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Why is Low-Carb Science so Freakin' Confusing? 🍟 **Give me 86 sec... Watch this trailer (🔊 on). Brief overview: There is terrible publication and media bias against carbohydrate-restricted and ketogenic diets that ranges from lowered publication standards to distorted headlines to full out lies authorized by peer review. In...

13,459 views • 9 months ago •via X (Twitter)

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$50 million! That’s the size of a new privately funded donation by the Baszucki Family to launch the Metabolic Health Coalition, a group of scientists and healthcare professionals committed to addressing the root causes of our metabolic health crisis. As both a PhD scientist and new MD and chronic disease patient, this hits home for me. Because one thing I know for certain: the system we’ve built isn’t designed to prioritize metabolic health. It’s optimized for treatments that maintain the business model—pharmaceuticals, procedures, and quick fixes—not long-term root-cause solutions. 🚨This coalition is different. It’s a move toward unbiased research and widespread education—for both clinicians and patients. It’s a serious effort to bring logic, science, and systems-level change to a crisis that’s been swept under the rug for too long. It’s sad that we need disruption, and that true change is being built of the backs of people like me and my friends and colleagues who became passionate about metabolic health because we or a loved one suffered in a dysfunction system. 🚨But that sad truth is also the reason this metabolic health movement is so robust. Enough have suffered. Let’s shake things up. 1⃣First, follow Coalition for Metabolic Health for further updates. 2⃣Then, check out the metabolic health coalition website (👇) 3⃣Finally, share if you care *Some members of the scientific advisory board and supporting experts you may know and love... Benjamin Bikman Dominic D'Agostino Andrew Koutnik, Ph.D. Georgia Ede MD Dr. David Ludwig Chris Palmer, MD and many more... Ht/ David Baszucki Jan Ellison Baszucki 🙏

Nick Norwitz MD PhD

21,229 views • 10 months ago

What if We're Using GLP-1 Medications All Wrong? Drugs like Ozempic, Wegovy, and Mounjaro are transforming the landscape of medical weight loss, but could their side effects be a sign that we’re not harnessing their full therapeutic potential? In this eye-opening conversation, Dr. Ben Bikman (Benjamin Bikman), metabolic health researcher and professor at BYU, joins Dr. Bret Scher (Bret Scher, MD) to explore a powerful new framework: using GLP-1 medications at low doses and for short durations to help curb carbohydrate cravings, break addictive eating cycles, and support long-term metabolic health. Rather than prescribing high doses indefinitely, Dr. Bikman proposes a more targeted approach: - Microdosing GLP-1s to enhance satiety and reduce cravings for processed carbs - Using the medication as a temporary metabolic tool to support transitions to lower-carb diets - Reducing long-term risks such as muscle loss, mood changes, and diminishing effectiveness - Emphasizing the importance of habit change, insulin regulation, and muscle preservation This conversation reimagines GLP-1s not as a lifelong solution, but as a catalyst for sustainable, low-insulin lifestyles, aligned with ketogenic and metabolic therapies. 📌 Could a 90-day microdosing protocol replace years of medication? Learn how this metabolic-first strategy could empower patients to reclaim their health, without becoming dependent on medication for life. #GLP1 #Ozempic #Wegovy #Mounjaro #BenBikman #MetabolicHealth #Microdosing #InsulinResistance #LowCarbDiet #KetogenicTherapy #MedicalWeightLoss #BretScher #MetabolicMind Expert Featured: Dr. Benjamin Bikman Benjamin Bikman Papers/Articles Mentioned: Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at Timestamps: 0:00 - What if we’re using GLP-1s all wrong? 1:40 - Dr. Benjamin Bikman’s interest in metabolic health and GLP-1s 3:20 - Unexpected side effect of GLP-1s 5:26 - Are GLP-1s actually beneficial? 10:55 - The difference between “weight loss” and metabolic health 15:10 - The role of cravings and satiety signals 19:58 - Dr. Bikman’s ideal use of GLP-1s 24:14 - “Self-discipline in a syringe” 25:11 - Are all weight loss interventions beneficial? 27:20- New studies examining microdosing GLP-1s 32:12 - Learn more about Dr. Bikman

