NEJM

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The New England Journal of Medicine is the world’s leading medical journal and website.

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Endoscopy in a 44-year-old man with a 4-year history of choking episodes while eating revealed luminal narrowing of the upper esophagus by a pulsating, cordlike structure (arrow) in the posterior wall of the esophagus. Full case details:

Endoscopy in a 44-year-old man with a 4-year history of choking episodes while eating revealed luminal narrowing of the upper esophagus by a pulsating, cordlike structure (arrow) in the posterior wall of the esophagus. Full case details:

650,914 просмотров

A video shows engineered heart muscle made up of allogeneic induced pluripotent stem-cell–derived cardiomyocytes and stromal cells for cardiac remuscularization in patients with heart failure. Read the full BioVAT-HF study results to learn more:

A video shows engineered heart muscle made up of allogeneic induced pluripotent stem-cell–derived cardiomyocytes and stromal cells for cardiac remuscularization in patients with heart failure. Read the full BioVAT-HF study results to learn more:

18,016 просмотров

Videos show echocardiography in a woman who died of an acute febrile illness with severe myocardial dysfunction. A novel thogotovirus, named the Oz virus, was identified in the myocardial tissue. Read the full case details in the correspondence “Fulminant Viral Myocarditis Associated with Thogotovirus”:

Videos show echocardiography in a woman who died of an acute febrile illness with severe myocardial dysfunction. A novel thogotovirus, named the Oz virus, was identified in the myocardial tissue. Read the full case details in the correspondence “Fulminant Viral Myocarditis Associated with Thogotovirus”:

17,580 просмотров

A man with impaired speech from amyotrophic lateral sclerosis (ALS) uses the speech neuroprosthesis to say whatever he wants for the first time. View more videos showing speech neuroprosthesis in practice:

A man with impaired speech from amyotrophic lateral sclerosis (ALS) uses the speech neuroprosthesis to say whatever he wants for the first time. View more videos showing speech neuroprosthesis in practice:

25,201 просмотров

Videos

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A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart. Full case details:

A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart. Full case details:

90,490 просмотров • 12 дней назад

NEJM Editorial Fellow Minali Nigam, MD, shares the key results of the ORIENTAL-MeVO trial, which investigated whether endovascular thrombectomy for acute ischemic stroke improves functional outcomes in patients with medium-vessel occlusion and moderate-to-severe deficits. Read the full trial results:

NEJM Editorial Fellow Minali Nigam, MD, shares the key results of the ORIENTAL-MeVO trial, which investigated whether endovascular thrombectomy for acute ischemic stroke improves functional outcomes in patients with medium-vessel occlusion and moderate-to-severe deficits. Read the full trial results:

16,994 просмотров • 2 дней назад

Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results and Research Summary:

Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results and Research Summary:

33,853 просмотров • 6 дней назад

A 71-year-old man was found to have a tapeworm (shown in a video) in his peritoneal cavity during elective repair of a right inguinal hernia. He recalled having consumed raw snake meat during his military service 50 years earlier. Read the full case presentation:

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A 71-year-old man was found to have a tapeworm (shown in a video) in his peritoneal cavity during elective repair of a right inguinal hernia. He recalled having consumed raw snake meat during his military service 50 years earlier. Read the full case presentation:

77,042 просмотров • 19 дней назад

Yes! Journal club! Our latest video in partnership with Dr. Glaucomflecken summarizes the B-Well 1 and B-Well 2 trials investigating bepirovirsen therapy for chronic hepatitis B virus infection. Read the full study for free: #hepatology

Yes! Journal club! Our latest video in partnership with Dr. Glaucomflecken summarizes the B-Well 1 and B-Well 2 trials investigating bepirovirsen therapy for chronic hepatitis B virus infection. Read the full study for free: #hepatology

