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🧬🔬 What exactly is this rejuvenation paradigm called “partial reprogramming” or “epigenetic rejuvenation” that has taken the longevity field by storm in the past few years with billion-dollar companies like Altos Labs dedicated to it, and visionary investors like Sam Altman, Brian Armstrong, Yuri Milner investing in it? This...

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Yuri Deigin

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88,315 görüntüleme • 1 yıl önce •via X (Twitter)

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See my full conversation with Iosif Gershteyn on Cognitum here (the clip starts at 10:50):

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Yuri Deigin1 yıl önce

If you are interested in partial reprogramming, check out this recent debate about the best longevity strategy to combat aging — partial reprogramming vs. replacement:

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Jason Hreha1 yıl önce

@altos_labs @sama terrific explanation

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Pavel Elad Zablotny1 yıl önce

@altos_labs @sama Blows me away that your grandmother held and nurtured your egg inside her even before you mother was born. 🤯

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Nomel-Cédric Beugré 👻✍️🔥1 yıl önce

@altos_labs @sama Very clear explanation, thanks for sharing !

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Davis Kelly 🧙🏼‍♂️🧙🏼‍♂️🍀1 yıl önce

@altos_labs @sama Yamanaka factors and totipotent stem cells. Throw back!

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@altos_labs @sama I'm 92, but when I get old one day, I may want to give this longevity thingy a try. 😎In the meantime I know that "My belief makes it so," "Thoughts are things," and "All things are possible." Follow to see my artwork.

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Tony VanDongen1 yıl önce

@altos_labs @sama The egg cell has the same age as the mother, but did it undergo the aging process as her somatic cells?

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Sam1 yıl önce

@altos_labs @sama Would love if someone used an epigenetic clock to determine Pres Biden's biol. age. He looks and behaves much older than his chronological age. Maybe some of the new interventions could have saved his Presidential run

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Sam1 yıl önce

@altos_labs @sama I bet Yamanaka factors are not the only factors that can reverse the deleterious epigenetic changes. There could be better ones with less risk. People haven't looked hard enough

Benzer Videolar

David Sinclair's lab just discovered that the same technology that reverses aging also kills cancer cells. His team has been using epigenetic reprogramming to reset old cells back to a younger state. It works. Old cells become young again. But when they tried it on cancer cells, something unexpected happened. The cancer cells didn't get younger. They killed themselves. Sinclair (David Sinclair) explained why. Cancer cells survive by ignoring the DNA damage inside them. They're filled with it. But they've shut down the part of the cell that would normally detect it and trigger self-destruction. Epigenetic reprogramming wakes that system back up. Sinclair put it this way: the cancer cell wakes up from its zombie-like state, looks at its own chromosomes, realizes they're destroyed, and says "I better kill myself." And it does. A normal cell gets reprogrammed and becomes young again. A cancer cell gets reprogrammed and destroys itself. Same technology. Two opposite outcomes. Both exactly what you'd want. His team has shown this works across many types of cancer. Side note: David Sinclair is speaking on May 6th at SynBioBeta this year - discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists who matter in this space will be in the room. Link for tickets below.
1:02

David Sinclair's lab just discovered that the same technology that reverses aging also kills cancer cells. His team has been using epigenetic reprogramming to reset old cells back to a younger state. It works. Old cells become young again. But when they tried it on cancer cells, something unexpected happened. The cancer cells didn't get younger. They killed themselves. Sinclair (David Sinclair) explained why. Cancer cells survive by ignoring the DNA damage inside them. They're filled with it. But they've shut down the part of the cell that would normally detect it and trigger self-destruction. Epigenetic reprogramming wakes that system back up. Sinclair put it this way: the cancer cell wakes up from its zombie-like state, looks at its own chromosomes, realizes they're destroyed, and says "I better kill myself." And it does. A normal cell gets reprogrammed and becomes young again. A cancer cell gets reprogrammed and destroys itself. Same technology. Two opposite outcomes. Both exactly what you'd want. His team has shown this works across many types of cancer. Side note: David Sinclair is speaking on May 6th at SynBioBeta this year - discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists who matter in this space will be in the room. Link for tickets below.

