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Samuel Hume

@DrSamuelBHume • 58,175 subscribers

Doctor, scientist | Trying to speed up science and solve disease

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One of the most amazing things I’ve ever seen: a standing ovation for the full Daraxonrasib results I feel inspired and energised, to put it mildly — we have a targeted therapy for pancreatic cancer now, and nothing is undruggable anymore

One of the most amazing things I’ve ever seen: a standing ovation for the full Daraxonrasib results I feel inspired and energised, to put it mildly — we have a targeted therapy for pancreatic cancer now, and nothing is undruggable anymore

2,006,230 views

Biggest medical discoveries of the week (🧵) 1. Why do some people get bitten by mosquitoes but others don't? It turns out that mosquitoes use three signals to pick their hosts: CO2 from breath, human odour, and the infrared radiation emitted by skin (

Biggest medical discoveries of the week (🧵) 1. Why do some people get bitten by mosquitoes but others don't? It turns out that mosquitoes use three signals to pick their hosts: CO2 from breath, human odour, and the infrared radiation emitted by skin (

845,990 views

This is amazing – I just made this in ~10 seconds "Produce a video to show how PD1 inhibitors kill cancer cells"

This is amazing – I just made this in ~10 seconds "Produce a video to show how PD1 inhibitors kill cancer cells"

80,838 views

The 10 biggest medical research papers from this week (🧵) 1. A high resolution structure of the dopamine transporter - key to Parkinson's, schizophrenia, and addiction Here's what it looks like bound to cocaine, one of its ligands (in orange) (Study:

The 10 biggest medical research papers from this week (🧵) 1. A high resolution structure of the dopamine transporter - key to Parkinson's, schizophrenia, and addiction Here's what it looks like bound to cocaine, one of its ligands (in orange) (Study:

186,270 views

Biggest medical discoveries of the week (🧵) 1/10 Spinal cord injury triggers activation of T cells, inflammation, and death of neurons Editing the T cell receptor, using mRNA, suppressed this, and helped recovery from the injury (in mice!) (Paper:

Biggest medical discoveries of the week (🧵) 1/10 Spinal cord injury triggers activation of T cells, inflammation, and death of neurons Editing the T cell receptor, using mRNA, suppressed this, and helped recovery from the injury (in mice!) (Paper:

170,117 views

This is how far science has come Mice can be engineered so that shining a light activates a very specific subset of neurons Shining the light in this case induces a 'wet dog shake' - a behaviour shared by many hairy mammals, from mice to bears This is called optogenetics - and that's how we know the precise neural pathway that explains how wet dogs shake Zhang et al in Science:

This is how far science has come Mice can be engineered so that shining a light activates a very specific subset of neurons Shining the light in this case induces a 'wet dog shake' - a behaviour shared by many hairy mammals, from mice to bears This is called optogenetics - and that's how we know the precise neural pathway that explains how wet dogs shake Zhang et al in Science:

89,306 views

Biggest medical discoveries of the week (🧵) 1/10 A new genetic condition, and insights into the gene that causes it: G protein, GNAI2 Patients' immune cells have impaired migration (videos) and hyperactivation - causing infections and autoimmunity

Biggest medical discoveries of the week (🧵) 1/10 A new genetic condition, and insights into the gene that causes it: G protein, GNAI2 Patients' immune cells have impaired migration (videos) and hyperactivation - causing infections and autoimmunity

88,033 views

Biggest medical discoveries of the week (🧵) #1 - Evo: generative AI for biology From scratch, Evo could: Design a functioning CRISPR-Cas enzyme (top right figure) Predict gene essentiality at genome-wide scale (bottom left figure) Generate genome-length DNA sequences, encoding a diverse set of proteins (though not quite able to support life! - bottom right figure) Study:

Biggest medical discoveries of the week (🧵) #1 - Evo: generative AI for biology From scratch, Evo could: Design a functioning CRISPR-Cas enzyme (top right figure) Predict gene essentiality at genome-wide scale (bottom left figure) Generate genome-length DNA sequences, encoding a diverse set of proteins (though not quite able to support life! - bottom right figure) Study:

79,287 views

The 10 biggest medical research papers from this week (🧵) 1. A brain implant in a man with motor neuron disease (ALS), who could no longer speak, decoded his neural activity and allowed him to speak via a computer - in his own voice (Study:

The 10 biggest medical research papers from this week (🧵) 1. A brain implant in a man with motor neuron disease (ALS), who could no longer speak, decoded his neural activity and allowed him to speak via a computer - in his own voice (Study:

46,873 views

Top 5 advances in medicine this week (🧵) 1. The first-in-human use of stem cells to repair the heart The video shows how the engineered heart muscle contracts - in a dish This approach requires surgery and immunosuppression, and with only one patient so far, so it's not perfect: larger trials are underway!

Top 5 advances in medicine this week (🧵) 1. The first-in-human use of stem cells to repair the heart The video shows how the engineered heart muscle contracts - in a dish This approach requires surgery and immunosuppression, and with only one patient so far, so it's not perfect: larger trials are underway!

