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The New England Journal of Medicine is the world’s leading medical journal and website.

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Endoscopy in a 44-year-old man with a 4-year history of choking episodes while eating revealed luminal narrowing of the upper esophagus by a pulsating, cordlike structure (arrow) in the posterior wall of the esophagus. Full case details:

Endoscopy in a 44-year-old man with a 4-year history of choking episodes while eating revealed luminal narrowing of the upper esophagus by a pulsating, cordlike structure (arrow) in the posterior wall of the esophagus. Full case details:

1,137,103 views

A woman presented with a 2-year history of pain, swelling, and stiffness in the wrists and fingers. When the patient’s hands were clenched into fists or pressed against the table, the joint deformities largely resolved. Read the full case details:

A woman presented with a 2-year history of pain, swelling, and stiffness in the wrists and fingers. When the patient’s hands were clenched into fists or pressed against the table, the joint deformities largely resolved. Read the full case details:

38,679 views

A man presented with a 2-week history of progressive, intermittent dyspnea and a 2-year history of hoarseness. Expiratory wheezes were heard over the neck, and partial upper-airway obstruction was seen on imaging (shown in a video). Full clinical case:

A man presented with a 2-week history of progressive, intermittent dyspnea and a 2-year history of hoarseness. Expiratory wheezes were heard over the neck, and partial upper-airway obstruction was seen on imaging (shown in a video). Full clinical case:

161,517 views

A video shows engineered heart muscle made up of allogeneic induced pluripotent stem-cell–derived cardiomyocytes and stromal cells for cardiac remuscularization in patients with heart failure. Read the full BioVAT-HF study results to learn more:

A video shows engineered heart muscle made up of allogeneic induced pluripotent stem-cell–derived cardiomyocytes and stromal cells for cardiac remuscularization in patients with heart failure. Read the full BioVAT-HF study results to learn more:

18,070 views

A man with impaired speech from amyotrophic lateral sclerosis (ALS) uses the speech neuroprosthesis to say whatever he wants for the first time. View more videos showing speech neuroprosthesis in practice:

A man with impaired speech from amyotrophic lateral sclerosis (ALS) uses the speech neuroprosthesis to say whatever he wants for the first time. View more videos showing speech neuroprosthesis in practice:

25,206 views

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“We essentially are told to, by default, include age, sex and race into all of our models that accounts for the majority of population health differences.” Shazia Siddique, MD, MSHP, explains how the common belief that race is biological in nature is now being challenged on the grounds that race is instead socially constructed. Watch the full Perspective Roundtable:
0:50
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“We essentially are told to, by default, include age, sex and race into all of our models that accounts for the majority of population health differences.” Shazia Siddique, MD, MSHP, explains how the common belief that race is biological in nature is now being challenged on the grounds that race is instead socially constructed. Watch the full Perspective Roundtable:

NEJM

31,884 views • 4 days ago

“We've seen more than 20,000 black patients now getting retroactive time adjusted on the waiting list and thousands of other patients actually getting kidney transplants.” Shazia Siddique, MD, MSHP, discusses the positive impact of recent revisions in creating a race-neutral equation in eGFR (estimated glomerular filtration rate). Watch the full Perspective Roundtable:
1:08
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“We've seen more than 20,000 black patients now getting retroactive time adjusted on the waiting list and thousands of other patients actually getting kidney transplants.” Shazia Siddique, MD, MSHP, discusses the positive impact of recent revisions in creating a race-neutral equation in eGFR (estimated glomerular filtration rate). Watch the full Perspective Roundtable:

NEJM

16,812 views • 2 days ago

For patients with atrial fibrillation and an intermediate risk of stroke, guidelines suggest that oral anticoagulation should be considered, but is this the best approach? Our latest video in partnership with Dr. Glaucomflecken explains new research. Full trial results:
1:13
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For patients with atrial fibrillation and an intermediate risk of stroke, guidelines suggest that oral anticoagulation should be considered, but is this the best approach? Our latest video in partnership with Dr. Glaucomflecken explains new research. Full trial results:

