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Thrust vectoring mount for model rocket project … soo spacex job offer yet? 😀😀

kavan

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80,336 Aufrufe • vor 5 Monaten •via X (Twitter)

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🚨🇺🇸 ANOTHER CLEAN RETURN FOR SPACEX AS FALCON HAS A FLAWLESS TOUCHDOWN SpaceX nailed it again. Falcon 9 booster successfully touched down at Landing Zone 4 moments ago after launching [payload/mission details if known, otherwise: its latest mission from Cape Canaveral. The booster, fresh off the pad, executed a textbook return to LZ 4 on Florida's Space Coast, legs deployed, engines relit, and a perfect vertical touchdown. This marks yet another precise landing for the reusable rocket program that's redefined spaceflight. With boosters now routinely flying multiple missions, SpaceX continues to drive down launch costs and push rapid reusability closer to reality. Falcon 9 landing at LZ-4 is the kind of routine that used to be impossible. Now it's just a Friday. Yet it still gets me every time. Source: SpaceX, NSF - NASASpaceflight.com

🚨🇺🇸 ANOTHER CLEAN RETURN FOR SPACEX AS FALCON HAS A FLAWLESS TOUCHDOWN SpaceX nailed it again. Falcon 9 booster successfully touched down at Landing Zone 4 moments ago after launching [payload/mission details if known, otherwise: its latest mission from Cape Canaveral. The booster, fresh off the pad, executed a textbook return to LZ 4 on Florida's Space Coast, legs deployed, engines relit, and a perfect vertical touchdown. This marks yet another precise landing for the reusable rocket program that's redefined spaceflight. With boosters now routinely flying multiple missions, SpaceX continues to drive down launch costs and push rapid reusability closer to reality. Falcon 9 landing at LZ-4 is the kind of routine that used to be impossible. Now it's just a Friday. Yet it still gets me every time. Source: SpaceX, NSF - NASASpaceflight.com

Mario Nawfal

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It was a clean, controlled ocean splashdown. The vehicle flipped vertically, completed its landing burn, and safely touched down before tipping and exploding, achieving 100% of its test objectives exactly as planned, including the explosion Yet, the legacy media like The Guardian deliberately choose headlines like "SpaceX rocket bursts into flames" to farm clicks, making it look like a failure when it's in fact the complete opposite, all for cheap sensationalism

It was a clean, controlled ocean splashdown. The vehicle flipped vertically, completed its landing burn, and safely touched down before tipping and exploding, achieving 100% of its test objectives exactly as planned, including the explosion Yet, the legacy media like The Guardian deliberately choose headlines like "SpaceX rocket bursts into flames" to farm clicks, making it look like a failure when it's in fact the complete opposite, all for cheap sensationalism

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How was the Super Bowl? I didn’t watch… I was too busy with my family to care. Catching the highlights of the halftime show, The NFL told hundreds of millions of English Speaking Americans to shut up, listen to this disgusting music you don’t even understand, and watch grown men dry hump each other. Goood job NFL for reminding me exactly why I don’t watch. 😀

How was the Super Bowl? I didn’t watch… I was too busy with my family to care. Catching the highlights of the halftime show, The NFL told hundreds of millions of English Speaking Americans to shut up, listen to this disgusting music you don’t even understand, and watch grown men dry hump each other. Goood job NFL for reminding me exactly why I don’t watch. 😀

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Dragon Launch Escape Initiated During the launch escape test, where SpaceX intentionally destroyed an entire rocket to prove its safety, Dragon was fed the normal launch sequence for an ISS mission. Dragon wasn’t told to escape, but its onboard autonomous flight computers noticed the loss of thrust on Falcon before the Merlin engines could even fully shut down. Once Dragon realized there was a mission critical anomaly, it instantly initiated the launch escape sequence firing all 8 SuperDraco thrusters, separating explosive bolts on the second stage, and took autonomous control of the mission, in less time than any human reaction on the ground or in the capsule could of realized. Falcon, the crew, Dragon, and the ground can all initiate an escape if required. Although this test was uncrewed (meaning nobody was on the rocket during the test), if there was a life threatening emergency that would put the mission at risk, Dragon could leave and get out of the situation immediately.

