including economic and methodological constraints -How processed and ultra-processed foods fit into the broader discussion of obesity and public health -More Watch or listen (Ep. # 368) to the full episode on my website or your favorite podcast player.

How Much Protein Should You Really Eat Daily? | David Allison, Ph.D. This clip is from episode # 368 of The Drive which was released today (10/13/25). In the full episode, we cover: -Why the protein RDA may be inadequate for most people and how to think about optimal intake -What current evidence shows about muscle protein synthesis and high-protein diets -The limitations and biases of nutrition research, including economic and methodological constraints -How processed and ultra-processed foods fit into the broader discussion of obesity and public health -More Watch or listen (Ep. # 368) to the full episode on my website or your favorite podcast player.

Peter Attia

97,435 views • 9 months ago