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Using a combination of modern cell biology techniques, including #trafficking assays, #CRISPR, and secretomics, Pereira, Stalder, David Gershlick et al. Cambridge University reveal that the exocyst complex has a fundamental role in protein secretion.

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Journal of Cell Biology

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16,269 просмотров • 3 лет назад •via X (Twitter)

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Fantastic to tour the impressive Autodesk in Birmingham. The technology center is using cutting-edge advanced manufacturing techniques that are reshaping the way things are designed and made for customers across a broad range of sectors including automotive and aerospace industries.

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A pro-Palestinian 🇵🇸 group slashed and spray-painted a century-old portrait of the author of the Balfour Declaration at the University of Cambridge in England 🏴󠁧󠁢󠁥󠁮󠁧󠁿 In March 2024; a pro-Palestinian group slashed and spray-painted a century-old portrait of Arthur James Balfour at the University of Cambridge on Friday, defacing a painting of the British official whose pledge of support in 1917 for “the establishment in Palestine of a national home for the Jewish people” helped pave the way to Israel’s founding three decades later. The group, Palestine Action, said in a statement that the destruction of the portrait in Trinity College, Cambridge, was intended to call attention to “the bloodshed of the Palestinian people since the Balfour Declaration was issued,” particularly in light of the current conflict in Gaza. A spokeswoman for Trinity, whose alumni include King Charles III as well as Balfour himself, said in a statement on Friday that the college “regrets the damage caused to a portrait of Arthur James Balfour during public opening hours” and that it had notified the police. A Cambridge police statement said officers were on the scene to investigate a report of “criminal damage.” Palestine Action posted a video of a protester first spraying the portrait, painted in 1914 by Philip Alexius de László, with red paint and then slashing it with a sharp object. The group’s statement said Balfour had given away the homeland of the Palestinians — “a land that wasn’t his to give away” — touching off what it described as decades of oppression. Since October 7 - 2023, when Hamas militants invading southern Israel killed approximately 1,200 people and abducted 240 others, Israeli bombings and invasions have killed more than 30,000 people, according to Gaza health officials. Defacing art has become a popular protest tactic in recent years. It is perhaps most closely associated with environmentalists, who have targeted paintings by van Gogh, Vermeer and Monet. In 2024, two women from an environmental group entered the Louvre and flung soup at the Mona Lisa. Most of the paintings that have been targeted were covered or protected in some way, and very few were damaged. The pro-Palestinian protesters have targeted art in New York. A few dozen demonstrators disrupted the opening of an Israeli artist’s show at a Manhattan gallery, Hyperallergic reported. In February 2024, protesters interrupted a conversation featuring an Israeli artist whose drawings depicting October 7, 2023 are being exhibited at the Jewish Museum and dozens chanted “Free Palestine” in a demonstration at the Museum of Modern Art. © The New York Times #archaeohistories
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A pro-Palestinian 🇵🇸 group slashed and spray-painted a century-old portrait of the author of the Balfour Declaration at the University of Cambridge in England 🏴󠁧󠁢󠁥󠁮󠁧󠁿 In March 2024; a pro-Palestinian group slashed and spray-painted a century-old portrait of Arthur James Balfour at the University of Cambridge on Friday, defacing a painting of the British official whose pledge of support in 1917 for “the establishment in Palestine of a national home for the Jewish people” helped pave the way to Israel’s founding three decades later. The group, Palestine Action, said in a statement that the destruction of the portrait in Trinity College, Cambridge, was intended to call attention to “the bloodshed of the Palestinian people since the Balfour Declaration was issued,” particularly in light of the current conflict in Gaza. A spokeswoman for Trinity, whose alumni include King Charles III as well as Balfour himself, said in a statement on Friday that the college “regrets the damage caused to a portrait of Arthur James Balfour during public opening hours” and that it had notified the police. A Cambridge police statement said officers were on the scene to investigate a report of “criminal damage.” Palestine Action posted a video of a protester first spraying the portrait, painted in 1914 by Philip Alexius de László, with red paint and then slashing it with a sharp object. The group’s statement said Balfour had given away the homeland of the Palestinians — “a land that wasn’t his to give away” — touching off what it described as decades of oppression. Since October 7 - 2023, when Hamas militants invading southern Israel killed approximately 1,200 people and abducted 240 others, Israeli bombings and invasions have killed more than 30,000 people, according to Gaza health officials. Defacing art has become a popular protest tactic in recent years. It is perhaps most closely associated with environmentalists, who have targeted paintings by van Gogh, Vermeer and Monet. In 2024, two women from an environmental group entered the Louvre and flung soup at the Mona Lisa. Most of the paintings that have been targeted were covered or protected in some way, and very few were damaged. The pro-Palestinian protesters have targeted art in New York. A few dozen demonstrators disrupted the opening of an Israeli artist’s show at a Manhattan gallery, Hyperallergic reported. In February 2024, protesters interrupted a conversation featuring an Israeli artist whose drawings depicting October 7, 2023 are being exhibited at the Jewish Museum and dozens chanted “Free Palestine” in a demonstration at the Museum of Modern Art. © The New York Times #archaeohistories

