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Endoscopy in a 44-year-old man with a 4-year history of choking episodes while eating revealed luminal narrowing of the upper esophagus by a pulsating, cordlike structure (arrow) in the posterior wall of the esophagus. Full case details:

Endoscopy in a 44-year-old man with a 4-year history of choking episodes while eating revealed luminal narrowing of the upper esophagus by a pulsating, cordlike structure (arrow) in the posterior wall of the esophagus. Full case details:

648,256 views

A man presented with a 2-week history of progressive, intermittent dyspnea and a 2-year history of hoarseness. Expiratory wheezes were heard over the neck, and partial upper-airway obstruction was seen on imaging (shown in a video). Full clinical case:

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A man presented with a 2-week history of progressive, intermittent dyspnea and a 2-year history of hoarseness. Expiratory wheezes were heard over the neck, and partial upper-airway obstruction was seen on imaging (shown in a video). Full clinical case:

155,031 views

Videos show echocardiography in a woman who died of an acute febrile illness with severe myocardial dysfunction. A novel thogotovirus, named the Oz virus, was identified in the myocardial tissue. Read the full case details in the correspondence “Fulminant Viral Myocarditis Associated with Thogotovirus”:

Videos show echocardiography in a woman who died of an acute febrile illness with severe myocardial dysfunction. A novel thogotovirus, named the Oz virus, was identified in the myocardial tissue. Read the full case details in the correspondence “Fulminant Viral Myocarditis Associated with Thogotovirus”:

17,580 views

A man with impaired speech from amyotrophic lateral sclerosis (ALS) uses the speech neuroprosthesis to say whatever he wants for the first time. View more videos showing speech neuroprosthesis in practice:

A man with impaired speech from amyotrophic lateral sclerosis (ALS) uses the speech neuroprosthesis to say whatever he wants for the first time. View more videos showing speech neuroprosthesis in practice:

25,179 views

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New in our partnership with Dr. Glaucomflecken: the KEYNOTE-905 trial evaluated enfortumab vedotin plus pembrolizumab as perioperative therapy in patients with muscle-invasive bladder cancer who were ineligible to receive cisplatin. Read the full study for free:
1:05
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New in our partnership with Dr. Glaucomflecken: the KEYNOTE-905 trial evaluated enfortumab vedotin plus pembrolizumab as perioperative therapy in patients with muscle-invasive bladder cancer who were ineligible to receive cisplatin. Read the full study for free:

NEJM

101,808 views • 1 month ago

A video shows cardiac computed tomography in a patient with heart failure treated with stem-cell–derived biologic ventricular assist tissue. Read the full BioVAT-HF study results to learn more:
0:29
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A video shows cardiac computed tomography in a patient with heart failure treated with stem-cell–derived biologic ventricular assist tissue. Read the full BioVAT-HF study results to learn more:

NEJM

40,411 views • 14 days ago

Phil, this is the kind of question with no clear answers and dozens of opinions that internists dream of! Our latest video in our partnership with Dr. Glaucomflecken summarizes the Ez-PAVE trial that evaluated the appropriate LDL cholesterol target for secondary prevention in patients with atherosclerotic cardiovascular disease. Read the full study for free: #Cardiology
1:34
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Phil, this is the kind of question with no clear answers and dozens of opinions that internists dream of! Our latest video in our partnership with Dr. Glaucomflecken summarizes the Ez-PAVE trial that evaluated the appropriate LDL cholesterol target for secondary prevention in patients with atherosclerotic cardiovascular disease. Read the full study for free: #Cardiology

NEJM

47,013 views • 21 days ago

A video shows a patient with Dravet syndrome performing activities of daily living before and after treatment with zorevunersen. Watch the full video and read the full report:
0:42
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A video shows a patient with Dravet syndrome performing activities of daily living before and after treatment with zorevunersen. Watch the full video and read the full report:

NEJM

155,128 views • 3 months ago

A 70-year-old man undergoing cholangioscopy to evaluate dilatation of the common bile duct was found to have flatworms in his biliary tract (shown in a video). Read the full clinical case:
0:20

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A 70-year-old man undergoing cholangioscopy to evaluate dilatation of the common bile duct was found to have flatworms in his biliary tract (shown in a video). Read the full clinical case:

NEJM

936,834 views • 2 years ago

Our latest video in our partnership with Dr. Glaucomflecken summarizes the final analysis of 23 years of follow-up to evaluate the long-term effects of PSA screening. Read the full analysis for free:
1:16
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Our latest video in our partnership with Dr. Glaucomflecken summarizes the final analysis of 23 years of follow-up to evaluate the long-term effects of PSA screening. Read the full analysis for free:

NEJM

185,143 views • 6 months ago

Low back pain has the highest global prevalence of all musculoskeletal conditions. A new Video in Clinical Medicine demonstrates how to perform a physical examination of the lumbar spine. Watch the full video and read the accompanying article:
0:30
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Low back pain has the highest global prevalence of all musculoskeletal conditions. A new Video in Clinical Medicine demonstrates how to perform a physical examination of the lumbar spine. Watch the full video and read the accompanying article:

NEJM

62,312 views • 2 months ago

Our latest video in our partnership with Dr. Glaucomflecken summarizes the POTCAST trial, which assessed a strategy of actively increasing plasma potassium levels to the high-normal range in patients at high risk for ventricular arrhythmias. Read the full study for free:
1:27
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Our latest video in our partnership with Dr. Glaucomflecken summarizes the POTCAST trial, which assessed a strategy of actively increasing plasma potassium levels to the high-normal range in patients at high risk for ventricular arrhythmias. Read the full study for free:

NEJM

89,732 views • 4 months ago

Our latest video in our partnership with Dr. Glaucomflecken summarizes the CORALreef Lipids trial, which assessed the efficacy of the oral PCSK9 inhibitor enlicitide in reducing LDL cholesterol levels over a 52-week period. Read the full study for free: #cardiology
1:18
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Our latest video in our partnership with Dr. Glaucomflecken summarizes the CORALreef Lipids trial, which assessed the efficacy of the oral PCSK9 inhibitor enlicitide in reducing LDL cholesterol levels over a 52-week period. Read the full study for free: #cardiology

NEJM

56,231 views • 2 months ago

Dr. Aaron Baugh, a Black pulmonologist in California, believed that using race-correction in lung-function tests was a way to reduce health inequities. That was until he ran the numbers himself. Shocked by the results, he began to study the harmful effects of race correction on Black patients with lung disease. Part two of 𝙏𝙝𝙚 𝙍𝙖𝙘𝙚 𝙀𝙦𝙪𝙖𝙩𝙞𝙤𝙣 uncovers the racist myths that led to today’s lung-function testing with Harvard historian of science Evelynn Hammonds and Brown professor Lundy Braun. Why is the race-corrected interpretation of spirometer test results still used by a majority of U.S. hospitals, when scientists have documented that the practice is harming patients? Explore this topic in the latest episode of the Intention to Treat podcast:
1:07
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Dr. Aaron Baugh, a Black pulmonologist in California, believed that using race-correction in lung-function tests was a way to reduce health inequities. That was until he ran the numbers himself. Shocked by the results, he began to study the harmful effects of race correction on Black patients with lung disease. Part two of 𝙏𝙝𝙚 𝙍𝙖𝙘𝙚 𝙀𝙦𝙪𝙖𝙩𝙞𝙤𝙣 uncovers the racist myths that led to today’s lung-function testing with Harvard historian of science Evelynn Hammonds and Brown professor Lundy Braun. Why is the race-corrected interpretation of spirometer test results still used by a majority of U.S. hospitals, when scientists have documented that the practice is harming patients? Explore this topic in the latest episode of the Intention to Treat podcast:

NEJM

27,106 views • 1 month ago

Our latest video in our partnership with Dr. Glaucomflecken summarizes a trial assessing the efficacy and safety of intravenous tenecteplase for acute central retinal artery occlusion. Read the full study for free:
1:17
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Our latest video in our partnership with Dr. Glaucomflecken summarizes a trial assessing the efficacy and safety of intravenous tenecteplase for acute central retinal artery occlusion. Read the full study for free:

NEJM

33,682 views • 1 month ago

For patients with generalized myasthenia gravis, existing treatments reduce mortality and alleviate symptoms, but side effects and poor efficacy leave many patients seeking alternatives. The latest video in our partnership with Dr. Glaucomflecken summarizes the MINT trial. 👉
1:40
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For patients with generalized myasthenia gravis, existing treatments reduce mortality and alleviate symptoms, but side effects and poor efficacy leave many patients seeking alternatives. The latest video in our partnership with Dr. Glaucomflecken summarizes the MINT trial. 👉

NEJM

137,306 views • 9 months ago

Our latest video in our partnership with Dr. Glaucomflecken summarizes a trial evaluating the clinical efficacy of tecovirimat against human clade II mpox. Read the full study for free:
1:23
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Our latest video in our partnership with Dr. Glaucomflecken summarizes a trial evaluating the clinical efficacy of tecovirimat against human clade II mpox. Read the full study for free:

NEJM

37,322 views • 2 months ago

A 72-year-old woman presented to the dermatology clinic with a 3.5-month history of an enlarging, painless lump on her left cheek. A punch biopsy showed dermal infiltration by small, round, blue cells arranged in nests, with scant cytoplasm and frequent mitoses. Immunohistochemical testing for perinuclear CK20 and synaptophysin was positive. What is the most likely diagnosis?
0:30
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A 72-year-old woman presented to the dermatology clinic with a 3.5-month history of an enlarging, painless lump on her left cheek. A punch biopsy showed dermal infiltration by small, round, blue cells arranged in nests, with scant cytoplasm and frequent mitoses. Immunohistochemical testing for perinuclear CK20 and synaptophysin was positive. What is the most likely diagnosis?

NEJM

90,104 views • 6 months ago

In the latest video in our partnership with Dr. Glaucomflecken, the REGENCY trial investigating the efficacy and safety of obinutuzumab when added to standard therapy in patients with active proliferative lupus nephritis is explained. Access the article for free:
1:46
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In the latest video in our partnership with Dr. Glaucomflecken, the REGENCY trial investigating the efficacy and safety of obinutuzumab when added to standard therapy in patients with active proliferative lupus nephritis is explained. Access the article for free:

NEJM

144,730 views • 11 months ago

Dr. Sanjiv Shah explains the H2FPEF score used to support clinical decision making. Watch “HFpEF Explained — Prevalence, New Advances, and How to Diagnose,” a new Double Take video, now available on our YouTube channel.
0:59
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Dr. Sanjiv Shah explains the H2FPEF score used to support clinical decision making. Watch “HFpEF Explained — Prevalence, New Advances, and How to Diagnose,” a new Double Take video, now available on our YouTube channel.

NEJM

25,761 views • 1 month ago

In the latest video in our partnership with Dr. Glaucomflecken, the INSEMA trial investigating axillary surgery in breast cancer is explained. Access the article for free:
1:22
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In the latest video in our partnership with Dr. Glaucomflecken, the INSEMA trial investigating axillary surgery in breast cancer is explained. Access the article for free:

NEJM

130,538 views • 1 year ago

Our latest video in our partnership with Dr. Glaucomflecken summarizes the results of a trial investigating the effectiveness of shunt surgery for idiopathic normal-pressure hydrocephalus. Read the full results for free: #neurology
1:23
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Our latest video in our partnership with Dr. Glaucomflecken summarizes the results of a trial investigating the effectiveness of shunt surgery for idiopathic normal-pressure hydrocephalus. Read the full results for free: #neurology

NEJM

56,370 views • 4 months ago

Which is better? Lactated Ringer’s solution or normal saline? The latest video in our partnership with Dr. Glaucomflecken summarizes the FLUID trial. 👉
1:27
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Which is better? Lactated Ringer’s solution or normal saline? The latest video in our partnership with Dr. Glaucomflecken summarizes the FLUID trial. 👉

NEJM

87,299 views • 8 months ago

A video shows the administration of DB-OTO, an adeno-associated virus 1 gene therapy that delivers OTOF cDNA to treat congenital deafness. Watch the full video and read the accompanying article: #Otolaryngology
0:32
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A video shows the administration of DB-OTO, an adeno-associated virus 1 gene therapy that delivers OTOF cDNA to treat congenital deafness. Watch the full video and read the accompanying article: #Otolaryngology

NEJM

37,023 views • 3 months ago