Dragon Launch Escape Initiated During the launch escape test, where SpaceX intentionally destroyed an entire rocket to prove its safety, Dragon was fed the normal launch sequence for an ISS mission. Dragon wasn’t told to escape, but its onboard autonomous flight computers noticed the loss of thrust on Falcon before the Merlin engines could even fully shut down. Once Dragon realized there was a mission critical anomaly, it instantly initiated the launch escape sequence firing all 8 SuperDraco thrusters, separating explosive bolts on the second stage, and took autonomous control of the mission, in less time than any human reaction on the ground or in the capsule could of realized. Falcon, the crew, Dragon, and the ground can all initiate an escape if required. Although this test was uncrewed (meaning nobody was on the rocket during the test), if there was a life threatening emergency that would put the mission at risk, Dragon could leave and get out of the situation immediately.

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I believe solving robotics = 90% engineering + 10% research vision. Project GR00T is NVIDIA's moonshot initiative to build physical AGI for humanoid robots. The GEAR Lab is assembling a crack team right now. Join us! Openings: - Sr. Research Engineer, Robotics Systems - Sr. RE, Reinforcement Learning - Sr. RE, Foundation Model Training Infrastructure - Sr. RE, Simulation - Sr. RE, ML Data Pipelines - Research Scientist - Research Intern (both part-time and summer full-time in 2025) For the Sr. positions, we strongly prefer candidates with many years of engineering experience at robotics/autonomous driving companies, or MLOps/large-scale AI teams at big techs. For interns, we welcome ace robotics hackers anywhere! Show me your past works. Job links in the thread. Apply today! Your resumes will be my best Christmas gifts:

I believe solving robotics = 90% engineering + 10% research vision. Project GR00T is NVIDIA's moonshot initiative to build physical AGI for humanoid robots. The GEAR Lab is assembling a crack team right now. Join us! Openings: - Sr. Research Engineer, Robotics Systems - Sr. RE, Reinforcement Learning - Sr. RE, Foundation Model Training Infrastructure - Sr. RE, Simulation - Sr. RE, ML Data Pipelines - Research Scientist - Research Intern (both part-time and summer full-time in 2025) For the Sr. positions, we strongly prefer candidates with many years of engineering experience at robotics/autonomous driving companies, or MLOps/large-scale AI teams at big techs. For interns, we welcome ace robotics hackers anywhere! Show me your past works. Job links in the thread. Apply today! Your resumes will be my best Christmas gifts:

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AI has made it easy to generate images, but not for artists to retain ownership or credit. TITLES is a studio for artists working with AI as part of their practice — your model is trained on your work, owned by you, and tied to your creative identity. Your process becomes something you can use, share, evolve, and get paid for, without losing authorship along the way. Built alongside artists who have trusted us with their work, like Ana María Caballero, Anna Condo, blake jamieson, ☁, derrick has started yet another project, Emily Xie, Empress Trash 🌈🖤, Goyong, guruguruhyena🍥, sierra renee, mdj, Mr Misang, Rangga Purnama Aji, RedruM | 🩸, 新星 🌠 Shinsei Galverse, Venkatesh Rao ☀️, and weseeclearly. Reintroducing TITLES, Your Creative Studio. Coming soon.

AI has made it easy to generate images, but not for artists to retain ownership or credit. TITLES is a studio for artists working with AI as part of their practice — your model is trained on your work, owned by you, and tied to your creative identity. Your process becomes something you can use, share, evolve, and get paid for, without losing authorship along the way. Built alongside artists who have trusted us with their work, like Ana María Caballero, Anna Condo, blake jamieson, ☁, derrick has started yet another project, Emily Xie, Empress Trash 🌈🖤, Goyong, guruguruhyena🍥, sierra renee, mdj, Mr Misang, Rangga Purnama Aji, RedruM | 🩸, 新星 🌠 Shinsei Galverse, Venkatesh Rao ☀️, and weseeclearly. Reintroducing TITLES, Your Creative Studio. Coming soon.

