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This is the COMPLETE Peptide Tier List compilation — Parts 1 through 3 combined into one deep dive. We break down the most talked-about compounds in fitness, longevity, anti-aging, and fat loss: Semaglutide, Tirzepatide, Retatrutide, Mazdutide, Growth Hormone (HGH), HCG, IGF-1 LR3, Tesamorelin, Sermorelin, CJC-1295, Ipamorelin, BPC-157, TB-500, NAD+,...

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Dr. Alex Tatem

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247,190 次观看 • 6 个月前 •via X (Twitter)

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BPC-157 causing cancer? FDA shutting down peptide trials? “No human RCTs have ever been done on peptides?” In this video, Dr. Alex Tatem — board-certified urologist and fellowship-trained men’s health specialist — reacts to viral claims made on Shawn Ryan Show about BPC-157, TB-500, peptides, angiogenesis, cancer risk, and peptide safety. We break down: • Whether BPC-157 actually causes cancer • The truth about angiogenesis and tumor growth • FDA regulation of peptides and compounding • Why the “no randomized controlled trials” claim is completely false • Human clinical trial data on peptides • The real history of BPC-157 clinical studies • Huberman’s correction of viral peptide misinformation • Why peptide fearmongering could push patients toward unsafe gray-market sourcing This is not bro-science or influencer hype. This is a deep dive into the actual published literature, peptide pharmacology, FDA policy, and performance medicine. Topics covered include: BPC-157, TB-500, peptides, angiogenesis, cancer biology, GLP-1 drugs, Ozempic, tirzepatide, semaglutide, TRT, peptide therapy, biohacking, longevity, anti-aging medicine, compounding pharmacies, peptide legality, Andrew D. Huberman, Ph.D. , Shawn Ryan Show, FDA peptide regulation, growth hormone history, and performance medicine. If you’ve ever wondered whether BPC-157 is dangerous, whether peptides are legal, or whether the internet is fearmongering about peptide therapy — this video is for you.
20:43

BPC-157 causing cancer? FDA shutting down peptide trials? “No human RCTs have ever been done on peptides?” In this video, Dr. Alex Tatem — board-certified urologist and fellowship-trained men’s health specialist — reacts to viral claims made on Shawn Ryan Show about BPC-157, TB-500, peptides, angiogenesis, cancer risk, and peptide safety. We break down: • Whether BPC-157 actually causes cancer • The truth about angiogenesis and tumor growth • FDA regulation of peptides and compounding • Why the “no randomized controlled trials” claim is completely false • Human clinical trial data on peptides • The real history of BPC-157 clinical studies • Huberman’s correction of viral peptide misinformation • Why peptide fearmongering could push patients toward unsafe gray-market sourcing This is not bro-science or influencer hype. This is a deep dive into the actual published literature, peptide pharmacology, FDA policy, and performance medicine. Topics covered include: BPC-157, TB-500, peptides, angiogenesis, cancer biology, GLP-1 drugs, Ozempic, tirzepatide, semaglutide, TRT, peptide therapy, biohacking, longevity, anti-aging medicine, compounding pharmacies, peptide legality, Andrew D. Huberman, Ph.D. , Shawn Ryan Show, FDA peptide regulation, growth hormone history, and performance medicine. If you’ve ever wondered whether BPC-157 is dangerous, whether peptides are legal, or whether the internet is fearmongering about peptide therapy — this video is for you.

Dr. Alex Tatem

77,332 次观看 • 3 个月前

BPC-157 and TB-500 are two of the most talked-about peptides in fitness, bodybuilding, and biohacking. Together they’re often called the “Wolverine Stack” — a peptide combination rumored to dramatically accelerate healing of tendons, ligaments, muscles, and injuries. But do BPC-157 and TB-500 actually work in humans, or is the Wolverine Stack just another example of internet bro-science? In this evidence-based deep dive, Dr. Alex Tatem (board-certified urologist and men’s health specialist) breaks down the real science behind BPC-157 and TB-500 — including their biochemical mechanisms, animal research, potential healing effects, safety concerns, and why pharmaceutical companies have never brought these peptides through full FDA clinical trials. We explore the nitric oxide signaling, angiogenesis, VEGF pathways, actin regulation, and tissue repair biology behind these compounds and explain why rodent studies look promising — but why human clinical evidence is still extremely limited. You’ll also learn about: • What BPC-157 (Body Protection Compound-157) actually is • TB-500 vs Thymosin Beta-4 explained • The origin of the Wolverine Stack peptide protocol • Peptides for tendon healing and ligament injuries • BPC-157 for gut healing and musculoskeletal repair • TB-500 and actin-mediated tissue regeneration • Why most peptide research comes from one Croatian research group • The patent law problem preventing pharmaceutical development • Real risks of grey-market peptide contamination • Why WADA bans BPC-157 and TB-500 in competitive athletes • Theoretical cancer risks related to angiogenesis • What the current scientific literature actually shows If you've ever searched: “Does BPC-157 work?” “What is TB-500?” “Peptides for healing injuries” “BPC-157 tendon repair” “Wolverine Stack peptides explained” — this video breaks down the science. The peptides may be promising. But promise and proof are not the same thing. Drop a comment below: Have you ever used BPC-157, TB-500, or other peptides? What was your experience? 👍 Like the video if you want more evidence-based breakdowns of supplements, PEDs, and peptides. Subscribe for deep dives on testosterone, steroids, peptides, supplements, and men’s health science.
30:26

BPC-157 and TB-500 are two of the most talked-about peptides in fitness, bodybuilding, and biohacking. Together they’re often called the “Wolverine Stack” — a peptide combination rumored to dramatically accelerate healing of tendons, ligaments, muscles, and injuries. But do BPC-157 and TB-500 actually work in humans, or is the Wolverine Stack just another example of internet bro-science? In this evidence-based deep dive, Dr. Alex Tatem (board-certified urologist and men’s health specialist) breaks down the real science behind BPC-157 and TB-500 — including their biochemical mechanisms, animal research, potential healing effects, safety concerns, and why pharmaceutical companies have never brought these peptides through full FDA clinical trials. We explore the nitric oxide signaling, angiogenesis, VEGF pathways, actin regulation, and tissue repair biology behind these compounds and explain why rodent studies look promising — but why human clinical evidence is still extremely limited. You’ll also learn about: • What BPC-157 (Body Protection Compound-157) actually is • TB-500 vs Thymosin Beta-4 explained • The origin of the Wolverine Stack peptide protocol • Peptides for tendon healing and ligament injuries • BPC-157 for gut healing and musculoskeletal repair • TB-500 and actin-mediated tissue regeneration • Why most peptide research comes from one Croatian research group • The patent law problem preventing pharmaceutical development • Real risks of grey-market peptide contamination • Why WADA bans BPC-157 and TB-500 in competitive athletes • Theoretical cancer risks related to angiogenesis • What the current scientific literature actually shows If you've ever searched: “Does BPC-157 work?” “What is TB-500?” “Peptides for healing injuries” “BPC-157 tendon repair” “Wolverine Stack peptides explained” — this video breaks down the science. The peptides may be promising. But promise and proof are not the same thing. Drop a comment below: Have you ever used BPC-157, TB-500, or other peptides? What was your experience? 👍 Like the video if you want more evidence-based breakdowns of supplements, PEDs, and peptides. Subscribe for deep dives on testosterone, steroids, peptides, supplements, and men’s health science.

Dr. Alex Tatem

22,510 次观看 • 5 个月前

YOU ALL GONNA BE EXCITED WITH THIS ONE, YOU CAN NOW GET A RELIABLE source of PEPTIDES FROM MYSELF FOLLOW SUPREME PEPTIDES AND WATCH THIS GROW, PEOPLE KNOW THEY CAN TRUST ME. BENEFITS BELOW ⬇️ Peptides are short chains of amino acids that act as signaling molecules in the body. Different peptides have very different effects, so the benefits depend entirely on which peptide you’re referring to. Here are some of the most commonly discussed peptide categories and their potential benefits: Healing and Recovery * BPC-157 – Often promoted for tendon, ligament, muscle, and gut healing. * TB-500 (Thymosin Beta-4 fragment) – May support tissue repair and reduce recovery time after injury. * Potential benefits: * Faster recovery from injuries * Improved wound healing * Reduced inflammation (evidence in humans is limited) Muscle Growth and Performance * CJC-1295 and Ipamorelin – Stimulate the body’s release of growth hormone. * Potential benefits: * Increased lean muscle mass * Better recovery after exercise * Improved sleep * Possible reduction in body fat Weight Loss * Tirzepatide and Semaglutide * Potential benefits: * Reduced appetite * Significant weight loss * Improved blood sugar control in people with diabetes Skin and Anti-Ageing * GHK-Cu (Copper Peptide) * Potential benefits: * Improved skin elasticity * Reduced appearance of fine lines * May promote hair growth * Supports wound healing Sexual Health * PT-141 (Bremelanotide) * Potential benefits: * Increased sexual desire in some people * Used for certain forms of low sexual desire Immune Function * Thymosin Alpha-1 * Potential benefits: * Supports immune system function * Studied in certain infections and cancers Are peptides safe? It depends on the peptide and how it’s used.
1:18

