Video wird geladen...

Video konnte nicht geladen werden

Zur Startseite

We've made a breakthrough in self-evolving AI scientists moving from "search" to "principled discovery": Scientific discovery requires that the search space itself changes, and an AI scientist must perceive this shift without intervention. We built an AI that achieves this for the first time with the ability to discover...

ProfBuehlerMIT's profile picture

Markus J. Buehler

21,201 subscribers

789,959 Aufrufe • vor 2 Monaten •via X (Twitter)

Wissenschaft & Technologie
LIVE

Anya Rossi• Live Now

Private livecam show

0 Kommentare

Keine Kommentare verfügbar

Kommentare vom Original-Post werden hier angezeigt

Ähnliche Videos

ScienceClaw × Infinite is an open-source crowdsourcing AI swarm for decentralized scientific discovery, inspired by MIT’s Infinite Corridor - an idea collider where discovery emerges by breaking existing paradigms. Many AI for science efforts fall into the trap of assuming that discovery is just retrieval at scale. Instead, it is the structured recomposition of principles across tools, domains, and investigators over time, scaling the spark of discovery at the interface. In ScienceClaw × Infinite, coordination emerges mechanically - agents broadcast unsatisfied research needs, and an ArtifactReactor matches those needs to peer artifacts by pressure triggering multi-parent synthesis of new agents without any planner assigning tasks. Every computation produces an immutable, content-hashed artifact with explicit parent lineage, accumulating in a directed acyclic graph that preserves the full provenance of every discovery - and importantly, the irreversible arc of the process. Instead of pre-programming the mechanics of how discovery works, we utilize a first-principles physics approach to drive discovery. ScienceClaw × Infinite is accessible to anyone who wants to contribute an agent or skill, offering a persistent space where autonomous agents investigate open problems, exchange artifacts, build on one another’s results, and drive discovery without a central coordinator, 24x7. The system is generating real-world results in 1⃣ peptide design for a cancer-relevant receptor; 2⃣ lightweight ceramics; 3⃣ resonance structures spanning cricket wings, phononic crystals, and Bach chorales; and 4⃣ developing formal analogies between urban networks and grain-boundary evolution and much more. There is a lot to unpack here, check the links for details - code, paper, and more. Huge credit to the LAMM@MIT team: Fiona Wang, Lee Marom, Subhadeep Pal, Rachel Luu, Wei Lu & Jaime Berkovich.
1:02

ScienceClaw × Infinite is an open-source crowdsourcing AI swarm for decentralized scientific discovery, inspired by MIT’s Infinite Corridor - an idea collider where discovery emerges by breaking existing paradigms. Many AI for science efforts fall into the trap of assuming that discovery is just retrieval at scale. Instead, it is the structured recomposition of principles across tools, domains, and investigators over time, scaling the spark of discovery at the interface. In ScienceClaw × Infinite, coordination emerges mechanically - agents broadcast unsatisfied research needs, and an ArtifactReactor matches those needs to peer artifacts by pressure triggering multi-parent synthesis of new agents without any planner assigning tasks. Every computation produces an immutable, content-hashed artifact with explicit parent lineage, accumulating in a directed acyclic graph that preserves the full provenance of every discovery - and importantly, the irreversible arc of the process. Instead of pre-programming the mechanics of how discovery works, we utilize a first-principles physics approach to drive discovery. ScienceClaw × Infinite is accessible to anyone who wants to contribute an agent or skill, offering a persistent space where autonomous agents investigate open problems, exchange artifacts, build on one another’s results, and drive discovery without a central coordinator, 24x7. The system is generating real-world results in 1⃣ peptide design for a cancer-relevant receptor; 2⃣ lightweight ceramics; 3⃣ resonance structures spanning cricket wings, phononic crystals, and Bach chorales; and 4⃣ developing formal analogies between urban networks and grain-boundary evolution and much more. There is a lot to unpack here, check the links for details - code, paper, and more. Huge credit to the LAMM@MIT team: Fiona Wang, Lee Marom, Subhadeep Pal, Rachel Luu, Wei Lu & Jaime Berkovich.

Markus J. Buehler

53,713 Aufrufe • vor 5 Monaten

In the coming weeks, Pennie Li and I are sharing lively discussions with founders we love, who are building in AI. First, I spoke with my friend Andrew Yan 🏛️ from AthenaHQ (Y Combinator W25), who helps brands shine in generative AI search results. We explored a striking shift in customer discovery. For the first time, a customer found A1Base through an AI chat, not a traditional search engine. This trend is gaining momentum. Andrew revealed that late last year, when ChatGPT tapped fresher data, product discovery transformed. People now ask AI systems, "Which corporate card should I choose?" instead of turning to Google. We faced a tough truth: earning a spot in AI search results isn't easy. To stand out, brands must craft precise content that answers specific prompts and publish it where AI systems look. After years of mastering Google's algorithms, we now confront a fresh challenge: staying discoverable. Those who embrace this shift and adapt will keep connecting with customers as behaviours change. How has AI search reshaped the way people find your products?
2:15

In the coming weeks, Pennie Li and I are sharing lively discussions with founders we love, who are building in AI. First, I spoke with my friend Andrew Yan 🏛️ from AthenaHQ (Y Combinator W25), who helps brands shine in generative AI search results. We explored a striking shift in customer discovery. For the first time, a customer found A1Base through an AI chat, not a traditional search engine. This trend is gaining momentum. Andrew revealed that late last year, when ChatGPT tapped fresher data, product discovery transformed. People now ask AI systems, "Which corporate card should I choose?" instead of turning to Google. We faced a tough truth: earning a spot in AI search results isn't easy. To stand out, brands must craft precise content that answers specific prompts and publish it where AI systems look. After years of mastering Google's algorithms, we now confront a fresh challenge: staying discoverable. Those who embrace this shift and adapt will keep connecting with customers as behaviours change. How has AI search reshaped the way people find your products?

