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Andrew Aiginin

@andrewaiginin • 1,998 subscribers

AI-ginin. All in AI 🤖 Generative Biologics product manager at @InSilicoMeds. Whatever I post here reflects my personal opinion.

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Hey Kyle Tretina, Ph.D., will you add this fruit fly model as well? 🪰 Lightweight, just 166K parameters. Let’s benchmark it against AlphaFold 😅 Demis Hassabis

Hey Kyle Tretina, Ph.D., will you add this fruit fly model as well? 🪰 Lightweight, just 166K parameters. Let’s benchmark it against AlphaFold 😅 Demis Hassabis

71,855 views

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GPT-6 Astra is now the best-performing frontier model for antibody developability prediction in our benchmark. 🧬 Finding an antibody that binds is only the beginning. Will it aggregate? Will it stay stable? Can it actually behave like a drug? GPT-6 Astra predicts these developability properties better than the other frontier models we tested. 🤯 And yes, the interactive visualization showing how an antibody actually works was also built with Astra in about 1 hour. This model looks seriously powerful. Congrats gbt Sam Altman #insilicoSOTAFM

GPT-6 Astra is now the best-performing frontier model for antibody developability prediction in our benchmark. 🧬 Finding an antibody that binds is only the beginning. Will it aggregate? Will it stay stable? Can it actually behave like a drug? GPT-6 Astra predicts these developability properties better than the other frontier models we tested. 🤯 And yes, the interactive visualization showing how an antibody actually works was also built with Astra in about 1 hour. This model looks seriously powerful. Congrats gbt Sam Altman #insilicoSOTAFM

303,491 views • 4 days ago

Yesterday, I built a cell model. 🧬 Today, it showed me how Ozempic works. I asked it to explain the mechanism. 1 hour later... THIS. 🤯 GPT-6 Astra is insanely powerful. 🚀 I can’t stop Derya Unutmaz, MD Greg Brockman Now I’m wondering... can it model the rentosertib mechanism? 👀

Yesterday, I built a cell model. 🧬 Today, it showed me how Ozempic works. I asked it to explain the mechanism. 1 hour later... THIS. 🤯 GPT-6 Astra is insanely powerful. 🚀 I can’t stop Derya Unutmaz, MD Greg Brockman Now I’m wondering... can it model the rentosertib mechanism? 👀

531,760 views • 7 days ago

Built an insane model of the human cell in just 30 minutes 🤯 GPT-6 Astra is ridiculously powerful. Can’t wait to put it to the test on biological tasks. Rim Derya Unutmaz, MD take a look!

Built an insane model of the human cell in just 30 minutes 🤯 GPT-6 Astra is ridiculously powerful. Can’t wait to put it to the test on biological tasks. Rim Derya Unutmaz, MD take a look!

191,979 views • 8 days ago

Built an app to show how Rentosertib actually works. 🧬✨ It recently showed an anti-aging effect in clinical trials. 👀 GPT-6 Astra again. The crazy part: ~40 minutes to build, plus an MD simulation 🤯 derya dn Evgeny Kirilin, this really feels like a new level of structural analysis. Rentosertib inhibits TNIK, a kinase and one of the molecular switches controlling signaling inside our cells. ⚙️ Kinase activity is also exactly the kind of property Insilico Medicine’s models are built to predict. 🤖🔬 #insilicoSOTAFM

Built an app to show how Rentosertib actually works. 🧬✨ It recently showed an anti-aging effect in clinical trials. 👀 GPT-6 Astra again. The crazy part: ~40 minutes to build, plus an MD simulation 🤯 derya dn Evgeny Kirilin, this really feels like a new level of structural analysis. Rentosertib inhibits TNIK, a kinase and one of the molecular switches controlling signaling inside our cells. ⚙️ Kinase activity is also exactly the kind of property Insilico Medicine’s models are built to predict. 🤖🔬 #insilicoSOTAFM

56,599 views • 5 days ago

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