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GPT-6 Astra is now the best-performing frontier model for antibody developability prediction in our benchmark. 🧬 Finding an antibody that binds is only the beginning. Will it aggregate? Will it stay stable? Can it actually behave like a drug? GPT-6 Astra predicts these developability properties better than the other... show more

Andrew Aiginin

1,998 subscribers

303,491 次观看 • 4 天前 •via X (Twitter)

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10 条评论

Andrew Aiginin 的头像

Andrew Aiginin4 天前

We checked the Insilico Score in our DDD Benchmark. GPT-6 Astra scored 37.98, calculated as the mean performance across 6 antibody developability assays. 🧪 Great work on the new model, @thekaransinghal @joyjiao12 @maggie_hott 👏

Andrew Aiginin 的头像

Andrew Aiginin4 天前

I think both the benchmark results and the visualization could be interesting for you. The visual is a compilation of multiple PDB structures from the Protein Data Bank, showing different states of how antibodies interact with pathogens

Vladimir Aladinskiy 的头像

Vladimir Aladinskiy4 天前

Wow, another strong result by Astra on @thekaransinghal

Dmitrii Vasilev 的头像

Dmitrii Vasilev4 天前

Amazing results 💪🏻🚀

Vladimir Naumov 的头像

Vladimir Naumov4 天前

Thank you! Now 2d models from books are live and 3d 🙌

Andrew Aiginin 的头像

Andrew Aiginin4 天前

Yep

Petrina Kamya 的头像

Petrina Kamya4 天前

…for now! Watch this space -> Right? @andrewaiginin 🙂

Andrew Aiginin 的头像

Andrew Aiginin4 天前

Exactly!

BiotechObserver 的头像

BiotechObserver3 天前

That it was built in only 1 hour is something to brag about?

Dom 的头像

Dom4 天前

great work, where can I find more on the benchmark methodology?

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Yesterday, I built a cell model. 🧬 Today, it showed me how Ozempic works. I asked it to explain the mechanism. 1 hour later... THIS. 🤯 GPT-6 Astra is insanely powerful. 🚀 I can’t stop Derya Unutmaz, MD Greg Brockman Now I’m wondering... can it model the rentosertib mechanism? 👀

Yesterday, I built a cell model. 🧬 Today, it showed me how Ozempic works. I asked it to explain the mechanism. 1 hour later... THIS. 🤯 GPT-6 Astra is insanely powerful. 🚀 I can’t stop Derya Unutmaz, MD Greg Brockman Now I’m wondering... can it model the rentosertib mechanism? 👀

Andrew Aiginin

531,760 次观看 • 7 天前

This AI created an interactive 3D textbook !! 💀 I didn't manually create any of these 3d models I built it using: 👉 GPT-6 Astra 👉 Hyper3D Rodin's MCP Hyper3D worked on the 3D Models And GPT-6 Astra made the website with the 3D Models integrated to the UI controls. It even added floating labels for the HEART !! This is what happens when an AI can actually CREATE 3D assets 👇

This AI created an interactive 3D textbook !! 💀 I didn't manually create any of these 3d models I built it using: 👉 GPT-6 Astra 👉 Hyper3D Rodin's MCP Hyper3D worked on the 3D Models And GPT-6 Astra made the website with the 3D Models integrated to the UI controls. It even added floating labels for the HEART !! This is what happens when an AI can actually CREATE 3D assets 👇

SARAH

135,934 次观看 • 2 天前

Sam Altman on Bloomberg Television: GPT-6 Astra is not the model that was paused over cybersecurity concerns; the paused model is a future model. "Astra has been done training for a while. The model that we recently talked about pausing, uh, is a future model. But with Astra, we did hit cyber-critical." ---- From "Bloomberg Television" YouTube channel, (full video link in comment)

Sam Altman on Bloomberg Television: GPT-6 Astra is not the model that was paused over cybersecurity concerns; the paused model is a future model. "Astra has been done training for a while. The model that we recently talked about pausing, uh, is a future model. But with Astra, we did hit cyber-critical." ---- From "Bloomberg Television" YouTube channel, (full video link in comment)

Rohan Paul

517,947 次观看 • 10 天前

Built an insane model of the human cell in just 30 minutes 🤯 GPT-6 Astra is ridiculously powerful. Can’t wait to put it to the test on biological tasks. Rim Derya Unutmaz, MD take a look!

