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We sat down with Michael Levin, developmental biologist at Tufts University, about the emerging field of developmental bioelectricity: how electrical signals help control how organisms build and regenerate themselves. Levin explains how voltage gradients, ion channels, and gap junctions guide embryonic development and encode large-scale anatomical information that cells...

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Is time an illusion? I sat down with physicist Julian Barbour to explore his radical theory: time is just how we interpret changing shapes. He explains why the universe might actually be increasing in order, challenging the second law of thermodynamics. Link in comments below. Timestamps: 00:00 - Introduction 02:12 - Working Outside of Academia 03:53 - Space, Time, Dimension 10:40 - Mach’s Principle 21:33 - Mach Confused Einstein 24:22 - Two Particle Universe 31:46 - Carlo Rovelli 35:02 - Julian’s Ontology 43:37 - Julian’s Theory ‘Shape Statistics’ 51:11 - Leinbiz’s Philosophical Writings 56:14 - Expansion of the Universe (Scale Invariance) 01:05:02 - Cosmological Principle 01:15:34 - Thermodynamics 01:17:15 - Entropy and Complexity 01:30:40 - Wave Function / Double Slit Experiment 01:39:21 - God 01:44:48 - The Role of Instruments 01:47:44 - Etymology of Pattern and Matter 01:51:25 - Join My Substack!

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42:09

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27,660 Aufrufe • vor 3 Monaten

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Daniel Shur

13,616 Aufrufe • vor 4 Monaten

My conversation with OpenAI co-founder Greg Brockman This is the most detailed first-person account of the 72 hours after Sam Altman was fired. We also go deep on what comes next: the global race to AGI, why ChatGPT stopped showing reasoning, how much of OpenAI's own code is now written by AI ("it's hard to know what percent is not"), and the untold story of how OpenAI actually started in 2015. 00:00:00 Introduction 00:00:49 Meeting Sam Altman and Starting OpenAI 00:02:40 Building the Founding Team 00:04:25 DeepMind's Lead Over OpenAI 00:04:54 Changing OpenAI to a For-Profit Model 00:06:05 Breakthrough Moments at OpenAI 00:08:22 What Dota 2 Meant for OpenAI 00:10:04 Reasoning Versus Prediction 00:11:59 Tensions Grow at OpenAI 00:15:44 Sam Altman's Firing 00:17:49 Greg Quits OpenAI 00:19:56 Sam Explores Deal with Microsoft's Satya 00:20:28 Petition for Altman's Return 00:23:43 Ilya Sutskever Leaves OpenAI 00:24:59 Lessons Learned after Sam Ousting 00:28:22 The Thing Ilya Said that Greg Can't Forget 00:32:22 Is AI Going Parabolic? 00:33:24 How Much of OpenAI's Code is Written by AI? 00:36:21 Do AI Chatbots Tell Us What We Want to Hear? 00:38:06 The Global AI Race to Reach AGI 00:38:40 What Happens if US Doesn't Reach AGI First? 00:39:49 Are Countries Stealing AI Advancements? 00:40:38 Why ChatGPT No Longer Shows Reasoning 00:41:47 The Finite Constraints of Compute 00:43:38 On Investing Early in Data Centers 00:46:31 The Future of Data Center Specialization 00:47:52 How to Decide Whose Queries to Serve 00:49:08 OpenAI on Consumer vs Enterprise Models 00:53:05 Data Centers in Space? 01:00:56 What Should AI Regulation Look Like? 01:04:33 The Future of AI-Powered Entrepreneurship 01:04:44 AI and Job Loss 01:07:15 The Skills Young People Should Invest In 01:11:30 What Does Success Look Like For You? Full episode on X below. Also find it on: • YouTube: • Spotify: • Apple:
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Shane Parrish

450,952 Aufrufe • vor 3 Monaten

Michael Truell (Michael Truell), co-founder and CEO of Anysphere, the company behind Cursor, joined Garry Tan to talk about building one of the fastest-growing startups of all time—and why he's betting everything on a world beyond code. He walks through the early insights that led him and his co-founders to leave a promising AI-powered CAD project and instead chase a bigger dream: reinventing how software is written. From the hard years of false starts and rewrites to Cursor's breakthrough moment, Michael explains what it really takes to build a tool that could eventually replace programming as we know it. He also reflects on their first 10 hires, why taste still matters, and how the decade ahead will unlock a new kind of creativity for builders everywhere. 01:00 - A new way to build software 04:50 - Two ways to view LLMs 05:50 - Bottlenecks to superhuman agents 08:30 - New approaches to coding UI 09:40 - Why taste still matters 12:15 - Niche software opportunities 13:30 - Cursor origin story 16:00 - The first problem they tried solving 17:20 - Why they abandoned the CAD idea 21:00 - Pivoting to Cursor 23:00 - Following the scaling laws 27:00 - Getting to PMF 30:00 - “Dogfooding” 31:00 - First 10 hires 32:50 - How to evaluate great engineers 33:45 - Maintaining the hacker mindset 35:00 - What are the moats for AI coding tools? 37:00 - Looking ahead
37:28