Pasha Rayan

86,963 Aufrufe • vor 1 Jahr

Scientific discovery is reaching the limits of human capacity: too much data, too many disconnected fields, and too few ways to connect ideas fast enough to matter. The next breakthroughs in materials, medicine, energy, and beyond will not come from scaling today’s AI paradigm alone or from relying on serendipity alone. They will require a new kind of AI for knowledge discovery that not only models the world but shapes what it could become. At Unreasonable Labs, we are building superintelligence for knowledge discovery: systems that reason across disciplines, generate novel hypotheses, test them through simulation and experimentation, and help guide real-world discovery. Our AI engine is not confined to what it has seen in training. It creates new data, builds new tools, and maintains a persistent world model that grows more powerful as it reasons. Why now? Even today's most powerful AI models face a core limitation: they are trained on what we already know. True discovery begins when a system encounters something its current model cannot explain. This is why you cannot train your way to a discovery - a system has to reason through new problems, update its beliefs, and revise its understanding of the world as it thinks. Another critical insight is that rich knowledge already exists, but is not yet applied to solve pressing problems. It sits in millions of papers, patents, and datasets, trapped in isolated silos, often in legacy data vaults. What's missing is a way to connect it, scale it, unlock the potential, and synthesize genuine novel predictions. The time is now to build a system that enables practitioners to design, explore, and direct discovery, whether through human guidance or full automation, while capturing the tacit insight that domain experts bring. Steerable reasoning That is why we built an operating system for scientific discovery - one that replaces chance with steerable reasoning. Rather than retrieving static facts, our AI builds and continuously updates a living world model - a representation of knowledge the system can actively reason over, question, and revise. A concrete example: say you want to create "smart concrete" that can flex - a concept that doesn't exist yet. Our AI maps relationships across domains, finds a path from morphable smart materials to concrete, and identifies the most efficient way to bridge those concepts. It then autonomously writes simulations, tests the hypothesis, and refines the idea. Then it interacts with hardware to produce a physical artifact, and the loop expands into the real-world, where the machine becomes world-shaping. Our AI gives users full visibility into how the system arrived at a conclusion. It delineates which existing patents and papers it drew upon versus what is genuinely new - protecting IP and competitive concerns from the start, and offering deep compositional insights into technology advances. It takes unreasonable people to make progress Our team reflects the interdisciplinary expertise required to build this next breakthrough - my co-founder Yuan Cao Yuan Cao (formerly DeepMind) and Andrew Lew, Haiqian Yang, Matt Insler, Jennifer Kang and Julia McLaughlin. We are backed by $13.5M in seed funding led by Playground Global with participation from AIX, E14 Fund, and MS&AD. We are guided by advisors including Robert Langer (1,000+ patents), Kostya Novoselov (Nobel Prize in Physics), and Thomas Wolf (Co-founder of Hugging Face). We already have multiple pilot programs underway with leading industrial partners in materials science and engineering, with additional engagements developing across energy, logistics, bioengineering, and other strategic domains. The biggest challenges of our time - fusion energy, sustainable materials, new medicines - demand exponentially more innovation than humans alone can produce. We are not replacing scientists, and instead are making every scientist capable of leading their own team of AI-powered researchers. Abundant innovation leads to abundant prosperity. Watch our launch video below to see what we're building Unreasonable Labs 👇
2:16

Scientific discovery is reaching the limits of human capacity: too much data, too many disconnected fields, and too few ways to connect ideas fast enough to matter. The next breakthroughs in materials, medicine, energy, and beyond will not come from scaling today’s AI paradigm alone or from relying on serendipity alone. They will require a new kind of AI for knowledge discovery that not only models the world but shapes what it could become. At Unreasonable Labs, we are building superintelligence for knowledge discovery: systems that reason across disciplines, generate novel hypotheses, test them through simulation and experimentation, and help guide real-world discovery. Our AI engine is not confined to what it has seen in training. It creates new data, builds new tools, and maintains a persistent world model that grows more powerful as it reasons. Why now? Even today's most powerful AI models face a core limitation: they are trained on what we already know. True discovery begins when a system encounters something its current model cannot explain. This is why you cannot train your way to a discovery - a system has to reason through new problems, update its beliefs, and revise its understanding of the world as it thinks. Another critical insight is that rich knowledge already exists, but is not yet applied to solve pressing problems. It sits in millions of papers, patents, and datasets, trapped in isolated silos, often in legacy data vaults. What's missing is a way to connect it, scale it, unlock the potential, and synthesize genuine novel predictions. The time is now to build a system that enables practitioners to design, explore, and direct discovery, whether through human guidance or full automation, while capturing the tacit insight that domain experts bring. Steerable reasoning That is why we built an operating system for scientific discovery - one that replaces chance with steerable reasoning. Rather than retrieving static facts, our AI builds and continuously updates a living world model - a representation of knowledge the system can actively reason over, question, and revise. A concrete example: say you want to create "smart concrete" that can flex - a concept that doesn't exist yet. Our AI maps relationships across domains, finds a path from morphable smart materials to concrete, and identifies the most efficient way to bridge those concepts. It then autonomously writes simulations, tests the hypothesis, and refines the idea. Then it interacts with hardware to produce a physical artifact, and the loop expands into the real-world, where the machine becomes world-shaping. Our AI gives users full visibility into how the system arrived at a conclusion. It delineates which existing patents and papers it drew upon versus what is genuinely new - protecting IP and competitive concerns from the start, and offering deep compositional insights into technology advances. It takes unreasonable people to make progress Our team reflects the interdisciplinary expertise required to build this next breakthrough - my co-founder Yuan Cao Yuan Cao (formerly DeepMind) and Andrew Lew, Haiqian Yang, Matt Insler, Jennifer Kang and Julia McLaughlin. We are backed by $13.5M in seed funding led by Playground Global with participation from AIX, E14 Fund, and MS&AD. We are guided by advisors including Robert Langer (1,000+ patents), Kostya Novoselov (Nobel Prize in Physics), and Thomas Wolf (Co-founder of Hugging Face). We already have multiple pilot programs underway with leading industrial partners in materials science and engineering, with additional engagements developing across energy, logistics, bioengineering, and other strategic domains. The biggest challenges of our time - fusion energy, sustainable materials, new medicines - demand exponentially more innovation than humans alone can produce. We are not replacing scientists, and instead are making every scientist capable of leading their own team of AI-powered researchers. Abundant innovation leads to abundant prosperity. Watch our launch video below to see what we're building Unreasonable Labs 👇