32,725 просмотров • 11 дней назад

A 35-year-old man with a history of moderate-to-severe plaque psoriasis presented to the dermatology clinic with new skin lesions. His psoriasis had been in remission for the past 18 months while on risankizumab. Two weeks before presentation, the patient had undergone his first ever session of wet cupping therapy to treat low back pain. During the treatment, clusters of small incisions had been made at different sites across his back, after which glass cups had been applied with negative pressure to draw out small amounts of blood. What is the most likely diagnosis? Submit your answer and see how others responded:

A 35-year-old man with a history of moderate-to-severe plaque psoriasis presented to the dermatology clinic with new skin lesions. His psoriasis had been in remission for the past 18 months while on risankizumab. Two weeks before presentation, the patient had undergone his first ever session of wet cupping therapy to treat low back pain. During the treatment, clusters of small incisions had been made at different sites across his back, after which glass cups had been applied with negative pressure to draw out small amounts of blood. What is the most likely diagnosis? Submit your answer and see how others responded:

28,531 просмотров • 15 дней назад

Dude, Phil, you can’t out-study Infectious Disease. Don’t even try. Our latest video in our partnership with Dr. Glaucomflecken summarizes the AZ-SWED trial that evaluated whether a 5-day course of azithromycin decreases the severity of illness in young children with wheezing. Read the full study for free: #pediatrics

Dude, Phil, you can’t out-study Infectious Disease. Don’t even try. Our latest video in our partnership with Dr. Glaucomflecken summarizes the AZ-SWED trial that evaluated whether a 5-day course of azithromycin decreases the severity of illness in young children with wheezing. Read the full study for free: #pediatrics

41,873 просмотров • 25 дней назад

New in our partnership with Dr. Glaucomflecken: the KEYNOTE-905 trial evaluated enfortumab vedotin plus pembrolizumab as perioperative therapy in patients with muscle-invasive bladder cancer who were ineligible to receive cisplatin. Read the full study for free:

New in our partnership with Dr. Glaucomflecken: the KEYNOTE-905 trial evaluated enfortumab vedotin plus pembrolizumab as perioperative therapy in patients with muscle-invasive bladder cancer who were ineligible to receive cisplatin. Read the full study for free:

103,911 просмотров • 2 месяцев назад

A video shows a patient with Dravet syndrome performing activities of daily living before and after treatment with zorevunersen. Watch the full video and read the full report:

A video shows a patient with Dravet syndrome performing activities of daily living before and after treatment with zorevunersen. Watch the full video and read the full report:

155,245 просмотров • 4 месяцев назад

Our latest video in our partnership with Dr. Glaucomflecken summarizes the final analysis of 23 years of follow-up to evaluate the long-term effects of PSA screening. Read the full analysis for free:

Our latest video in our partnership with Dr. Glaucomflecken summarizes the final analysis of 23 years of follow-up to evaluate the long-term effects of PSA screening. Read the full analysis for free:

185,502 просмотров • 7 месяцев назад

Among participants 4 to 66 years of age with acquired hypothalamic obesity, setmelanotide, a melanocortin-4 receptor agonist, led to significantly greater reductions in body-mass index and hunger than placebo at 52 weeks. Read the full TRANSCEND trial results:

Among participants 4 to 66 years of age with acquired hypothalamic obesity, setmelanotide, a melanocortin-4 receptor agonist, led to significantly greater reductions in body-mass index and hunger than placebo at 52 weeks. Read the full TRANSCEND trial results:

17,950 просмотров • 20 дней назад

Phil, this is the kind of question with no clear answers and dozens of opinions that internists dream of! Our latest video in our partnership with Dr. Glaucomflecken summarizes the Ez-PAVE trial that evaluated the appropriate LDL cholesterol target for secondary prevention in patients with atherosclerotic cardiovascular disease. Read the full study for free: #Cardiology

Phil, this is the kind of question with no clear answers and dozens of opinions that internists dream of! Our latest video in our partnership with Dr. Glaucomflecken summarizes the Ez-PAVE trial that evaluated the appropriate LDL cholesterol target for secondary prevention in patients with atherosclerotic cardiovascular disease. Read the full study for free: #Cardiology