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A sneak peak of a complex and technically challenging experiment that my lab developed: Super proud of PhD candidate Hannah Johnson for showcasing our Whole-gut spatial genomic analysis in #zebrafish. This video illustrates one landmark in the protocol after multiple rounds of sequential #HCR and 3D imaging in zebrafish larvae to reveal spatial expression of numerous mRNAs in the same specimen. Data from these imaging data sets are then computationally analyzed for spatial cell groups, spatially variable genes, and differentially expressed genes along 3D. We are leveraging this systems-level SGA to uncover unappreciated mechanistic insight at the cell and tissue levels into #ENS construction. Stay tuned for our work that exploits this pipeline within various mutant and perturbation conditions. Reach out if you are interested in trying this! #fruitypebbles

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Robotic surgery in pancreatic cancer care: *Quo vadis?* 🩺🤖 In 2000, one of the first robot-assisted cholecystectomies in Belgium was performed UZ Leuven using the ZEUS system. Shortly after, the technology was acquired by Intuitive — a company that would become the global leader in robotic surgery. In 2013, this pioneering trajectory continued with one of Belgium’s first robotic Whipple procedures, using the da Vinci platform. After several cases, however, the robotic approach was paused due to its high cost and limited advantage over laparoscopy at that time. Today, robotic surgery is deeply integrated in complex abdominal procedures — including pancreatic resections. Industry investment in conventional laparoscopy has declined. Intuitive’s business model has evolved, and the cost of robotic surgery is now approaching parity with laparoscopic approaches. Technology has evolved. The market has too. **Is now the time to fully embrace robotic surgery – even for complex procedures like the Whipple?** 👇 Curious to hear your thoughts: Vote in the poll below and feel free to elaborate in the comments. #RoboticSurgery #Pancreaticcancer #Whipple #MedTech #SurgicalInnovation #Healthcare #MinimallyInvasive

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Facial reconstruction of a 315,000-year-old man from Morocco The first discovery at the Jebel Irhoud site was made in 1961, when a remarkably complete skull of an archaic human was unearthed. Subsequent excavations revealed another cranial vault, the mandible of a child, and several additional bone fragments. The site has been dated multiple times, with estimates ranging from 30,000 to 190,000 years ago. By 2007, the accepted age was approximately 160,000 years. However, new analyses conducted by the same research team demonstrated that the Jebel Irhoud deposits are significantly older, dating between 240,000 ± 35,000 and 378,000 ± 30,000 years ago, with an average age of approximately 315,000 ± 34,000 years. The Jebel Irhoud individuals occupy an intermediate position between modern humans (including Upper Paleolithic Cro-Magnons) and more archaic groups such as Heidelberg humans, Neanderthals, and African Middle Pleistocene populations. This pattern is evident across nearly all studied anatomical features, including the skull, mandible, brain, and dentition. The occipital and temporal bones of Irhoud 1 retain several archaic characteristics, whereas the frontal bone exhibits more derived traits. The face of Jebel Irhoud 1 is essentially indistinguishable from that of modern humans and, in some respects, appears even more modern than that of certain Upper Paleolithic Homo sapiens specimens. The mandible displays a receding chin, although a very weak indication of chin prominence may be present. Considered in isolation, the jaw appears relatively archaic; however, in combination with the facial morphology, it does not seem particularly primitive. Viewed from a three-quarter angle, Irhoud 1 appears remarkably modern, while its archaic features become most apparent in profile. The cranial vault bones of Jebel Irhoud 1 are thick, and the vault itself is low and elongated. The forehead is low and receding, although less sloping than that of European Neanderthals. The brow ridge is massive, postorbital constriction is pronounced, and the occipital region exhibits a chignon-like morphology. The mandibular fossa of the temporal bone is moderately deep and spacious. The articular eminence is well developed, and the postglenoid process is large. The face is extremely high and broad. The upper face is relatively flattened, while alveolar prognathism is strongly expressed. The orbits are tall and square-shaped, and the nose is very broad. A canine fossa is absent, and the alveolar process is high. The teeth are large. The brain morphology resembles that of the Kabwe (Broken Hill) specimen. Cranial capacity has been estimated at 1,305–1,480 cm³. (Hublin et al. (2017), Richter et al. (2017), Antropogenez, S. Drobyshevski (2017)).

