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The result: • Increased fat oxidation (Cell Metabolism) • Better insulin sensitivity (Diabetologia) • Lower visceral fat AMPK is the same pathway targeted by drugs like Metformin. Thomas DeLauer

Shayan Sen

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64,305 次观看 • 1 年前 •via X (Twitter)

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Shayan Sen1 年前

NICOTINE: The Most Lied-About Molecule in Medicine They let us believe it causes cancer. They didn't tell us that it enhances focus, improves metabolism, and protects your brain. Time to expose the real story and the science Big Pharma buried 🧵:

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Shayan Sen1 年前

1. Nicotine is not the same as Smoking Nicotine is not the villain. Smoke is. It’s a natural compound found in tomatoes, potatoes, and eggplant. Its structure closely resembles acetylcholine, your brain’s signal for calm focus. @hubermanlab

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Shayan Sen1 年前

Nicotine binds to receptors called nAChRs. These regulate: • Dopamine (motivation) • Glutamate (learning) • GABA (relaxation) • Serotonin (mood) This isn’t just an addictive molecule. It’s a fast-acting neural modulator.

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Shayan Sen1 年前

2. Cognitive Effects Nicotine improves cognition almost immediately. It boosts: • Working memory (UCLA, 2012) • Attention span (Nature, 1998) • Processing speed (Psychopharmacology, 2000) But how? @maxlugavere

Shayan Sen 的头像

Shayan Sen1 年前

It amplifies signals in your prefrontal cortex. The part of the brain that handles focus, judgment, and working memory. It sharpens thought without overstimulation.

Shayan Sen 的头像

Shayan Sen1 年前

3. Brain Protection Nicotine increases BDNF, a protein involved in memory, plasticity, and brain repair. BDNF: a protein involved in brain repair and learning

Shayan Sen 的头像

Shayan Sen1 年前

Higher BDNF levels are linked to stronger long-term cognition. • 30% lower Parkinson’s risk (Annals of Neurology) • Delayed Alzheimer’s onset (J. Neurochemistry) • Fewer Tourette’s symptoms (NEJM) This isn’t fringe science. It’s peer-reviewed and reproducible.

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Shayan Sen1 年前

Nicotine also reduces brain inflammation by modulating microglia. Microglia are immune cells that clean up cellular damage. Less inflammation = slower cognitive decline.

Shayan Sen 的头像

Shayan Sen1 年前

4. Metabolic Benefits Nicotine activates AMPK. It's an enzyme that tells your cells to burn fat and use energy more efficiently. It mimics fasting signals at the cellular level.

Shayan Sen 的头像

Shayan Sen1 年前

5. Why You Never Heard This: Because you weren’t supposed to. 3 reasons: A. Guilt by association: Smoking harms but nicotine isn’t smoke. B. Regulatory bias: The FDA approves synthetic drugs (like varenicline) but denies benefits of natural nicotine. And finally..

Shayan Sen 的头像

Shayan Sen1 年前

C. Pharma profits: Nicotine patches and gum generate over $1.3 billion per year. After the 1998 tobacco settlement, public health messaging was legally bound to portray all nicotine as harmful, regardless of delivery method. Even patches and gum.

Shayan Sen 的头像

Shayan Sen1 年前

I wish someone had explained this to me 20 years ago. It would’ve changed how I saw caffeine, nicotine, even ADHD meds. We were told to fear nicotine. Then prescribed drugs that work the same way, but with more side effects.

Shayan Sen 的头像

Shayan Sen1 年前

6. How to Use It Safely Nicotine isn’t harmless. But it can be used strategically. Clean delivery methods: • Patch • Gum • Sublingual tablets Avoid: • Cigarettes • High-dose vapes • Daily use without breaks Start low: 1–2 mg per session Use 2–4x per week Cycle to avoid tolerance Avoid if hypertensive, pregnant, or highly anxious. Not for anyone under 21. Nicotine can disrupt brain development and increase addiction risk in adolescents. Disclaimer: It's not for everyone. Do your research and make sure it's safe for you.

Shayan Sen 的头像

Shayan Sen1 年前

The Bottom Line: Nicotine isn’t harmless. But it’s not what you were told either. Do your research. If this thread challenged what you’ve been told, it did its job. Follow @DrShayanSen for more evidence-based threads. Bookmark & share it if it made you think.

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3. Sprinting. • Burns visceral fat • Grows mitochondria • Increases testosterone • Boosts growth hormone • Enhances insulin sensitivity Better than all the other forms of cardio.

3. Sprinting. • Burns visceral fat • Grows mitochondria • Increases testosterone • Boosts growth hormone • Enhances insulin sensitivity Better than all the other forms of cardio.