YOU ALL GONNA BE EXCITED WITH THIS ONE, YOU CAN NOW GET A RELIABLE source of PEPTIDES FROM MYSELF FOLLOW SUPREME PEPTIDES AND WATCH THIS GROW, PEOPLE KNOW THEY CAN TRUST ME. BENEFITS BELOW ⬇️ Peptides are short chains of amino acids that act as signaling molecules in the body. Different peptides have very different effects, so the benefits depend entirely on which peptide you’re referring to. Here are some of the most commonly discussed peptide categories and their potential benefits: Healing and Recovery * BPC-157 – Often promoted for tendon, ligament, muscle, and gut healing. * TB-500 (Thymosin Beta-4 fragment) – May support tissue repair and reduce recovery time after injury. * Potential benefits: * Faster recovery from injuries * Improved wound healing * Reduced inflammation (evidence in humans is limited) Muscle Growth and Performance * CJC-1295 and Ipamorelin – Stimulate the body’s release of growth hormone. * Potential benefits: * Increased lean muscle mass * Better recovery after exercise * Improved sleep * Possible reduction in body fat Weight Loss * Tirzepatide and Semaglutide * Potential benefits: * Reduced appetite * Significant weight loss * Improved blood sugar control in people with diabetes Skin and Anti-Ageing * GHK-Cu (Copper Peptide) * Potential benefits: * Improved skin elasticity * Reduced appearance of fine lines * May promote hair growth * Supports wound healing Sexual Health * PT-141 (Bremelanotide) * Potential benefits: * Increased sexual desire in some people * Used for certain forms of low sexual desire Immune Function * Thymosin Alpha-1 * Potential benefits: * Supports immune system function * Studied in certain infections and cancers Are peptides safe? It depends on the peptide and how it’s used.

Anthony Fowler

28,226 次观看 • 1 个月前

CHECK out YOU ALL GONNA BE EXCITED WITH THIS ONE, YOU CAN NOW GET A RELIABLE source of PEPTIDES FROM MYSELF FOLLOW SUPREME PEPTIDES AND WATCH THIS GROW, PEOPLE KNOW THEY CAN TRUST ME. BENEFITS BELOW ⬇️ all p Peptides are short chains of amino acids that act as signaling molecules in the body. Different peptides have very different effects, so the benefits depend entirely on which peptide you’re referring to. Here are some of the most commonly discussed peptide categories and their potential benefits: Healing and Recovery * BPC-157 – Often promoted for tendon, ligament, muscle, and gut healing. * TB-500 (Thymosin Beta-4 fragment) – May support tissue repair and reduce recovery time after injury. * Potential benefits: * Faster recovery from injuries * Improved wound healing * Reduced inflammation (evidence in humans is limited) Muscle Growth and Performance * CJC-1295 and Ipamorelin – Stimulate the body’s release of growth hormone. * Potential benefits: * Increased lean muscle mass * Better recovery after exercise * Improved sleep * Possible reduction in body fat Weight Loss * Tirzepatide and Semaglutide * Potential benefits: * Reduced appetite * Significant weight loss * Improved blood sugar control in people with diabetes Skin and Anti-Ageing * GHK-Cu (Copper Peptide) * Potential benefits: * Improved skin elasticity * Reduced appearance of fine lines * May promote hair growth * Supports wound healing Sexual Health * PT-141 (Bremelanotide) * Potential benefits: * Increased sexual desire in some people * Used for certain forms of low sexual desire Immune Function * Thymosin Alpha-1 * Potential benefits: * Supports immune system function * Studied in certain infections and cancers All here
1:06

CHECK out YOU ALL GONNA BE EXCITED WITH THIS ONE, YOU CAN NOW GET A RELIABLE source of PEPTIDES FROM MYSELF FOLLOW SUPREME PEPTIDES AND WATCH THIS GROW, PEOPLE KNOW THEY CAN TRUST ME. BENEFITS BELOW ⬇️ all p Peptides are short chains of amino acids that act as signaling molecules in the body. Different peptides have very different effects, so the benefits depend entirely on which peptide you’re referring to. Here are some of the most commonly discussed peptide categories and their potential benefits: Healing and Recovery * BPC-157 – Often promoted for tendon, ligament, muscle, and gut healing. * TB-500 (Thymosin Beta-4 fragment) – May support tissue repair and reduce recovery time after injury. * Potential benefits: * Faster recovery from injuries * Improved wound healing * Reduced inflammation (evidence in humans is limited) Muscle Growth and Performance * CJC-1295 and Ipamorelin – Stimulate the body’s release of growth hormone. * Potential benefits: * Increased lean muscle mass * Better recovery after exercise * Improved sleep * Possible reduction in body fat Weight Loss * Tirzepatide and Semaglutide * Potential benefits: * Reduced appetite * Significant weight loss * Improved blood sugar control in people with diabetes Skin and Anti-Ageing * GHK-Cu (Copper Peptide) * Potential benefits: * Improved skin elasticity * Reduced appearance of fine lines * May promote hair growth * Supports wound healing Sexual Health * PT-141 (Bremelanotide) * Potential benefits: * Increased sexual desire in some people * Used for certain forms of low sexual desire Immune Function * Thymosin Alpha-1 * Potential benefits: * Supports immune system function * Studied in certain infections and cancers All here

Anthony Fowler

156,157 次观看 • 29 天前

Peptides aren’t “bro science” anymore. Dr. Alex Tatum just sat down on Diary of a CEO and calmly dropped the 15 most useful ones right now — what they actually do, who they’re for, and how they’re used. Here’s the no-BS version: BPC-157 → Torn muscle, tendon, or gut issues? It grows new blood vessels at the injury site. Healing on overdrive. GHK-Cu → Fine lines, sagging skin, thinning hair. Real collagen + elastin boost (topical). Semax → Brain fog and mental fatigue? Nasal spray that hits focus in minutes. Melanotan 2 → Fair-skinned and hate burning? Tells your body to tan harder with less sun. PT-141 → Low libido or ED that Viagra can’t fix. Works on the nervous system, not blood flow. Retatrutide → Extreme fat loss + fatty liver. Triple agonist (GLP-1/GIP/glucagon). Bodybuilders already treat it as the new standard. Tesamorelin → Stubborn belly fat after 30. Targets visceral fat specifically via GH. CJC-1295 + Ipamorelin → Better sleep, recovery, and slow fat loss without the harsh sides. Bedtime stack. TB-500 → Nagging injuries that won’t heal. Pairs perfectly with BPC-157. Tirzepatide → More aggressive fat loss than semaglutide when insulin is high. DSIP → Broken sleep cycles (shift work, travel). Deep delta-wave repair sleep. MOTS-c → Endurance and cellular energy without stimulants. More ATP. Epitalon → Longevity play. Activates telomerase. IGF-1 LR3 → Advanced body-composition tool. Only works with hard training. These aren’t magic. Most still need proper sourcing, dosing, and medical oversight. But the mechanisms are real and the results some people are getting are hard to ignore. Which one surprised you the most?
1:14

Peptides aren’t “bro science” anymore. Dr. Alex Tatum just sat down on Diary of a CEO and calmly dropped the 15 most useful ones right now — what they actually do, who they’re for, and how they’re used. Here’s the no-BS version: BPC-157 → Torn muscle, tendon, or gut issues? It grows new blood vessels at the injury site. Healing on overdrive. GHK-Cu → Fine lines, sagging skin, thinning hair. Real collagen + elastin boost (topical). Semax → Brain fog and mental fatigue? Nasal spray that hits focus in minutes. Melanotan 2 → Fair-skinned and hate burning? Tells your body to tan harder with less sun. PT-141 → Low libido or ED that Viagra can’t fix. Works on the nervous system, not blood flow. Retatrutide → Extreme fat loss + fatty liver. Triple agonist (GLP-1/GIP/glucagon). Bodybuilders already treat it as the new standard. Tesamorelin → Stubborn belly fat after 30. Targets visceral fat specifically via GH. CJC-1295 + Ipamorelin → Better sleep, recovery, and slow fat loss without the harsh sides. Bedtime stack. TB-500 → Nagging injuries that won’t heal. Pairs perfectly with BPC-157. Tirzepatide → More aggressive fat loss than semaglutide when insulin is high. DSIP → Broken sleep cycles (shift work, travel). Deep delta-wave repair sleep. MOTS-c → Endurance and cellular energy without stimulants. More ATP. Epitalon → Longevity play. Activates telomerase. IGF-1 LR3 → Advanced body-composition tool. Only works with hard training. These aren’t magic. Most still need proper sourcing, dosing, and medical oversight. But the mechanisms are real and the results some people are getting are hard to ignore. Which one surprised you the most?

