allen institute

@AllenInstitute • 68,849 subscribers

accelerating science for a healthier world

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allen institute

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Neurons don't connect randomly. In this video by our #ElectronMicroscopy team, a blue neuron's axon forms a connection to a far neuron. Along the way, it links to some neighbors while skipping thousands. Connectomics seeks to understand what makes those connections special.

Freely access electrophysiological, morphological, and transcriptomic data measured from thousands of individual mouse &amp; human brain cells via the Allen Cell Types Database: #openscience #SfN23

Our #CellLineOfTheWeek is Nucleoporin Nup153! 🧫 Our human iPS cell lines &amp; plasmids – fluorescently-tagged to illuminate structures – are available for just the cost of shipping to support scientific discovery. 📦 Distributed by Coriell Institute &amp; Addgene

Freely access electrophysiological, morphological, and transcriptomic data measured from thousands of individual mouse &amp; human brain cells via the Allen Cell Types Database:

Researchers can freely access the Allen Mouse Brain Common Coordinate Framework (v3), a complete and high-resolution 3D atlas of the mouse brain. Learn more about it at #SfN23

Our #CellLineOfTheWeek is SOX-2 - our first cell line to go into space! 🚀 Last year, @axiom_space and Regenerative Medicine Institute at Cedars-Sinai researchers Arun Sharma and @CliveSvendsen sent SOX-2 to the ISS National Lab to study stem cell production in microgravity.

New study in Current Biology gives the most detailed description yet of cilia in the mouse visual cortex. The study was a collaboration including researchers from the Allen Institute HHMI | Janelia, University at Albany, Harvard Medical School, and others.

Videos

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How does the brain work? Scientists are closer to the answer with the largest wiring diagram and functional map of a mammalian brain to date. 🧵

The fireworks in your mind. 🧠✨ This sparkling video shows the neurotransmitter glutamate being released into synapses, made possible by an indicator developed by Abhi Aggarwal, MD, Kaspar Podgorski, and team. #HappyNewYear #NYE

The brain as it's never been seen before. Last year, scientists created the largest wiring diagram and functional map of a mammal brain to date. #BrainAwarenessWeek Dana Foundation🧠

How do different brain cell types connect with each other? We're mapping the brain to learn more. In this video from our #ElectronMicroscopy team, we see how complex brain cells can be. #BrainAwarenessWeek

The fireworks in your mind. 🧠✨ This sparkling video shows the neurotransmitter glutamate being released into synapses, made possible by an indicator developed by Abhi Aggarwal, MD, Kaspar Podgorski, and team. #HappyNewYear #NYE

Brain imaging without compromise. ✨🔬 Using technology originally designed for defect detection in electronics manufacturing, the ExA-SPIM microscope is showing scientists the brain as it’s never been seen before. Learn more:

Glutamate is the primary molecule that neurons use to communicate with each other. Previously, scientists have mostly recorded when neurons fire output signals, but now with a new glutamate indicator, they can record the many inputs that causes cells to fire. 🧵

MICrONs is a big dataset that allows you to see the little details of brain cells in a whole new way. Get up close to the synapses between two layer 2/3 pyramidal cells (in green and purple) in this mesmerizing video by our #ElectronMicroscopy team.

Brain imaging without compromise. ✨🔬 Using technology originally designed for defect detection in electronics manufacturing, the ExA-SPIM microscope is showing scientists the brain as it’s never been seen before. Look into the future of #microscopy at

What happens when you combine 10 years of brain data with one of the world’s fastest supercomputers? A virtual mouse cortex simulation, thanks to a global collaboration. Discover how it was made and how it could help researchers study brain diseases:

Our scientists developed the MICrONS Explorer, a virtual observatory of the cortex, to support #neuroscience discovery 🧠🔭 This #opendata portal includes #electronmicroscopy-based reconstructions of circuitry from mouse visual cortex.

Neurons come in many different morphologies or shapes. Check out just some of the diversity of just inhibitory neurons in this beautiful video by our #ElectronMicroscopy team.

Electron microscopy is @nature's Method of the Year! 🧠🔬🏆 Nature Methods shares why MICrONS and FlyWire are proof that #ElectronMicroscopy is helping us gain a deeper understanding of the brain and its incredible complexity: #studyBRAIN

Holy Soma Batman! You never know what you may find when you cruise our MICrONS Explorer, such as a blood vessel piercing the soma of a neuron! 👀 See this incredible find up close using this shortcut:

A new era of cellular biology. Today, we’re launching CellScapes. The mission – to uncover the foundational principles of how cells behave collectively and change states in health and disease.

Dive into the intricate connections in the mouse brain! This video showcases 107 reconstructed neurons, thanks to the combined efforts of our teams at the Allen Institute, global collaborators, and tools from Google AI. Imaged using our cutting-edge ExA-SPIM microscope. 🧠✨

Brain-wide neuron tracing reveals that the mysterious mouse claustrum is highly connected to the rest of the brain. In this extreme example, several neurons wrap their axons entirely around the cortex, forming a crown-like structure. 👑 More: #SciShots

Glia derives from the greek word for glue, but they are so much than that. In this video by our #ElectronMicroscopy team, shows a pyramidal neuron (PyC) surrounded by 8 glia brain cells – 5 microglia (MG) and 3 oligodendrocyte progenitor cells (OPC). 🔗

Microglia feet are highly dynamic and can be in contact with dense networks of axons. In this video by our #ElectronMicroscopy team using MICrONS data, a microglia (purple) contacts with an excitatory pyramidal neuron (gold). Slowly the axons under the feet are revealed.

✨ Announcing a new glutamate indicator - iGluSnFR4! ✨ Launched as a pair, iGLuSnFR4s and iGluSnFR4f have high-sensitivity and fast activation/deactivation for recording synapses. More on the indicators and what they are already revealing:

Freely access electrophysiological, morphological, and transcriptomic data measured from thousands of individual mouse & human brain cells via the Allen Cell Types Database: #openscience #SfN23

Our #CellLineOfTheWeek is Nucleoporin Nup153! 🧫 Our human iPS cell lines & plasmids – fluorescently-tagged to illuminate structures – are available for just the cost of shipping to support scientific discovery. 📦 Distributed by Coriell Institute & Addgene

Freely access electrophysiological, morphological, and transcriptomic data measured from thousands of individual mouse & human brain cells via the Allen Cell Types Database: