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Dr. Alex Tatem

@DrAlexTatem • 20,078 subscribers

Board Certified Men’s Health Urologist specializing in TRT, Penile Implant Surgery, Male Fertility, Erectile Dysfunction, and Vasectomy Reversal at @UrologyofIN

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Is retatrutide already OLD NEWS? 👀 Eli Lilly’s next weight loss drug, eloralintide, just posted some wild numbers. Combined with tirzepatide, it delivered 23% weight loss in under a year, compared to 21% for retatrutide over a longer period in a separate diabetes trial. But there’s a catch: 27% quit due to side effects in one combo group. Better weight loss means nothing if you can’t tolerate the drug. Here’s what the data actually says. 👇

Is retatrutide already OLD NEWS? 👀 Eli Lilly’s next weight loss drug, eloralintide, just posted some wild numbers. Combined with tirzepatide, it delivered 23% weight loss in under a year, compared to 21% for retatrutide over a longer period in a separate diabetes trial. But there’s a catch: 27% quit due to side effects in one combo group. Better weight loss means nothing if you can’t tolerate the drug. Here’s what the data actually says. 👇

29,111 views • 4 days ago

Retatrutide just delivered RECORD weight loss in patients with type 2 diabetes… but there's a catch. 19% weight loss vs. 25% in previous trials involving people without diabetes. Sounds like diabetes won, right? Not so fast. At the highest dose, 1 in 3 patients reached NORMAL blood sugar levels. Blood pressure dropped, triglycerides fell by a third, and inflammation was cut in half. But what about the side effects? I read the trial data, and the weight loss might actually be the LEAST interesting part. Here's what the headlines missed👇

Retatrutide just delivered RECORD weight loss in patients with type 2 diabetes… but there's a catch. 19% weight loss vs. 25% in previous trials involving people without diabetes. Sounds like diabetes won, right? Not so fast. At the highest dose, 1 in 3 patients reached NORMAL blood sugar levels. Blood pressure dropped, triglycerides fell by a third, and inflammation was cut in half. But what about the side effects? I read the trial data, and the weight loss might actually be the LEAST interesting part. Here's what the headlines missed👇

24,927 views • 8 days ago

HGH doesn't build muscle? Then explain bodybuilding. 27 clinical trials. No significant strength gains. Yet growth hormone remains a staple in the bodybuilding world. So what's actually going on? We're diving into the science of HGH, its effects on muscle growth, fat loss, tendons, and recovery, and the bizarre federal law that helped create an entire industry of HGH-related peptides. The HGH paradox is deeper than you think.FULL VIDEO RIGHT HERE. 👇🧪

HGH doesn't build muscle? Then explain bodybuilding. 27 clinical trials. No significant strength gains. Yet growth hormone remains a staple in the bodybuilding world. So what's actually going on? We're diving into the science of HGH, its effects on muscle growth, fat loss, tendons, and recovery, and the bizarre federal law that helped create an entire industry of HGH-related peptides. The HGH paradox is deeper than you think.FULL VIDEO RIGHT HERE. 👇🧪

107,048 views • 1 month ago

Nothing—and I mean NOTHING—ever hit harder than OG Jack3d. The legendary pre-workout contained DMAA, a stimulant originally developed as a nasal decongestant in the 1940s. Then came the FDA crackdown, a replacement ingredient, a liver injury outbreak, and federal prison sentences. What started as the strongest pre-workout in gym history turned into a $400 million supplement scandal. This rabbit hole gets INSANE. Did you ever try OG Jack3d? 👇

Nothing—and I mean NOTHING—ever hit harder than OG Jack3d. The legendary pre-workout contained DMAA, a stimulant originally developed as a nasal decongestant in the 1940s. Then came the FDA crackdown, a replacement ingredient, a liver injury outbreak, and federal prison sentences. What started as the strongest pre-workout in gym history turned into a $400 million supplement scandal. This rabbit hole gets INSANE. Did you ever try OG Jack3d? 👇

16,847 views • 6 days ago

I ignore the instructions that come with my testosterone. Instead of one big shot every week—or even every few weeks—I use tiny daily injections. Less of a roller coaster. Tiny needle. Takes about 10 seconds. Here’s exactly how I set up my TRT for the week. Your regimen should always be discussed with your prescriber before making changes.

I ignore the instructions that come with my testosterone. Instead of one big shot every week—or even every few weeks—I use tiny daily injections. Less of a roller coaster. Tiny needle. Takes about 10 seconds. Here’s exactly how I set up my TRT for the week. Your regimen should always be discussed with your prescriber before making changes.

81,906 views • 1 month ago

I testified at the FDA meeting Doctor Mike is talking about. So when I watched his peptide video, I had one question: Did he actually read the paperwork? I went through the FDA rules, the committee roster, the timeline, and the evidence he cited—and there are some major problems with the story millions of people just watched. Watch it, check the documents, and decide for yourself.

I testified at the FDA meeting Doctor Mike is talking about. So when I watched his peptide video, I had one question: Did he actually read the paperwork? I went through the FDA rules, the committee roster, the timeline, and the evidence he cited—and there are some major problems with the story millions of people just watched. Watch it, check the documents, and decide for yourself.

82,423 views • 1 month ago

Retatrutide just posted Phase 3 numbers that are hard to ignore. ~30% average body weight loss. ~70 pounds lost. Even the lowest dose outperformed what used to be considered best-in-class. But the most interesting part of the story isn't the weight loss. It's the thousands of people already using grey-market Retatrutide before there's an approved pharmacy version available. What did the trials actually do? What dose produced the best balance of results and tolerability? And why might the biggest risk have nothing to do with the drug itself?

Retatrutide just posted Phase 3 numbers that are hard to ignore. ~30% average body weight loss. ~70 pounds lost. Even the lowest dose outperformed what used to be considered best-in-class. But the most interesting part of the story isn't the weight loss. It's the thousands of people already using grey-market Retatrutide before there's an approved pharmacy version available. What did the trials actually do? What dose produced the best balance of results and tolerability? And why might the biggest risk have nothing to do with the drug itself?

232,738 views • 4 months ago

This is the COMPLETE Peptide Tier List compilation — Parts 1 through 3 combined into one deep dive. We break down the most talked-about compounds in fitness, longevity, anti-aging, and fat loss: Semaglutide, Tirzepatide, Retatrutide, Mazdutide, Growth Hormone (HGH), HCG, IGF-1 LR3, Tesamorelin, Sermorelin, CJC-1295, Ipamorelin, BPC-157, TB-500, NAD+, Melanotan, Selank, SEMAX, MOTS-C, Kisspeptin, Insulin, and more. If you’ve ever searched: • Best peptides for fat loss • Best peptide for muscle growth • GLP-1 vs growth hormone • Is BPC-157 legit? • Is insulin dangerous for bodybuilding? This thread answers it. We cover: ✔️ Real human data vs hype ✔️ Fat loss vs muscle-building compounds ✔️ GLP-1 agonists (semaglutide, tirzepatide, retatrutide) ✔️ Growth hormone secretagogues ✔️ Longevity + nootropic peptides ✔️ The compounds people massively overestimate Some are revolutionary. Some are promising. Some are pure internet fantasy. This isn’t bro science. It’s mechanism + data + real-world application. If you’re considering peptides for weight loss, muscle gain, performance, anti-aging, or cognition — read this before you inject anything. 👇 Which compound surprised you the most?