NEJM

31,578 views • 11 days ago

A video shows a patient with progressive multiple sclerosis attempting to walk before and after treatment with JY231, an off-the-shelf lentiviral vector designed for the direct in vivo engineering of CD19-targeted CAR T cells. Learn more in the preliminary results of a phase 1 trial:
0:20
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A video shows a patient with progressive multiple sclerosis attempting to walk before and after treatment with JY231, an off-the-shelf lentiviral vector designed for the direct in vivo engineering of CD19-targeted CAR T cells. Learn more in the preliminary results of a phase 1 trial:

NEJM

113,580 views • 1 month ago

You speak rheumatology?? Our latest video in partnership with Dr. Glaucomflecken summarizes the REPLENISH trial that evaluated the efficacy and safety of secukinumab for the treatment of polymyalgia rheumatica. Read the full study for free: #rheumatology
1:16
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You speak rheumatology?? Our latest video in partnership with Dr. Glaucomflecken summarizes the REPLENISH trial that evaluated the efficacy and safety of secukinumab for the treatment of polymyalgia rheumatica. Read the full study for free: #rheumatology

NEJM

39,514 views • 25 days ago

In older adults without cardiovascular disease, treatment with atorvastatin led to a lower risk of major cardiovascular events than placebo at a median of 5.9 years but did not result in longer disability-free survival. Full STAREE trial results and Research Summary: #ESCCongress
1:25
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In older adults without cardiovascular disease, treatment with atorvastatin led to a lower risk of major cardiovascular events than placebo at a median of 5.9 years but did not result in longer disability-free survival. Full STAREE trial results and Research Summary: #ESCCongress

NEJM

34,235 views • 27 days ago

As the director of an internal medicine residency program, would you recommend a 2-year “fast-track” option for residents or maintain the current 3-year program? Read more and cast your vote:
0:59
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As the director of an internal medicine residency program, would you recommend a 2-year “fast-track” option for residents or maintain the current 3-year program? Read more and cast your vote:

NEJM

84,605 views • 2 months ago

A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart. Full case details:
0:25
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A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart. Full case details:

NEJM

91,175 views • 3 months ago

A baby girl was noted to have severe swelling and discoloration of the left arm immediately after birth by cesarean section at 38 weeks’ gestation. Prenatal ultrasonography at 28 weeks had shown soft-tissue swelling of the left arm of undetermined cause. Examination showed swelling, cyanosis, and limited movement of the left arm, shoulder, and chest. Two areas of constriction were present at the wrist and proximal forearm, although brachial and radial pulses remained detectable by Doppler ultrasonography. MRI showed two fibrous bands extending through the deep fascia. What is the most likely diagnosis? Submit your answer and see how others responded:
0:53
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A baby girl was noted to have severe swelling and discoloration of the left arm immediately after birth by cesarean section at 38 weeks’ gestation. Prenatal ultrasonography at 28 weeks had shown soft-tissue swelling of the left arm of undetermined cause. Examination showed swelling, cyanosis, and limited movement of the left arm, shoulder, and chest. Two areas of constriction were present at the wrist and proximal forearm, although brachial and radial pulses remained detectable by Doppler ultrasonography. MRI showed two fibrous bands extending through the deep fascia. What is the most likely diagnosis? Submit your answer and see how others responded:

NEJM

37,788 views • 1 month ago

Our latest video in partnership with Dr. Glaucomflecken summarizes the ALLEGORY trial that evaluated the efficacy and safety of obinutuzumab when added to standard therapy in adults with active systemic lupus erythematosus. Read the full study for free: #rheumatology
1:20
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Our latest video in partnership with Dr. Glaucomflecken summarizes the ALLEGORY trial that evaluated the efficacy and safety of obinutuzumab when added to standard therapy in adults with active systemic lupus erythematosus. Read the full study for free: #rheumatology

NEJM

33,667 views • 1 month ago

What is the best oxygenation strategy for patients with acute hypoxemic respiratory failure? NEJM Editorial Fellow Katerina Lin, MD, shares the key results of a trial comparing high-flow to standard oxygen in respiratory failure. Read the full study at
1:22
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What is the best oxygenation strategy for patients with acute hypoxemic respiratory failure? NEJM Editorial Fellow Katerina Lin, MD, shares the key results of a trial comparing high-flow to standard oxygen in respiratory failure. Read the full study at