49,527 просмотров • 2 месяцев назад

A video shows cardiac computed tomography in a patient with heart failure treated with stem-cell–derived biologic ventricular assist tissue. Read the full BioVAT-HF study results to learn more:

A video shows cardiac computed tomography in a patient with heart failure treated with stem-cell–derived biologic ventricular assist tissue. Read the full BioVAT-HF study results to learn more:

40,524 просмотров • 2 месяцев назад

GLP-1s and Pancreatitis: New Data NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), shares some key results of a recent analysis of a VA database on the relation between GLP-1s and pancreatitis. Read more from Dr. David Weisman: Visit to discover what else matters this week, including: ❤️ Cardiovascular Chest Pain in Women — Differences to Keep in Mind 🧠 Updated Guidelines for Managing Migraine in the ED 🔬 Long-Term Follow-up of Colon Cancer Screening Trials 🩺 Balanced Fluids or Normal Saline for Pediatric Septic Shock

GLP-1s and Pancreatitis: New Data NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD (Raja-Elie Abdulnour), shares some key results of a recent analysis of a VA database on the relation between GLP-1s and pancreatitis. Read more from Dr. David Weisman: Visit to discover what else matters this week, including: ❤️ Cardiovascular Chest Pain in Women — Differences to Keep in Mind 🧠 Updated Guidelines for Managing Migraine in the ED 🔬 Long-Term Follow-up of Colon Cancer Screening Trials 🩺 Balanced Fluids or Normal Saline for Pediatric Septic Shock

27,086 просмотров • 1 месяц назад

Our latest video in our partnership with Dr. Glaucomflecken summarizes the POTCAST trial, which assessed a strategy of actively increasing plasma potassium levels to the high-normal range in patients at high risk for ventricular arrhythmias. Read the full study for free:

Our latest video in our partnership with Dr. Glaucomflecken summarizes the POTCAST trial, which assessed a strategy of actively increasing plasma potassium levels to the high-normal range in patients at high risk for ventricular arrhythmias. Read the full study for free:

89,790 просмотров • 5 месяцев назад

Low back pain has the highest global prevalence of all musculoskeletal conditions. A new Video in Clinical Medicine demonstrates how to perform a physical examination of the lumbar spine. Watch the full video and read the accompanying article:

Low back pain has the highest global prevalence of all musculoskeletal conditions. A new Video in Clinical Medicine demonstrates how to perform a physical examination of the lumbar spine. Watch the full video and read the accompanying article:

62,465 просмотров • 3 месяцев назад

In patients with resected clear-cell renal-cell carcinoma, pembrolizumab plus belzutifan led to higher disease-free survival than pembrolizumab alone but with an increased risk of grade 3 or higher adverse events. Full phase 3 LITESPARK-022 trial results and Research Summary:

In patients with resected clear-cell renal-cell carcinoma, pembrolizumab plus belzutifan led to higher disease-free survival than pembrolizumab alone but with an increased risk of grade 3 or higher adverse events. Full phase 3 LITESPARK-022 trial results and Research Summary:

12,637 просмотров • 18 дней назад

For patients with generalized myasthenia gravis, existing treatments reduce mortality and alleviate symptoms, but side effects and poor efficacy leave many patients seeking alternatives. The latest video in our partnership with Dr. Glaucomflecken summarizes the MINT trial. 👉

For patients with generalized myasthenia gravis, existing treatments reduce mortality and alleviate symptoms, but side effects and poor efficacy leave many patients seeking alternatives. The latest video in our partnership with Dr. Glaucomflecken summarizes the MINT trial. 👉

137,398 просмотров • 10 месяцев назад

Would you choose surgery or antibiotics for acute appendicitis in a young patient? Share your reasoning in the comments and help form community opinion by casting your vote at

Would you choose surgery or antibiotics for acute appendicitis in a young patient? Share your reasoning in the comments and help form community opinion by casting your vote at

17,386 просмотров • 28 дней назад