Dr. Dawn Michael

21,795 次观看 • 19 天前

Dr. Annette Bosworth (Dr. Boz) dropped a strong warning about Ozempic for weight loss. She said we should put her words in a time capsule and open them in 15 years. While the drug produces dramatic weight loss, she argues the mechanism is essentially starvation-level weight loss, which causes people to lose muscle mass at a dangerously high rate — especially concerning for older patients, since that muscle is extremely hard to regain. Science nugget: Clinical studies show that a significant portion of weight lost on GLP-1 agonists like Ozempic (semaglutide) comes from lean mass (muscle) rather than fat alone — in some trials up to 25–40% of total weight loss was lean tissue, which can impair metabolic rate, immune function, bone density, and long-term physical resilience. Her bottom line: this kind of rapid, muscle-wasting loss may shorten longevity rather than extend it. It’s a sobering counterpoint to the current hype around these medications. What do you think — are we celebrating the weight loss without fully understanding the long-term trade-offs?
0:43

Dr. Annette Bosworth (Dr. Boz) dropped a strong warning about Ozempic for weight loss. She said we should put her words in a time capsule and open them in 15 years. While the drug produces dramatic weight loss, she argues the mechanism is essentially starvation-level weight loss, which causes people to lose muscle mass at a dangerously high rate — especially concerning for older patients, since that muscle is extremely hard to regain. Science nugget: Clinical studies show that a significant portion of weight lost on GLP-1 agonists like Ozempic (semaglutide) comes from lean mass (muscle) rather than fat alone — in some trials up to 25–40% of total weight loss was lean tissue, which can impair metabolic rate, immune function, bone density, and long-term physical resilience. Her bottom line: this kind of rapid, muscle-wasting loss may shorten longevity rather than extend it. It’s a sobering counterpoint to the current hype around these medications. What do you think — are we celebrating the weight loss without fully understanding the long-term trade-offs?

Camus

88,096 次观看 • 4 个月前

“This is going to be a trillion-dollar drug.” Andrew D. Huberman, Ph.D. says retatrutide is the peptide that’s about to “change everything.” Currently in a Phase III clinical trial in humans, retatrutide caused up to one-third body weight loss in just six months, with some degree of muscle sparing. “The bodybuilding community has been onto this for a long time.” “Then it shows up in Hollywood. Everyone lies or avoids answering the question of how they got so jacked. They talk about eating chicken breasts, and they’re actually taking growth hormone, Winstrol, and retatrutide.” “We are looking at a potential change in the laws around peptides such that buying peptides would become illegal. I think this is a terrible idea, but the motivation behind this is largely because Eli Lilly owns the patent.” “Lilly would like to protect the domain over that patent. This is going to be a trillion-dollar drug.”
3:16

“This is going to be a trillion-dollar drug.” Andrew D. Huberman, Ph.D. says retatrutide is the peptide that’s about to “change everything.” Currently in a Phase III clinical trial in humans, retatrutide caused up to one-third body weight loss in just six months, with some degree of muscle sparing. “The bodybuilding community has been onto this for a long time.” “Then it shows up in Hollywood. Everyone lies or avoids answering the question of how they got so jacked. They talk about eating chicken breasts, and they’re actually taking growth hormone, Winstrol, and retatrutide.” “We are looking at a potential change in the laws around peptides such that buying peptides would become illegal. I think this is a terrible idea, but the motivation behind this is largely because Eli Lilly owns the patent.” “Lilly would like to protect the domain over that patent. This is going to be a trillion-dollar drug.”

TBPN

1,977,854 次观看 • 6 个月前

RETATRUTIDE is NOT JUST for WEIGHT LOSS… …and the fact that that’s what everyone is obsessing over tells me we’re still missing the point. 🙃 Because what I’m looking at? It’s not just the scale. It’s what’s happening underneath it. We’re talking 24% body weight reduction in trials… sure. BUT ALSO: 47% drop in inflammatory markers in 12 weeks. 2.1% drop in HbA1c. 42% reduction in visceral fat (the dangerous kind hugging your organs). 🫁 And then it gets uncomfortable… 31% lower cardiovascular mortality. 28% fewer heart attacks. 22% fewer strokes. Like… pause there. Because if this was just about weight loss… those numbers wouldn’t exist. This is metabolism. This is inflammation. This is mitochondrial signaling. 🧬 And THIS is where I start side-eyeing the narrative. Because you’ve been told this is about “calories” and “willpower.” Meanwhile your body is sitting there like— “Hey… I’m inflamed. I’m insulin resistant. I’m storing for a reason.” 👀 And instead of asking why… We’ve been handed drugs and told to shrink. But here’s the part nobody’s talking about… What happens when you stop? With semaglutide (Ozempic)… about 72% of people regain the weight. Tirzepatide? Around 60%. Retatrutide? ONLY 5–10%. That’s not a small difference. That’s a completely different conversation. Because now we’re NOT just talking about weight suppression… We’re talking about whether the terrain (esp hormones and body talk) actually changed. And if you’ve ever felt like you’re doing everything right… but your body keeps pulling you back… this matters more than you think. Because your body isn’t trying to sabotage you. It’s responding to something deeper. If you want me to break down what this actually means… and how peptides are shifting the entire conversation— Comment PEPTIDES and I’ll send you the full breakdown. 💡 #peptides #biohacking #womenshealth #hormones #healthandwellbeing
1:15

RETATRUTIDE is NOT JUST for WEIGHT LOSS… …and the fact that that’s what everyone is obsessing over tells me we’re still missing the point. 🙃 Because what I’m looking at? It’s not just the scale. It’s what’s happening underneath it. We’re talking 24% body weight reduction in trials… sure. BUT ALSO: 47% drop in inflammatory markers in 12 weeks. 2.1% drop in HbA1c. 42% reduction in visceral fat (the dangerous kind hugging your organs). 🫁 And then it gets uncomfortable… 31% lower cardiovascular mortality. 28% fewer heart attacks. 22% fewer strokes. Like… pause there. Because if this was just about weight loss… those numbers wouldn’t exist. This is metabolism. This is inflammation. This is mitochondrial signaling. 🧬 And THIS is where I start side-eyeing the narrative. Because you’ve been told this is about “calories” and “willpower.” Meanwhile your body is sitting there like— “Hey… I’m inflamed. I’m insulin resistant. I’m storing for a reason.” 👀 And instead of asking why… We’ve been handed drugs and told to shrink. But here’s the part nobody’s talking about… What happens when you stop? With semaglutide (Ozempic)… about 72% of people regain the weight. Tirzepatide? Around 60%. Retatrutide? ONLY 5–10%. That’s not a small difference. That’s a completely different conversation. Because now we’re NOT just talking about weight suppression… We’re talking about whether the terrain (esp hormones and body talk) actually changed. And if you’ve ever felt like you’re doing everything right… but your body keeps pulling you back… this matters more than you think. Because your body isn’t trying to sabotage you. It’s responding to something deeper. If you want me to break down what this actually means… and how peptides are shifting the entire conversation— Comment PEPTIDES and I’ll send you the full breakdown. 💡 #peptides #biohacking #womenshealth #hormones #healthandwellbeing

Dr Diane Kazer

78,513 次观看 • 4 个月前

There's a question that keeps coming up: is retatrutide better than tirzepatide? In my experience, this is the wrong question. It's like asking whether steak or chicken is better. Steak is arguably more nutrient-dense, but some people do better on chicken, and there's no reason you wouldn't vary your protein sources. It's the same with GLPs. It's not either/or, you have to experiment. > Tirzepatide is a dual agonist. It hits GLP-1 and GIP receptors. > Retatrutide is a triple agonist. It hits GLP-1, GIP, and glucagon receptors. That glucagon piece is the key difference. It changes how your body uses fuel in a way tirzepatide simply doesn't. In clinical trials, retatrutide produced 24% average weight loss in 48 weeks. Tirzepatide produced 21% in 72 weeks. Reta produced better results in almost half the time. The glucagon receptor drives thermogenesis and fat oxidation, which you don't get with a dual agonist. But retatrutide comes with a tradeoff. It raises resting heart rate by 5-10 BPM, driven by the glucagon receptor, and happens at every dose level. Reta peaks around week 24 and reverses when you stop. This doesn't happen with tirzepatide. And that's exactly why you shouldn't be on either of these indefinitely. The problem is that most people are scared to cycle off because they've heard the horror stories about weight rebound. As a result, they stay on way too long. This isn't medical advice, but I believe the right approach is to be 12-16 weeks on, 8-10 weeks off. You cycle, monitor, and adjust. If you don't know how to properly come off a GLP, you have no business being on one. On top of that, if you're running the experiment but not tracking it, you're wasting it. - Get labs done: fasting insulin, blood glucose, A1C, etc. - Wear a tracker: monitor heart rate and HRV These compounds impact metabolic markers that matter way more than bodyweight. If you have weight to lose and you're interested in GLPs, run at least one cycle of each. See how your body responds to retatrutide. Then see how it responds to tirzepatide. Compare the data, and that's how you'll find what works. Because in performance healthcare, data wins, not the math. Comment "FATLOSS" below, and I'll send you my 70-page Peptide Bible. P.S. None of this is medical advice nor a recommendation.
1:09

