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"This is only possible because we control the design, make, and test steps within one connected system rather than handing off between disconnected tools and teams." Once molecules are designed in silico, they must be synthesized and tested in the real world. In Part 7 of our platform series,...

167,691 görüntüleme • 22 gün önce •via X (Twitter)

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Sergei Narykov | UHBSE profil fotoğrafı
Sergei Narykov | UHBSE22 gün önce

Connecting design, make and test in one loop is a major advantage. The next challenge is preserving that evidence chain when moving from experimental hits to human response: what transfers, what fails, and what still needs independent validation?

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PeaceWarrior22 gün önce

Future of Medicine...!

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Helicool21 gün önce

Big‑model firms like OpenAI are into AI‑drug but lack auto. Auto is the key bottleneck; owners can be the TSMC of AI pharma. Don’t bear new‑drug risks. Raise capital to build automated factories, lease to OpenAI for their payment, like building AIDCs for them.@RecursiveChris

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"Across our programs, we've advanced quality novel candidates after synthesizing only around 300 compounds, roughly 90% fewer than the industry average." Now that we have mapped the biology, we need to design the exact molecule to target it. In Part 5 of our platform series, SVP of Drug Design Donovan Chin, Ph.D., and VP of Pharmacology Martin Redhead, Ph.D., break down how we transition from biological target discovery to navigating complex chemical space. Just like our approach to biology, we solve chemistry problems through a continuous feedback loop between computation and experimentation. Before a single molecule is ever synthesized in the lab, our team uses Centaur, our integrated drug design environment. By combining hundreds of machine learning and physics-based models into a single platform, we can iteratively design novel molecular structures starting directly from target properties. This generative de novo design approach automatically updates our models so they improve with every single cycle. Our AI-native product engine has already produced over 10 development candidates. By holding our chemistry to the same rigorous standards as our biology, we can synthesize a fraction of the traditional compound volume while delivering superior novel molecules. We believe this focus on quality and novelty over sheer volume will define the true impact of AI on drug development. 🚀 Follow along over the coming weeks as we continue this series, covering how Recursion maps biology, optimizes precision drug design, and closes the gap between patient and discovery. #TechBio #DrugDesign #AIDrugDiscovery #DrugDiscovery #Chemistry

Recursion

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"Our integrated system narrows millions of molecules down to a short list that's synthetically accessible. Not just promising in silico, but actually makeable before a single one is sent to the labs." Traditional drug design often leans on decades of precedent and familiar chemistry. In Part 6 of our platform series, SVP of Drug Design Donovan Chin, Ph.D., explains how Recursion breaks that mold by getting a full computational design cycle up and running in about a day. Our AI-native engine vastly increases the aperture for our chemists. Instead of relying solely on known binding pockets, they can efficiently explore entirely novel and complex chemical space. By leveraging our integrated data, the team can forecast non-obvious design hypotheses and predict how to synthesize molecules even when nothing like them currently exists. This process begins by scoring binding affinity using advanced 3D structural models like Nesso-1. From there, the team runs hundreds of integrated models covering ADME, potency, advanced simulations, and AI retrosynthesis. This unified system rapidly filters millions of potential molecules down to a precise shortlist of high-quality candidates that are physically ready for the lab. 🚀 Follow along over the coming weeks as we continue this series, covering how Recursion maps biology, optimizes precision drug design, and closes the gap between patient and discovery. #TechBio #DrugDesign #ComputationalChemistry #DrugDiscovery #MachineLearning

Recursion

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