John Cumbers

95,588 görüntüleme • 3 ay önce

David Sinclair just announced at the World Government Summit that next month (March 2026), human clinical trials begin — the first in history to test whether we can reverse aging and cure diseases. His core claim: Aging isn't wear-and-tear like a car; it's like scratches on a CD. DNA is the music, but in old age, cells can't read it correctly — leading to confusion, wrong proteins, and disease. The breakthrough? They can "polish the CD" via partial epigenetic reprogramming (using Yamanaka factors like OSK) to restore youthful gene expression without altering DNA itself. Science nugget: In lab and animal studies (published 2020–2025), Sinclair's team reversed epigenetic age by up to 75% in six weeks in mouse optic nerves, restoring vision in blind animals. The approach reactivates youthful gene patterns while avoiding full cellular reprogramming risks like tumors. Current status: The FDA cleared Life Biosciences' Phase 1 trial (ER-100, Sinclair co-founded) in January 2026 for safety in patients with optic neuropathies (e.g., glaucoma, NAION). Enrollment starts soon, with initial results expected by late 2026/early 2027. This targets eye disease first — not whole-body aging — but success could open doors to broader rejuvenation. Sinclair envisions a future where kids with cancer gather under gentle plasma lights that shatter tumors painlessly, one cell at a time. Sci-fi becoming science fact? Are you hopeful this trial delivers — or skeptical it's overhyped?
2:18

David Sinclair just announced at the World Government Summit that next month (March 2026), human clinical trials begin — the first in history to test whether we can reverse aging and cure diseases. His core claim: Aging isn't wear-and-tear like a car; it's like scratches on a CD. DNA is the music, but in old age, cells can't read it correctly — leading to confusion, wrong proteins, and disease. The breakthrough? They can "polish the CD" via partial epigenetic reprogramming (using Yamanaka factors like OSK) to restore youthful gene expression without altering DNA itself. Science nugget: In lab and animal studies (published 2020–2025), Sinclair's team reversed epigenetic age by up to 75% in six weeks in mouse optic nerves, restoring vision in blind animals. The approach reactivates youthful gene patterns while avoiding full cellular reprogramming risks like tumors. Current status: The FDA cleared Life Biosciences' Phase 1 trial (ER-100, Sinclair co-founded) in January 2026 for safety in patients with optic neuropathies (e.g., glaucoma, NAION). Enrollment starts soon, with initial results expected by late 2026/early 2027. This targets eye disease first — not whole-body aging — but success could open doors to broader rejuvenation. Sinclair envisions a future where kids with cancer gather under gentle plasma lights that shatter tumors painlessly, one cell at a time. Sci-fi becoming science fact? Are you hopeful this trial delivers — or skeptical it's overhyped?

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THE REJUVENATION OF WATERPARKS: ARE THEY GOING TO GAIN EVERYTHING?
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THE REJUVENATION OF WATERPARKS: ARE THEY GOING TO GAIN EVERYTHING?

WATERPARKS

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Today’s guest on the Free Radicals podcast is Michael Ringel, JD PhD, COO Life Biosciences and former Managing Director at Boston Consulting Group. Michael is a leader in longevity and pharma who spent 25+ years advising top pharma companies on their R&D strategy. He is now COO at Life Biosciences where he is bringing the first ever partial epigenetic reprogramming therapy to human clinical trials - a major milestone for the longevity industry. In this episode, we discuss Michael’s insightful paper on why aging is an optimization by evolution, why that means it’s malleable, and how to push the longevity field forward. Michael also sits on the US board of Hevolution Foundation and on the board of the AFAR. Be sure to follow me and Eric Dai to stay up to date on the latest news in longevity biotech! 0:00 Intro 2:30 Why aging is an optimization by evolution 15:10 Why scientists miss the role of evolution in aging 19:31 Evidence that aging is a regulated process 24:40 Hormesis and adaptive stress responses 28:55 The promise of partial epigenetic reprogramming in humans 35:08 Life Bio's first therapy proceeding to clinical trials 47:47 Why targeting the eye, particularly glaucoma and NION, is a strategic choice 52:03 The pharma industry's perspective on anti-aging research 56:39 The importance of public engagement for funding and policy change 1:05:42 Reasons for optimism in longevity 1:08:26 Advice on how to have an impactful and interdisciplinary career 1:11:54 The ethical case for longevity 1:17:34 Concrete steps for audience members to support longevity research
1:20:44