There's a question that keeps coming up: is retatrutide better than tirzepatide? In my experience, this is the wrong question. It's like asking whether steak or chicken is better. Steak is arguably more nutrient-dense, but some people do better on chicken, and there's no reason you wouldn't vary your protein sources. It's the same with GLPs. It's not either/or, you have to experiment. > Tirzepatide is a dual agonist. It hits GLP-1 and GIP receptors. > Retatrutide is a triple agonist. It hits GLP-1, GIP, and glucagon receptors. That glucagon piece is the key difference. It changes how your body uses fuel in a way tirzepatide simply doesn't. In clinical trials, retatrutide produced 24% average weight loss in 48 weeks. Tirzepatide produced 21% in 72 weeks. Reta produced better results in almost half the time. The glucagon receptor drives thermogenesis and fat oxidation, which you don't get with a dual agonist. But retatrutide comes with a tradeoff. It raises resting heart rate by 5-10 BPM, driven by the glucagon receptor, and happens at every dose level. Reta peaks around week 24 and reverses when you stop. This doesn't happen with tirzepatide. And that's exactly why you shouldn't be on either of these indefinitely. The problem is that most people are scared to cycle off because they've heard the horror stories about weight rebound. As a result, they stay on way too long. This isn't medical advice, but I believe the right approach is to be 12-16 weeks on, 8-10 weeks off. You cycle, monitor, and adjust. If you don't know how to properly come off a GLP, you have no business being on one. On top of that, if you're running the experiment but not tracking it, you're wasting it. - Get labs done: fasting insulin, blood glucose, A1C, etc. - Wear a tracker: monitor heart rate and HRV These compounds impact metabolic markers that matter way more than bodyweight. If you have weight to lose and you're interested in GLPs, run at least one cycle of each. See how your body responds to retatrutide. Then see how it responds to tirzepatide. Compare the data, and that's how you'll find what works. Because in performance healthcare, data wins, not the math. Comment "FATLOSS" below, and I'll send you my 70-page Peptide Bible. P.S. None of this is medical advice nor a recommendation.

Michael Morelli

39,309 次观看 • 4 个月前

Think your blood glucose tells the whole story? Think again. Dr. Ben Bikman (Benjamin Bikman) joins me to discuss insulin resistance, including why it often remains hidden until late stages and simple ways to detect it early. We explore insulin’s lesser-known roles in fat storage, appetite regulation, inflammation, and chronic disease. You’ll also learn how macronutrients, meal timing, and frequency uniquely influence your insulin sensitivity, and the critical differences between visceral and subcutaneous fat. Finally, we dive into how stress, sleep deprivation, nicotine, and environmental toxins shape your metabolism and unpack the realities of popular GLP-1 receptor agonist medications (like Ozempic), including their benefits, risks, and the intriguing potential of microdosing. We also provide practical, actionable strategies, dietary adjustments, exercise protocols, and targeted supplements that you can implement today to significantly boost insulin sensitivity and support long-term metabolic health. If you want to understand insulin resistance and take immediate steps to improve your metabolic health - this conversation is a must-watch. Watch the full episode on X and YouTube or listen on Spotify and Apple Podcasts now. Links in the comments. Timestamps: 0:00 - Introduction 1:33 - Can you be insulin resistant with normal glucose levels? 5:13 - Can glucose monitors detect hidden insulin resistance? 6:43 - What your skin reveals about insulin resistance 8:07 - Why is insulin resistance behind so many chronic diseases? 12:28 - Does obesity cause insulin resistance—or vice versa? 19:20 - Insulin’s surprising roles beyond blood sugar control 20:18 - What’s driving weight gain—insulin or calories? 27:12 - Do saturated fats cause insulin resistance? 33:44 - Why refined carbs amplify risks from saturated fat 36:46 - Fructose vs. refined sugar—which spikes insulin more? 37:43 - High-carb vs. keto—which diet controls hunger better? 42:09 - Why low-carb diets might provide a metabolic advantage 44:18 - Does exercise give you metabolic ‘wiggle room’? 48:42 - Why strength training beats cardio for insulin sensitivity 53:54 - Does meal frequency drive insulin resistance? 57:14 - Is nighttime snacking giving you insomnia? 59:06 - Can a sugary breakfast lead to overeating later? 1:04:01 - Does late-night eating disrupt sleep more than blue light? 1:05:41 - Can one bad night’s sleep trigger insulin resistance? 1:09:06 - Can air pollution cause weight gain? 1:12:58 - Vaping vs. smoking—which is worse for metabolic health? 1:14:20 - Can statins and antidepressants trigger weight gain? 1:17:04 - How to reverse insulin resistance in 90 days 1:27:35 - Ketone supplements—are the metabolic benefits real? 1:33:16 - Why some ethnicities get diabetes without obesity 1:41:11 - How oversized fat cells trigger metabolic chaos 1:46:10 - Do seed oils silently promote insulin resistance? 1:49:27 - Seed oils—always harmful or only when heated? 2:01:03 - Do fat cells shrink or disappear with weight loss? 2:03:48 - Are shrunken fat cells still insulin resistant? 2:06:23 - Injecting insulin for muscle—are the risks worth it? 2:09:27 - Are drugs like Ozempic a shortcut or solution for obesity? 2:15:55 - Are current GLP-1 agonist doses too high? 2:16:44 - Microdosing GLP-1 drugs—a solution for carb cravings? 2:22:43 - Do these medications cause muscle loss? 2:25:12 - Do GLP-1 agonist benefits extend beyond weight loss? 2:27:23 - Could these treatments actually promote longevity? 2:32:55 - The dark side of GLP-1 drugs—can they trigger depression? 2:36:14 - Insulin vs. glucose—what really drives accelerated aging? 2:41:16 - How high glucose levels damage cells 2:43:23 - How insulin shuts down your body’s stress defenses 2:47:57 - Which biomarkers best predict biological aging? 2:54:01 - Does eating dinner early improve insulin sensitivity?
2:56:50

Think your blood glucose tells the whole story? Think again. Dr. Ben Bikman (Benjamin Bikman) joins me to discuss insulin resistance, including why it often remains hidden until late stages and simple ways to detect it early. We explore insulin’s lesser-known roles in fat storage, appetite regulation, inflammation, and chronic disease. You’ll also learn how macronutrients, meal timing, and frequency uniquely influence your insulin sensitivity, and the critical differences between visceral and subcutaneous fat. Finally, we dive into how stress, sleep deprivation, nicotine, and environmental toxins shape your metabolism and unpack the realities of popular GLP-1 receptor agonist medications (like Ozempic), including their benefits, risks, and the intriguing potential of microdosing. We also provide practical, actionable strategies, dietary adjustments, exercise protocols, and targeted supplements that you can implement today to significantly boost insulin sensitivity and support long-term metabolic health. If you want to understand insulin resistance and take immediate steps to improve your metabolic health - this conversation is a must-watch. Watch the full episode on X and YouTube or listen on Spotify and Apple Podcasts now. Links in the comments. Timestamps: 0:00 - Introduction 1:33 - Can you be insulin resistant with normal glucose levels? 5:13 - Can glucose monitors detect hidden insulin resistance? 6:43 - What your skin reveals about insulin resistance 8:07 - Why is insulin resistance behind so many chronic diseases? 12:28 - Does obesity cause insulin resistance—or vice versa? 19:20 - Insulin’s surprising roles beyond blood sugar control 20:18 - What’s driving weight gain—insulin or calories? 27:12 - Do saturated fats cause insulin resistance? 33:44 - Why refined carbs amplify risks from saturated fat 36:46 - Fructose vs. refined sugar—which spikes insulin more? 37:43 - High-carb vs. keto—which diet controls hunger better? 42:09 - Why low-carb diets might provide a metabolic advantage 44:18 - Does exercise give you metabolic ‘wiggle room’? 48:42 - Why strength training beats cardio for insulin sensitivity 53:54 - Does meal frequency drive insulin resistance? 57:14 - Is nighttime snacking giving you insomnia? 59:06 - Can a sugary breakfast lead to overeating later? 1:04:01 - Does late-night eating disrupt sleep more than blue light? 1:05:41 - Can one bad night’s sleep trigger insulin resistance? 1:09:06 - Can air pollution cause weight gain? 1:12:58 - Vaping vs. smoking—which is worse for metabolic health? 1:14:20 - Can statins and antidepressants trigger weight gain? 1:17:04 - How to reverse insulin resistance in 90 days 1:27:35 - Ketone supplements—are the metabolic benefits real? 1:33:16 - Why some ethnicities get diabetes without obesity 1:41:11 - How oversized fat cells trigger metabolic chaos 1:46:10 - Do seed oils silently promote insulin resistance? 1:49:27 - Seed oils—always harmful or only when heated? 2:01:03 - Do fat cells shrink or disappear with weight loss? 2:03:48 - Are shrunken fat cells still insulin resistant? 2:06:23 - Injecting insulin for muscle—are the risks worth it? 2:09:27 - Are drugs like Ozempic a shortcut or solution for obesity? 2:15:55 - Are current GLP-1 agonist doses too high? 2:16:44 - Microdosing GLP-1 drugs—a solution for carb cravings? 2:22:43 - Do these medications cause muscle loss? 2:25:12 - Do GLP-1 agonist benefits extend beyond weight loss? 2:27:23 - Could these treatments actually promote longevity? 2:32:55 - The dark side of GLP-1 drugs—can they trigger depression? 2:36:14 - Insulin vs. glucose—what really drives accelerated aging? 2:41:16 - How high glucose levels damage cells 2:43:23 - How insulin shuts down your body’s stress defenses 2:47:57 - Which biomarkers best predict biological aging? 2:54:01 - Does eating dinner early improve insulin sensitivity?

