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The New England Journal of Medicine is the world’s leading medical journal and website.

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Endoscopy in a 44-year-old man with a 4-year history of choking episodes while eating revealed luminal narrowing of the upper esophagus by a pulsating, cordlike structure (arrow) in the posterior wall of the esophagus. Full case details:

Endoscopy in a 44-year-old man with a 4-year history of choking episodes while eating revealed luminal narrowing of the upper esophagus by a pulsating, cordlike structure (arrow) in the posterior wall of the esophagus. Full case details:

650,914 views

A video shows engineered heart muscle made up of allogeneic induced pluripotent stem-cell–derived cardiomyocytes and stromal cells for cardiac remuscularization in patients with heart failure. Read the full BioVAT-HF study results to learn more:

A video shows engineered heart muscle made up of allogeneic induced pluripotent stem-cell–derived cardiomyocytes and stromal cells for cardiac remuscularization in patients with heart failure. Read the full BioVAT-HF study results to learn more:

18,016 views

Videos show echocardiography in a woman who died of an acute febrile illness with severe myocardial dysfunction. A novel thogotovirus, named the Oz virus, was identified in the myocardial tissue. Read the full case details in the correspondence “Fulminant Viral Myocarditis Associated with Thogotovirus”:

Videos show echocardiography in a woman who died of an acute febrile illness with severe myocardial dysfunction. A novel thogotovirus, named the Oz virus, was identified in the myocardial tissue. Read the full case details in the correspondence “Fulminant Viral Myocarditis Associated with Thogotovirus”:

17,580 views

A man with impaired speech from amyotrophic lateral sclerosis (ALS) uses the speech neuroprosthesis to say whatever he wants for the first time. View more videos showing speech neuroprosthesis in practice:

A man with impaired speech from amyotrophic lateral sclerosis (ALS) uses the speech neuroprosthesis to say whatever he wants for the first time. View more videos showing speech neuroprosthesis in practice:

25,201 views

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A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart. Full case details:
0:25
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A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart. Full case details:

NEJM

90,490 views • 12 days ago

NEJM Editorial Fellow Minali Nigam, MD, shares the key results of the ORIENTAL-MeVO trial, which investigated whether endovascular thrombectomy for acute ischemic stroke improves functional outcomes in patients with medium-vessel occlusion and moderate-to-severe deficits. Read the full trial results:
1:28
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NEJM Editorial Fellow Minali Nigam, MD, shares the key results of the ORIENTAL-MeVO trial, which investigated whether endovascular thrombectomy for acute ischemic stroke improves functional outcomes in patients with medium-vessel occlusion and moderate-to-severe deficits. Read the full trial results:

NEJM

16,994 views • 2 days ago

Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results and Research Summary:
1:16
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Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results and Research Summary:

NEJM

33,853 views • 6 days ago

A 71-year-old man was found to have a tapeworm (shown in a video) in his peritoneal cavity during elective repair of a right inguinal hernia. He recalled having consumed raw snake meat during his military service 50 years earlier. Read the full case presentation:
0:33

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A 71-year-old man was found to have a tapeworm (shown in a video) in his peritoneal cavity during elective repair of a right inguinal hernia. He recalled having consumed raw snake meat during his military service 50 years earlier. Read the full case presentation:

NEJM

77,042 views • 19 days ago

Yes! Journal club! Our latest video in partnership with Dr. Glaucomflecken summarizes the B-Well 1 and B-Well 2 trials investigating bepirovirsen therapy for chronic hepatitis B virus infection. Read the full study for free: #hepatology
1:13
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Yes! Journal club! Our latest video in partnership with Dr. Glaucomflecken summarizes the B-Well 1 and B-Well 2 trials investigating bepirovirsen therapy for chronic hepatitis B virus infection. Read the full study for free: #hepatology