Today’s guest on the Free Radicals podcast is Michael Ringel, JD PhD, COO Life Biosciences and former Managing Director at Boston Consulting Group. Michael is a leader in longevity and pharma who spent 25+ years advising top pharma companies on their R&D strategy. He is now COO at Life Biosciences where he is bringing the first ever partial epigenetic reprogramming therapy to human clinical trials - a major milestone for the longevity industry. In this episode, we discuss Michael’s insightful paper on why aging is an optimization by evolution, why that means it’s malleable, and how to push the longevity field forward. Michael also sits on the US board of Hevolution Foundation and on the board of the AFAR. Be sure to follow me and Eric Dai to stay up to date on the latest news in longevity biotech! 0:00 Intro 2:30 Why aging is an optimization by evolution 15:10 Why scientists miss the role of evolution in aging 19:31 Evidence that aging is a regulated process 24:40 Hormesis and adaptive stress responses 28:55 The promise of partial epigenetic reprogramming in humans 35:08 Life Bio's first therapy proceeding to clinical trials 47:47 Why targeting the eye, particularly glaucoma and NION, is a strategic choice 52:03 The pharma industry's perspective on anti-aging research 56:39 The importance of public engagement for funding and policy change 1:05:42 Reasons for optimism in longevity 1:08:26 Advice on how to have an impactful and interdisciplinary career 1:11:54 The ethical case for longevity 1:17:34 Concrete steps for audience members to support longevity research

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🚨🇨🇳 PRESIDENT XI: SERVICE MEMBERS MUST BACK CHINA’S GREAT REJUVENATION "All service members should provide strategic support for the great rejuvenation of the Chinese nation and make greater contributions to the peace and development of the world. History carries the legacy of the past and inspires the future on a new journey in a new era." Source: CGTN
2:30

🚨🇨🇳 PRESIDENT XI: SERVICE MEMBERS MUST BACK CHINA’S GREAT REJUVENATION "All service members should provide strategic support for the great rejuvenation of the Chinese nation and make greater contributions to the peace and development of the world. History carries the legacy of the past and inspires the future on a new journey in a new era." Source: CGTN

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🚨🇰🇵 New Era of Rural Rejuvenation in the DPRK!
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🚨🇰🇵 New Era of Rural Rejuvenation in the DPRK!

Jackson Hinkle 🇺🇸

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This video of the Musi Rejuvenation & Riverfront development looks dreamy and almost too good to be real. Even if 1 or 2 kms of phase 1 of the riverfront project gets developed like this, it would be awesome!
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This video of the Musi Rejuvenation & Riverfront development looks dreamy and almost too good to be real. Even if 1 or 2 kms of phase 1 of the riverfront project gets developed like this, it would be awesome!

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David Sinclair says the first person to live to 150 is a teenager who's alive today. He's taken flak from colleagues for years over this prediction. He doesn't care. He still stands by it. "The first person to live to 150 has already been born." Here's why: A 14-year-old today has 80+ years of exponential technological progress ahead of them. Just look at what's happened in the last 10 years: • His lab reversed aging in monkey eyes by 95% • AI now does in 2 months what would have taken thousands of years. • His team has oral molecules that made old mice young again in 4 weeks • The first human age-reversal trial begins in January And that's just the beginning. There'll be more advancements in major medical technologies and therapies soon, including in: • Gene therapy • AI-designed drugs • Whole-body rejuvenation • Epigenetic reprogramming All of it will arrive within a teenager's lifetime. Sinclair believes this is a realistic projection of where the science is heading. Sinclair's advice for everyone is to stay healthy long enough to intercept what's coming. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.
1:04

David Sinclair says the first person to live to 150 is a teenager who's alive today. He's taken flak from colleagues for years over this prediction. He doesn't care. He still stands by it. "The first person to live to 150 has already been born." Here's why: A 14-year-old today has 80+ years of exponential technological progress ahead of them. Just look at what's happened in the last 10 years: • His lab reversed aging in monkey eyes by 95% • AI now does in 2 months what would have taken thousands of years. • His team has oral molecules that made old mice young again in 4 weeks • The first human age-reversal trial begins in January And that's just the beginning. There'll be more advancements in major medical technologies and therapies soon, including in: • Gene therapy • AI-designed drugs • Whole-body rejuvenation • Epigenetic reprogramming All of it will arrive within a teenager's lifetime. Sinclair believes this is a realistic projection of where the science is heading. Sinclair's advice for everyone is to stay healthy long enough to intercept what's coming. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.