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👌 SEED BIRD NFT: FROM A BIRD TO A MIGHTY WARRIOR 👌 TON Kombat spreads our wings! As a proud part of SEED Combinator, we’re honoring SEED Bird NFT holders with exclusive in-game perks. Here’s What You Get: 🛫 Exclusive Equipment: Bind your SEED Bird NFT to unlock and use it as a powerful in-game equipment. 😀 Extra $TOK: Verify your SEED balance to claim extra $TOK. You 👛 Wallet Flexibility: Easily disconnect and reconnect via TON Connect. ⬆️ Bonus Reward: Top Rankers might have a chance to earn SEED. 💻 If you haven't had the NFT yet, get one for yourself here on the marketplace: ✔️ OKX Marketplace ( ✔️ Getgems ( 👉 Bind your SEED Bird NFT, claim exclusive gear and $TOK, and secure your place on Board! #TONKombat

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🚨 A FORMER NASA ENGINEER CLAIMS HE’S DISCOVERED A “NEW FORCE” THAT CAN OVERCOME EARTH’S GRAVITY WITHOUT ANY PROPELLANT. Charles Buhler, who spent years leading NASA’s Electrostatics and Surface Physics Laboratory at Kennedy Space Center, says his private company Exodus Propulsion Technologies has found a way to generate thrust using only electric fields. In vacuum chamber tests, their device reportedly produced enough force to counteract Earth’s gravity a claim that would completely rewrite the rules of propulsion. Why this matters: For over a century, every rocket we’ve ever launched has had to carry massive amounts of fuel. If this “New Force” is real, spacecraft could one day maneuver indefinitely without expelling mass potentially making deep space travel, satellite station-keeping, and even atmospheric flight dramatically cheaper and more efficient. The deeper implication is staggering: We may be looking at the first real breakthrough in propellantless propulsion since the invention of the rocket. If verified, this wouldn’t just change space travel it could reshape how we think about energy, momentum, and the fundamental laws of physics. Of course, extraordinary claims require extraordinary evidence. As of now, the work is still awaiting independent replication by outside laboratories. But if this holds up… What changes first space travel, energy production, or something we haven’t even imagined yet? Follow for more frontier physics and emerging technologies.

🚨 A FORMER NASA ENGINEER CLAIMS HE’S DISCOVERED A “NEW FORCE” THAT CAN OVERCOME EARTH’S GRAVITY WITHOUT ANY PROPELLANT. Charles Buhler, who spent years leading NASA’s Electrostatics and Surface Physics Laboratory at Kennedy Space Center, says his private company Exodus Propulsion Technologies has found a way to generate thrust using only electric fields. In vacuum chamber tests, their device reportedly produced enough force to counteract Earth’s gravity a claim that would completely rewrite the rules of propulsion. Why this matters: For over a century, every rocket we’ve ever launched has had to carry massive amounts of fuel. If this “New Force” is real, spacecraft could one day maneuver indefinitely without expelling mass potentially making deep space travel, satellite station-keeping, and even atmospheric flight dramatically cheaper and more efficient. The deeper implication is staggering: We may be looking at the first real breakthrough in propellantless propulsion since the invention of the rocket. If verified, this wouldn’t just change space travel it could reshape how we think about energy, momentum, and the fundamental laws of physics. Of course, extraordinary claims require extraordinary evidence. As of now, the work is still awaiting independent replication by outside laboratories. But if this holds up… What changes first space travel, energy production, or something we haven’t even imagined yet? Follow for more frontier physics and emerging technologies.

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Look at these photos Falcon 9 soaring into the sky. Falcon Heavy and Starship ready for the next mission. Starlink antennas simple, clean, ready for any terrain. The Boring Company’s machine that looks like industrial sculpture. Futuristic tunnels full of Teslas. And the man whose vision stands behind it all. It’s not a coincidence. It’s not just “technology.” It’s class itself. Zero unnecessary ornaments. Zero exaggeration. Just a pure, very high-quality product. You hold it in your hand, step inside, or look at it and immediately feel that everything is refined to the last detail. It works. It looks right. It lasts. Elon Musk has this rare quality: he’s a man with class. He doesn’t flaunt luxury or add things just “because they photograph well.” He chooses simplicity but the kind that’s executed perfectly. And he transferred exactly that same philosophy to his companies. The result? Engineering at the level of fashion. Design that’s modern yet has timeless elegance. Products that don’t just do the job they impress with their quality and quiet confidence. It’s no accident that the rocket looks like a work of art. That a Tesla interior feels minimalist yet luxurious. That a Starlink dish looks like it was designed by someone who understands aesthetics, not just connectivity. They all share one common thread: class. Not the loud, flashy kind. The real kind quiet, self-assured, and uncompromising. If you value things that are simply well-made without unnecessary bling, but full of character and top-tier quality this is the essence of what Elon has built. Elon Musk Starlink The Boring Company SpaceX Tesla Neuralink