Michael Truell (Michael Truell), co-founder and CEO of Anysphere, the company behind Cursor, joined Garry Tan to talk about building one of the fastest-growing startups of all time—and why he's betting everything on a world beyond code. He walks through the early insights that led him and his co-founders to leave a promising AI-powered CAD project and instead chase a bigger dream: reinventing how software is written. From the hard years of false starts and rewrites to Cursor's breakthrough moment, Michael explains what it really takes to build a tool that could eventually replace programming as we know it. He also reflects on their first 10 hires, why taste still matters, and how the decade ahead will unlock a new kind of creativity for builders everywhere. 01:00 - A new way to build software 04:50 - Two ways to view LLMs 05:50 - Bottlenecks to superhuman agents 08:30 - New approaches to coding UI 09:40 - Why taste still matters 12:15 - Niche software opportunities 13:30 - Cursor origin story 16:00 - The first problem they tried solving 17:20 - Why they abandoned the CAD idea 21:00 - Pivoting to Cursor 23:00 - Following the scaling laws 27:00 - Getting to PMF 30:00 - “Dogfooding” 31:00 - First 10 hires 32:50 - How to evaluate great engineers 33:45 - Maintaining the hacker mindset 35:00 - What are the moats for AI coding tools? 37:00 - Looking ahead

Y Combinator

337,015 Aufrufe • vor 1 Jahr

Episode 64 with Claynosaurz This is our dot com era. This is the future and we believe that. We have this current model that works We spoke about the past, present and future of Claynosaurz, IP tokenization, DATs It was great to have a casual sit down with the team and talk shop Timestamps: 0:01:58 Intro 0:04:38 Clayno quarterly workshop 0:05:56 Cab 🌋 new role at Claynosaurz 0:10:23 Navy seals 0:16:01 Tokenize everything 0:20:07 "Disney will buy us or we will buy them" Andrew 0:23:11 The thing we are really thinking about 0:29:20 Future of digital asset treasuries 0:34:30 GameSquare Holdings Inc. acquiring high value punks 0:37:50 Alpha 0:40:47 How is it to have DAVID HORVATH on the team 0:44:00 Assessing the Asian markets 0:48:00 Retaining top talent and the core team 0:48:50 William Liu joins the set + new position 0:56:29 Clayno's first event experience ever 1:00:10 How Plaposaur | CC 🌋 and the team went full time Clayno 1:07:34 Team member growth 1:17:02 Disney 1:20:00 Future of IP 1:30:30 "No way im saying this on air"
1:39:47

Episode 64 with Claynosaurz This is our dot com era. This is the future and we believe that. We have this current model that works We spoke about the past, present and future of Claynosaurz, IP tokenization, DATs It was great to have a casual sit down with the team and talk shop Timestamps: 0:01:58 Intro 0:04:38 Clayno quarterly workshop 0:05:56 Cab 🌋 new role at Claynosaurz 0:10:23 Navy seals 0:16:01 Tokenize everything 0:20:07 "Disney will buy us or we will buy them" Andrew 0:23:11 The thing we are really thinking about 0:29:20 Future of digital asset treasuries 0:34:30 GameSquare Holdings Inc. acquiring high value punks 0:37:50 Alpha 0:40:47 How is it to have DAVID HORVATH on the team 0:44:00 Assessing the Asian markets 0:48:00 Retaining top talent and the core team 0:48:50 William Liu joins the set + new position 0:56:29 Clayno's first event experience ever 1:00:10 How Plaposaur | CC 🌋 and the team went full time Clayno 1:07:34 Team member growth 1:17:02 Disney 1:20:00 Future of IP 1:30:30 "No way im saying this on air"