Dr. Rhonda Patrick

148,954 次观看 • 1 年前

🚨 “EVERYONE WILL BE ON THIS” — TOP PLASTIC SURGEON CALLS RETATRUTIDE THE GREATEST DRUG EVER CREATED A viral interview featuring Dr. Terry Dubrow is exploding after he made a claim that’s catching serious attention: Retatrutide, a new drug from Eli Lilly and Company, could be the most powerful peptide we’ve ever seen. And according to him, it’s already spreading before approval. • Completed all 3 clinical trial phases (not FDA approved yet) • Expected approval timeline: potentially within months • Triple-hormone mechanism (fat loss + muscle preservation + appetite control) • Being called the next evolution of GLP-1 drugs He claims compounding pharmacies are already making versions of it. Meaning people are taking it right now, without regulation. • “Everyone’s on it” - especially in gym circles • No oversight on sourcing, purity, or dosing • Unknown additives, contamination risks, or long-term effects • No clarity on where it’s being manufactured And yet the hype is exploding: • Being labeled a potential trillion-dollar drug • Said to outperform current weight-loss injections • Designed to burn fat while preserving muscle, something older drugs struggled with But it doesn’t stop at weight loss. According to Dr. Dubrow, drugs in this category are being explored or used for: • Alzheimer’s • Heart disease (already approved in some cases) • Arthritis • Addiction (including alcohol dependence) • Schizophrenia • Early-stage cancer research (tumor growth slowdown) The logic? It all comes back to blood sugar control, inflammation, and metabolic health. Systems tied to nearly every major disease. Which leads to the bigger claim: That in the near future… people won’t just take these drugs to lose weight. They’ll take them to live longer. But here’s the part no one can answer yet: If millions are already using unregulated versions… what exactly are they putting into their bodies? Is this the biggest medical breakthrough of the decade... or a mass rollout happening before anyone’s ready? 📹: YouTube/truehustlepodcast
5:47

🚨 “EVERYONE WILL BE ON THIS” — TOP PLASTIC SURGEON CALLS RETATRUTIDE THE GREATEST DRUG EVER CREATED A viral interview featuring Dr. Terry Dubrow is exploding after he made a claim that’s catching serious attention: Retatrutide, a new drug from Eli Lilly and Company, could be the most powerful peptide we’ve ever seen. And according to him, it’s already spreading before approval. • Completed all 3 clinical trial phases (not FDA approved yet) • Expected approval timeline: potentially within months • Triple-hormone mechanism (fat loss + muscle preservation + appetite control) • Being called the next evolution of GLP-1 drugs He claims compounding pharmacies are already making versions of it. Meaning people are taking it right now, without regulation. • “Everyone’s on it” - especially in gym circles • No oversight on sourcing, purity, or dosing • Unknown additives, contamination risks, or long-term effects • No clarity on where it’s being manufactured And yet the hype is exploding: • Being labeled a potential trillion-dollar drug • Said to outperform current weight-loss injections • Designed to burn fat while preserving muscle, something older drugs struggled with But it doesn’t stop at weight loss. According to Dr. Dubrow, drugs in this category are being explored or used for: • Alzheimer’s • Heart disease (already approved in some cases) • Arthritis • Addiction (including alcohol dependence) • Schizophrenia • Early-stage cancer research (tumor growth slowdown) The logic? It all comes back to blood sugar control, inflammation, and metabolic health. Systems tied to nearly every major disease. Which leads to the bigger claim: That in the near future… people won’t just take these drugs to lose weight. They’ll take them to live longer. But here’s the part no one can answer yet: If millions are already using unregulated versions… what exactly are they putting into their bodies? Is this the biggest medical breakthrough of the decade... or a mass rollout happening before anyone’s ready? 📹: YouTube/truehustlepodcast

HustleBitch

664,702 次观看 • 3 个月前

Bill Maher hits Huberman with a simple question: “What are peptides?” The answer unfolds into something much bigger. Peptides are short chains of amino acids our bodies produce naturally — insulin is one, GLP-1 is another. Now we’re synthesizing advanced versions like retatrutide, a triple agonist (GLP-1 + GIP + glucagon) that’s showing impressive results in trials, with substantial body weight reduction when combined with exercise. Huberman notes this could become a trillion-dollar drug for Eli Lilly, which is fiercely protecting its patent. Meanwhile, cheaper versions are circulating through compounding pharmacies and gray markets at a fraction of the cost and dose — creating a messy tension between big pharma exclusivity, FDA oversight, faster approval pathways, and real-world access. It reveals a deep split in how people view these tools: some trust only full pharma + FDA pipelines with extensive trials, while others see the pharma-FDA connection itself as a reason to seek alternatives. Peptides aren’t a standalone fix — lifestyle still matters hugely — but the discussion exposes the real friction: innovation needs investment, yet high prices and regulation push people toward less-controlled options with safety risks. What part of this landscape feels most unresolved to you — the breakthrough potential, the access vs. patent fight, or the growing trust divide?
4:35

Bill Maher hits Huberman with a simple question: “What are peptides?” The answer unfolds into something much bigger. Peptides are short chains of amino acids our bodies produce naturally — insulin is one, GLP-1 is another. Now we’re synthesizing advanced versions like retatrutide, a triple agonist (GLP-1 + GIP + glucagon) that’s showing impressive results in trials, with substantial body weight reduction when combined with exercise. Huberman notes this could become a trillion-dollar drug for Eli Lilly, which is fiercely protecting its patent. Meanwhile, cheaper versions are circulating through compounding pharmacies and gray markets at a fraction of the cost and dose — creating a messy tension between big pharma exclusivity, FDA oversight, faster approval pathways, and real-world access. It reveals a deep split in how people view these tools: some trust only full pharma + FDA pipelines with extensive trials, while others see the pharma-FDA connection itself as a reason to seek alternatives. Peptides aren’t a standalone fix — lifestyle still matters hugely — but the discussion exposes the real friction: innovation needs investment, yet high prices and regulation push people toward less-controlled options with safety risks. What part of this landscape feels most unresolved to you — the breakthrough potential, the access vs. patent fight, or the growing trust divide?

Camus

452,262 次观看 • 4 个月前

Up to 30% of the weight lost while dieting can come from lean muscle mass—but the right training and nutrition can help you preserve muscle, which is key for metabolic health and reducing the risk of sarcopenia. You can lose fat and gain muscle at the same time—a process called body recomposition—if you train and eat strategically. The most important factor is resistance training. Lifting heavy 2–3 times per week is essential for maintaining and building muscle while losing fat. Without it, muscle mass inevitably declines. Nutrition also plays a major role. Eating in a slight calorie deficit—around 10–20% below maintenance—allows for steady fat loss without sacrificing muscle, energy levels, or training performance. Protein intake is another key priority. Research shows that consuming 1.8 to 2.2 grams of protein per kilogram of body weight per day is optimal for muscle retention and growth during a calorie deficit, and going even higher may provide additional benefits. Beyond training and nutrition, recovery is just as crucial. Adequate sleep, stress management, and tracking progress help ensure you’re making real, sustainable changes. Get this right and you have a powerful strategy to build muscle and lose fat. If you want to learn more about optimizing body recomposition, improving VO2 max, and enhancing brain health, tune into the latest episode of the FoundMyFitness podcast, where and I break it all down with insights from top experts. Link to the full episode on YouTube:
3:56