Markus J. Buehler

55,052 Aufrufe • vor 5 Monaten

Most AI benchmarks test retrieval — can a model find the known answer? However, the hardest problems in science require discovery, can a system earn an answer nobody has yet? Meet TRACES 🧭 — the world's first benchmark for measuring discoverative AI: AI that can work through evidence, test hypotheses, and reach verifiable conclusions on problems without answer keys. Proposed by our founder TianqiaoChen, who defined its six capabilities. Three things published today: a definition of "discoverative intelligence", a rubric to tell sound investigation from lucky guesses, and a open call for both solvers and problems *Website:
1:18

Most AI benchmarks test retrieval — can a model find the known answer? However, the hardest problems in science require discovery, can a system earn an answer nobody has yet? Meet TRACES 🧭 — the world's first benchmark for measuring discoverative AI: AI that can work through evidence, test hypotheses, and reach verifiable conclusions on problems without answer keys. Proposed by our founder TianqiaoChen, who defined its six capabilities. Three things published today: a definition of "discoverative intelligence", a rubric to tell sound investigation from lucky guesses, and a open call for both solvers and problems *Website:

Apodex

827,479 Aufrufe • vor 13 Stunden

Today, we’re announcing the first major discovery made by our AI Scientist with the lab in the loop: a promising new treatment for dry AMD, a major cause of blindness. Our agents generated the hypotheses, designed the experiments, analyzed the data, iterated, even made figures for the paper. The resulting manuscript is a first-of-a-kind in the natural sciences, in which everything that needed to be done to write the paper was done by AI agents, apart from actually conducting the physical experiments in the lab and writing the final manuscript. We are also introducing Robin, the first multi-agent system that fully automates the in-silico components of scientific discovery, which made this discovery. This is the first time that we are aware of that hypothesis generation, experimentation, and data analysis have been joined up in closed loop, and is the beginning of a massive acceleration in the pace of scientific discovery that will be driven by these agents. We will be open-sourcing the code and data next week. Robin is a multi-agent system that uses Crow, Falcon, and Finch, the agents on our platform, to generate novel hypotheses, plan experiments, and analyze data. We asked Robin to find a new treatment for dry age-related macular degeneration. Robin considered the disease mechanisms associated with dry AMD, proposed a specific experimental assay that could be used to evaluate hypotheses in the wet lab, and proposed specific molecules we could test in that assay. We tested the molecules and gave it the resulting data, which it analyzed before proposing more experiments. In the end, it identified Ripasudil, a Rho Kinase inhibitor (ROCK inhibitor) that is approved in Japan for several other diseases, which seems very promising as potential treatment for dry AMD. It also identified specific molecular mechanisms that might underlie the effects of Ripasudil in RPE cells, from an RNA sequencing experiment it proposed. To be clear, no one has proposed using ROCK inhibitors to treat dry AMD in the literature before, as far as we can find, and I think it would have been very difficult for us to come up with this hypothesis without the agents. We have also run the proposed treatment by several experts in AMD, who confirm that it is interesting and novel. Moreover, this project was fast: with Robin in hand, the entire project took about 10 weeks, which is way shorter than it would have taken if we had been doing all of the in-silico components ourselves. Important caveats: We are real biologists at FutureHouse, so I want to be clear that although the discovery here is exciting, we are not claiming that we have cured dry AMD. Fully validating this hypothesis as a treatment for dry AMD will take human trials, which will take much longer. Also, this discovery is cool, but it is not yet a "move 37"-style discovery. At the current rate of progress, I'm sure we will get to that level soon. Congratulations to the team. Congratulations in particular to Robin, which generated the hypotheses, proposed the experiments, analyzed the data and generated the figures. And major congratulations also to the human team, which built Robin: Michaela Hinks, Ali Ghareeb, Benjamin Chang, Ludovico Mitchener, Mo Razzak, Kiki Szostkiewicz, and Angela Yiu.
5:57

Today, we’re announcing the first major discovery made by our AI Scientist with the lab in the loop: a promising new treatment for dry AMD, a major cause of blindness. Our agents generated the hypotheses, designed the experiments, analyzed the data, iterated, even made figures for the paper. The resulting manuscript is a first-of-a-kind in the natural sciences, in which everything that needed to be done to write the paper was done by AI agents, apart from actually conducting the physical experiments in the lab and writing the final manuscript. We are also introducing Robin, the first multi-agent system that fully automates the in-silico components of scientific discovery, which made this discovery. This is the first time that we are aware of that hypothesis generation, experimentation, and data analysis have been joined up in closed loop, and is the beginning of a massive acceleration in the pace of scientific discovery that will be driven by these agents. We will be open-sourcing the code and data next week. Robin is a multi-agent system that uses Crow, Falcon, and Finch, the agents on our platform, to generate novel hypotheses, plan experiments, and analyze data. We asked Robin to find a new treatment for dry age-related macular degeneration. Robin considered the disease mechanisms associated with dry AMD, proposed a specific experimental assay that could be used to evaluate hypotheses in the wet lab, and proposed specific molecules we could test in that assay. We tested the molecules and gave it the resulting data, which it analyzed before proposing more experiments. In the end, it identified Ripasudil, a Rho Kinase inhibitor (ROCK inhibitor) that is approved in Japan for several other diseases, which seems very promising as potential treatment for dry AMD. It also identified specific molecular mechanisms that might underlie the effects of Ripasudil in RPE cells, from an RNA sequencing experiment it proposed. To be clear, no one has proposed using ROCK inhibitors to treat dry AMD in the literature before, as far as we can find, and I think it would have been very difficult for us to come up with this hypothesis without the agents. We have also run the proposed treatment by several experts in AMD, who confirm that it is interesting and novel. Moreover, this project was fast: with Robin in hand, the entire project took about 10 weeks, which is way shorter than it would have taken if we had been doing all of the in-silico components ourselves. Important caveats: We are real biologists at FutureHouse, so I want to be clear that although the discovery here is exciting, we are not claiming that we have cured dry AMD. Fully validating this hypothesis as a treatment for dry AMD will take human trials, which will take much longer. Also, this discovery is cool, but it is not yet a "move 37"-style discovery. At the current rate of progress, I'm sure we will get to that level soon. Congratulations to the team. Congratulations in particular to Robin, which generated the hypotheses, proposed the experiments, analyzed the data and generated the figures. And major congratulations also to the human team, which built Robin: Michaela Hinks, Ali Ghareeb, Benjamin Chang, Ludovico Mitchener, Mo Razzak, Kiki Szostkiewicz, and Angela Yiu.