John Cumbers

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.NewLimit is building medicines that target aging itself—not just individual diseases. Their approach is elegant and deeply technical: run the largest epigenetic reprogramming experiments and use the data to train frontier AI models. Proud to lead their Series B and back Brian Armstrong, Blake Byers, Jacob Kimmel, and Cathy O’Hare on this mission. Interested in joining their talented team on the journey? They’re hiring:
1:43

.NewLimit is building medicines that target aging itself—not just individual diseases. Their approach is elegant and deeply technical: run the largest epigenetic reprogramming experiments and use the data to train frontier AI models. Proud to lead their Series B and back Brian Armstrong, Blake Byers, Jacob Kimmel, and Cathy O’Hare on this mission. Interested in joining their talented team on the journey? They’re hiring:

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Action for Rural Rejuvenation is a rural revitalization program that has impacted over 7500 villages in rural Southern India. Under Sadhguru's guidance, it takes a comprehensive approach to the challenges faced by rural communities by implementing a range of holistic health care, community revitalization, disaster management and livelihood programs. Here is a glimpse of the pioneering work the Action for Rural Rejuvenation volunteers have undertaken in the last 21 years. To know more: Sadhguru Isha Foundation #ConsciousPlanet #RuralIndia
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Action for Rural Rejuvenation is a rural revitalization program that has impacted over 7500 villages in rural Southern India. Under Sadhguru's guidance, it takes a comprehensive approach to the challenges faced by rural communities by implementing a range of holistic health care, community revitalization, disaster management and livelihood programs. Here is a glimpse of the pioneering work the Action for Rural Rejuvenation volunteers have undertaken in the last 21 years. To know more: Sadhguru Isha Foundation #ConsciousPlanet #RuralIndia

Conscious Planet #SaveSoil

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I asked 4 longevity experts; "Over the next 5 years, which therapeutic wins?" Kaeberlein ranked them in this order: 1) Rapamycin 2) Plasma dilution 3) Senolytics 4) Partial reprogramming 5) NAD boosters Rapamycin tops it because it has the best, most reproducible data by far. He also says reprogramming has the highest ceiling of all. — Matt Kaeberlein (.Matt Kaeberlein)
0:53

I asked 4 longevity experts; "Over the next 5 years, which therapeutic wins?" Kaeberlein ranked them in this order: 1) Rapamycin 2) Plasma dilution 3) Senolytics 4) Partial reprogramming 5) NAD boosters Rapamycin tops it because it has the best, most reproducible data by far. He also says reprogramming has the highest ceiling of all. — Matt Kaeberlein (.Matt Kaeberlein)

Julian Issa

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Inviting Vladimir Putin to the Gaza Board of Peace? Having to pay $1 Billion to join the board? This has devolved into an embarrassing vanity project that has nothing to do with eradicating Hamas, deradicalizing Gaza, promoting reconciliation, or launching rejuvenation or renewal
0:52

Inviting Vladimir Putin to the Gaza Board of Peace? Having to pay $1 Billion to join the board? This has devolved into an embarrassing vanity project that has nothing to do with eradicating Hamas, deradicalizing Gaza, promoting reconciliation, or launching rejuvenation or renewal

Ahmed Fouad Alkhatib

32,521 görüntüleme • 5 ay önce

Rejuvenation of ponds in Mumbai is an effort to create a better and sustainable future. 🌱
1:19

Rejuvenation of ponds in Mumbai is an effort to create a better and sustainable future. 🌱

Piyush Goyal

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.R3 Stem Cell here with the gang at R3 Stem Cell in Orlando...their newest location getting the rejuvenation therapy everyone can enjoy for maintaining good health and take the Creakiness out of your joints #BaldysBreakdowns
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.R3 Stem Cell here with the gang at R3 Stem Cell in Orlando...their newest location getting the rejuvenation therapy everyone can enjoy for maintaining good health and take the Creakiness out of your joints #BaldysBreakdowns

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the immune system is central to human life if it doesn't work you die immune system rejuvenation, modulation and weaponisation will produce trillion dollar companies together, $NAUT, $IBRX and $MINK are the platform read, reboot, weaponise: combined market cap of $8B
20:23

the immune system is central to human life if it doesn't work you die immune system rejuvenation, modulation and weaponisation will produce trillion dollar companies together, $NAUT, $IBRX and $MINK are the platform read, reboot, weaponise: combined market cap of $8B

Antonio Linares

67,477 görüntüleme • 1 ay önce

The rejuvenation of the Chinese nation is unstoppable and humanity's cause of peace and development will prevail, said President Xi Jinping on Wednesday. Xi called on Chinese people of all ethnic groups to stay united and work hard under the strong leadership of the CPC to build a strong country and advance national rejuvenation on all fronts through Chinese modernization. #XiJinping #80thAnniversary
1:32

The rejuvenation of the Chinese nation is unstoppable and humanity's cause of peace and development will prevail, said President Xi Jinping on Wednesday. Xi called on Chinese people of all ethnic groups to stay united and work hard under the strong leadership of the CPC to build a strong country and advance national rejuvenation on all fronts through Chinese modernization. #XiJinping #80thAnniversary

