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The most radically recoded genome yet! Syn57 is E Coli with only 57 codons, freeing space to encode up to 4 non-canonical amino acids. That, combined with its virus resistance, will make it an incredible tool for biomanufacturing. From the Chin Lab in Science Magazine
30,194 görüntüleme • 1 yıl önce •via X (Twitter)
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Link to the paper:
CORRECTION‼️: Syn61 can incorporate 3 ncAAs, Syn57 can incorporate 7. My mistake comes from the assuption that you'd need to reengineer the native E Coli tRNAs for charging with different amino acids, in which case there would not be enough codon-anticodon specificity to use some freed-up codons. But ofc synthetic biologists have engineered a way around this, by using orthogonal tRNA-aaRS systems from other species. Getting 7 orthogonal pairs to work together in Syn57 might be a fun new challenge.
@ScienceMagazine incredible resource for synbio
@ScienceMagazine so cool thanks for posting this
@ScienceMagazine Good stuff! Thanks!
@ScienceMagazine Amazing. What is the growth rate? If we get rid if redundancies.
@ScienceMagazine It’s ~4x slower than parental strain
Scientists just created bacteria stripped down to only the essential genetic code, “more efficient than nature itself" This breakthrough shows humans can now rewrite life at a fundamental level. Now, imagine combining this with existing patents like: US20190017050A1: Engineered bacteria that suppress immune checkpoints like PD-L1 and VISTA. WO2020176809A1: Bacteria designed to colonize tumors and suppress anti-tumor immunity. This isn't science fiction. Humanity is literally playing God and challenging Him. #Syn57 #Sin57
@ScienceMagazine Making medicines is blasphemy?
@ScienceMagazine Try reading it again. You'll get it. God bless. Have a great night
@ScienceMagazine Or some really interesting hard to fight bacterial infections
@ScienceMagazine Antibiotics still work
@ScienceMagazine I would hope so. But off target effects down stream, both chemically and metabolically is what I'd be vigilant about wrt surveillance
@ScienceMagazine 100M permutations on the lower bound ☠️💀
@ScienceMagazine Wow 👏
My (RichardKCollin2, The Internet Foundation) perspective on this post: Thank you for sharing and reminding. ( "Syn57" ) shows 25,300 entries on Google search today. That is many people and not trivial resources and connections, but they are not working as a whole. AIs can gather, index, verify, analyze and hold that as one body of knowledge - for all to understand and apply and use. With all the dependencies and implications and methods needed. As a whole it can be mastered now.
@ScienceMagazine Hmmm. Serious question: I would like to know if the codon editing leaves it more susceptible - or less susceptible - to RNA editing? 🤷🏻♀️
![$LLY $NVO $HIMS 🚨 ELI LILLY SUED THE FDA TO GET RETATRUTIDE RECLASSIFIED AS A 'BIOLOGIC' "THIS IS THE MOST IMPORTANT EVENT" IN GLP-1s RIGHT NOW Bijan Salehizadeh: "Many years ago, the FDA said the definition of what is a biologic in the peptide world is more than 40 amino acids. Retatrutide is 39. That's just the facts." "And then there are 2 "linker" amino acids that... look, I went to medical school. Those aren't amino acids! They're like other things that [the amino acids] link onto to give it longer biological life in your body." "Lilly is claiming those two other entities are actually amino acids. So they proactively sued the FDA, Lilly did, and said, 'Retatrutide needs to be defined as a biologic.'" "Now, why are they so aggressive on this? Because if it's a biologic, you get 13 years of market exclusivity [versus only 9 years for a normal drug]... plus the price of biologics are typically into the upper thousands of month." "The peak sales estimates for retatrutide are ten billion or more a year. Some people call it the first trillion-dollar drug." Oral arguments are Sep 24 in Chicago. Bijan says he expects a ruling 3-4 months later:](https://image.24vids.com/tw-2092599543007175130/amplify_video_thumb/2092599084146159616/img/-RyIk3p1-5I8uH2t.jpg)