NEJM

32,725 views • 11 days ago

A 35-year-old man with a history of moderate-to-severe plaque psoriasis presented to the dermatology clinic with new skin lesions. His psoriasis had been in remission for the past 18 months while on risankizumab. Two weeks before presentation, the patient had undergone his first ever session of wet cupping therapy to treat low back pain. During the treatment, clusters of small incisions had been made at different sites across his back, after which glass cups had been applied with negative pressure to draw out small amounts of blood. What is the most likely diagnosis? Submit your answer and see how others responded:
0:40
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A 35-year-old man with a history of moderate-to-severe plaque psoriasis presented to the dermatology clinic with new skin lesions. His psoriasis had been in remission for the past 18 months while on risankizumab. Two weeks before presentation, the patient had undergone his first ever session of wet cupping therapy to treat low back pain. During the treatment, clusters of small incisions had been made at different sites across his back, after which glass cups had been applied with negative pressure to draw out small amounts of blood. What is the most likely diagnosis? Submit your answer and see how others responded:

NEJM

28,531 views • 15 days ago

Dude, Phil, you can’t out-study Infectious Disease. Don’t even try. Our latest video in our partnership with Dr. Glaucomflecken summarizes the AZ-SWED trial that evaluated whether a 5-day course of azithromycin decreases the severity of illness in young children with wheezing. Read the full study for free: #pediatrics
1:17
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Dude, Phil, you can’t out-study Infectious Disease. Don’t even try. Our latest video in our partnership with Dr. Glaucomflecken summarizes the AZ-SWED trial that evaluated whether a 5-day course of azithromycin decreases the severity of illness in young children with wheezing. Read the full study for free: #pediatrics

NEJM

41,873 views • 25 days ago

New in our partnership with Dr. Glaucomflecken: the KEYNOTE-905 trial evaluated enfortumab vedotin plus pembrolizumab as perioperative therapy in patients with muscle-invasive bladder cancer who were ineligible to receive cisplatin. Read the full study for free:
1:05
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New in our partnership with Dr. Glaucomflecken: the KEYNOTE-905 trial evaluated enfortumab vedotin plus pembrolizumab as perioperative therapy in patients with muscle-invasive bladder cancer who were ineligible to receive cisplatin. Read the full study for free:

NEJM

103,911 views • 2 months ago

A video shows a patient with Dravet syndrome performing activities of daily living before and after treatment with zorevunersen. Watch the full video and read the full report:
0:42
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A video shows a patient with Dravet syndrome performing activities of daily living before and after treatment with zorevunersen. Watch the full video and read the full report:

NEJM

155,245 views • 4 months ago

Our latest video in our partnership with Dr. Glaucomflecken summarizes the final analysis of 23 years of follow-up to evaluate the long-term effects of PSA screening. Read the full analysis for free:
1:16
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Our latest video in our partnership with Dr. Glaucomflecken summarizes the final analysis of 23 years of follow-up to evaluate the long-term effects of PSA screening. Read the full analysis for free:

NEJM

185,502 views • 7 months ago

Among participants 4 to 66 years of age with acquired hypothalamic obesity, setmelanotide, a melanocortin-4 receptor agonist, led to significantly greater reductions in body-mass index and hunger than placebo at 52 weeks. Read the full TRANSCEND trial results:
1:23
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Among participants 4 to 66 years of age with acquired hypothalamic obesity, setmelanotide, a melanocortin-4 receptor agonist, led to significantly greater reductions in body-mass index and hunger than placebo at 52 weeks. Read the full TRANSCEND trial results:

NEJM

17,950 views • 20 days ago

Phil, this is the kind of question with no clear answers and dozens of opinions that internists dream of! Our latest video in our partnership with Dr. Glaucomflecken summarizes the Ez-PAVE trial that evaluated the appropriate LDL cholesterol target for secondary prevention in patients with atherosclerotic cardiovascular disease. Read the full study for free: #Cardiology
1:34
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Phil, this is the kind of question with no clear answers and dozens of opinions that internists dream of! Our latest video in our partnership with Dr. Glaucomflecken summarizes the Ez-PAVE trial that evaluated the appropriate LDL cholesterol target for secondary prevention in patients with atherosclerotic cardiovascular disease. Read the full study for free: #Cardiology