Metabolic Mind

20,561 views • 1 year ago

Since there’s been discussion about Colon Cancer over the past few days, I’ve decided to release my video covering new data on a ketogenic diet for colorectal cancer early. Below is a 79 second teaser. 🚨Some Key Considerations: 👉Epidemiology will never truly reveal cause-effect relationships between lifestyle and colon cancer. It’s fine for hypothesis generation, but not sufficient to make causal claims. 👉Animal model studies are limited insofar as they are non-human. That's true. However, have the power to provide insights into causal connections and mechanisms. In this study, to improve human relevance, the researchers used microbiome-humanized mice (see clip). *Don't disregard data because "oh, it's just animals." Sometimes, those are the most insightful and information data available on a given topic* 🚨Key Findings 👉Ketogenic diet reduced colon cancer tumor size and overall tumor burden 👉The mechanism appears to be due to the ketogenic diet altering the microbiome so as to increase the production of endogenous stearic acid, an 18 carbon saturated fat rich in cocoa butter, tallow, and shea butter. 👉Fecal transplant and exogenous stearic acid feeding experiments reveal the importance of the microbiome shift and anti-cancer potential of stearic acid 👉The stearic acid reduced inflammation and killed off cancer cells by apoptosis 🥓On Red Meat 👉As I review in the video briefly, red (and processed) meats are complex foods. They’re not just stearic acid. I will not rule out the possibility that meat, and particularly processed meats, could be a net negative for colon cancer risk given factors iron overload and/or chemical additives including processing. 👉However, I think it’s essential to keep in mind (1) dietary patterns and overall metabolic health matter MUCH more than any single food or ingredient. Effect size matters. (2) Given healthy user bias and food ‘lumping’ in epidemiology, it’s easy to draw misleading conclusions, e.g. red meat = universally bad for colon cancer risk. cc, with respect Dr. Rhonda Patrick 👉 As I review in the video (🔗 in first reply): “It’s entirely possible that a fatty ribeye steak [rich in stearic acid] could promote colon cancer when eaten with a side of fries by someone with obesity, while that same fatty ribeye steak could suppress cancer when eaten in the context of a clean ketogenic diet and by a healthy individual” ... CONTEXT MATTERS. Food for thought. cc Dr Shawn Baker 🥩 Joel "Heart Prevention" Kahn MD, FACC Meat Head Viva Longevity! Dave Feldman Adrian Soto-Mota Keith Siau Ken D Berry MD Nina Teicholz, PhD Jan Ellison Baszucki Tucker Goodrich Eric Rodgers

Nick Norwitz

17,445 views • 1 year ago

Mitochondria do more than power our cells: they shape how we think, feel, and experience the world. In this interview, Martin Picard breaks down his new research that illuminates how mitochondria affect brain energy, brain networks, mental health, and ultimately, our quality of life. Dr. Picard walks us through his team's revolutionary brain mapping study, which examined over 700 sections of the human brain to uncover how mitochondria are distributed and specialized by brain region and cell type. The results have profound implications for how we understand, cognitive decline, and psychiatric disorders like depression bipolar disorder and schizophrenia. In this episode, you'll learn: - Why mitochondrial health is essential for brain function - How different brain regions rely on different types of mitochondria - Why people respond so differently to the same metabolic dysfunction - How future scans and biomarkers could help us measure brain energy non-invasively - What it means to think of ourselves as “energetic beings” rather than just biological machines When it comes to metabolic psychiatry, mitochondria are a key player. This research is a huge step towards better understanding these tiny organelles and the role they play in mental health and cognitive function. Expert Featured: Dr. Martin Picard Martin Picard Resources Mentioned: Three Ways to Keep Your Mitochondria Healthy - A human brain map of mitochondrial respiratory capacity and diversity - CMEs Mentioned: Managing Major Mental Illness with Dietary Change: The New Science of Hope - Brain Energy: The Metabolic Theory of Mental Illness - Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at