Built an insane model of the human cell in just 30 minutes 🤯 GPT-6 Astra is ridiculously powerful. Can’t wait to put it to the test on biological tasks. Rim Derya Unutmaz, MD take a look!

Andrew Aiginin

191,979 次观看 • 8 天前

If you’re an AI investor, this is a must watch interview of Sam Altman today talking about the release for GPT-6 Astra, which is perhaps the most powerful model up to date. Looks like we’ve achieved AGI folks… ARGI-AGI 3, from 7.8% to 98.6%…absolutely insane!!

If you’re an AI investor, this is a must watch interview of Sam Altman today talking about the release for GPT-6 Astra, which is perhaps the most powerful model up to date. Looks like we’ve achieved AGI folks… ARGI-AGI 3, from 7.8% to 98.6%…absolutely insane!!

Nicholas Mugalli

119,649 次观看 • 11 天前

🔥 img2threejs × GPT-6 Astra × Hyper3D Live showcase: This is probably one of the most commercially valuable workflows I’ve tested so far. Image → Hyper3D → img2threejs → GPT-6 Astra → Interactive Three.js experience. 1/ Hyper3D handles the 3D reconstruction. 2/ img2threejs turns that result into a structured workflow that an AI coding model can actually work with. 3/ And GPT-6 Astra follows the img2threejs pipeline - turning the reconstructed asset into a structured, editable, and interactive Three.js experience with animation, VFX, lighting, and application logic. The important part isn’t just generating a 3D model, It’s what happens after the model exists. Instead of ending with a static asset, you can continue building around it with code: → Games → Interactive product experiences → 3D websites → Character showcases → Virtual worlds → Rapid prototypes 3D generation becomes the beginning of the workflow - not the final output. And when you combine high-quality reconstruction with an AI model capable of understanding and building the surrounding experience, the path from image → 3D → usable product becomes dramatically shorter. This is exactly the direction I want to push img2threejs. More experiments with OpenAI GPT-6 Astra × Hyper3D by Deemos are coming this month. 👨‍🍳

🔥 img2threejs × GPT-6 Astra × Hyper3D Live showcase: This is probably one of the most commercially valuable workflows I’ve tested so far. Image → Hyper3D → img2threejs → GPT-6 Astra → Interactive Three.js experience. 1/ Hyper3D handles the 3D reconstruction. 2/ img2threejs turns that result into a structured workflow that an AI coding model can actually work with. 3/ And GPT-6 Astra follows the img2threejs pipeline - turning the reconstructed asset into a structured, editable, and interactive Three.js experience with animation, VFX, lighting, and application logic. The important part isn’t just generating a 3D model, It’s what happens after the model exists. Instead of ending with a static asset, you can continue building around it with code: → Games → Interactive product experiences → 3D websites → Character showcases → Virtual worlds → Rapid prototypes 3D generation becomes the beginning of the workflow - not the final output. And when you combine high-quality reconstruction with an AI model capable of understanding and building the surrounding experience, the path from image → 3D → usable product becomes dramatically shorter. This is exactly the direction I want to push img2threejs. More experiments with OpenAI GPT-6 Astra × Hyper3D by Deemos are coming this month. 👨‍🍳

Nick

11,542 次观看 • 7 天前

GPT-6 Astra lost to Kimi K3 in chess, LOL I built a chess game where they play against each other via API. Thought Astra would win easily since it’s the best model right now. But Kimi K3 played surprisingly well and beat it. Is Astra nerfed or what?

GPT-6 Astra lost to Kimi K3 in chess, LOL I built a chess game where they play against each other via API. Thought Astra would win easily since it’s the best model right now. But Kimi K3 played surprisingly well and beat it. Is Astra nerfed or what?