This is the COMPLETE Peptide Tier List compilation — Parts 1 through 3 combined into one deep dive. We break down the most talked-about compounds in fitness, longevity, anti-aging, and fat loss: Semaglutide, Tirzepatide, Retatrutide, Mazdutide, Growth Hormone (HGH), HCG, IGF-1 LR3, Tesamorelin, Sermorelin, CJC-1295, Ipamorelin, BPC-157, TB-500, NAD+, Melanotan, Selank, SEMAX, MOTS-C, Kisspeptin, Insulin, and more. If you’ve ever searched: • Best peptides for fat loss • Best peptide for muscle growth • GLP-1 vs growth hormone • Is BPC-157 legit? • Is insulin dangerous for bodybuilding? This thread answers it. We cover: ✔️ Real human data vs hype ✔️ Fat loss vs muscle-building compounds ✔️ GLP-1 agonists (semaglutide, tirzepatide, retatrutide) ✔️ Growth hormone secretagogues ✔️ Longevity + nootropic peptides ✔️ The compounds people massively overestimate Some are revolutionary. Some are promising. Some are pure internet fantasy. This isn’t bro science. It’s mechanism + data + real-world application. If you’re considering peptides for weight loss, muscle gain, performance, anti-aging, or cognition — read this before you inject anything. 👇 Which compound surprised you the most?

296,881 views • 8 months ago

BPC-157 is FINALLY getting a real human trial. A U.S. medical school is preparing to test it on patients recovering from shoulder tendon surgery. 90 days of daily injections. Placebo-controlled. MRI scans. Actual strength measurements. But there's a catch: the trial is too small to prove whether BPC-157 actually works. After decades of hype, we're finally getting somewhere. Here's what you need to know. 👇

BPC-157 is FINALLY getting a real human trial. A U.S. medical school is preparing to test it on patients recovering from shoulder tendon surgery. 90 days of daily injections. Placebo-controlled. MRI scans. Actual strength measurements. But there's a catch: the trial is too small to prove whether BPC-157 actually works. After decades of hype, we're finally getting somewhere. Here's what you need to know. 👇

21,893 views • 15 days ago

Clav’s stack is absolutely wild. Testosterone. Reta. Dutasteride. Minoxidil. Emsam. Nebivolol. Tadalafil. Do I recommend it? No. But pretending people can’t get these drugs without a doctor doesn’t make anyone safer. You can’t harm-reduce something you refuse to talk about. Welcome to medicine in 2026.

Clav’s stack is absolutely wild. Testosterone. Reta. Dutasteride. Minoxidil. Emsam. Nebivolol. Tadalafil. Do I recommend it? No. But pretending people can’t get these drugs without a doctor doesn’t make anyone safer. You can’t harm-reduce something you refuse to talk about. Welcome to medicine in 2026.

95,278 views • 2 months ago

The “steroid killer” might finally be real. Myostatin inhibitors are doing something we’ve never really had a drug do before: Lose fat. Preserve muscle. And potentially increase lean mass. Apitegromab. Bimagrumab. Trevogrumab. Garetosmab. The data is getting VERY interesting—but there’s a massive catch almost nobody is talking about. Here’s everything we know so far 👇

The “steroid killer” might finally be real. Myostatin inhibitors are doing something we’ve never really had a drug do before: Lose fat. Preserve muscle. And potentially increase lean mass. Apitegromab. Bimagrumab. Trevogrumab. Garetosmab. The data is getting VERY interesting—but there’s a massive catch almost nobody is talking about. Here’s everything we know so far 👇

73,709 views • 2 months ago

Your TRT clinic might be making these 3 mistakes. 💉 Giving everyone the same testosterone dose. 🩸 Ignoring WHY your testosterone was low. ⚠️ Forgetting that TRT can shut down sperm production. Testosterone replacement therapy isn't one-size-fits-all. If your entire protocol is 1 CC a week and an estrogen blocker, it's worth asking whether your treatment is actually optimized for YOU. Here's what every man on TRT needs to know. 👇

Your TRT clinic might be making these 3 mistakes. 💉 Giving everyone the same testosterone dose. 🩸 Ignoring WHY your testosterone was low. ⚠️ Forgetting that TRT can shut down sperm production. Testosterone replacement therapy isn't one-size-fits-all. If your entire protocol is 1 CC a week and an estrogen blocker, it's worth asking whether your treatment is actually optimized for YOU. Here's what every man on TRT needs to know. 👇

24,650 views • 20 days ago

Can you actually buy the ability to lock in for 12 hours? Modafinil might be the closest thing we have to a real “Limitless pill”—but the science is a lot stranger than the hype. We dug into the human trials, dopamine, sleep deprivation, Modafinil vs. Adderall, side effects, and why this drug becomes a completely different animal when you’re running on empty. The “smart drug” that actually works? Full breakdown 👇