Andrew Panella

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Regular alcohol intake strongly drives visceral fat gain and fatty liver When you drink, your liver prioritizes metabolizing alcohol above everything else (fat metabolism, glucose regulation, and other key metabolic processes all take a backseat) At the same time, alcohol compromises the gut barrier, allowing more inflammatory signals through, triggering a stress response, and disrupting glucose regulation and insulin sensitivity Over time, that means more visceral fat, an inflamed and fibrotic liver, and impaired blood sugar control

Regular alcohol intake strongly drives visceral fat gain and fatty liver When you drink, your liver prioritizes metabolizing alcohol above everything else (fat metabolism, glucose regulation, and other key metabolic processes all take a backseat) At the same time, alcohol compromises the gut barrier, allowing more inflammatory signals through, triggering a stress response, and disrupting glucose regulation and insulin sensitivity Over time, that means more visceral fat, an inflamed and fibrotic liver, and impaired blood sugar control

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They call it "Nature's Ozempic". Berberine is the best supplement in the world for insulin resistance and fat loss. It activates your metabolic master switch AMPK, lowers blood sugar and burns visceral fat. Here are all its health benefits (and how to use it correctly): 🧵

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Unlike intense workouts, walking keeps you in the fat-burning zone, where your body uses fat as its main source of energy. Consistent daily walks boost metabolism, improve insulin sensitivity, and help reduce belly fat, all without stressing your joints.

Unlike intense workouts, walking keeps you in the fat-burning zone, where your body uses fat as its main source of energy. Consistent daily walks boost metabolism, improve insulin sensitivity, and help reduce belly fat, all without stressing your joints.

Alex Stanciu

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Just two weeks of sleeping 4 hours a night increased visceral fat by 11% in healthy young men, with almost no change on the scale In other words, they were accumulating harmful visceral fat (the deep, inflammatory fat stored around your organs) even though body weight barely moved Mechanistically, even one night of short sleep can cause acute insulin resistance, while repeated sleep loss raises cortisol, cravings for high-energy foods, and calorie intake The result is a metabolic setup that makes visceral fat accumulation much more likely over time

Just two weeks of sleeping 4 hours a night increased visceral fat by 11% in healthy young men, with almost no change on the scale In other words, they were accumulating harmful visceral fat (the deep, inflammatory fat stored around your organs) even though body weight barely moved Mechanistically, even one night of short sleep can cause acute insulin resistance, while repeated sleep loss raises cortisol, cravings for high-energy foods, and calorie intake The result is a metabolic setup that makes visceral fat accumulation much more likely over time

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The belly fat you can't pinch is the fat that kills your health. Visceral fat hides deep inside your abdomen, wraps around your organs and fuels insulin resistance and heart disease. Here are 8 ways to burn visceral fat:🧵 1. Resistance train to build muscle

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The belly fat you can't pinch is the fat that kills your health. Visceral fat hides deep inside your abdomen, wraps around your organs and fuels insulin resistance and heart disease. Here are 7 ways to burn visceral fat:🧵 1. Resistance train to build muscle

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THE #1 MOST DANGEROUS FAT In Your Body! Visceral fat is the most dangerous fat in your entire body. It wraps around your organs, drives inflammation, disrupts hormones — and the data is crystal clear: a reduction in visceral fat is strongly associated with lower all-cause mortality. Meaning the opposite is also true: when visceral fat goes up, your risk for disease and early death goes up with it. That’s why decreasing visceral fat isn’t just about looking lean — it’s one of the most important longevity levers you have. #visceralfat #bellyfat #weightloss #longevity

Chris MMHealth

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Visceral fat is inflammatory tissue that can increase your disease risk in a major way. Higher visceral fat is associated with up to a 44% higher risk of several major cancers, including colon, pancreatic, and liver cancer, and this persists even after accounting for waist circumference (suggesting visceral fat itself is a key driver and not just body size). Visceral fat releases inflammatory molecules that can damage cells over time and may even cause normal cells to become cancerous. It tracks with longevity too. Studies using waist circumference as a proxy for visceral fat find people with higher abdominal/visceral fat are about 2 times more likely to die early compared with those without high central fat. If you care about long-term healthspan, reducing visceral fat is one of the most impactful targets. Clip from my recent appearance on Thomas DeLauer podcast!

Visceral fat is inflammatory tissue that can increase your disease risk in a major way. Higher visceral fat is associated with up to a 44% higher risk of several major cancers, including colon, pancreatic, and liver cancer, and this persists even after accounting for waist circumference (suggesting visceral fat itself is a key driver and not just body size). Visceral fat releases inflammatory molecules that can damage cells over time and may even cause normal cells to become cancerous. It tracks with longevity too. Studies using waist circumference as a proxy for visceral fat find people with higher abdominal/visceral fat are about 2 times more likely to die early compared with those without high central fat. If you care about long-term healthspan, reducing visceral fat is one of the most impactful targets. Clip from my recent appearance on Thomas DeLauer podcast!