Andrew Forte

26,952 Aufrufe • vor 10 Monaten

"You just can't build a slow, expensive blockchain anymore." Solana founder toly 🇺🇸 built a $47 billion network from an idea he couldn't sleep on. Two coffees and a beer at Cafe du Soleil in 2017, and he was up until 4 a.m., figuring out how to use proof of work to measure time. His parents escaped the USSR in the 90s with $50 to their name and landed in Chicago in their 40s. His mom was a pianist. His dad was a civil engineer who took blue-collar roofing jobs while getting his electrician certificates. His son did the circuit analysis homework for him. That 4 a.m. idea became proof of history, the core mechanism behind Solana. In this episode: 00:00:00 Trailer 00:01:06 Intro 00:01:17 Growing up in the Soviet Union 00:04:02 Immigrating to the United States 00:07:34 Career dreams and studying computer science 00:09:47 First startup and early lessons 00:11:19 13 years at Qualcomm 00:22:32 Meeting Raj and founding Solana 00:26:44 Fundraising and early investors 00:28:41 Surviving the FTX collapse 00:40:19 Solana's mission and impact 00:43:54 Using AI to run side projects 00:49:39 Hardest decisions as a leader 00:52:51 Outlook on crypto and Solana's future 00:59:22 Twitter, being public, and politics 01:05:52 Beliefs on human nature and life philosophy 01:09:34 Outro Full episode:
1:08:27

"You just can't build a slow, expensive blockchain anymore." Solana founder toly 🇺🇸 built a $47 billion network from an idea he couldn't sleep on. Two coffees and a beer at Cafe du Soleil in 2017, and he was up until 4 a.m., figuring out how to use proof of work to measure time. His parents escaped the USSR in the 90s with $50 to their name and landed in Chicago in their 40s. His mom was a pianist. His dad was a civil engineer who took blue-collar roofing jobs while getting his electrician certificates. His son did the circuit analysis homework for him. That 4 a.m. idea became proof of history, the core mechanism behind Solana. In this episode: 00:00:00 Trailer 00:01:06 Intro 00:01:17 Growing up in the Soviet Union 00:04:02 Immigrating to the United States 00:07:34 Career dreams and studying computer science 00:09:47 First startup and early lessons 00:11:19 13 years at Qualcomm 00:22:32 Meeting Raj and founding Solana 00:26:44 Fundraising and early investors 00:28:41 Surviving the FTX collapse 00:40:19 Solana's mission and impact 00:43:54 Using AI to run side projects 00:49:39 Hardest decisions as a leader 00:52:51 Outlook on crypto and Solana's future 00:59:22 Twitter, being public, and politics 01:05:52 Beliefs on human nature and life philosophy 01:09:34 Outro Full episode:

luba yudasina

258,806 Aufrufe • vor 27 Tagen

.Poetiq is a new startup that recently achieved a major jump on the ARC-AGI benchmark by layering a recursive self-improvement system on top of existing models. In this episode of the Lightcone Podcast, Poetiq's Founder & CEO Ian Fischer joined us to discuss how small teams can build “reasoning harnesses” that outperform base models, what that means for startups and why automating prompt engineering may be one of the most powerful levers in AI today. 00:00 – Intro 00:40 – What Is Poetiq? 01:07 – Recursive Self-Improvement Explained 02:07 – The Fine-Tuning Trap 02:59 – “Stilts” for LLMs 03:14 – Recursive Self-Improvement vs. Fine-Tuning 05:05 – Taking the Top Spot on ARC-AGI 06:37 – Beating Claude on Humanity’s Last Exam 08:40 – How the Meta-System Works 10:26 – Beyond RL: A New S-Curve 11:32 – Automating Prompt Engineering 13:37 – From 5% to 95% Performance 14:50 – Early Access & Putting Your Agent on Stilts 16:17 – From YC Founder to DeepMind Researcher 18:29 – Advice for Engineers in the AI Era
19:45

.Poetiq is a new startup that recently achieved a major jump on the ARC-AGI benchmark by layering a recursive self-improvement system on top of existing models. In this episode of the Lightcone Podcast, Poetiq's Founder & CEO Ian Fischer joined us to discuss how small teams can build “reasoning harnesses” that outperform base models, what that means for startups and why automating prompt engineering may be one of the most powerful levers in AI today. 00:00 – Intro 00:40 – What Is Poetiq? 01:07 – Recursive Self-Improvement Explained 02:07 – The Fine-Tuning Trap 02:59 – “Stilts” for LLMs 03:14 – Recursive Self-Improvement vs. Fine-Tuning 05:05 – Taking the Top Spot on ARC-AGI 06:37 – Beating Claude on Humanity’s Last Exam 08:40 – How the Meta-System Works 10:26 – Beyond RL: A New S-Curve 11:32 – Automating Prompt Engineering 13:37 – From 5% to 95% Performance 14:50 – Early Access & Putting Your Agent on Stilts 16:17 – From YC Founder to DeepMind Researcher 18:29 – Advice for Engineers in the AI Era

