正在加载视频...

视频加载失败

The one shot longevity solution is around the corner. Crémieux casually mentioned on Health Care Network this week that there’s a PCSK9 + GLP-1 fusion drug already in development. Add a BP agent and you’ve knocked out ~90% of what actually kills people. What’s actually in the pipeline right...

17,890 次观看 • 2 个月前 •via X (Twitter)

14 条评论

Cédric Kovacs-Johnson 的头像
Cédric Kovacs-Johnson2 个月前

@cremieuxrecueil @watchhcn Lmao we’re all gonna look the same at 150 yrs old

Dr Danish 的头像
Dr Danish2 个月前

@cremieuxrecueil @watchhcn you’ll have more hair

Gone 的头像
Gone2 个月前

@cremieuxrecueil @watchhcn Add in an anti myostatin drug to deal with muscle loss and you're golden.

Dr Danish 的头像
Dr Danish2 个月前

@cremieuxrecueil @watchhcn 100%

Arham 的头像
Arham2 个月前

@cremieuxrecueil @watchhcn This is garbage. Absolute nonsense. Anti scientific. Pathetic. Lipids do not kill people.

Dr Danish 的头像
Dr Danish2 个月前

@cremieuxrecueil @watchhcn hilariously incorrect.

Arham 的头像
Arham2 个月前

@cremieuxrecueil @watchhcn Provide cause and effect evidence lipids cause disease. It does not exist. Do you have it?

Dr Danish 的头像
Dr Danish2 个月前

@cremieuxrecueil @watchhcn @cremieuxrecueil has like a million tweets on this.

Crémieux 的头像
Crémieux2 个月前

@arhamgrowthcap @watchhcn

Arham 的头像
Arham2 个月前

@operationdanish @watchhcn How many measurements of blood lipids (x axis) per subject in his graph?

Crémieux 的头像
Crémieux2 个月前

@operationdanish @watchhcn Depends on the particular study. Click in if you'd like to learn more. The causal evidence is totally unambiguous and leaves no room for doubt.

Arham 的头像
Arham2 个月前

@operationdanish @watchhcn Nobody said anything of substance. One guy said hey this other guy has posts on this. That guy says go look at it instead of answering critiques (many times). Both have hands over their ears and say just believe me. illustration of what goes on when u have no scientific integrity

Brett Hudson | Zyndio 的头像
Brett Hudson | Zyndio2 个月前

A PCSK9 plus GLP-1 fusion drug is a massive development. Addressing LDL, glycemia, and weight in one injection could reshape longevity medicine. But the real opportunity is pairing these tools with biomarker education so people understand what their numbers mean and why these interventions matter. At we believe informed patients make the best decisions. God Bless the researchers pushing this forward 🙏

Valar Research 的头像
Valar Research2 个月前

@cremieuxrecueil @watchhcn The really interesting question is whether combining these targets creates true synergy or just pharmacologic convenience. The cardiovascular outcome data will matter far more than the number of pathways one molecule hits.

相关视频

Alex Karnal (Alex Karnal) is the most talented bio and healthcare investor I've ever met. He's spent 20 years in the industry and says 2025 was the single most exciting year he's seen. The start of a once-in-a-lifetime, trillion-dollar revolution in public health. He explains how few people realize we already have the medicines to prevent our deadliest diseases. The problem is that almost no one takes them. There's a population of people born with a mutation that means their bodies don't produce a protein called PCSK9. Their lifetime risk of cardiovascular disease is 88% lower than yours. Pharma turned that genetic advantage into a drug. It's been approved for years, but the number of people taking it is still vanishingly small. Partly because high cholesterol is a silent killer. You feel nothing, right up until you have a heart attack. And partly because the health system makes it punishingly hard to stay on a preventive drug like a PCSK9 inhibitor. In other words, the medicine works, but the system around it doesn't. That's what's starting to change, and in this episode, Alex explains why. We discuss the "health stack" he believes can add a decade to most lives, why oral GLP-1s are breaking every adoption record in pharma, peptides and citizen pharmacology, and what AI is doing to drug discovery. I wish I had an "Alex" for every interesting topic. We've been having versions of this conversation for over five years, and every single one is as clear and as useful as this one. Enjoy! Timestamps: 0:00 Intro 1:00 The State of Modern Medicine 5:00 Designing the Modern Health Stack 12:17 The GLP-1 Inflection Point 19:18 The Biological Mechanisms of GLP-1 30:36 Overcoming Frictions in Healthcare 34:19 Cardiovascular Disease 44:04 Addressing Alzheimer's 47:04 The Future of Cancer 57:33 Drug Discovery 1:05:25 AI and Scientific Super Intelligence 1:14:40 Citizen Pharmacology and the Peptide Movement 1:18:13 Background and Career Journey 1:31:09 Braidwell's Investment Approach 1:33:30 The Kindest Thing

Patrick OShaughnessy

679,696 次观看 • 6 个月前