Up to 30% of the weight lost while dieting can come from lean muscle mass—but the right training and nutrition can help you preserve muscle, which is key for metabolic health and reducing the risk of sarcopenia. You can lose fat and gain muscle at the same time—a process called body recomposition—if you train and eat strategically. The most important factor is resistance training. Lifting heavy 2–3 times per week is essential for maintaining and building muscle while losing fat. Without it, muscle mass inevitably declines. Nutrition also plays a major role. Eating in a slight calorie deficit—around 10–20% below maintenance—allows for steady fat loss without sacrificing muscle, energy levels, or training performance. Protein intake is another key priority. Research shows that consuming 1.8 to 2.2 grams of protein per kilogram of body weight per day is optimal for muscle retention and growth during a calorie deficit, and going even higher may provide additional benefits. Beyond training and nutrition, recovery is just as crucial. Adequate sleep, stress management, and tracking progress help ensure you’re making real, sustainable changes. Get this right and you have a powerful strategy to build muscle and lose fat. If you want to learn more about optimizing body recomposition, improving VO2 max, and enhancing brain health, tune into the latest episode of the FoundMyFitness podcast, where and I break it all down with insights from top experts. Link to the full episode on YouTube:

Dr. Rhonda Patrick

120,402 次观看 • 1 年前

October 2025 - 265lbs May 2026 (today) - 185lbs Down 80lbs in 8months. Goal: 10% body fat and lower by the end of Q1 2027. Nowhere near where I want to be yet with my body composition. Still a long road ahead. I want to lean out 10x more. Goal is deep striations and every muscle group looking carved out Macros (currently): 190grams protein 150-160grams carbs (training days) 100-90grams carbs (non training days) 40-50grams fats I’m adjusting carbs as I progress, learning about my body and its reactions. Foods I eat to achieve my macros: Top sirloin filet mignon, ground beef / chicken (leanest options), chicken, shrimp, eggs, white rice, potatoes, fruits with my yogurt. I rotate them to enjoy my meals. Don’t be afraid of seasoning and hot sauce. Training days I keep jasmine white rice around my workouts for fuel, performance, and recovery. Sweet potatoes are usually away from my workouts to keep me fuller longer throughout the day. White rice = faster digesting carbs. Sweet potatoes = slower digesting carbs with more volume and satiety Peptide Stack: Retatrutide - Appetite suppression and fat loss. Long-term: major weight reduction, improved insulin sensitivity, lower food cravings. Tesamorelin - Increases growth hormone. Long-term: reduced visceral fat, improved recovery, fuller muscle appearance. MOTS-c - Supports metabolism and energy. Long-term: improved endurance, insulin sensitivity, fat metabolism, cellular energy production. BPC-157 - Recovery and healing peptide. Long-term: improved tendon/joint recovery, reduced inflammation, better gut support. GHK-Cu - Skin and hair regeneration peptide. (I mainly use for beard growth) Long-term: healthier skin, thicker hair, improved healing, collagen support. DSIP - Sleep and relaxation peptide. Long-term: deeper sleep, reduced stress, improved recovery and nervous system balance.
0:55

October 2025 - 265lbs May 2026 (today) - 185lbs Down 80lbs in 8months. Goal: 10% body fat and lower by the end of Q1 2027. Nowhere near where I want to be yet with my body composition. Still a long road ahead. I want to lean out 10x more. Goal is deep striations and every muscle group looking carved out Macros (currently): 190grams protein 150-160grams carbs (training days) 100-90grams carbs (non training days) 40-50grams fats I’m adjusting carbs as I progress, learning about my body and its reactions. Foods I eat to achieve my macros: Top sirloin filet mignon, ground beef / chicken (leanest options), chicken, shrimp, eggs, white rice, potatoes, fruits with my yogurt. I rotate them to enjoy my meals. Don’t be afraid of seasoning and hot sauce. Training days I keep jasmine white rice around my workouts for fuel, performance, and recovery. Sweet potatoes are usually away from my workouts to keep me fuller longer throughout the day. White rice = faster digesting carbs. Sweet potatoes = slower digesting carbs with more volume and satiety Peptide Stack: Retatrutide - Appetite suppression and fat loss. Long-term: major weight reduction, improved insulin sensitivity, lower food cravings. Tesamorelin - Increases growth hormone. Long-term: reduced visceral fat, improved recovery, fuller muscle appearance. MOTS-c - Supports metabolism and energy. Long-term: improved endurance, insulin sensitivity, fat metabolism, cellular energy production. BPC-157 - Recovery and healing peptide. Long-term: improved tendon/joint recovery, reduced inflammation, better gut support. GHK-Cu - Skin and hair regeneration peptide. (I mainly use for beard growth) Long-term: healthier skin, thicker hair, improved healing, collagen support. DSIP - Sleep and relaxation peptide. Long-term: deeper sleep, reduced stress, improved recovery and nervous system balance.

AYCE

19,874 次观看 • 3 个月前

Jillian Michaels presents a devastatingly logical case against Ozempic/semaglutide, arguing that even in the best-case scenario, users are set up for long-term failure. The "Best Case" Scenario is a Trap: Imagine you're a "perfect" responder: no side effects, significant weight loss, and improved biomarkers. The catch? These health gains are a result of the weight loss, not the drug itself. The mechanism is caloric restriction. But this success is temporary. Here’s the inevitable chain of events: 1. The Plateau: Your body develops a tolerance to the exogenous hormone. You will plateau. This is a physiological fact. 2. The Lifelong Handcuff: When the drug stops working, you face a dilemma: stay on an expensive drug forever or get off it. Meta-analyses show you will gain all the weight back if you stop. 3. The Metabolic Disaster: Getting off the drug triggers a "devastating rebound." Why? - Muscle & Bone Loss: Citing experts like Peter Attia, she highlights "alarming" muscle loss and compromised bone density, which cripples your metabolism. - Lowered Metabolic Set Point: The prolonged caloric restriction mimics a famine, epigenetically signaling your body to conserve energy. Your metabolism is now permanently slower. - Endogenous Hormone Suppression: By introducing GLP-1 from outside, your body likely downregulates its own production, leaving you hormonally vulnerable off the drug. The Root Cause is Ignored: The drug merely masks the symptom—insatiable hunger—without addressing the cause: a food environment filled with hyper-palatable, addictive, non-satiating foods, combined with modern-day loneliness, anxiety, and sedentariness. A chemical solution cannot fix a multifactorial lifestyle problem. The Worst-Case Scenario: This is a harrowing list of documented risks: stomach paralysis, intestinal blockage, pancreatitis, kidney failure, gallbladder issues, accelerated facial aging, hair loss, and suicidal ideation. Michaels questions the silence from many doctors, suggesting financial ties to Big Pharma play a role. She concludes that these drugs are a dangerous gamble, creating a cycle of dependency while failing to solve the underlying health crisis. The question remains: Why are we opting for a short-term fix that guarantees a long-term catastrophe?
9:18

Jillian Michaels presents a devastatingly logical case against Ozempic/semaglutide, arguing that even in the best-case scenario, users are set up for long-term failure. The "Best Case" Scenario is a Trap: Imagine you're a "perfect" responder: no side effects, significant weight loss, and improved biomarkers. The catch? These health gains are a result of the weight loss, not the drug itself. The mechanism is caloric restriction. But this success is temporary. Here’s the inevitable chain of events: 1. The Plateau: Your body develops a tolerance to the exogenous hormone. You will plateau. This is a physiological fact. 2. The Lifelong Handcuff: When the drug stops working, you face a dilemma: stay on an expensive drug forever or get off it. Meta-analyses show you will gain all the weight back if you stop. 3. The Metabolic Disaster: Getting off the drug triggers a "devastating rebound." Why? - Muscle & Bone Loss: Citing experts like Peter Attia, she highlights "alarming" muscle loss and compromised bone density, which cripples your metabolism. - Lowered Metabolic Set Point: The prolonged caloric restriction mimics a famine, epigenetically signaling your body to conserve energy. Your metabolism is now permanently slower. - Endogenous Hormone Suppression: By introducing GLP-1 from outside, your body likely downregulates its own production, leaving you hormonally vulnerable off the drug. The Root Cause is Ignored: The drug merely masks the symptom—insatiable hunger—without addressing the cause: a food environment filled with hyper-palatable, addictive, non-satiating foods, combined with modern-day loneliness, anxiety, and sedentariness. A chemical solution cannot fix a multifactorial lifestyle problem. The Worst-Case Scenario: This is a harrowing list of documented risks: stomach paralysis, intestinal blockage, pancreatitis, kidney failure, gallbladder issues, accelerated facial aging, hair loss, and suicidal ideation. Michaels questions the silence from many doctors, suggesting financial ties to Big Pharma play a role. She concludes that these drugs are a dangerous gamble, creating a cycle of dependency while failing to solve the underlying health crisis. The question remains: Why are we opting for a short-term fix that guarantees a long-term catastrophe?