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They Don’t Work for You The H‑1B Isn’t Just Stealing Jobs... It’s Not Even Doing the Work. They said the H‑1B was about “top talent.” In reality, it’s become a passport for fraud, offshoring, and economic sabotage. Here’s the Game: • The H‑1B gets the badge, the cubicle, the paycheck • The actual work is done by a cousin back in Hyderabad • Remote login, fake résumés, offshore handoffs, it's routine • We train them. They train the next guy. The next guy is in India “He couldn’t answer a single technical question. His cousin was doing the coding from India.” – r/cscareerquestions “I reported it. HR told me to stop being racist.” – r/consulting This isn’t about immigration. It’s a deliberate proxy labor cartel, operating inside your own economy. And It Gets Worse... Every H‑1B is a pipeline: 1. Remittance Drain • $20K–$30K per worker sent abroad annually • That’s over $12 billion gone, not invested in your city, your schools, your community creating more jobs. 2. Proxy Networks & Job Sharing • Visa holder here, subcontractor there • One job split between two countries • Zero accountability 3. Trojan Horse for Offshoring • Train the H‑1B. Lose your job. • Six months later, your whole department is in Bangalore “We trained our Infosys replacements. Six months later we were gone.” – Former U.S. tech worker, r/cscareerquestions The Real Math: • 1 visa = 2 paychecks → One here, one overseas • 1 job = 3 U.S. workers lost → The jobholder, the trainee, and the one who never got the offer • 1 lie = a thousand closed doors → Americans can't compete with a transnational lie This is not a “talent strategy.” It’s job laundering. It’s extraction. It’s theft. And everyone in power knows it. Anyone pushing for more of it is literally selling American jobs for the money their lobby gives them. Globalists love cheap labor - its making the companies they own worth trillions and screwing Americans is just a side bonus they have zero guilt over. There is not a single American worker that benefits from foreign labor or foreign students- no other country on earth is doing what America is. They just keep calling it "diversity"... so you won’t call it what it is: Treason against the American worker. So common yet posting about this could get your post taken down by the very folks exploiting this. It already happened to an account that has been search banned, demonetized, throttled, and yet - keeps growing.

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From the KGB to #Narges_Mohammadi and the Risk of Repeating the Soviet Experience in Iran At the end of the Soviet Union, systemic inefficiency led the KGB to pursue a controlled power makeover to preserve their influence. During the failed 1991 coup—which is largely attributed to the KGB—Boris Yeltsin, a former communist turned reformist, climbed onto a tank. CNN portrayed him as a symbol of courage and democracy, yet the core of power remained unchanged. Eventually, Putin took control, and a kleptocratic system replaced communism. In Iran, some security-minded reformists appear to have the same model in mind. Narges Mohammadi, with her global Nobel recognition and support from reformists, was brought to a ceremony in Mashhad (commemorating lawyer Khosrow Alikordy, killed by the Islamic Republic) to serve as a figure for a controlled power transition. However, the smart reaction and protests of the public effectively neutralized the project. Had the people allowed it, global media could have elevated Narges, just like Yeltsin, into a leader and symbol of transition. Key lesson: Without Crown Prince Reza Pahlavi, a Yeltsin-Putin-style model for a controlled power transition in Iran becomes plausible.

From the KGB to #Narges_Mohammadi and the Risk of Repeating the Soviet Experience in Iran At the end of the Soviet Union, systemic inefficiency led the KGB to pursue a controlled power makeover to preserve their influence. During the failed 1991 coup—which is largely attributed to the KGB—Boris Yeltsin, a former communist turned reformist, climbed onto a tank. CNN portrayed him as a symbol of courage and democracy, yet the core of power remained unchanged. Eventually, Putin took control, and a kleptocratic system replaced communism. In Iran, some security-minded reformists appear to have the same model in mind. Narges Mohammadi, with her global Nobel recognition and support from reformists, was brought to a ceremony in Mashhad (commemorating lawyer Khosrow Alikordy, killed by the Islamic Republic) to serve as a figure for a controlled power transition. However, the smart reaction and protests of the public effectively neutralized the project. Had the people allowed it, global media could have elevated Narges, just like Yeltsin, into a leader and symbol of transition. Key lesson: Without Crown Prince Reza Pahlavi, a Yeltsin-Putin-style model for a controlled power transition in Iran becomes plausible.