Bhavy☄️

30,409 次观看 • 5 天前

Built an app to show how Rentosertib actually works. 🧬✨ It recently showed an anti-aging effect in clinical trials. 👀 GPT-6 Astra again. The crazy part: ~40 minutes to build, plus an MD simulation 🤯 derya dn Evgeny Kirilin, this really feels like a new level of structural analysis. Rentosertib inhibits TNIK, a kinase and one of the molecular switches controlling signaling inside our cells. ⚙️ Kinase activity is also exactly the kind of property Insilico Medicine’s models are built to predict. 🤖🔬 #insilicoSOTAFM

Built an app to show how Rentosertib actually works. 🧬✨ It recently showed an anti-aging effect in clinical trials. 👀 GPT-6 Astra again. The crazy part: ~40 minutes to build, plus an MD simulation 🤯 derya dn Evgeny Kirilin, this really feels like a new level of structural analysis. Rentosertib inhibits TNIK, a kinase and one of the molecular switches controlling signaling inside our cells. ⚙️ Kinase activity is also exactly the kind of property Insilico Medicine’s models are built to predict. 🤖🔬 #insilicoSOTAFM

Andrew Aiginin

56,599 次观看 • 5 天前

We are officially in the AGI era🤯 I built this in 2 hours with GPT-6 Astra. > pointed Astra at an open anatomy dataset > Codex wrote the whole interface, all 206 bones > shipped it as a Claude Code Artifact Spin it, blow it apart, cut it in half, click any bone to read what it is. I know nothing about anatomy.

We are officially in the AGI era🤯 I built this in 2 hours with GPT-6 Astra. > pointed Astra at an open anatomy dataset > Codex wrote the whole interface, all 206 bones > shipped it as a Claude Code Artifact Spin it, blow it apart, cut it in half, click any bone to read what it is. I know nothing about anatomy.

Emm | scenario.com

24,606 次观看 • 4 天前

Sam Altman (CEO of Open AI): "You no longer need to write prompts, if you use GPT-6 Astra” In just 1 hour, he explains how to use GPT-6 Astra at a level that most people can't even imagine. After watching it, I realized I was only taking advantage of about 15% of what this tool can really do. Watch it and then read the guide l leave below on how to use it at it's fullest 👇🏼

Sam Altman (CEO of Open AI): "You no longer need to write prompts, if you use GPT-6 Astra” In just 1 hour, he explains how to use GPT-6 Astra at a level that most people can't even imagine. After watching it, I realized I was only taking advantage of about 15% of what this tool can really do. Watch it and then read the guide l leave below on how to use it at it's fullest 👇🏼

darkzodchi

801,127 次观看 • 8 天前

This AI video is a Masterpiece 🤯 Took an experiment further than planned: feeding one concept shot into GPT-6 Astra, generating the base geometry in Blender, and pushing the final render through Flova. Made it with FlovaAI

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William AI

605,997 次观看 • 4 天前

GPT-6 Astra could take the next step in medicine "A full interactive skeleton with all 206 bones got built in two hours" ∙ Astra was pointed at an open anatomy dataset ∙ Codex wrote the entire interface, bone by bone, all 206 of them ∙ It shipped as a Claude Code artifact, ready to open and use The model spins, breaks apart into an exploded view, splits in half, and lets anyone click a single bone to read exactly what it is. Nobody involved in building it had any background in anatomy. That's less a statement about anatomy and more about what two hours with the right tools can now produce.

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Zentrix⌚️

20,901 次观看 • 4 天前

Someone is building a game they dreamed of for 15 years using GPT-6 Astra and on day 10, five creature animations that used to take weeks at a 3D studio took an hour and a half, with the Scorpid running in Unity an hour after that. → Scorpid modeled in Tripo P2.0 with optimized mesh and well-organized parts for easier bone placement → Video references generated with SD 2.5 using the same workflow → About an hour and a half with GPT-6 Astra on xhigh for five animations including feedback rounds → Another hour to get it running in Unity

Someone is building a game they dreamed of for 15 years using GPT-6 Astra and on day 10, five creature animations that used to take weeks at a 3D studio took an hour and a half, with the Scorpid running in Unity an hour after that. → Scorpid modeled in Tripo P2.0 with optimized mesh and well-organized parts for easier bone placement → Video references generated with SD 2.5 using the same workflow → About an hour and a half with GPT-6 Astra on xhigh for five animations including feedback rounds → Another hour to get it running in Unity