29,277 views

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If everybody had low LDL cholesterol (between 35-50 mg/dL) for their whole life, there may be no more heart attacks. Dr. Sek Kathiresan (Sek Kathiresan MD), CEO at Verve Therapeutics and head of obesity research at Eli Lilly, explains:

If everybody had low LDL cholesterol (between 35-50 mg/dL) for their whole life, there may be no more heart attacks. Dr. Sek Kathiresan (Sek Kathiresan MD), CEO at Verve Therapeutics and head of obesity research at Eli Lilly, explains:

288,047 views • 6 days ago

Age-related atrophy is a growing problem, but there are no biomarkers, no medicines, the trials aren't working and the data aren't good enough. Peter Crane started Entelo Bio to solve this, with a novel biobank and an obsessive focus on patients. 03:20 Origination of Entelo Bio 08:30 The focus on muscle, atrophy, and intrinsic capacity 13:48 Make something patients want 17:00 Drugs need to be safe, selective, and simple 19:10 Entelo's biobank, platform and the focus on function 24:13 The musculoskeletal system is >40% of bodyweight and <1% of data 25:35 Figuring out the heterogeneity of disease 28:30 Bimagrumab 30:50 GLP1s 36:13 Peptides, BPC-157 and the ne1study 41:38 The diseases that piss people off 43:50 Surrogate endpoints for long-term trials 47:15 High-quality bio data in the AI era 54:54 Automated labs 1:01:54 Exciting future companies and ideas

Age-related atrophy is a growing problem, but there are no biomarkers, no medicines, the trials aren't working and the data aren't good enough. Peter Crane started Entelo Bio to solve this, with a novel biobank and an obsessive focus on patients. 03:20 Origination of Entelo Bio 08:30 The focus on muscle, atrophy, and intrinsic capacity 13:48 Make something patients want 17:00 Drugs need to be safe, selective, and simple 19:10 Entelo's biobank, platform and the focus on function 24:13 The musculoskeletal system is >40% of bodyweight and <1% of data 25:35 Figuring out the heterogeneity of disease 28:30 Bimagrumab 30:50 GLP1s 36:13 Peptides, BPC-157 and the ne1study 41:38 The diseases that piss people off 43:50 Surrogate endpoints for long-term trials 47:15 High-quality bio data in the AI era 54:54 Automated labs 1:01:54 Exciting future companies and ideas

13,100 views • 28 days ago

Biggest medical discoveries of the week (🧵) 1/10 A complete map of the fruit fly brain - the biggest and most detailed to date 140,000 neurons, which connect through 55 million synapses to permit vision, movement, and memory formation (

Biggest medical discoveries of the week (🧵) 1/10 A complete map of the fruit fly brain - the biggest and most detailed to date 140,000 neurons, which connect through 55 million synapses to permit vision, movement, and memory formation (

135,481 views • 1 year ago

Top 5 advances in medicine this week (🧵) 𝟏. 𝟖 𝐡𝐞𝐚𝐥𝐭𝐡𝐲 𝐛𝐢𝐫𝐭𝐡𝐬 𝐟𝐫𝐨𝐦 𝐦𝐢𝐭𝐨𝐜𝐡𝐨𝐧𝐝𝐫𝐢𝐚𝐥 𝐝𝐨𝐧𝐚𝐭𝐢𝐨𝐧⁣ Women with mitochondrial disease can pass the condition to their children – because mitochondria, and the DNA it carries, are exclusively passed from mothers to children This technique uses mitochondrial 𝘥𝘰𝘯𝘢𝘵𝘪𝘰𝘯, where 𝘯𝘶𝘤𝘭𝘦𝘢𝘳 DNA comes from parents but 𝘮𝘪𝘵𝘰𝘤𝘩𝘰𝘯𝘥𝘳𝘪𝘢𝘭 DNA comes from a healthy donor All 8 babies are developing normally, and all have healthy (or mostly healthy) mitochondria – the oldest is just over 2! Source:

Top 5 advances in medicine this week (🧵) 𝟏. 𝟖 𝐡𝐞𝐚𝐥𝐭𝐡𝐲 𝐛𝐢𝐫𝐭𝐡𝐬 𝐟𝐫𝐨𝐦 𝐦𝐢𝐭𝐨𝐜𝐡𝐨𝐧𝐝𝐫𝐢𝐚𝐥 𝐝𝐨𝐧𝐚𝐭𝐢𝐨𝐧⁣ Women with mitochondrial disease can pass the condition to their children – because mitochondria, and the DNA it carries, are exclusively passed from mothers to children This technique uses mitochondrial 𝘥𝘰𝘯𝘢𝘵𝘪𝘰𝘯, where 𝘯𝘶𝘤𝘭𝘦𝘢𝘳 DNA comes from parents but 𝘮𝘪𝘵𝘰𝘤𝘩𝘰𝘯𝘥𝘳𝘪𝘢𝘭 DNA comes from a healthy donor All 8 babies are developing normally, and all have healthy (or mostly healthy) mitochondria – the oldest is just over 2! Source:

13,572 views • 1 year ago

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