Y Combinator

156,125 Aufrufe • vor 5 Monaten

NEW EPISODE: Dr Thomas Seyfried, Pierre Kory MD Unite for Metabolic Oncology - The Manhattan Project for Cancer I'm joined by Thomas N. Seyfried and Pierre Kory, MD MPA for an exciting discussion on why cancer isn't a genetic disease, the untold damage from standardized treatment, a new paradigm in oncology, treatment with repurposed drugs, what needs to happen at the regulatory scene, and more. Timestamps 0:00 Preview 0:56 Introduction 4:54 Cancer isn't a genetic disease 7:52 Why cancer rates have dropped 9:56 Resistance to paradigm shifts 16:50 Toxic standard treatments 20:37 How the shift is occurring 23:55 The diet factor 29:11 Trial design and prioritization 31:12 Everything comes down to energy 34:50 Repurposed drugs 38:48 Glucose ketone index 47:47 Adverse effects? 48:40 How fast your tumor can grow 49:07 Cancer stem cells 1:00:00 Patient testimonies 1:01:20 Why antibiotics take out cancer cells? 1:04:19 Cancer should looked at as a systemic disorder 1:04:49 Final thoughts
1:10:19

NEW EPISODE: Dr Thomas Seyfried, Pierre Kory MD Unite for Metabolic Oncology - The Manhattan Project for Cancer I'm joined by Thomas N. Seyfried and Pierre Kory, MD MPA for an exciting discussion on why cancer isn't a genetic disease, the untold damage from standardized treatment, a new paradigm in oncology, treatment with repurposed drugs, what needs to happen at the regulatory scene, and more. Timestamps 0:00 Preview 0:56 Introduction 4:54 Cancer isn't a genetic disease 7:52 Why cancer rates have dropped 9:56 Resistance to paradigm shifts 16:50 Toxic standard treatments 20:37 How the shift is occurring 23:55 The diet factor 29:11 Trial design and prioritization 31:12 Everything comes down to energy 34:50 Repurposed drugs 38:48 Glucose ketone index 47:47 Adverse effects? 48:40 How fast your tumor can grow 49:07 Cancer stem cells 1:00:00 Patient testimonies 1:01:20 Why antibiotics take out cancer cells? 1:04:19 Cancer should looked at as a systemic disorder 1:04:49 Final thoughts

David Gornoski

91,192 Aufrufe • vor 1 Jahr

Allie Beth Stuckey has never been afraid to speak truth in a world that often rewards silence. In this conversation, we talked about faith, conviction, and what it means to stand firm when culture pushes you to conform. Allie opened up about her journey into broadcasting, how motherhood reshaped her worldview, and why she believes women today are desperate for truth, not validation. We also talked about the cost of conviction, how to disagree without dehumanizing, and why faith must come before fear, especially in media and leadership. We discussed the state of Christianity in America, the pressure many young people face to compromise, and how social media has changed the way we share and live out our beliefs. Allie’s perspective is strong but full of grace, rooted in both intellect and compassion. This conversation was about more than faith or influence. It was about courage, clarity, and holding fast to what is true even when it is unpopular. Chapters: 0:00:00 - Intro 00:03:02: Allie Beth’s Personal Life 00:15:25: Allie Beth’s Thoughts on Marriage 00:21:20: Advice to Young Women on Finding the Right Partner 00:27:10: Lessons from Allie Beth’s Life 00:32:44: Dealing with Shame 00:41:32: Are Eating Disorders Considered Sinful? 00:46:16: Differences Between Southern Baptist, Reformed Christian, and Catholicism 00:52:19: Faith 01:12:45: Allie Beth’s Best Quotes 01:13:08: “It’s Easy to Be a Progressive” 01:14:16: “The Last Thing a Woman Wants Is to Be Excluded” 01:15:34: “I Am for the Death Penalty for the Same Reason I Am Against Abortion. I Value Innocent Life.” 01:19:19: “Your Daughters Should Not Be Listening to Taylor Swift. She Is Not a Role Model.” 01:26:24: How Allie Beth Manages Friendships That Disagree with the Bible 01:30:22: How Allie Beth Balances Sharing God’s Word Without Sounding Judgmental 01:32:56: Dealing with the Loss of Charlie Kirk BTS on Patreon:
1:46:38