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Hi everyone, this week I finally received the new ANyONe Relay! ANyONe Protocol is an interesting DePIN focused on building a more decentralized internet and making our privacy more secure 💯 I'm still waiting to release a video because the new Dashboard isn't active yet but for those interested the most important points that I want to highlight are these: 1) The #Miner is Plug&Play so easy to install, just follow the initial steps and you're fine, once installed you don't have to do anything else. 2) There is no limit for IP but if for example you put 2 Relays in the same #IP it isn't certain that you will have double rewards, because they basically do the same job, to get more rewards it's better to use different IPs. 3) To make the Relay operational it's necessary to open port 9001 in your Modem. Without this operation the #mining will basically not start, so make sure you have a modem or connection that can open the ports. If you have the classic public IP you should definitely be able to do it 4) Currently the rewards arrive automatically every week, usually Friday, and I received 8 $ANYONE as first earnings 👍 Since the new #Dashboard isn't yet operational the #rewards aren't yet clear (which is why I am still waiting to release the video) and personally I expect there will be more 🔥 The only negative note that I have found so far in the project is that: ANYONE #token is only on Ethereum So unfortunately the fees for the swap or even future claims and sendings will not be low, I hope that the team in the future will also consider Arbitrum or Base for the rewards to Nodes 🙏 $ANYONE: Docs to learn more: If you are interested in the project you can order the Anyone on @ampchampment and you can receive it in a few weeks 🚀 They ship Worldwide, Paypal and Crypto are available, and you can use the coupon ILCAPOFOX for a 5% discount! Shop: For Europe I also recommend FreshMiners, they also ship quickly and you can use the coupon ILCAPOFOX3 for a 10€ discount! Shop: #DePIN #Anyone #Relay #Node #Privacy #Internet

Hi everyone, this week I finally received the new ANyONe Relay! ANyONe Protocol is an interesting DePIN focused on building a more decentralized internet and making our privacy more secure 💯 I'm still waiting to release a video because the new Dashboard isn't active yet but for those interested the most important points that I want to highlight are these: 1) The #Miner is Plug&Play so easy to install, just follow the initial steps and you're fine, once installed you don't have to do anything else. 2) There is no limit for IP but if for example you put 2 Relays in the same #IP it isn't certain that you will have double rewards, because they basically do the same job, to get more rewards it's better to use different IPs. 3) To make the Relay operational it's necessary to open port 9001 in your Modem. Without this operation the #mining will basically not start, so make sure you have a modem or connection that can open the ports. If you have the classic public IP you should definitely be able to do it 4) Currently the rewards arrive automatically every week, usually Friday, and I received 8 $ANYONE as first earnings 👍 Since the new #Dashboard isn't yet operational the #rewards aren't yet clear (which is why I am still waiting to release the video) and personally I expect there will be more 🔥 The only negative note that I have found so far in the project is that: ANYONE #token is only on Ethereum So unfortunately the fees for the swap or even future claims and sendings will not be low, I hope that the team in the future will also consider Arbitrum or Base for the rewards to Nodes 🙏 $ANYONE: Docs to learn more: If you are interested in the project you can order the Anyone on @ampchampment and you can receive it in a few weeks 🚀 They ship Worldwide, Paypal and Crypto are available, and you can use the coupon ILCAPOFOX for a 5% discount! Shop: For Europe I also recommend FreshMiners, they also ship quickly and you can use the coupon ILCAPOFOX3 for a 10€ discount! Shop: #DePIN #Anyone #Relay #Node #Privacy #Internet