Dr. Rhonda Patrick

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Losing weight is ridiculously easy in 2025. But if your insulin is high, your body can't burn fat. Ever worse? High insulin wrecks testosterone and quietly drives your blood pressure through the roof. Here are 6 ways to lower it naturally👇 1. Lower your carbohydrate intake Carbs break down into glucose the fastest, forcing your pancreas to pump out insulin to control the spike. When you reduce daily carb load, your blood sugar stays stable. Stable blood sugar = less insulin released = easier fat-burning mode 2. Walk after every meal (even inside the house) A 5-minute walk acts like a glucose sponge. Your muscles pull sugar out of your bloodstream for energy, which lowers the insulin needed to process that meal. Even slow indoor walking reduces post-meal glucose by up to 30% in some studies. 3. Eat protein & fat before carbs Protein and fat slow stomach emptying. When carbs hit your bloodstream more slowly, insulin rises gently instead of spiking. This “food order” trick can reduce the insulin response by 20–40% with the same exact meal. Crazy, right? 4. Fasting. When you’re not eating, your insulin drops. And the longer insulin stays low... The more your body shifts into burning stored fat for energy. Want to supercharge your fasting and knock down blood sugar faster? Berberine might help. It doesn’t simply lower blood sugar and insulin the “natural way”. It activates the enzyme AMP‑activated protein kinase (AMPK) — a fat-burn accelerator. Find it here (Black Friday Amazon Deals) 👇 I also created a FULL-GUIDE on how to use Berberine properly (even if you have never taken it before). Comment "Send" and I'll send it over. (must Follow so I can DM) 4. Strength training. Your muscles act like insulin sponges. The more muscle you have, the more glucose you can store without needing high insulin. Even a single strength workout can increase insulin sensitivity for up to 24–48 hours. 5. Get 7–8 hours of sleep. Poor sleep raises cortisol, and cortisol tells your body to pump out more glucose. More glucose = more insulin. Good sleep resets your hormones overnight and improves insulin sensitivity the next day by 20–30%. 6. Get enough sunlight. Sunlight triggers nitric oxide release in the skin, which helps improve glucose uptake. - Lowers cortisol - Reduces cravings - Stabilizing blood sugar - Sets your circadian rhythm More sunlight = lower insulin throughout the day. My DMs are always open for ANY questions you might have. Thanks for reading until the end, see you in the next one. Every body works differently, this is not medical advice, just what worked on me." Always consult a health expert before following any protocols." Affiliate links included.

Achilleas

60,484 次观看 • 8 个月前

How to ACTUALLY reverse Insulin Resistance That frustrating diagnosis of insulin resistance means the old rulebook for your body is obsolete. What once worked to manage your weight no longer applies. The good news? The new playbook for metabolic recovery doesn’t demand superhuman willpower. As Dr. Annette Bosworth (Dr. Boz) clarifies, reversing insulin resistance hinges on three fundamental shifts. First, track insulin, not calories. The primary lever is your insulin response, not energy units. Carbohydrates trigger the most significant insulin spike, protein a moderate one, and fat the most negligible. In a low-insulin state, dietary fat becomes a powerful metabolic fuel. The directive: embrace fat and restrict carbs to under 20 grams daily. Second, don't eat after dark. The timing of your fat-based meals is critical. Consuming food after sunset carries a heavier metabolic penalty for those with insulin resistance. The golden rule: lengthen the interval between your last bite and bedtime to optimize next-day insulin sensitivity. Third, "measure it if you want to change it." Since you can't easily test insulin directly, Dr. Boz recommends tracking its two most controlled molecules: glucose and ketones. Her innovative "Dr. Boz Ratio" (Glucose ÷ Ketones) serves as a powerful proxy. A lower ratio signals lower insulin, and the ideal time for this measurement is first thing upon waking. The path to reversing insulin resistance is not about deprivation, but about strategic, informed choices.

How to ACTUALLY reverse Insulin Resistance That frustrating diagnosis of insulin resistance means the old rulebook for your body is obsolete. What once worked to manage your weight no longer applies. The good news? The new playbook for metabolic recovery doesn’t demand superhuman willpower. As Dr. Annette Bosworth (Dr. Boz) clarifies, reversing insulin resistance hinges on three fundamental shifts. First, track insulin, not calories. The primary lever is your insulin response, not energy units. Carbohydrates trigger the most significant insulin spike, protein a moderate one, and fat the most negligible. In a low-insulin state, dietary fat becomes a powerful metabolic fuel. The directive: embrace fat and restrict carbs to under 20 grams daily. Second, don't eat after dark. The timing of your fat-based meals is critical. Consuming food after sunset carries a heavier metabolic penalty for those with insulin resistance. The golden rule: lengthen the interval between your last bite and bedtime to optimize next-day insulin sensitivity. Third, "measure it if you want to change it." Since you can't easily test insulin directly, Dr. Boz recommends tracking its two most controlled molecules: glucose and ketones. Her innovative "Dr. Boz Ratio" (Glucose ÷ Ketones) serves as a powerful proxy. A lower ratio signals lower insulin, and the ideal time for this measurement is first thing upon waking. The path to reversing insulin resistance is not about deprivation, but about strategic, informed choices.

Camus

17,349 次观看 • 8 个月前