🧬🔬 What exactly is this rejuvenation paradigm called “partial reprogramming” or “epigenetic rejuvenation” that has taken the longevity field by storm in the past few years with billion-dollar companies like Altos Labs dedicated to it, and visionary investors like Sam Altman, Brian Armstrong, Yuri Milner investing in it? This... clip provides a quick overview of partial reprogramming, Yamanaka factors, the rejuvenation they produce during cellular reprogramming, and their potential connection to germline reset of aging — the active rejuvenation process triggered upon fertilization that enables new babies to be born young despite starting out as an egg cell of the same age as their mother.show more

See my full conversation with Iosif Gershteyn on Cognitum here (the clip starts at 10:50):

If you are interested in partial reprogramming, check out this recent debate about the best longevity strategy to combat aging — partial reprogramming vs. replacement:

@altos_labs @sama terrific explanation

@altos_labs @sama Blows me away that your grandmother held and nurtured your egg inside her even before you mother was born. 🤯

@altos_labs @sama Very clear explanation, thanks for sharing !

@altos_labs @sama Yamanaka factors and totipotent stem cells. Throw back!

@altos_labs @sama I'm 92, but when I get old one day, I may want to give this longevity thingy a try. 😎In the meantime I know that "My belief makes it so," "Thoughts are things," and "All things are possible." Follow to see my artwork.

@altos_labs @sama The egg cell has the same age as the mother, but did it undergo the aging process as her somatic cells?

@altos_labs @sama Would love if someone used an epigenetic clock to determine Pres Biden's biol. age. He looks and behaves much older than his chronological age. Maybe some of the new interventions could have saved his Presidential run

@altos_labs @sama I bet Yamanaka factors are not the only factors that can reverse the deleterious epigenetic changes. There could be better ones with less risk. People haven't looked hard enough