Osvaldo

28,170 Aufrufe • vor 1 Jahr

HAPPENING NOW: Secretary of War Pete Hegseth just arrived at Castelion to meet with the company’s founders as part of the Department of War 🇺🇸’s Arsenal Freedom Tour. Castelion Corporation is a U.S. defense technology startup founded in late 2022 by former SpaceX engineers, including CEO Bryon Hargis, Sean Pitt, and Andrew Kreitz. The company specializes in designing, testing, and manufacturing affordable, mass-producible hypersonic strike missiles to restore America's conventional deterrence capabilities, particularly against adversaries like China and Russia in hypersonic weapons. Their flagship product is the Blackbeard hypersonic missile system, engineered for high-volume production (thousands per year), lower costs (potentially 10x cheaper than comparable legacy systems), rapid development cycles (months instead of years), and compatibility with existing U.S. military platforms like HIMARS for the Army and various Navy systems. Castelion employs a SpaceX-inspired approach: vertical integration, rapid iteration, high-cadence testing (over 25 flight tests by late 2025), and scalable manufacturing using nontraditional suppliers to cut costs and speed. Castelion is Headquartered in Torrance, California, with facilities in Texas and a major new 1,000-acre solid rocket motor campus in Sandoval County, New Mexico called Project Ranger. The company has secured significant funding, including a $350 million Series B round in December 2025 following earlier rounds, to ramp up production. It has won multiple Department of War 🇺🇸 contracts, including integration awards with the U.S. Army and Navy, SBIR phases, and AFWERX programs for hypersonic development. Castelion aims to address the U.S. lag in hypersonic munitions by focusing on scale and affordability rather than boutique, high-end designs from traditional suppliers like Lockheed Martin Lockheed Martin or Raytheon Raytheon. Upon Pete Hegseth’s arrival, a large screen in the Castelion lobby lit up with a message that read “Welcome Secretary of War Pete Hegseth” and “Arsenal of Freedom” with a video of a missile launch.

HAPPENING NOW: Secretary of War Pete Hegseth just arrived at Castelion to meet with the company’s founders as part of the Department of War 🇺🇸’s Arsenal Freedom Tour. Castelion Corporation is a U.S. defense technology startup founded in late 2022 by former SpaceX engineers, including CEO Bryon Hargis, Sean Pitt, and Andrew Kreitz. The company specializes in designing, testing, and manufacturing affordable, mass-producible hypersonic strike missiles to restore America's conventional deterrence capabilities, particularly against adversaries like China and Russia in hypersonic weapons. Their flagship product is the Blackbeard hypersonic missile system, engineered for high-volume production (thousands per year), lower costs (potentially 10x cheaper than comparable legacy systems), rapid development cycles (months instead of years), and compatibility with existing U.S. military platforms like HIMARS for the Army and various Navy systems. Castelion employs a SpaceX-inspired approach: vertical integration, rapid iteration, high-cadence testing (over 25 flight tests by late 2025), and scalable manufacturing using nontraditional suppliers to cut costs and speed. Castelion is Headquartered in Torrance, California, with facilities in Texas and a major new 1,000-acre solid rocket motor campus in Sandoval County, New Mexico called Project Ranger. The company has secured significant funding, including a $350 million Series B round in December 2025 following earlier rounds, to ramp up production. It has won multiple Department of War 🇺🇸 contracts, including integration awards with the U.S. Army and Navy, SBIR phases, and AFWERX programs for hypersonic development. Castelion aims to address the U.S. lag in hypersonic munitions by focusing on scale and affordability rather than boutique, high-end designs from traditional suppliers like Lockheed Martin Lockheed Martin or Raytheon Raytheon. Upon Pete Hegseth’s arrival, a large screen in the Castelion lobby lit up with a message that read “Welcome Secretary of War Pete Hegseth” and “Arsenal of Freedom” with a video of a missile launch.

Laura Loomer

177,419 Aufrufe • vor 7 Monaten

🧬 We have many foundation models or language models for DNAs, but can we control them? We introduce Ctrl-DNA: Controllable Cell-Type-Specific Regulatory DNA Design via Constrained RL — a reinforcement learning framework for controllable cis-regulatory sequence generation. Paper: Code: 🔬What’s the challenge? Designing regulatory DNA that is both highly expressive in target cell types and inactive in others is essential for synthetic biology, gene therapy, and precision medicine. Yet, controlling these trade-offs is challenging due to sparse, sequence-level rewards and biological constraints. 🔥Why Ctrl-DNA? Ctrl-DNA fine-tunes pre-trained DNA language models using a value model free, Lagrangian-guided RL framework, enabling flexible and customizable constraint optimization. Users can define application-specific thresholds across cell types, balancing expression strength with specificity. ✅ Maximize target-cell expression ✅ Constrain off-target activity under user-defined thresholds ✅ Preserve cell-type-specific TF motif structure Benchmarked on human enhancer and promoter datasets, Ctrl-DNA consistently outperforms prior methods, achieving stronger specificity, higher fitness, and more biologically grounded sequence generation — all with direct control over regulatory trade-offs. Shoutout to the PhD students Xingyu Chen (Xingyu Chen ) and Rex Ma (Rex Ma) for their amazing work leading this project!