Xi's Moments

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Xi Jinping: The Party has led the people in overcoming great hardships, successfully blazed and upheld the path of socialism with Chinese characteristics, completed in just a few decades the process of industrialization that took developed countries several hundred years, and created the two miracles of rapid economic development and long-term social stability. Today, the great rejuvenation of the Chinese nation is showing an unstoppable momentum and a bright prospect like never before.
1:17

Xi Jinping: The Party has led the people in overcoming great hardships, successfully blazed and upheld the path of socialism with Chinese characteristics, completed in just a few decades the process of industrialization that took developed countries several hundred years, and created the two miracles of rapid economic development and long-term social stability. Today, the great rejuvenation of the Chinese nation is showing an unstoppable momentum and a bright prospect like never before.

Clash Report

25,363 görüntüleme • 7 gün önce

Scientists just figured out how to reverse aging using AI. And this is a massive breakthrough. We can now reprogram any human cell back to age 20. Heart cells, brain cells, skin cells, all reset to their biological prime. And here’s the wildest part…the technology to do this, has already existed since 2012 (it won the Nobel Prize). But the real breakthrough wasn’t possible until this year, when they supercharged it with AI. It’s a wild story. So in 2006, scientists discovered Yamanaka factors. They’re proteins that can basically convert any normal cell into a universal stem cell. Now this was a huge deal, because these stem cells are basically like magic healers. If you have torn muscle tissue, you could inject these stem cells into the area and they will turn into the youthful muscle cells you need. So Yamanaka factors were this insane breakthrough, because they allowed any human to turn any cell you already have into these magic healers. But, there was one big problem… It turns out, the original Yamanaka factors weren’t very good at this stem cell conversion. They could do it, but they just weren’t very reliable. Enter OpenAI...and this is where things get crazy. OpenAI designed a special AI model built specifically to create new proteins. Think of it like ChatGPT but for protein engineering. So they took all the Yamanaka research and asked this new AI to go ham on improving it. And get this… Their version was 50x more effective than the original. They tested it on 50 year old cells and it successfully started repairing 30% of their cells in just 7 days. This is just science fiction…it actually happened. And it sounds crazy, but in a few years, humans will be able to take a shot that will literally reverse the age of their cells.
1:32

Scientists just figured out how to reverse aging using AI. And this is a massive breakthrough. We can now reprogram any human cell back to age 20. Heart cells, brain cells, skin cells, all reset to their biological prime. And here’s the wildest part…the technology to do this, has already existed since 2012 (it won the Nobel Prize). But the real breakthrough wasn’t possible until this year, when they supercharged it with AI. It’s a wild story. So in 2006, scientists discovered Yamanaka factors. They’re proteins that can basically convert any normal cell into a universal stem cell. Now this was a huge deal, because these stem cells are basically like magic healers. If you have torn muscle tissue, you could inject these stem cells into the area and they will turn into the youthful muscle cells you need. So Yamanaka factors were this insane breakthrough, because they allowed any human to turn any cell you already have into these magic healers. But, there was one big problem… It turns out, the original Yamanaka factors weren’t very good at this stem cell conversion. They could do it, but they just weren’t very reliable. Enter OpenAI...and this is where things get crazy. OpenAI designed a special AI model built specifically to create new proteins. Think of it like ChatGPT but for protein engineering. So they took all the Yamanaka research and asked this new AI to go ham on improving it. And get this… Their version was 50x more effective than the original. They tested it on 50 year old cells and it successfully started repairing 30% of their cells in just 7 days. This is just science fiction…it actually happened. And it sounds crazy, but in a few years, humans will be able to take a shot that will literally reverse the age of their cells.

Whiplash347

68,643 görüntüleme • 8 ay önce

Alex Jones claims that Peter Nygard and Jeffrey Epstein fathered children with the purpose of using their blood for health and anti-aging treatments. According to the allegations, Nygard forced women in his trafficking network to become pregnant, then induced abortions to harvest fetal stem cells and tissues for experimental longevity treatments. Nygard and Epstein are alleged to be part of an elite network using children’s blood for supposed rejuvenation.
2:09

Alex Jones claims that Peter Nygard and Jeffrey Epstein fathered children with the purpose of using their blood for health and anti-aging treatments. According to the allegations, Nygard forced women in his trafficking network to become pregnant, then induced abortions to harvest fetal stem cells and tissues for experimental longevity treatments. Nygard and Epstein are alleged to be part of an elite network using children’s blood for supposed rejuvenation.

Shadow of Ezra

139,927 görüntüleme • 6 ay önce