NEJM

36,483 views • 1 month ago

A video shows a patient with Dravet syndrome performing activities of daily living before and after treatment with zorevunersen. Watch the full video and read the full report:
0:42
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A video shows a patient with Dravet syndrome performing activities of daily living before and after treatment with zorevunersen. Watch the full video and read the full report:

NEJM

155,737 views • 7 months ago

A 71-year-old man was found to have a tapeworm (shown in a video) in his peritoneal cavity during elective repair of a right inguinal hernia. He recalled having consumed raw snake meat during his military service 50 years earlier. Read the full case presentation:
0:33

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A 71-year-old man was found to have a tapeworm (shown in a video) in his peritoneal cavity during elective repair of a right inguinal hernia. He recalled having consumed raw snake meat during his military service 50 years earlier. Read the full case presentation:

NEJM

77,147 views • 3 months ago

Our latest video in our partnership with Dr. Glaucomflecken summarizes the final analysis of 23 years of follow-up to evaluate the long-term effects of PSA screening. Read the full analysis for free:
1:16
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Our latest video in our partnership with Dr. Glaucomflecken summarizes the final analysis of 23 years of follow-up to evaluate the long-term effects of PSA screening. Read the full analysis for free:

NEJM

185,751 views • 10 months ago

New in our partnership with Dr. Glaucomflecken: the KEYNOTE-905 trial evaluated enfortumab vedotin plus pembrolizumab as perioperative therapy in patients with muscle-invasive bladder cancer who were ineligible to receive cisplatin. Read the full study for free:
1:05
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New in our partnership with Dr. Glaucomflecken: the KEYNOTE-905 trial evaluated enfortumab vedotin plus pembrolizumab as perioperative therapy in patients with muscle-invasive bladder cancer who were ineligible to receive cisplatin. Read the full study for free:

NEJM

104,754 views • 5 months ago

You’re a primary care physician discussing options for colorectal cancer screening with 46-year-old man in the average-risk category. Would you recommend a colonoscopy or a stool-based test? Read the case vignette and treatment options and vote:
1:27
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You’re a primary care physician discussing options for colorectal cancer screening with 46-year-old man in the average-risk category. Would you recommend a colonoscopy or a stool-based test? Read the case vignette and treatment options and vote:

NEJM

30,023 views • 1 month ago

Do the mountains of the Grand Teton range resemble lungs? Our latest video in partnership with Dr. Glaucomflecken summarizes the TETON-2 trial that evaluated the efficacy and safety of inhaled treprostinil in patients with idiopathic pulmonary fibrosis. Read the full study for free: #pulmonology
1:05
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Do the mountains of the Grand Teton range resemble lungs? Our latest video in partnership with Dr. Glaucomflecken summarizes the TETON-2 trial that evaluated the efficacy and safety of inhaled treprostinil in patients with idiopathic pulmonary fibrosis. Read the full study for free: #pulmonology

NEJM

31,800 views • 1 month ago

A 54-year-old woman presented with a 4-month history of progressively worsening asthenia and falls and 5 days of dyspnea. On exam, there was also head drop and mild symmetric weakness of the proximal upper and lower limbs. The creatine kinase level was 373 U per liter (reference range, 24 to 173). Magnetic resonance imaging of the head and cervical spine was notable for fatty infiltration of the tongue and paravertebral muscles. What is the most likely disease category? Submit your answer and see how others responded:
0:36
NEJM's profile picture

A 54-year-old woman presented with a 4-month history of progressively worsening asthenia and falls and 5 days of dyspnea. On exam, there was also head drop and mild symmetric weakness of the proximal upper and lower limbs. The creatine kinase level was 373 U per liter (reference range, 24 to 173). Magnetic resonance imaging of the head and cervical spine was notable for fatty infiltration of the tongue and paravertebral muscles. What is the most likely disease category? Submit your answer and see how others responded:

NEJM

28,235 views • 1 month ago

A new Video in Clinical Medicine demonstrates how to insert a catheter for emergency peritoneal dialysis in adults with a technique created specifically for environments that may have limited access to resources. Watch the full video:
0:47
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A new Video in Clinical Medicine demonstrates how to insert a catheter for emergency peritoneal dialysis in adults with a technique created specifically for environments that may have limited access to resources. Watch the full video:

NEJM

35,447 views • 2 months ago