NEJM

49,527 views • 2 months ago

A video shows cardiac computed tomography in a patient with heart failure treated with stem-cell–derived biologic ventricular assist tissue. Read the full BioVAT-HF study results to learn more:
0:29
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A video shows cardiac computed tomography in a patient with heart failure treated with stem-cell–derived biologic ventricular assist tissue. Read the full BioVAT-HF study results to learn more:

NEJM

40,524 views • 2 months ago

GLP-1s and Pancreatitis: New Data NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), shares some key results of a recent analysis of a VA database on the relation between GLP-1s and pancreatitis. Read more from Dr. David Weisman: Visit to discover what else matters this week, including: ❤️ Cardiovascular Chest Pain in Women — Differences to Keep in Mind 🧠 Updated Guidelines for Managing Migraine in the ED 🔬 Long-Term Follow-up of Colon Cancer Screening Trials 🩺 Balanced Fluids or Normal Saline for Pediatric Septic Shock
1:45
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GLP-1s and Pancreatitis: New Data NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), shares some key results of a recent analysis of a VA database on the relation between GLP-1s and pancreatitis. Read more from Dr. David Weisman: Visit to discover what else matters this week, including: ❤️ Cardiovascular Chest Pain in Women — Differences to Keep in Mind 🧠 Updated Guidelines for Managing Migraine in the ED 🔬 Long-Term Follow-up of Colon Cancer Screening Trials 🩺 Balanced Fluids or Normal Saline for Pediatric Septic Shock

NEJM

27,086 views • 1 month ago

Our latest video in our partnership with Dr. Glaucomflecken summarizes the POTCAST trial, which assessed a strategy of actively increasing plasma potassium levels to the high-normal range in patients at high risk for ventricular arrhythmias. Read the full study for free:
1:27
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Our latest video in our partnership with Dr. Glaucomflecken summarizes the POTCAST trial, which assessed a strategy of actively increasing plasma potassium levels to the high-normal range in patients at high risk for ventricular arrhythmias. Read the full study for free:

NEJM

89,790 views • 5 months ago

Low back pain has the highest global prevalence of all musculoskeletal conditions. A new Video in Clinical Medicine demonstrates how to perform a physical examination of the lumbar spine. Watch the full video and read the accompanying article:
0:30
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Low back pain has the highest global prevalence of all musculoskeletal conditions. A new Video in Clinical Medicine demonstrates how to perform a physical examination of the lumbar spine. Watch the full video and read the accompanying article:

NEJM

62,465 views • 3 months ago

In patients with resected clear-cell renal-cell carcinoma, pembrolizumab plus belzutifan led to higher disease-free survival than pembrolizumab alone but with an increased risk of grade 3 or higher adverse events. Full phase 3 LITESPARK-022 trial results and Research Summary:
1:14
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In patients with resected clear-cell renal-cell carcinoma, pembrolizumab plus belzutifan led to higher disease-free survival than pembrolizumab alone but with an increased risk of grade 3 or higher adverse events. Full phase 3 LITESPARK-022 trial results and Research Summary:

NEJM

12,637 views • 18 days ago

For patients with generalized myasthenia gravis, existing treatments reduce mortality and alleviate symptoms, but side effects and poor efficacy leave many patients seeking alternatives. The latest video in our partnership with Dr. Glaucomflecken summarizes the MINT trial. 👉
1:40
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For patients with generalized myasthenia gravis, existing treatments reduce mortality and alleviate symptoms, but side effects and poor efficacy leave many patients seeking alternatives. The latest video in our partnership with Dr. Glaucomflecken summarizes the MINT trial. 👉

NEJM

137,398 views • 10 months ago

Would you choose surgery or antibiotics for acute appendicitis in a young patient? Share your reasoning in the comments and help form community opinion by casting your vote at
1:11
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Would you choose surgery or antibiotics for acute appendicitis in a young patient? Share your reasoning in the comments and help form community opinion by casting your vote at

NEJM

17,386 views • 28 days ago