Metabolic Mind

14,566 views • 1 year ago

What if everything we thought we knew about cholesterol and heart disease risk… doesn’t apply to everyone? In this episode, world-renowned cardiologist Dr. Matthew Budoff unpacks the results of a landmark one-year study tracking 100 lean, metabolically healthy individuals on a ketogenic diet with extremely elevated LDL levels. Dr. Budoff is the Program Director, Director of Cardiac CT, and the endowed chair of preventive cardiology at The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. In this interview, Dr. Scher and Dr. Budoff further break down the results of his new publication, which used advanced imaging to demonstrate that LDL cholesterol and ApoB levels are not associated with plaque progression in Lean-Mass Hyper Responders following a #ketogenicdiet. 📊 Surprising insights: • Elevated LDL and ApoB did not predict plaque progression • Some participants with LDLs over 500 showed no plaque at all • A few participants even experienced plaque regression • Existing plaque—not LDL-C or ApoB—did predict plaque accumulation in this population Dr. Budoff explains what these results mean for clinicians, for patients using ketogenic therapy as a medical intervention, and for the broader conversation around cardiovascular disease risk. “It is important that clinicians, along with the general public, are made aware that personalized, data-driven approaches to assessing risk should be considered based on individual conditions,” said Dr. Budoff. “The existence of this phenotype suggests that alternative markers or tests should be used to establish metabolic health in some cases.” 🎬 These exciting new findings are featured in Dave Feldman and Jen Isenhart’s upcoming documentary, The Cholesterol Code, the story of how a software engineer conducts a groundbreaking study on an unusual group of people—lean, healthy individuals whose doctors are convinced they’ll die young. Real stories of healing with ketogenic diets provide a blueprint for using food as powerful medicine. Visit to learn more about the film and to be the first to hear about private screenings and the general release in the fall. Expert Featured: Dr. Matthew Budoff Matthew Budoff MD Resources Mentioned: Plaque Begets Plaque, ApoB Does Not Diagnostic and Preventative Cardiovascular Imaging Center CMEs Mentioned: Managing Major Mental Illness with Dietary Change: The New Science of Hope Brain Energy: The Metabolic Theory of Mental Illness Learn more about metabolic psychiatry and find helpful resources at

Metabolic Mind

10,423 views • 1 year ago

There’s been a lot of buzz—and confusion—about the new Keto-CTA study, examining plaque progression in Lean Mass Hyper-Responders (LMHRs). Much of the social media debate has centered on whether high LDL on keto is safe or dangerous, driven largely by how to interpret the supplemental table comparing this study to others on LDL and plaque progression. In this episode of the Metabolic Mind Podcast, we sit down with Dr. Matthew Budoff, a world-renowned cardiologist, cardiac CT researcher, and the study's lead investigator, to discuss the the supplemental table, what the plaque markers mean, and how this fits into the discussion of high- vs -low-risk plaque progression. In this episode, we cover: ✅ What PAV (Percent Atheroma Volume) is, what it actually measures, and why it matters ✅ Why a 50% increase in plaque may sound scary, but can be deceiving ✅ The difference between “treatment-naive” and “treated” participants ✅ What the Miami Heart Study comparison reveals about keto, LDL, and plaque ✅ Why LDL alone may not tell the whole story about heart disease risk ✅ How some high-risk individuals may still benefit from statins and other therapies This study doesn’t answer whether keto causes heart disease or not. Instead, it shows that high LDL on a ketogenic diet is not a reliable predictor of plaque progression across all individuals. What is predictive? The presence of existing plaque. 💡 Key takeaway: Relying on surrogate markers of heart disease, like LDL and ApoB, is not the best way to assess heart disease risk in all populations. If you're concerned about how elevated LDL may be affecting your heart health, the best next step is to speak with your doctor about cardiac imaging to directly assess plaque and gain a clearer picture of your individual risk. Expert Featured: - Dr. Matthew Budoff - X: - Resources Mentioned: Plaque Begets Plaque, ApoB Does Not CMEs Mentioned: Managing Major Mental Illness with Dietary Change: The New Science of Hope Brain Energy: The Metabolic Theory of Mental Illness Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at