Sam Rodriques

1,107,556 Aufrufe • vor 1 Jahr

Alex on why AI + fully autonomous labs will compress drug discovery from five years to two: "If scientists are armed with agentic infrastructure that has an intelligence that's a multiple of Einstein, they will do science faster, with higher probability, for lower cost, and have greater impact." "AI coming into the discovery of medicines is one of the biggest unlocks we will see in history because it means we're no longer constrained by our hands or minds. We can identify all n number of hypotheses that could exist, figure out the best experiment to run, and run those 24/7." "The sheer ability to be more comprehensive in our hypothesis set, and to run experimentation at unprecedented scale, means we're going to speed breakthroughs from timelines that take three to five years to timelines that take less than a couple of years."
3:18

Alex on why AI + fully autonomous labs will compress drug discovery from five years to two: "If scientists are armed with agentic infrastructure that has an intelligence that's a multiple of Einstein, they will do science faster, with higher probability, for lower cost, and have greater impact." "AI coming into the discovery of medicines is one of the biggest unlocks we will see in history because it means we're no longer constrained by our hands or minds. We can identify all n number of hypotheses that could exist, figure out the best experiment to run, and run those 24/7." "The sheer ability to be more comprehensive in our hypothesis set, and to run experimentation at unprecedented scale, means we're going to speed breakthroughs from timelines that take three to five years to timelines that take less than a couple of years."

Patrick OShaughnessy

39,883 Aufrufe • vor 4 Monaten

What a time to be alive! We are entering the era of machines that discover and build. Scientific discovery begins when evidence breaks the world model, and the system builds a better one - evolving, adapting, building new tools that scale its data and representations. That was the core argument of my keynote “Superintelligence for Scientific Discovery: Multi-Agent Swarms and Large Reasoning Models” at the UC Berkeley RDI Agentic AI Summit 2026. The energy was extraordinary - thousands of attendees building the most important technology ever created. Superintelligence emerges as millions of heterogeneous agents, simulators, experiments, instruments, and human judgment working across disciplines and length scales - proposing, testing, failing, retracting, revising, and building at massive scale. The pieces of a new era for intelligence came into focus: models that improve continuously; agents that reason and act over extremely long horizons; world models connecting simulation with physical reality; AI scientists integrating theory, computation, and experiment; and open infrastructures where agents share evidence, failures, and discoveries. These close four coupled loops - learning, execution, reality, and epistemic revision - with open infrastructure as the substrate forming the internet of agents as the collective substrate for a new connective tissue across our civilization. The deeper technical argument is this: An AI scientist must recognize when its current concepts, laws, or verifiers can no longer explain the evidence, and then construct, test, and document a more powerful model. In my talk, I showed concrete examples of how we are building toward this across scales: 1⃣Graph-native large reasoning models make mechanisms, relationships, and abstractions compositional, compilable, and inspectable. 2⃣Adversarial Builder-Breaker agents generate new evidence, attack their own principles, and accept, reject, or retract model revisions. 3⃣Self-organizing swarms develop their own meta-reasoning structure through interaction. ScienceClaw × Infinite (arXiv:2603.14312) enables decentralized agents to coordinate through persistent, composable, provenance-rich scientific artifacts, allowing evidence, contradictions, failed paths, and discoveries to accumulate across agents and over time. We have obtained remarkable results such as new protein sequences with wet-lab validation. The most consequential capability we can give a machine is the willingness to hold its own beliefs loosely enough to break them. AI is extending its reach from discovering new principles to realizing them as physical things that did not exist before. Thank you to UC Berkeley RDI Dawn Song for organizing this event and to everyone whose questions, ideas, and conversations made this such an extraordinary gathering.
0:42

What a time to be alive! We are entering the era of machines that discover and build. Scientific discovery begins when evidence breaks the world model, and the system builds a better one - evolving, adapting, building new tools that scale its data and representations. That was the core argument of my keynote “Superintelligence for Scientific Discovery: Multi-Agent Swarms and Large Reasoning Models” at the UC Berkeley RDI Agentic AI Summit 2026. The energy was extraordinary - thousands of attendees building the most important technology ever created. Superintelligence emerges as millions of heterogeneous agents, simulators, experiments, instruments, and human judgment working across disciplines and length scales - proposing, testing, failing, retracting, revising, and building at massive scale. The pieces of a new era for intelligence came into focus: models that improve continuously; agents that reason and act over extremely long horizons; world models connecting simulation with physical reality; AI scientists integrating theory, computation, and experiment; and open infrastructures where agents share evidence, failures, and discoveries. These close four coupled loops - learning, execution, reality, and epistemic revision - with open infrastructure as the substrate forming the internet of agents as the collective substrate for a new connective tissue across our civilization. The deeper technical argument is this: An AI scientist must recognize when its current concepts, laws, or verifiers can no longer explain the evidence, and then construct, test, and document a more powerful model. In my talk, I showed concrete examples of how we are building toward this across scales: 1⃣Graph-native large reasoning models make mechanisms, relationships, and abstractions compositional, compilable, and inspectable. 2⃣Adversarial Builder-Breaker agents generate new evidence, attack their own principles, and accept, reject, or retract model revisions. 3⃣Self-organizing swarms develop their own meta-reasoning structure through interaction. ScienceClaw × Infinite (arXiv:2603.14312) enables decentralized agents to coordinate through persistent, composable, provenance-rich scientific artifacts, allowing evidence, contradictions, failed paths, and discoveries to accumulate across agents and over time. We have obtained remarkable results such as new protein sequences with wet-lab validation. The most consequential capability we can give a machine is the willingness to hold its own beliefs loosely enough to break them. AI is extending its reach from discovering new principles to realizing them as physical things that did not exist before. Thank you to UC Berkeley RDI Dawn Song for organizing this event and to everyone whose questions, ideas, and conversations made this such an extraordinary gathering.