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Today in Kyiv, I had the pleasure of meeting with Sanna Marin, former Prime Minister of Finland. Sanna has been a true friend of Ukraine. From the very first days of the full-scale invasion, she made a clear and unwavering choice to stand with us. Our countries have grown much closer during this most difficult period in our history, and her personal leadership has played an important role in that. She represents a form of women’s leadership that strengthens global politics across all areas, including security, particularly in times of historic challenge. Thank you for the thoughtful gift, Hope in Action, which speaks so powerfully about Ukraine and the resilience of our people. It is always a pleasure to welcome Sanna to Ukraine ❤️

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The IDF confirms killing two Hezbollah operatives in separate drone strikes in Lebanon earlier today. The first strike, near the southern Lebanon town of Naqoura, killed Abd a-Sayed, who the military says served as Hezbollah's local representative in the nearby village of Ras al-Bayada, and as part of his role, he was responsible for liaising between the terror group and the residents "on economic and military matters." The IDF says a-Sayed was also involved in efforts to restore Hezbollah military capabilities in the village. The second strike near the village of Nabi Chit in the eastern Beqaa Valley killed Ali Hussein al-Mousawi, who the IDF says was a weapons smuggler for the terror group. The IDF says that as part of his role, "he handled the purchasing and transfer of weapons from Syria to Lebanon," and he also "played a significant role in the reestablishment and strengthening of Hezbollah." "Throughout the past year, the terrorist has continuously smuggled weapons for Hezbollah," the military says.

Emanuel (Mannie) Fabian

16,739 просмотров • 9 месяцев назад

The bacterial flagellum looks like a simple tail, or whip. But it’s actually a rotating motor, and perhaps the most sophisticated protein complex nature has ever evolved. In e. coli, these motors are capable of astonishing speeds; about 15,000 rpm. (The world record, according to one study, is for a Vibrio cell that was “clocked at 100,000 rpm by laser microscopy.) The flagellum propels the cell forward at speeds of 20-30 microns per second, or roughly 15 body lengths per second. If scaled up to the size of a cheetah, E. coli would *nearly* be the fastest land organism. The darting movements of a microbe were first observed in 1676 by Antony van Leeuwenhoek, a Dutch cloth merchant. Antony was delighted by the motion of his “animalcules,” writing: “I must say, for my part, that no more pleasant sight has ever yet come before my eye than these many thousands of living creatures, seen all alive in a little drop of water, moving among one another, each several creature having its own proper motion.” But Leeuwenhoek did not see flagella. He assumed, rather, that these animalcules must be “furnished with paws” instead. Christian Ehrenberg would not properly describe flagella until 1836. But amazingly, all the way up until the 1970s, nobody actually knew how the flagellum spun! In 1973, there were two competing models people argued over: the helical-wave (bending) model and the rotating (corkscrew) model. The first model suggested that the flagellum whipped back and forth, side-to-side, to propel the cell like paddle. The corkscrew model suggested that the whole flagellum instead spins around like a screw. In 1974, the corkscrew model finally won out. For two separate studies, scientists affixed flagella to glass slides using antibodies, and watched as the cells spun around and around like corkscrews. And finally, in just the last year, high-resolution structures of the flagellum have revealed a LOT more about its intricate assembly. The tail is made from ~20,000 self-assembling copies of a single protein, called flagellin. A “driveshaft,” or rod, spins the tail and is itself made of 26 protein subunits. Each “motor” in E. coli consists of 11 stators, each of which is made from 7 proteins.(Other types of cells have even more stators, and swim with much higher torques.) The flagellum spins when protons flow into the cell through tiny channels in these stators; akin to water running through a turbine. Each proton makes a small part of the stator change shape and push against the rotor, nudging it forward one step. With dozens of stators working at once, these nudges quickly spin the propeller. I'm writing an essay for Asimov Press about this now, and am really enjoying learning about the flagellum and its history. It's an extraordinarily complicated structure, though, and has been a challenge to understand!
0:05

The bacterial flagellum looks like a simple tail, or whip. But it’s actually a rotating motor, and perhaps the most sophisticated protein complex nature has ever evolved. In e. coli, these motors are capable of astonishing speeds; about 15,000 rpm. (The world record, according to one study, is for a Vibrio cell that was “clocked at 100,000 rpm by laser microscopy.) The flagellum propels the cell forward at speeds of 20-30 microns per second, or roughly 15 body lengths per second. If scaled up to the size of a cheetah, E. coli would *nearly* be the fastest land organism. The darting movements of a microbe were first observed in 1676 by Antony van Leeuwenhoek, a Dutch cloth merchant. Antony was delighted by the motion of his “animalcules,” writing: “I must say, for my part, that no more pleasant sight has ever yet come before my eye than these many thousands of living creatures, seen all alive in a little drop of water, moving among one another, each several creature having its own proper motion.” But Leeuwenhoek did not see flagella. He assumed, rather, that these animalcules must be “furnished with paws” instead. Christian Ehrenberg would not properly describe flagella until 1836. But amazingly, all the way up until the 1970s, nobody actually knew how the flagellum spun! In 1973, there were two competing models people argued over: the helical-wave (bending) model and the rotating (corkscrew) model. The first model suggested that the flagellum whipped back and forth, side-to-side, to propel the cell like paddle. The corkscrew model suggested that the whole flagellum instead spins around like a screw. In 1974, the corkscrew model finally won out. For two separate studies, scientists affixed flagella to glass slides using antibodies, and watched as the cells spun around and around like corkscrews. And finally, in just the last year, high-resolution structures of the flagellum have revealed a LOT more about its intricate assembly. The tail is made from ~20,000 self-assembling copies of a single protein, called flagellin. A “driveshaft,” or rod, spins the tail and is itself made of 26 protein subunits. Each “motor” in E. coli consists of 11 stators, each of which is made from 7 proteins.(Other types of cells have even more stators, and swim with much higher torques.) The flagellum spins when protons flow into the cell through tiny channels in these stators; akin to water running through a turbine. Each proton makes a small part of the stator change shape and push against the rotor, nudging it forward one step. With dozens of stators working at once, these nudges quickly spin the propeller. I'm writing an essay for Asimov Press about this now, and am really enjoying learning about the flagellum and its history. It's an extraordinarily complicated structure, though, and has been a challenge to understand!

Niko McCarty.

51,893 просмотров • 11 месяцев назад

✅Explanation of Meaning (by parts): 1. “Having studied and confirmed that biological evolution on planet Earth” : The author begins by referencing the study of biological evolution on Earth, asserting that scientific investigation has established a clear understanding of its processes, setting a foundation for further claims. 2. “which gave birth to all living things” : Evolution is credited with the origin of all life on Earth, emphasizing its role as the mechanism through which the diversity and complexity of living organisms, including humans, arose over billions of years. 3. “had no purpose” : The author asserts that this evolutionary process lacks a predetermined purpose or intentional design, suggesting that life’s development is driven by natural, undirected mechanisms like mutation and selection, not a teleological goal. 4. “one can easily find answers to other fundamental questions of existence” : By accepting evolution’s purposelessness, the author claims that it becomes simpler to address broader existential questions, implying that this understanding provides a framework for tackling issues like the meaning of life or the Universe’s nature. 🗝️Main Idea (refined version): The author asserts that scientific study confirms biological evolution on Earth, which produced all life, operates without purpose, driven by natural mechanisms rather than intentional design. This understanding facilitates answers to fundamental existential questions, offering clarity on life’s meaning and our place in the cosmos. Recognizing evolution’s purposelessness challenges teleological views, fostering a perspective rooted in empirical reality. It encourages humility, acknowledging our existence as a product of chance rather than destiny. This insight simplifies complex philosophical inquiries, aligning them with scientific principles. It inspires a rational approach to exploring existence, free from preconceived notions of purpose. Ultimately, it empowers us to construct personal and collective meaning within a Universe governed by natural laws, embracing our role as products of a remarkable, undirected process.
0:11