Camus

80,850 次观看 • 11 个月前

It really is this simple. Yes or no… Do you want to be fully mobile into your 50s and beyond? It doesn’t matter if you enjoy the work. Anything of value requires investment. And here’s the part you fitness bros don’t want to hear: Lifting ain’t it. Loss of strength isn’t what makes your body old, it’s loss of mobility. In fact, too much strength/mass is detrimental to longevity. Just look around—the fittest, most physically capable people in their 50s and beyond aren’t meatheads. You want to be lean, mobile, and strong *enough*. 🪛Maintaining range of motion and healthy spine/joints should be the #1 priority—and the older you get the more you need to “tighten the screws”. That’s why highly varied, functional sports like climbing, jiu-jitsu, and surfing are the best forms of exercise. They hit all the dimensions of fitness, including mind-body connection, which is crucial for brain health and longevity. Start with a 3-minute deep squat each morning. The deep squat is called “the anti-aging exercise”—it’s one movement that builds strength and mobility in your ankles, knees, hips and lower back. 3 minutes a day now, or a lifetime of pain and limitations later.
0:24

It really is this simple. Yes or no… Do you want to be fully mobile into your 50s and beyond? It doesn’t matter if you enjoy the work. Anything of value requires investment. And here’s the part you fitness bros don’t want to hear: Lifting ain’t it. Loss of strength isn’t what makes your body old, it’s loss of mobility. In fact, too much strength/mass is detrimental to longevity. Just look around—the fittest, most physically capable people in their 50s and beyond aren’t meatheads. You want to be lean, mobile, and strong *enough*. 🪛Maintaining range of motion and healthy spine/joints should be the #1 priority—and the older you get the more you need to “tighten the screws”. That’s why highly varied, functional sports like climbing, jiu-jitsu, and surfing are the best forms of exercise. They hit all the dimensions of fitness, including mind-body connection, which is crucial for brain health and longevity. Start with a 3-minute deep squat each morning. The deep squat is called “the anti-aging exercise”—it’s one movement that builds strength and mobility in your ankles, knees, hips and lower back. 3 minutes a day now, or a lifetime of pain and limitations later.

Kevin Dahlstrom

50,094 次观看 • 7 个月前

Nick Fuentes just recommended Ozempic to his 1M+ mostly Gen-Z fans, so now I need to rant. This is absolutely HORRIBLE advice. Ozempic and other GLP-1 drugs literally paralyze your stomach so you can't digest food properly, and in countless cases have led to gastroparesis, intestinal blockage, BLINDNESS, and a laundry list of other horrific side effects. NOBODY should be taking this poison. If you're struggling with weight loss, here's some actually useful advice that will make you healthier without destroying your body: EAT MORE FATTY RED MEAT. And any high-fat animal products, really. (Excluding dairy, which is a growth agent in nature and thus triggers addictive pathways in your brain). Beef, butter, bacon, and eggs. Those 4 are your best friend. Carbohydrates, even the "healthy ones" like salad, fruit, whole grains, etc. are NOT satiating your body; they're glorified sugar/fiber bulk that strain your digestion and make you fart/shit more, while giving you zero actual nutritional value as you are not a cow or rabbit with the specialized digestive system required to digest break these materials down. (More details on why plants in any quantity are unhealthy for humans in the thread to follow). The reason why an overweight person's body is stuck in the constant craving mode is, very simply, because they are protein/fat-deficient. (Carbohydrates are non-essential, Protein/Fat are essential). The carbohydrate industry is far bigger than the other two, however, so they've thrown a ton of money around to convince the world that DIETARY FAT is bad for you, and causes BODYFAT. This is completely backwards from reality. Dietary fat is what turns off your hunger signals, i.e. gets your body to the NOURISHMENT point where it no longer craves food, which is where weight loss happens. I can practically promise you right now: if you're on the heavy side and just eliminate all carbs (even fruit/salad) and start eating bacon/eggs for breakfast, and a couple pounds of steak or ground beef for dinner (again, with NO CARBS on the side of either of these meals), you will see the the easiest, most delicious weight loss progress of your life. And if you're really dedicated to making progress as fast as possible? Work your way toward eating a TON of steak for dinner, and making that your singular meal for the day. (One meal in a day sounds crazy to the carb-addicted mind, but trust me, that protein/fat combo has carrying power. I've done this one-meal-of-steak-per-day routine for years, it's easy once you're acclimated to it.) I've done tons of podcast episodes and blog posts on the weight loss topic in the past, featuring personal friends of mine who've lost HUNDREDS of pounds on the Carnivore (Zero Carb) Diet, when NOTHING else worked for them, from vegan, to paleo, to mediterranean, keto, and everything in between. I'll turn this post into a thread, and link some of the resources I've gotten the most positive feedback on below for you to explore. Take a look, and share with any friends you know who are struggling with weight! 🧵👇
0:51

Nick Fuentes just recommended Ozempic to his 1M+ mostly Gen-Z fans, so now I need to rant. This is absolutely HORRIBLE advice. Ozempic and other GLP-1 drugs literally paralyze your stomach so you can't digest food properly, and in countless cases have led to gastroparesis, intestinal blockage, BLINDNESS, and a laundry list of other horrific side effects. NOBODY should be taking this poison. If you're struggling with weight loss, here's some actually useful advice that will make you healthier without destroying your body: EAT MORE FATTY RED MEAT. And any high-fat animal products, really. (Excluding dairy, which is a growth agent in nature and thus triggers addictive pathways in your brain). Beef, butter, bacon, and eggs. Those 4 are your best friend. Carbohydrates, even the "healthy ones" like salad, fruit, whole grains, etc. are NOT satiating your body; they're glorified sugar/fiber bulk that strain your digestion and make you fart/shit more, while giving you zero actual nutritional value as you are not a cow or rabbit with the specialized digestive system required to digest break these materials down. (More details on why plants in any quantity are unhealthy for humans in the thread to follow). The reason why an overweight person's body is stuck in the constant craving mode is, very simply, because they are protein/fat-deficient. (Carbohydrates are non-essential, Protein/Fat are essential). The carbohydrate industry is far bigger than the other two, however, so they've thrown a ton of money around to convince the world that DIETARY FAT is bad for you, and causes BODYFAT. This is completely backwards from reality. Dietary fat is what turns off your hunger signals, i.e. gets your body to the NOURISHMENT point where it no longer craves food, which is where weight loss happens. I can practically promise you right now: if you're on the heavy side and just eliminate all carbs (even fruit/salad) and start eating bacon/eggs for breakfast, and a couple pounds of steak or ground beef for dinner (again, with NO CARBS on the side of either of these meals), you will see the the easiest, most delicious weight loss progress of your life. And if you're really dedicated to making progress as fast as possible? Work your way toward eating a TON of steak for dinner, and making that your singular meal for the day. (One meal in a day sounds crazy to the carb-addicted mind, but trust me, that protein/fat combo has carrying power. I've done this one-meal-of-steak-per-day routine for years, it's easy once you're acclimated to it.) I've done tons of podcast episodes and blog posts on the weight loss topic in the past, featuring personal friends of mine who've lost HUNDREDS of pounds on the Carnivore (Zero Carb) Diet, when NOTHING else worked for them, from vegan, to paleo, to mediterranean, keto, and everything in between. I'll turn this post into a thread, and link some of the resources I've gotten the most positive feedback on below for you to explore. Take a look, and share with any friends you know who are struggling with weight! 🧵👇

₿en Wehrman

15,674 次观看 • 2 个月前

NAD is the molecule behind energy, recovery, and aging. But most people still can’t explain what it actually does or what it means to “raise” it. In this episode, Dr. Charles Brenner (Charles Brenner, PhD), the scientist who discovered nicotinamide riboside, walks through NAD biology to explain how it's part of the “wiring” that moves energy through living systems, powering ATP production, building new tissue, and fueling repair. We dig into why NAD matters for DNA repair, how inflammation and metabolic disease put the NAD system “under attack,” and why blood NAD levels don’t always tell you what’s happening inside tissues like liver, muscle, or brain. We also discuss the real differences between NR and NMN, conditions where NAD boosting shows promise, such as inflammation, peripheral artery disease, respiratory infections, cognitive impairment, and fertility, and important safety concerns, including sourcing, product quality, and cancer. If you’ve ever wondered whether NAD boosters are legit, what they’re actually doing in the body, and how to leverage them for health and longevity, this is the episode. Dr. Charles Brenner is a true pioneer in NAD science. Links to the episode on all platforms in the comments below. Timestamps: 0:00 - Introduction 1:58 - Why disease states disrupt NAD 6:42 - How coronavirus infection affects NAD 9:55 - Inflating NAD with diet & supplements 11:49 - Why blood NAD can mislead 13:20 - Can obesity drain NAD resources? 16:01 - Does poor sleep reduce NAD? 16:53 - Anti-inflammatory effects of NR 21:38 - Can one lifestyle change fix NAD? 24:22 - NAD precursors & cognitive benefits 27:58 - Should you measure NAD levels? 30:59 - Exercise for boosting NAD 33:01 - NR for exercise recovery 35:35 - How acute sleep loss affects NAD 37:07 - NR during pregnancy 43:48 - Does NR benefit fertility? 44:58 - NAD precursors for jet lag & shift work 47:41 - Best time to take NR? 50:41 - NAD supplements vs. precursors 54:28 - NAD IV drips 55:36 - Oral vs. IV nicotinamide riboside 57:06 - Do oral NAD supplements work? 58:58 - NMN vs. NR 1:02:06 - Gut microbiome & NAD levels 1:04:44 - NR supplements & immune function 1:08:02 - NR for peripheral artery disease 1:12:26 - Can NR reduce liver fat? 1:17:33 - Recovery benefits 1:19:18 - Safe dosage for nicotinamide riboside 1:21:21 - Resveratrol & pterostilbene 1:22:57 - NAD precursors—why sourcing matters 1:25:09 - NAD supplements & cancer risk 1:30:55 - Should healthy people take NR? 1:33:43 - Charles Brenner’s NAD journey 1:38:13 - NAD’s role in energy & repair 1:45:00 - Why NAD fuels DNA repair 1:46:50 - How PARP enzymes consume NAD 1:49:29 - NAD’s role in gene regulation 1:51:49 - Why NAD shortages hit the brain hardest
1:54:17