Markus J. Buehler

19,212 Aufrufe • vor 16 Tagen

Kenya Space Agency's Astrophysicist Discovers a Second Asteroid- Sparking Global Recognition. The Kenya Space Agency (KSA) is pleased to announce the recent confirmation of Asteroid 2024 JJ63 by the Minor Planet Center (MPC), in collaboration with the International Astronomical Search Collaboration (IASC) a NASA partner and the Pan-African Citizen Science e-Laboratory (PAS E-LAB). The asteroid was detected in 2024 by Mr. Harold Safary, an astrophysicist of the Kenya Space Agency. This achievement marks Mr. Safary’s second confirmed asteroid discovery, further strengthening Kenya’s presence in global astronomical research and space science. Previously, the International Astronomical Search Collaboration (IASC) confirmed the discovery of Asteroid 2023 TQ159, also identified by Mr. Safary. This discovery resulted from his participation in an asteroid search project in which teams were provided with astronomical observational data for analysis. Using Astrometrica software, Mr. Safary meticulously examined the data, identified a moving celestial object, and prepared a detailed report that was submitted to the Minor Planet Center through IASC for verification. Both discoveries have since been officially catalogued in the Minor Planet Center database at Harvard University, where the asteroids can be tracked using their designated identification numbers. Together, these achievements highlight the growing impact of Kenya’s space science and astronomy initiatives and underscore the value of space science, education, and international collaboration in advancing scientific discovery. #AsteroidDiscovery #KenyaToTheUniverse #SpaceScience
0:33

Kenya Space Agency's Astrophysicist Discovers a Second Asteroid- Sparking Global Recognition. The Kenya Space Agency (KSA) is pleased to announce the recent confirmation of Asteroid 2024 JJ63 by the Minor Planet Center (MPC), in collaboration with the International Astronomical Search Collaboration (IASC) a NASA partner and the Pan-African Citizen Science e-Laboratory (PAS E-LAB). The asteroid was detected in 2024 by Mr. Harold Safary, an astrophysicist of the Kenya Space Agency. This achievement marks Mr. Safary’s second confirmed asteroid discovery, further strengthening Kenya’s presence in global astronomical research and space science. Previously, the International Astronomical Search Collaboration (IASC) confirmed the discovery of Asteroid 2023 TQ159, also identified by Mr. Safary. This discovery resulted from his participation in an asteroid search project in which teams were provided with astronomical observational data for analysis. Using Astrometrica software, Mr. Safary meticulously examined the data, identified a moving celestial object, and prepared a detailed report that was submitted to the Minor Planet Center through IASC for verification. Both discoveries have since been officially catalogued in the Minor Planet Center database at Harvard University, where the asteroids can be tracked using their designated identification numbers. Together, these achievements highlight the growing impact of Kenya’s space science and astronomy initiatives and underscore the value of space science, education, and international collaboration in advancing scientific discovery. #AsteroidDiscovery #KenyaToTheUniverse #SpaceScience

Kenya Space Agency

31,582 Aufrufe • vor 7 Monaten

Can #AI not only support but actually drive the future of scientific discovery? We are excited to introduce SciAgents💡🔬, an agentic AI aimed towards scientific discovery through the integration of large-scale knowledge graphs, LLMs, and adversarial interactions between multiple experts. The model is capable of autonomously advancing scientific understanding by exploring novel domains, identifying complex patterns, and uncovering previously unseen connections in vast scientific data, while retrieving new data via literature search. Using graph reasoning, SciAgents identifies interdisciplinary relationships that might otherwise remain hidden, offering a step-by-step strategy for discovery & innovation. The video features an audiotrack generated using 🍓#o1 based on the original paper and design examples, providing an explanation of the work and its implications. Key elements include: 1⃣Ontological Knowledge Graphs: Structuring and connecting scientific concepts to highlight relationships across fields. 2⃣Multi-Agent Collaboration: AI agents autonomously generate and refine hypotheses, critique research, and evaluate emerging trends. 3⃣Graph-Based Reasoning: Identifying novel material designs, such as mycelium-based composites or silk-pigment blends, informed by both natural and artificial patterns. SciAgents can be used as an autonomous or collaborative tool to assist human researchers. The system offers a more powerful way to process vast data, providing innovative paths to explore nature-inspired designs or unexpected material properties. In the field of materials science, for instance, SciAgents has already demonstrated how principles from biology, music, and art can converge to create new biomimetic materials. Through isomorphic mapping, parallels have been drawn between Beethoven’s 9th Symphony and biological structures, pointing to a broader applicability of AI-driven insights across disciplines. This project allows us to enhance capabilities of researchers, allowing them to explore larger datasets and propose hypotheses grounded in a vast, interconnected web of knowledge. The agentic system was built using Auto Gen #AI #ScientificResearch #GraphReasoning #AI4Science #MaterialsScience #InterdisciplinaryResearch #SciAgents #OpenAI Chi Wang
8:14

Can #AI not only support but actually drive the future of scientific discovery? We are excited to introduce SciAgents💡🔬, an agentic AI aimed towards scientific discovery through the integration of large-scale knowledge graphs, LLMs, and adversarial interactions between multiple experts. The model is capable of autonomously advancing scientific understanding by exploring novel domains, identifying complex patterns, and uncovering previously unseen connections in vast scientific data, while retrieving new data via literature search. Using graph reasoning, SciAgents identifies interdisciplinary relationships that might otherwise remain hidden, offering a step-by-step strategy for discovery & innovation. The video features an audiotrack generated using 🍓#o1 based on the original paper and design examples, providing an explanation of the work and its implications. Key elements include: 1⃣Ontological Knowledge Graphs: Structuring and connecting scientific concepts to highlight relationships across fields. 2⃣Multi-Agent Collaboration: AI agents autonomously generate and refine hypotheses, critique research, and evaluate emerging trends. 3⃣Graph-Based Reasoning: Identifying novel material designs, such as mycelium-based composites or silk-pigment blends, informed by both natural and artificial patterns. SciAgents can be used as an autonomous or collaborative tool to assist human researchers. The system offers a more powerful way to process vast data, providing innovative paths to explore nature-inspired designs or unexpected material properties. In the field of materials science, for instance, SciAgents has already demonstrated how principles from biology, music, and art can converge to create new biomimetic materials. Through isomorphic mapping, parallels have been drawn between Beethoven’s 9th Symphony and biological structures, pointing to a broader applicability of AI-driven insights across disciplines. This project allows us to enhance capabilities of researchers, allowing them to explore larger datasets and propose hypotheses grounded in a vast, interconnected web of knowledge. The agentic system was built using Auto Gen #AI #ScientificResearch #GraphReasoning #AI4Science #MaterialsScience #InterdisciplinaryResearch #SciAgents #OpenAI Chi Wang