✅Explanation of Meaning (by parts): 1. “Having studied and confirmed that biological evolution on planet Earth” : The author begins by referencing the study of biological evolution on Earth, asserting that scientific investigation has established a clear understanding of its processes, setting a foundation for further claims. 2. “which gave birth to all living things” : Evolution is credited with the origin of all life on Earth, emphasizing its role as the mechanism through which the diversity and complexity of living organisms, including humans, arose over billions of years. 3. “had no purpose” : The author asserts that this evolutionary process lacks a predetermined purpose or intentional design, suggesting that life’s development is driven by natural, undirected mechanisms like mutation and selection, not a teleological goal. 4. “one can easily find answers to other fundamental questions of existence” : By accepting evolution’s purposelessness, the author claims that it becomes simpler to address broader existential questions, implying that this understanding provides a framework for tackling issues like the meaning of life or the Universe’s nature. 🗝️Main Idea (refined version): The author asserts that scientific study confirms biological evolution on Earth, which produced all life, operates without purpose, driven by natural mechanisms rather than intentional design. This understanding facilitates answers to fundamental existential questions, offering clarity on life’s meaning and our place in the cosmos. Recognizing evolution’s purposelessness challenges teleological views, fostering a perspective rooted in empirical reality. It encourages humility, acknowledging our existence as a product of chance rather than destiny. This insight simplifies complex philosophical inquiries, aligning them with scientific principles. It inspires a rational approach to exploring existence, free from preconceived notions of purpose. Ultimately, it empowers us to construct personal and collective meaning within a Universe governed by natural laws, embracing our role as products of a remarkable, undirected process.

Zafar Mirzo | Quotes

2,924,909 просмотров • 1 год назад

The IDF destroyed the headquarters of the Shajeya terrorist organization Hamas; The combat teams of the commando formation and the 7th brigade raided terrorist infrastructures and eliminated terrorists in the heart of the city of Khan Yunis During the operation, the fighters eliminated terrorists and destroyed a tunnel shaft containing a terrorist who tried to throw a bomb at our forces. The complex was destroyed by air force aircraft, tanks and engineering forces. Also, the fighters of the 414th collection battalion made the first use of a "Maoz" drone, in which they exposed and attacked a terrorist cell in the area. In the last day, the combat teams of the commando formation and the 7th brigade raided terrorist infrastructures in the heart of the city of Khan Yunis, eliminated many terrorists and located tunnel shafts of the terrorist organization Hamas. During the raids, the forces destroyed a weapons warehouse using a "steel stinger". In addition, the fighters located a tunnel shaft with motorcycles inside it that were used by the Hamas terrorists in the murderous attack on October 7. In addition, an Air Force fighter jet attacked a building that was used as a hiding place for terrorists and an aircraft eliminated three terrorists who tried to attack our forces.
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The IDF destroyed the headquarters of the Shajeya terrorist organization Hamas; The combat teams of the commando formation and the 7th brigade raided terrorist infrastructures and eliminated terrorists in the heart of the city of Khan Yunis During the operation, the fighters eliminated terrorists and destroyed a tunnel shaft containing a terrorist who tried to throw a bomb at our forces. The complex was destroyed by air force aircraft, tanks and engineering forces. Also, the fighters of the 414th collection battalion made the first use of a "Maoz" drone, in which they exposed and attacked a terrorist cell in the area. In the last day, the combat teams of the commando formation and the 7th brigade raided terrorist infrastructures in the heart of the city of Khan Yunis, eliminated many terrorists and located tunnel shafts of the terrorist organization Hamas. During the raids, the forces destroyed a weapons warehouse using a "steel stinger". In addition, the fighters located a tunnel shaft with motorcycles inside it that were used by the Hamas terrorists in the murderous attack on October 7. In addition, an Air Force fighter jet attacked a building that was used as a hiding place for terrorists and an aircraft eliminated three terrorists who tried to attack our forces.

Mossad Commentary

455,369 просмотров • 2 лет назад