🧬 We have many foundation models or language models for DNAs, but can we control them? We introduce Ctrl-DNA: Controllable Cell-Type-Specific Regulatory DNA Design via Constrained RL — a reinforcement learning framework for controllable cis-regulatory sequence generation. Paper: Code: 🔬What’s the challenge? Designing regulatory DNA that is both highly expressive in target cell types and inactive in others is essential for synthetic biology, gene therapy, and precision medicine. Yet, controlling these trade-offs is challenging due to sparse, sequence-level rewards and biological constraints. 🔥Why Ctrl-DNA? Ctrl-DNA fine-tunes pre-trained DNA language models using a value model free, Lagrangian-guided RL framework, enabling flexible and customizable constraint optimization. Users can define application-specific thresholds across cell types, balancing expression strength with specificity. ✅ Maximize target-cell expression ✅ Constrain off-target activity under user-defined thresholds ✅ Preserve cell-type-specific TF motif structure Benchmarked on human enhancer and promoter datasets, Ctrl-DNA consistently outperforms prior methods, achieving stronger specificity, higher fitness, and more biologically grounded sequence generation — all with direct control over regulatory trade-offs. Shoutout to the PhD students Xingyu Chen (Xingyu Chen ) and Rex Ma (Rex Ma) for their amazing work leading this project!

Bo Wang

30,719 Aufrufe • vor 1 Jahr

It’s hard to believe we're on the final day of our campaign to save the farm and keep our special Esther Magic in Campbellville with Operation Angels. In just two short months, we've raised over half a million dollars to help bring this dream to life. Although we haven't hit our goal yet, what we've achieved is incredible. With over 6,100 contributors from 39 countries totaling over $560,000, this is a global affair in typical Esther fashion. This project is designed to generate revenue to support sanctuaries and rescue organizations and serve as a model for revenue-generating programs at existing facilities. What sets us apart is our approach to drawing revenue from a new demographic to ease the pressure on current donors and an educational program to better equip animal organizations for the challenges they face. This project represents everything Esther stood for: kindness, compassion, inclusion, and support. I can't think of a better way to honor her and the community of like-minded people who make our little corner of the internet unique. The campaign will remain active until 4 am ET on August 1st, so we have less than 17 hours to give it our best and finish strong. To anyone who hasn't contributed, I hope you’ll consider doing so today because we could certainly use your help. We may not reach our goal, and that’s okay. Don’t be discouraged. It just means we keep going because come hell or high water, we’re going back to Campbellville. Thank you to everyone who has contributed so far and to everyone who has liked, shared, and commented on campaign posts these last two months. You have all played a critical role, and I am eternally grateful for your support and encouragement. It is an honor and a privilege to be part of this project with all of you. It represents the end of an era and the start of a new and exciting one. We’re going to do amazing things together, and I can't wait to get back to work. See you all live tonight for our final campaign Garden Chat at 6:30 PM ET. xoxo Steve.

It’s hard to believe we're on the final day of our campaign to save the farm and keep our special Esther Magic in Campbellville with Operation Angels. In just two short months, we've raised over half a million dollars to help bring this dream to life. Although we haven't hit our goal yet, what we've achieved is incredible. With over 6,100 contributors from 39 countries totaling over $560,000, this is a global affair in typical Esther fashion. This project is designed to generate revenue to support sanctuaries and rescue organizations and serve as a model for revenue-generating programs at existing facilities. What sets us apart is our approach to drawing revenue from a new demographic to ease the pressure on current donors and an educational program to better equip animal organizations for the challenges they face. This project represents everything Esther stood for: kindness, compassion, inclusion, and support. I can't think of a better way to honor her and the community of like-minded people who make our little corner of the internet unique. The campaign will remain active until 4 am ET on August 1st, so we have less than 17 hours to give it our best and finish strong. To anyone who hasn't contributed, I hope you’ll consider doing so today because we could certainly use your help. We may not reach our goal, and that’s okay. Don’t be discouraged. It just means we keep going because come hell or high water, we’re going back to Campbellville. Thank you to everyone who has contributed so far and to everyone who has liked, shared, and commented on campaign posts these last two months. You have all played a critical role, and I am eternally grateful for your support and encouragement. It is an honor and a privilege to be part of this project with all of you. It represents the end of an era and the start of a new and exciting one. We’re going to do amazing things together, and I can't wait to get back to work. See you all live tonight for our final campaign Garden Chat at 6:30 PM ET. xoxo Steve.

Esther TheWonder Pig

11,759 Aufrufe • vor 2 Jahren