Can you actually buy the ability to lock in for 12 hours? Modafinil might be the closest thing we have to a real “Limitless pill”—but the science is a lot stranger than the hype. We dug into the human trials, dopamine, sleep deprivation, Modafinil vs. Adderall, side effects, and why this drug becomes a completely different animal when you’re running on empty. The “smart drug” that actually works? Full breakdown 👇

54,344 views • 1 month ago

Back in 2005, you could walk into GNC, hand over $40, and walk out with one of the most potent oral anabolic steroids ever sold as a supplement. No prescription. No doctor. Just Superdrol. It built muscle. It built strength. And for some, it absolutely wrecked their liver and kidneys. The craziest part? It took over 6 YEARS after the FDA declared it an illegal, unapproved drug for the DEA to officially classify it as a controlled substance. So how did a steroid that was never approved for human use end up on supplement store shelves? We're breaking down the history, chemistry, insane potency claims, and real medical evidence behind one of bodybuilding's most notorious steroids. Full breakdown 🧪👇

Back in 2005, you could walk into GNC, hand over $40, and walk out with one of the most potent oral anabolic steroids ever sold as a supplement. No prescription. No doctor. Just Superdrol. It built muscle. It built strength. And for some, it absolutely wrecked their liver and kidneys. The craziest part? It took over 6 YEARS after the FDA declared it an illegal, unapproved drug for the DEA to officially classify it as a controlled substance. So how did a steroid that was never approved for human use end up on supplement store shelves? We're breaking down the history, chemistry, insane potency claims, and real medical evidence behind one of bodybuilding's most notorious steroids. Full breakdown 🧪👇

15,987 views • 13 days ago

Peter Attia went after peptides. So I went through his argument point by point. BPC-157. CJC-1295. Human evidence. Safety data. FDA regulation. The patent problem. And the difference between “we need more research” and “this doesn’t work.” Peter’s a smart guy—but I think he’s getting part of this conversation wrong. Full breakdown below. 🧵🧪

Peter Attia went after peptides. So I went through his argument point by point. BPC-157. CJC-1295. Human evidence. Safety data. FDA regulation. The patent problem. And the difference between “we need more research” and “this doesn’t work.” Peter’s a smart guy—but I think he’s getting part of this conversation wrong. Full breakdown below. 🧵🧪

44,431 views • 1 month ago

Most TRT clinics give you one testosterone shot a week. I inject every day. Not more testosterone. The same weekly dose, divided into much smaller injections. Why? Fewer dramatic peaks and troughs—and a much flatter week. Here’s why injection frequency can completely change your TRT experience:

Most TRT clinics give you one testosterone shot a week. I inject every day. Not more testosterone. The same weekly dose, divided into much smaller injections. Why? Fewer dramatic peaks and troughs—and a much flatter week. Here’s why injection frequency can completely change your TRT experience:

35,602 views • 1 month ago

NAD+ has been studied since 1906. It has 2 Nobel Prizes, randomized human trials, and over a century of biochemistry behind it. Yet in 2017, the FDA advisory committee voted against adding it to the 503A bulks list. The reason wasn't what most people think.

NAD+ has been studied since 1906. It has 2 Nobel Prizes, randomized human trials, and over a century of biochemistry behind it. Yet in 2017, the FDA advisory committee voted against adding it to the 503A bulks list. The reason wasn't what most people think.