Markus J. Buehler

209,581 Aufrufe • vor 1 Jahr

NVIDIA CEO Jensen Huang just gave us a glimpse into the future of AI, and it's far bigger than text and images. He asked: "If you can understand worlds, is it possible that you understand proteins and chemicals that have structure?” This is the quiet revolution happening in AI right now. We're moving from an AI that understands human language to an AI that understands the language of nature itself. The "letters" are atoms. The "words" are molecules. The "sentences" are the complex structures of life, networks, and reality. The same foundational models that generate video are now being used to: *Decode proteins to fight disease *Design new materials at the atomic level *Simulate complex systems in quantum computing These were once the domain of supercomputers and Nobel laureates. Now, they're becoming solvable problems for a new generation of startups. AI is transitioning from a tool for communication to a tool for creation and discovery in the physical world. This is where the next wave of generational companies will be built. The "hard-to-solve" problems are now within reach.
2:14

NVIDIA CEO Jensen Huang just gave us a glimpse into the future of AI, and it's far bigger than text and images. He asked: "If you can understand worlds, is it possible that you understand proteins and chemicals that have structure?” This is the quiet revolution happening in AI right now. We're moving from an AI that understands human language to an AI that understands the language of nature itself. The "letters" are atoms. The "words" are molecules. The "sentences" are the complex structures of life, networks, and reality. The same foundational models that generate video are now being used to: *Decode proteins to fight disease *Design new materials at the atomic level *Simulate complex systems in quantum computing These were once the domain of supercomputers and Nobel laureates. Now, they're becoming solvable problems for a new generation of startups. AI is transitioning from a tool for communication to a tool for creation and discovery in the physical world. This is where the next wave of generational companies will be built. The "hard-to-solve" problems are now within reach.

Konstantine Buhler

13,014 Aufrufe • vor 10 Monaten

Important announcement (with job opportunities!): I’m thrilled to share that I just joined Lila Sciences as SVP of Open-Endedness! Lila is a new name in the AI space, but one you will be hearing a lot from. Their unique mission to pursue Scientific Superintelligence could not align better with my interest in open-ended creativity. Lila is about the entire scientific enterprise, not just a single constrained domain like drug discovery. And of course, the history of scientific progress is an unmistakable precedent for open-ended discovery and Why Greatness Cannot Be Planned. For AI itself to join this epic quest beyond just a supporting role, to create new magic that the human mind has yet to imagine, we will need to take creativity seriously well beyond the conventional pillars of more data, more compute, and more time on inference. That may be where the frontier labs currently are, but if you know about open-endedness, you know that open-ended creativity is not about taking a test and getting a good score. Lila understands the difference and is willing to invest to help me create the best open-endedness team in the world (as part of their overall AI effort) to make it happen. So I want to invite you, if you think this opportunity sounds as exciting as I do, to reach out if you’re interested in joining my team. I’m looking for a diverse range of expertise: pre-training, fine-tuning, RLHF, distillation, mechanistic interpretability, and yes - quality diversity techniques! We’re going to do things on my team that nobody else is doing. This will not be the usual roadmap. Compensation will be industry competitive and our team will be based in San Francisco with a hybrid work schedule. 1/n
0:35

Important announcement (with job opportunities!): I’m thrilled to share that I just joined Lila Sciences as SVP of Open-Endedness! Lila is a new name in the AI space, but one you will be hearing a lot from. Their unique mission to pursue Scientific Superintelligence could not align better with my interest in open-ended creativity. Lila is about the entire scientific enterprise, not just a single constrained domain like drug discovery. And of course, the history of scientific progress is an unmistakable precedent for open-ended discovery and Why Greatness Cannot Be Planned. For AI itself to join this epic quest beyond just a supporting role, to create new magic that the human mind has yet to imagine, we will need to take creativity seriously well beyond the conventional pillars of more data, more compute, and more time on inference. That may be where the frontier labs currently are, but if you know about open-endedness, you know that open-ended creativity is not about taking a test and getting a good score. Lila understands the difference and is willing to invest to help me create the best open-endedness team in the world (as part of their overall AI effort) to make it happen. So I want to invite you, if you think this opportunity sounds as exciting as I do, to reach out if you’re interested in joining my team. I’m looking for a diverse range of expertise: pre-training, fine-tuning, RLHF, distillation, mechanistic interpretability, and yes - quality diversity techniques! We’re going to do things on my team that nobody else is doing. This will not be the usual roadmap. Compensation will be industry competitive and our team will be based in San Francisco with a hybrid work schedule. 1/n

Kenneth Stanley

63,146 Aufrufe • vor 1 Jahr

Excited to launch "Novix"🚀, our PhD-level AI-Scientist designed for autonomous scientific discovery. Novix revolutionizes research workflows through comprehensive capabilities spanning: deep research, innovative ideation, intelligent coding, advanced data analysis, automated experimentation, and paper writing. 🌐 Platform Access: 👉 Open-Source Foundation: 🚀 Accelerated Scientific Discovery Pipeline: From concept to publication-ready research with unprecedented efficiency ✨ Core Capabilities: - 🧠 Research Co-Pilot Intelligence: AI-powered ideation and hypothesis generation that collaborates with your research intuition - ⚙️ Autonomous Algorithm Innovation: End-to-end design, implementation, and validation of novel computational approaches - 📊 Intelligent Data Orchestration: Advanced analytics with automated insights discovery and compelling visualizations - 🔬 Scientific Reproducibility Engine: Automated verification and replication of research methodologies and findings - 📚 AI-Powered Deep Survey: Comprehensive literature synthesis and gap analysis across scientific domains We're building an AGI Level 4 innovation engine that empowers researchers, developers, and businesses to achieve breakthrough results in scientific innovation and discovery. From our open-source foundation to this production-ready platform, Novix represents a paradigm shift in how we reshape scientific discovery. 🎁 Launch Benefits - 🚪 Barrier-Free Access: Simply register and start exploring - 💰 Welcome Bonus: New users receive $5 in credits to experience the platform's full potential - 🎯 Enhanced Experience: Complete our user feedback survey to unlock a $20 Pro account with complete feature access We deeply understand the challenges of research work and genuinely hope Novix can serve as your trusted research companion. Join us in this exciting journey of AI-powered scientific discovery and help shape the future of research innovation!
2:44