Metabolic Mind

98,147 views • 1 year ago

Last night Dr David Unwin was on mainstream news talking about the benefits of reducing carbs for those living with diabetes. The results he gets are amazing. I know it can be replicated by others because I copy what he does in my own clinical practice using David Oliver, Freshwell resources (which are free btw). As a result, in 2024 forty of my patients achieved remission too. The news report featured an endocrinologist Shivani Misra who, at the 4mins 27s timestamp in the video, said: "If someone does a low carb with higher fat what does that mean for their cholesterol and their cardiovascular disease risk? We don't know the answer to this" I'm here to tell you this is a false statement. The research has been done. Let me show you: In 2020 a meta analysis looking at the effects of low carb on CVD risk found: "For total cholesterol there was no significant change in the data corresponding to low-carbohydrate diets lasting 12–23 months and over 24 months" With regards LDL the meta analysis says: "For plasma LDL, as the forest map shows, that there was no significant difference between the low-carbohydrate diet group and the control group at 6–11 months, 12–23 months, and 24 months" All other factors improved (blood pressure, triglycerides, etc) The meta analysis concluded: "In conclusion, the overall effect of a low-carbohydrate diet on cardiovascular risk factors tended to be favorable at less than 6 months and 6–11 months, but after 2 years of a low-carbohydrate diet, there was no significant effect on cardiovascular risk factors" So short term: CVD risk factors are improved, long term, things don't get worse". This mirrors what I see in clinical practice and with myself having been low carb full time since the start of 2020 - all my CVD risk markers are in the normal range. Study source: The reporter also talks about low carb as a "restrictive diet". What's more restrictive: Giving up bagels, bread, sweets and other junk IN FAVOUR OF protein, vegetables etc Or Giving up solid food entirely for a 850kcal liquid diet for months? Despite the latter being far more restrictive it has been rolled out nationally by the NHS. Nothing wrong with this as it works but so does low carb. Why not give patients a choice? The reporter also says Dr Unwins results are just because of the support he provides. Whilst support matters (a lot), this is blatant misinformation. Plenty of studies show that reducing carbs is disproportionately better for those with diabetes than low fat. Here are some: In 2023 Novo Nordisk published a randomized controlled trial comparing low carb to low fat for diabetes. They found: 🩸 Low carb led to the greatest reduction in hba1c 💉 Only the low carb group reduced medications 📉 Low carb had the greatest reduction in triglycerides + higher HDL (LDL was similar) ⚖️ Low carb group lost more weight + more fat spontaneously despite eating more calories 🩸 Systolic blood pressure was lower for low carb The low carb group non significantly raises their LDL but 0.23mmol. The researchers said: "we consider the beneficial effects of low carb to outweigh the minor increase in LDL (0.23mmol) induced by the diet. This is supported by other studies" So low carb is better and CVD risk markers overall improved. Naturally, the study was hidden behind a Paywall. Link: I can hear the skeptics now: "But Mike, this is one study, it's not enough" Ok here's a meta analysis showing that hba1c is directly proportional to the carbs eaten: This meta analysis concluded:

Mike - Low Carb Dietitian

17,028 views • 1 year ago

You are being told cancer is “genetic” and that the only solutions are $500,000 checkpoint inhibitors that openly admit on TV they can kill you faster than the disease. Now listen to this 96-second clip from Dr. Thomas Seyfried, Professor of Biology at Boston College, former Harvard researcher, and one of the most cited scientists alive on cancer metabolism: “Most oncologists at Dana-Farber, MD Anderson, Sloan-Kettering, Fred Hutchinson, Moffitt… have NEVER heard that glucose is the primary driver of tumor growth.1,700 Americans die every single day while the people paid to know the biochemistry of this disease… admit they have never read the papers on metabolic therapy. Patients walk in asking about it and get told ‘there’s no evidence’ — by doctors who haven’t even opened the studies.” He then drops the line that’s going to live rent-free in millions of heads: “How can you say there’s no evidence when you haven’t read the literature to know there IS evidence?” And the kicker: “We can put patients into therapeutic ketosis and make Keytruda, Opdivo, and chemotherapy vastly less toxic… while simultaneously starving the tumor of its primary fuels: glucose and glutamine.” This is not a random podcast bro. This is the scientist whose 2012 book “Cancer as a Metabolic Disease” has been cited >3,000 times and whose papers are published in Nature, Lancet Oncology, and Science Signaling. The same establishment that ridiculed him 15 years ago is now quietly running clinical trials on ketogenic diets + standard of care because the preclinical data became impossible to ignore. Yet patients are still being mocked in the very same clinics for bringing it up. Watch these 96 seconds and ask yourself one question: If the 50-year “war on cancer” has barely moved overall survival for most solid tumors… why is a non-patentable metabolic strategy — backed by thousands of peer-reviewed papers — treated like medical heresy? 96-second clip below. Sound on.

Camus

42,919 views • 7 months ago