45,421 views • 2 months ago

BPC-157 causing cancer? FDA shutting down peptide trials? “No human RCTs have ever been done on peptides?” In this video, Dr. Alex Tatem — board-certified urologist and fellowship-trained men’s health specialist — reacts to viral claims made on Shawn Ryan Show about BPC-157, TB-500, peptides, angiogenesis, cancer risk, and peptide safety. We break down: • Whether BPC-157 actually causes cancer • The truth about angiogenesis and tumor growth • FDA regulation of peptides and compounding • Why the “no randomized controlled trials” claim is completely false • Human clinical trial data on peptides • The real history of BPC-157 clinical studies • Huberman’s correction of viral peptide misinformation • Why peptide fearmongering could push patients toward unsafe gray-market sourcing This is not bro-science or influencer hype. This is a deep dive into the actual published literature, peptide pharmacology, FDA policy, and performance medicine. Topics covered include: BPC-157, TB-500, peptides, angiogenesis, cancer biology, GLP-1 drugs, Ozempic, tirzepatide, semaglutide, TRT, peptide therapy, biohacking, longevity, anti-aging medicine, compounding pharmacies, peptide legality, Andrew D. Huberman, Ph.D. , Shawn Ryan Show, FDA peptide regulation, growth hormone history, and performance medicine. If you’ve ever wondered whether BPC-157 is dangerous, whether peptides are legal, or whether the internet is fearmongering about peptide therapy — this video is for you.

BPC-157 causing cancer? FDA shutting down peptide trials? “No human RCTs have ever been done on peptides?” In this video, Dr. Alex Tatem — board-certified urologist and fellowship-trained men’s health specialist — reacts to viral claims made on Shawn Ryan Show about BPC-157, TB-500, peptides, angiogenesis, cancer risk, and peptide safety. We break down: • Whether BPC-157 actually causes cancer • The truth about angiogenesis and tumor growth • FDA regulation of peptides and compounding • Why the “no randomized controlled trials” claim is completely false • Human clinical trial data on peptides • The real history of BPC-157 clinical studies • Huberman’s correction of viral peptide misinformation • Why peptide fearmongering could push patients toward unsafe gray-market sourcing This is not bro-science or influencer hype. This is a deep dive into the actual published literature, peptide pharmacology, FDA policy, and performance medicine. Topics covered include: BPC-157, TB-500, peptides, angiogenesis, cancer biology, GLP-1 drugs, Ozempic, tirzepatide, semaglutide, TRT, peptide therapy, biohacking, longevity, anti-aging medicine, compounding pharmacies, peptide legality, Andrew D. Huberman, Ph.D. , Shawn Ryan Show, FDA peptide regulation, growth hormone history, and performance medicine. If you’ve ever wondered whether BPC-157 is dangerous, whether peptides are legal, or whether the internet is fearmongering about peptide therapy — this video is for you.

78,362 views • 5 months ago

Today I testified before the FDA's Pharmacy Compounding Advisory Committee to advocate for patient access to BPC-157, TB-500, KPV, and MOTS-c. The committee voted to recommend moving all four peptides forward—but this is not final FDA approval. There are still important steps ahead. I break down exactly what happened, what this vote actually means, and what comes next.👇

Today I testified before the FDA's Pharmacy Compounding Advisory Committee to advocate for patient access to BPC-157, TB-500, KPV, and MOTS-c. The committee voted to recommend moving all four peptides forward—but this is not final FDA approval. There are still important steps ahead. I break down exactly what happened, what this vote actually means, and what comes next.👇

45,205 views • 3 months ago

Primobolan might be the most elegant anabolic steroid ever made. No estrogen. No DHT amplification. Higher androgen receptor affinity than testosterone. It was once considered gentle enough to give to premature infants. So why did it disappear from medicine—and why is it now one of the most expensive and counterfeited steroids in bodybuilding? I went all the way back to the human trials, receptor data, side effects, black-market testing, and a wild new muscle receptor discovered in 2025. The deeper I went, the stranger Primo got. Full Primobolan deep dive 👇

Primobolan might be the most elegant anabolic steroid ever made. No estrogen. No DHT amplification. Higher androgen receptor affinity than testosterone. It was once considered gentle enough to give to premature infants. So why did it disappear from medicine—and why is it now one of the most expensive and counterfeited steroids in bodybuilding? I went all the way back to the human trials, receptor data, side effects, black-market testing, and a wild new muscle receptor discovered in 2025. The deeper I went, the stranger Primo got. Full Primobolan deep dive 👇

36,172 views • 2 months ago