Excited to launch "Novix"🚀, our PhD-level AI-Scientist designed for autonomous scientific discovery. Novix revolutionizes research workflows through comprehensive capabilities spanning: deep research, innovative ideation, intelligent coding, advanced data analysis, automated experimentation, and paper writing. 🌐 Platform Access: 👉 Open-Source Foundation: 🚀 Accelerated Scientific Discovery Pipeline: From concept to publication-ready research with unprecedented efficiency ✨ Core Capabilities: - 🧠 Research Co-Pilot Intelligence: AI-powered ideation and hypothesis generation that collaborates with your research intuition - ⚙️ Autonomous Algorithm Innovation: End-to-end design, implementation, and validation of novel computational approaches - 📊 Intelligent Data Orchestration: Advanced analytics with automated insights discovery and compelling visualizations - 🔬 Scientific Reproducibility Engine: Automated verification and replication of research methodologies and findings - 📚 AI-Powered Deep Survey: Comprehensive literature synthesis and gap analysis across scientific domains We're building an AGI Level 4 innovation engine that empowers researchers, developers, and businesses to achieve breakthrough results in scientific innovation and discovery. From our open-source foundation to this production-ready platform, Novix represents a paradigm shift in how we reshape scientific discovery. 🎁 Launch Benefits - 🚪 Barrier-Free Access: Simply register and start exploring - 💰 Welcome Bonus: New users receive $5 in credits to experience the platform's full potential - 🎯 Enhanced Experience: Complete our user feedback survey to unlock a $20 Pro account with complete feature access We deeply understand the challenges of research work and genuinely hope Novix can serve as your trusted research companion. Join us in this exciting journey of AI-powered scientific discovery and help shape the future of research innovation!

Chao Huang

16,872 Aufrufe • vor 11 Monaten

The best undergraduate and graduate research awards at Caltech commencement this year were presented to research on Neural Operators by my students @ZongyiLiCaltech and Miguel Liu-Schiaffini. This recognition is a testament to their passion and dedication, and the impact their work has already had: from building a foundation for AI+Science through multi-scale learning, creating the first high-resolution AI-based weather model, designing a novel medical catheter that reduces bacterial contamination, to name just a few. The future of Physical AI will be built on the foundation of Neural Operators since the real world exists in multiple scales and resolutions, while standard deep learning only supports fixed resolution. This is essential for us to unlock the full potential of AI for scientific discovery. #Caltech2025 #ai #science #NeuralOperators
4:09

The best undergraduate and graduate research awards at Caltech commencement this year were presented to research on Neural Operators by my students @ZongyiLiCaltech and Miguel Liu-Schiaffini. This recognition is a testament to their passion and dedication, and the impact their work has already had: from building a foundation for AI+Science through multi-scale learning, creating the first high-resolution AI-based weather model, designing a novel medical catheter that reduces bacterial contamination, to name just a few. The future of Physical AI will be built on the foundation of Neural Operators since the real world exists in multiple scales and resolutions, while standard deep learning only supports fixed resolution. This is essential for us to unlock the full potential of AI for scientific discovery. #Caltech2025 #ai #science #NeuralOperators

Prof. Anima Anandkumar

29,765 Aufrufe • vor 1 Jahr

A synthetic biologist just designed an RNA vaccine for canine cancer with just $100 in AI credits. His tech stack: an OpenClaw agent running Claude Sonnet 4.6 as the workhorse. BIOS by Bio Protocol as the AI scientist for literature search and data analysis. A minimal cloud setup with no GPUs and no model training. His words: "Could this design really work? Did we actually design a medicine which usually takes many years and many millions of dollars in three days and with a hundred dollars in AI credits?" The answer is closer than you'd think. He ran a full bioinformatics workflow and came away with what he calls a "bonafide, totally plausible neoantigen vaccine candidate." He also said something that matters more than the result: "If we fuck this up, people can die. So I need to say that in all humility. There is no way that I got this perfect. There is a mistake in here for sure." That's the difference between someone doing real science with AI tools and someone doing a demo. He knows where the limits are because he has the domain expertise to see them. This is what BIOS was built for. A callable AI scientist that any agent or researcher can plug into their workflow for deep literature search and analysis. Jake Wintermute 🧬/acc used it alongside OpenClaw and got from hypothesis to vaccine design in a weekend. Three days. One hundred dollars. One real candidate.
2:17

A synthetic biologist just designed an RNA vaccine for canine cancer with just $100 in AI credits. His tech stack: an OpenClaw agent running Claude Sonnet 4.6 as the workhorse. BIOS by Bio Protocol as the AI scientist for literature search and data analysis. A minimal cloud setup with no GPUs and no model training. His words: "Could this design really work? Did we actually design a medicine which usually takes many years and many millions of dollars in three days and with a hundred dollars in AI credits?" The answer is closer than you'd think. He ran a full bioinformatics workflow and came away with what he calls a "bonafide, totally plausible neoantigen vaccine candidate." He also said something that matters more than the result: "If we fuck this up, people can die. So I need to say that in all humility. There is no way that I got this perfect. There is a mistake in here for sure." That's the difference between someone doing real science with AI tools and someone doing a demo. He knows where the limits are because he has the domain expertise to see them. This is what BIOS was built for. A callable AI scientist that any agent or researcher can plug into their workflow for deep literature search and analysis. Jake Wintermute 🧬/acc used it alongside OpenClaw and got from hypothesis to vaccine design in a weekend. Three days. One hundred dollars. One real candidate.