NAD is the molecule behind energy, recovery, and aging. But most people still can’t explain what it actually does or what it means to “raise” it. In this episode, Dr. Charles Brenner (Charles Brenner, PhD), the scientist who discovered nicotinamide riboside, walks through NAD biology to explain how it's part of the “wiring” that moves energy through living systems, powering ATP production, building new tissue, and fueling repair. We dig into why NAD matters for DNA repair, how inflammation and metabolic disease put the NAD system “under attack,” and why blood NAD levels don’t always tell you what’s happening inside tissues like liver, muscle, or brain. We also discuss the real differences between NR and NMN, conditions where NAD boosting shows promise, such as inflammation, peripheral artery disease, respiratory infections, cognitive impairment, and fertility, and important safety concerns, including sourcing, product quality, and cancer. If you’ve ever wondered whether NAD boosters are legit, what they’re actually doing in the body, and how to leverage them for health and longevity, this is the episode. Dr. Charles Brenner is a true pioneer in NAD science. Links to the episode on all platforms in the comments below. Timestamps: 0:00 - Introduction 1:58 - Why disease states disrupt NAD 6:42 - How coronavirus infection affects NAD 9:55 - Inflating NAD with diet & supplements 11:49 - Why blood NAD can mislead 13:20 - Can obesity drain NAD resources? 16:01 - Does poor sleep reduce NAD? 16:53 - Anti-inflammatory effects of NR 21:38 - Can one lifestyle change fix NAD? 24:22 - NAD precursors & cognitive benefits 27:58 - Should you measure NAD levels? 30:59 - Exercise for boosting NAD 33:01 - NR for exercise recovery 35:35 - How acute sleep loss affects NAD 37:07 - NR during pregnancy 43:48 - Does NR benefit fertility? 44:58 - NAD precursors for jet lag & shift work 47:41 - Best time to take NR? 50:41 - NAD supplements vs. precursors 54:28 - NAD IV drips 55:36 - Oral vs. IV nicotinamide riboside 57:06 - Do oral NAD supplements work? 58:58 - NMN vs. NR 1:02:06 - Gut microbiome & NAD levels 1:04:44 - NR supplements & immune function 1:08:02 - NR for peripheral artery disease 1:12:26 - Can NR reduce liver fat? 1:17:33 - Recovery benefits 1:19:18 - Safe dosage for nicotinamide riboside 1:21:21 - Resveratrol & pterostilbene 1:22:57 - NAD precursors—why sourcing matters 1:25:09 - NAD supplements & cancer risk 1:30:55 - Should healthy people take NR? 1:33:43 - Charles Brenner’s NAD journey 1:38:13 - NAD’s role in energy & repair 1:45:00 - Why NAD fuels DNA repair 1:46:50 - How PARP enzymes consume NAD 1:49:29 - NAD’s role in gene regulation 1:51:49 - Why NAD shortages hit the brain hardest

Dr. Rhonda Patrick

145,988 次观看 • 6 个月前

Fasting's the most underrated longevity hack on Earth. Doctors said skipping meals destroys your metabolism... Yet fasting is proven to boost your hormones, burn toxic fat, and repair DNA damage naturally. Here are 7 insane fasting benefits (bookmark this):👇️️️️️️ 1. Activates Autophagy Autophagy kicks in after 12–16 hours of fasting. It's your built-in cleanup system, recycling toxic and old cells into new, fresh ones. It also removes toxic debris linked to Alzheimer's, cancer, & accelerated aging. 2. Burns excess fat Fasting flips your body's fuel switch. When glycogen runs low, it start breaking down stored fat into ketones for energy. And the fact that no more calories are coming in your body... Means you're now forced to burn your own fat. 3. Boosts your hormones Fasting increases human growth hormone (HGH) by up to 5x baseline levels. Higher HGH means: - Faster fat loss - Enhanced recovery - Preserved lean muscle It also improves testosterone in men by reducing insulin resistance. 4. Repairs DNA damage With no food to process, your cells focus on SURVIVAL: - Repairing DNA strands - Cleaning out broken parts - Recycling damaged proteins Fasting's one of the few medicines that helps you rebuild from the inside out naturally. 5. Enhances Insulin Sensitivity Fasting gives your pancreas a break from constant insulin production. Over time, your cells become more responsive to insulin → better glucose control & lower diabetes risk. One study found 16:8 fasting improved insulin sensitivity by ~30% in just 8 weeks. I've found a supplement that increases fasting's benefits by 5X. It keeps insulin low, stabilizes energy, even lets you stay lean year-round. It allows me to stay at 10–12% body fat all year effortlessly, without energy crashes. Here's the one I use (AMAZON PRODUCT LINK): 6. Lowers Inflammation Fasting suppresses inflammatory cytokines like IL-6 and TNF-alpha — the molecular triggers behind: - Brain fog - Chronic pain - Slow recovery By quieting that response, your body heals faster and ages slower. I use fasting daily for the past year and here's exactly why: It gives me: - More energy - Leaner body - Better focus And I feel more alive than EVER. I've made a guide with my fasting protocol. Comment "Fasting" and I'll send it over. (Must Follow so I can DM) 🤝 *Every body works differently, this is not medical advice, just what worked on me." *Always consult a health expert before following any protocols." *Affiliate links included.*
0:30

Fasting's the most underrated longevity hack on Earth. Doctors said skipping meals destroys your metabolism... Yet fasting is proven to boost your hormones, burn toxic fat, and repair DNA damage naturally. Here are 7 insane fasting benefits (bookmark this):👇️️️️️️ 1. Activates Autophagy Autophagy kicks in after 12–16 hours of fasting. It's your built-in cleanup system, recycling toxic and old cells into new, fresh ones. It also removes toxic debris linked to Alzheimer's, cancer, & accelerated aging. 2. Burns excess fat Fasting flips your body's fuel switch. When glycogen runs low, it start breaking down stored fat into ketones for energy. And the fact that no more calories are coming in your body... Means you're now forced to burn your own fat. 3. Boosts your hormones Fasting increases human growth hormone (HGH) by up to 5x baseline levels. Higher HGH means: - Faster fat loss - Enhanced recovery - Preserved lean muscle It also improves testosterone in men by reducing insulin resistance. 4. Repairs DNA damage With no food to process, your cells focus on SURVIVAL: - Repairing DNA strands - Cleaning out broken parts - Recycling damaged proteins Fasting's one of the few medicines that helps you rebuild from the inside out naturally. 5. Enhances Insulin Sensitivity Fasting gives your pancreas a break from constant insulin production. Over time, your cells become more responsive to insulin → better glucose control & lower diabetes risk. One study found 16:8 fasting improved insulin sensitivity by ~30% in just 8 weeks. I've found a supplement that increases fasting's benefits by 5X. It keeps insulin low, stabilizes energy, even lets you stay lean year-round. It allows me to stay at 10–12% body fat all year effortlessly, without energy crashes. Here's the one I use (AMAZON PRODUCT LINK): 6. Lowers Inflammation Fasting suppresses inflammatory cytokines like IL-6 and TNF-alpha — the molecular triggers behind: - Brain fog - Chronic pain - Slow recovery By quieting that response, your body heals faster and ages slower. I use fasting daily for the past year and here's exactly why: It gives me: - More energy - Leaner body - Better focus And I feel more alive than EVER. I've made a guide with my fasting protocol. Comment "Fasting" and I'll send it over. (Must Follow so I can DM) 🤝 *Every body works differently, this is not medical advice, just what worked on me." *Always consult a health expert before following any protocols." *Affiliate links included.*

Achilleas

66,492 次观看 • 9 个月前