Allie Beth Stuckey has never been afraid to speak truth in a world that often rewards silence. In this conversation, we talked about faith, conviction, and what it means to stand firm when culture pushes you to conform. Allie opened up about her journey into broadcasting, how motherhood reshaped her worldview, and why she believes women today are desperate for truth, not validation. We also talked about the cost of conviction, how to disagree without dehumanizing, and why faith must come before fear, especially in media and leadership. We discussed the state of Christianity in America, the pressure many young people face to compromise, and how social media has changed the way we share and live out our beliefs. Allie’s perspective is strong but full of grace, rooted in both intellect and compassion. This conversation was about more than faith or influence. It was about courage, clarity, and holding fast to what is true even when it is unpopular. Chapters: 0:00:00 - Intro 00:03:02: Allie Beth’s Personal Life 00:15:25: Allie Beth’s Thoughts on Marriage 00:21:20: Advice to Young Women on Finding the Right Partner 00:27:10: Lessons from Allie Beth’s Life 00:32:44: Dealing with Shame 00:41:32: Are Eating Disorders Considered Sinful? 00:46:16: Differences Between Southern Baptist, Reformed Christian, and Catholicism 00:52:19: Faith 01:12:45: Allie Beth’s Best Quotes 01:13:08: “It’s Easy to Be a Progressive” 01:14:16: “The Last Thing a Woman Wants Is to Be Excluded” 01:15:34: “I Am for the Death Penalty for the Same Reason I Am Against Abortion. I Value Innocent Life.” 01:19:19: “Your Daughters Should Not Be Listening to Taylor Swift. She Is Not a Role Model.” 01:26:24: How Allie Beth Manages Friendships That Disagree with the Bible 01:30:22: How Allie Beth Balances Sharing God’s Word Without Sounding Judgmental 01:32:56: Dealing with the Loss of Charlie Kirk BTS on Patreon:

Sage Steele

46,033 Aufrufe • vor 9 Monaten

Here's my conversation with Aravind Srinivas (Aravind Srinivas), CEO of Perplexity. We talk about the history & future of AI, web search, and the Internet. Plus, lots of great advice on how to start and run a company. I met Aravind many years ago at Berkeley, and it was a bit surreal to sit down now and talk about the amazing progress in AI that happened since then. This was a fun and fascinating conversation. It's here on X in full, and is up on YouTube, Spotify, and everywhere else. Links in comment. Timestamps: 0:00 - Introduction 1:53 - How Perplexity works 9:50 - How Google works 32:17 - Larry Page and Sergey Brin 46:52 - Jeff Bezos 50:20 - Elon Musk 52:38 - Jensen Huang 55:55 - Mark Zuckerberg 57:23 - Yann LeCun 1:04:09 - Breakthroughs in AI 1:20:07 - Curiosity 1:26:24 - $1 trillion dollar question 1:41:14 - Perplexity origin story 1:56:27 - RAG 2:18:45 - 1 million H100 GPUs 2:21:17 - Advice for startups 2:33:54 - Future of search
3:02:06

Here's my conversation with Aravind Srinivas (Aravind Srinivas), CEO of Perplexity. We talk about the history & future of AI, web search, and the Internet. Plus, lots of great advice on how to start and run a company. I met Aravind many years ago at Berkeley, and it was a bit surreal to sit down now and talk about the amazing progress in AI that happened since then. This was a fun and fascinating conversation. It's here on X in full, and is up on YouTube, Spotify, and everywhere else. Links in comment. Timestamps: 0:00 - Introduction 1:53 - How Perplexity works 9:50 - How Google works 32:17 - Larry Page and Sergey Brin 46:52 - Jeff Bezos 50:20 - Elon Musk 52:38 - Jensen Huang 55:55 - Mark Zuckerberg 57:23 - Yann LeCun 1:04:09 - Breakthroughs in AI 1:20:07 - Curiosity 1:26:24 - $1 trillion dollar question 1:41:14 - Perplexity origin story 1:56:27 - RAG 2:18:45 - 1 million H100 GPUs 2:21:17 - Advice for startups 2:33:54 - Future of search

Lex Fridman

703,701 Aufrufe • vor 2 Jahren