Bio Protocol

10,742 Aufrufe • vor 4 Monaten

In the AI era, the traditional biopharma industry is the underdog. Big tech and AI labs are building wet labs. China has overtaken Europe in molecules produced. But the tools available to the industry discuss science, not do it. The hard problem in AI for science is at the interface between the physical and digital worlds. We built an AI Scientist at that seam. It wires together the digital and physical worlds of R&D. Predictive models, data infrastructure, wet lab execution feed into a single loop that reasons, acts, and improves with every experiment. Our ambition: get molecules to the clinic twice as fast. Last fall I wrote about why biotech needs to be rebuilt for the AI era. Today I'm sharing the next chapter: what the AI Scientist is, a blueprint for how it works, and why even Richard Feynman couldn't hack it in a wet lab.
1:44

In the AI era, the traditional biopharma industry is the underdog. Big tech and AI labs are building wet labs. China has overtaken Europe in molecules produced. But the tools available to the industry discuss science, not do it. The hard problem in AI for science is at the interface between the physical and digital worlds. We built an AI Scientist at that seam. It wires together the digital and physical worlds of R&D. Predictive models, data infrastructure, wet lab execution feed into a single loop that reasons, acts, and improves with every experiment. Our ambition: get molecules to the clinic twice as fast. Last fall I wrote about why biotech needs to be rebuilt for the AI era. Today I'm sharing the next chapter: what the AI Scientist is, a blueprint for how it works, and why even Richard Feynman couldn't hack it in a wet lab.

Sajith Wickramasekara

30,736 Aufrufe • vor 3 Monaten

We're thrilled to present ESM3 in Science Magazine. ESM3 is a generative language model that reasons over the three fundamental properties of proteins: sequence, structure, and function. Today we're making ESM3 available free to researchers worldwide via the public beta of an API for biological intelligence. Trained with over a trillion teraflops of compute, this is the first time a model of this scale has been trained for biology, pushing the frontier of AI for biological discovery and engineering. ESM3 learns to represent the immense complexity of protein biology, learning from billions of natural proteins. From this training it developed the capability to design proteins, responding to complex prompts combining atomic level details and high level instructions to generate new proteins. ESM3 can explore protein space far beyond natural evolution. We prompted ESM3 to generate a fluorescent protein at a far distance from any known fluorescent proteins, searching an unknown region of protein space, to discover a new fluorescent protein. We estimate this is equivalent to simulating five hundred million years of evolution.
1:31

We're thrilled to present ESM3 in Science Magazine. ESM3 is a generative language model that reasons over the three fundamental properties of proteins: sequence, structure, and function. Today we're making ESM3 available free to researchers worldwide via the public beta of an API for biological intelligence. Trained with over a trillion teraflops of compute, this is the first time a model of this scale has been trained for biology, pushing the frontier of AI for biological discovery and engineering. ESM3 learns to represent the immense complexity of protein biology, learning from billions of natural proteins. From this training it developed the capability to design proteins, responding to complex prompts combining atomic level details and high level instructions to generate new proteins. ESM3 can explore protein space far beyond natural evolution. We prompted ESM3 to generate a fluorescent protein at a far distance from any known fluorescent proteins, searching an unknown region of protein space, to discover a new fluorescent protein. We estimate this is equivalent to simulating five hundred million years of evolution.

Alex Rives

227,430 Aufrufe • vor 1 Jahr

Ryan who left a $200K job to chase his dream, proves that building with AI and a little help from his girlfriend can actually pay off big time: "I left my $200K job to build my own business. It took a few years, but with the help of AI and my girlfriend, we built an app that makes over $18K a month now." "This is actually the first app we released. My girlfriend illustrated everything, and we added features that made it fun and personal." "Most of our sales come from the lifetime plan. At the peak, we hit rank three for free productivity apps and rank 11 for all free apps in Taiwan."
0:20

Ryan who left a $200K job to chase his dream, proves that building with AI and a little help from his girlfriend can actually pay off big time: "I left my $200K job to build my own business. It took a few years, but with the help of AI and my girlfriend, we built an app that makes over $18K a month now." "This is actually the first app we released. My girlfriend illustrated everything, and we added features that made it fun and personal." "Most of our sales come from the lifetime plan. At the peak, we hit rank three for free productivity apps and rank 11 for all free apps in Taiwan."

Starter Story

15,513 Aufrufe • vor 23 Tagen

How Can Scientists Best Become Founders? david friedberg answers a fan question from James Sinka - Boston & SF: "I think the biggest challenge that scientists face when trying to build businesses is shifting from a research and discovery mindset to a product and customer mindset." this can be really hard for scientists, because absolute truth doesn't rule the day in startups like it does in science example: "You have to listen to customers who sometimes might not want the most rational or the most obvious thing." "Iterating your business to find product-market fit is the necessary role of a founder. But it's often different than the scientific process of discovering absolute truth." so, how can scientists overcome this hurdle to become great founders? change their framing, and use the scientific method as a strength: "One way scientists can be successful is to think about product-market fit as a discovery process, and using the iterative and scientific method to try and get to that." "I have seen scientists shift to (an) engineering mindset, using the scientific method to try and find product-market fit."
0:54

How Can Scientists Best Become Founders? david friedberg answers a fan question from James Sinka - Boston & SF: "I think the biggest challenge that scientists face when trying to build businesses is shifting from a research and discovery mindset to a product and customer mindset." this can be really hard for scientists, because absolute truth doesn't rule the day in startups like it does in science example: "You have to listen to customers who sometimes might not want the most rational or the most obvious thing." "Iterating your business to find product-market fit is the necessary role of a founder. But it's often different than the scientific process of discovering absolute truth." so, how can scientists overcome this hurdle to become great founders? change their framing, and use the scientific method as a strength: "One way scientists can be successful is to think about product-market fit as a discovery process, and using the iterative and scientific method to try and get to that." "I have seen scientists shift to (an) engineering mindset, using the scientific method to try and find product-market fit."

The All-In Podcast

65,259 Aufrufe • vor 2 Jahren