0xMarioNawfal

38,719 次观看 • 2 天前

AI generated the poster. Turns out GPT-6 Astra + Dreamina Seedance 2.5 is an actual pipeline. AI also did the boring Photoshop work. I started by creating the visual in Dreamina, then asked GPT-6 Astra to take it into Photoshop and separate the different elements into individual layers. So instead of manually masking everything, I get an editable layered file to keep working on. Dreamina → Astra → Photoshop → editable design. Honestly, this is much closer to how I actually want AI to fit into my design workflow. #Dreamina #DreaminaPartner

AI generated the poster. Turns out GPT-6 Astra + Dreamina Seedance 2.5 is an actual pipeline. AI also did the boring Photoshop work. I started by creating the visual in Dreamina, then asked GPT-6 Astra to take it into Photoshop and separate the different elements into individual layers. So instead of manually masking everything, I get an editable layered file to keep working on. Dreamina → Astra → Photoshop → editable design. Honestly, this is much closer to how I actually want AI to fit into my design workflow. #Dreamina #DreaminaPartner

Leonardo

88,381 次观看 • 3 天前

Imagine having an idea for a space game… and actually being able to start building it . I wanted to test what an AI-powered game creation workflow could look like. MeshyAI helped create spacecraft models, and GPT 6 Astra helped bring those assets into an interactive space environment. The coolest part for me is seeing individual 3D models become part of something bigger. A ship is cool. A whole universe built around those ships is even cooler. #Astra #MeshyAI #GameDev #AI3D

Imagine having an idea for a space game… and actually being able to start building it . I wanted to test what an AI-powered game creation workflow could look like. MeshyAI helped create spacecraft models, and GPT 6 Astra helped bring those assets into an interactive space environment. The coolest part for me is seeing individual 3D models become part of something bigger. A ship is cool. A whole universe built around those ships is even cooler. #Astra #MeshyAI #GameDev #AI3D

Isabella

41,144 次观看 • 2 天前

36 GROK AGENTS. ASTRA ON FREE CREDITS. DUAL-MODEL ROUTING IS THE EDGE. not one chat window burning a paid invoice all day a swarm that routes cheap work to grok and only wakes gpt-6 astra when the task is actually hard ▹ the stack 36 agents on grok bot with flexible settings per role monitor, plan, write, code, QA, ship, each with its own lane part of the fleet is wired to gpt-6 astra through a china free-credit service layer free credits are not a toy promo here they are the fuel for frontier spikes without a monthly bleed ▹ dual-model routing easy jobs stay on grok: speed, volume, always-on loops hard jobs jump to astra: reasoning, long builds, sharp code the router decides by task type, not by ego if astra is not needed, astra does not spend free-credit bursts buy the expensive brain grok agents keep the factory running between bursts that is how the system feels unlimited not by breaking quotas, by refusing to waste them ▹ why it hits different most people pay frontier prices for every mid task operators split the brain and protect the credits 36 agents = parallel throughput dual routing = cost control with quality when it matters free credits = astra access without living on the invoice the constraint moved from "can i afford the model" to "did i route the job to the right model" ▹ the take single-model stacks die on bills and on boredom multi-agent + dual routing is the new default factory grok for the grind astra for the cut free credits for the spikes that used to empty the wallet bookmark this before everyone copies the route map comments: what % of your tasks actually deserve astra

36 GROK AGENTS. ASTRA ON FREE CREDITS. DUAL-MODEL ROUTING IS THE EDGE. not one chat window burning a paid invoice all day a swarm that routes cheap work to grok and only wakes gpt-6 astra when the task is actually hard ▹ the stack 36 agents on grok bot with flexible settings per role monitor, plan, write, code, QA, ship, each with its own lane part of the fleet is wired to gpt-6 astra through a china free-credit service layer free credits are not a toy promo here they are the fuel for frontier spikes without a monthly bleed ▹ dual-model routing easy jobs stay on grok: speed, volume, always-on loops hard jobs jump to astra: reasoning, long builds, sharp code the router decides by task type, not by ego if astra is not needed, astra does not spend free-credit bursts buy the expensive brain grok agents keep the factory running between bursts that is how the system feels unlimited not by breaking quotas, by refusing to waste them ▹ why it hits different most people pay frontier prices for every mid task operators split the brain and protect the credits 36 agents = parallel throughput dual routing = cost control with quality when it matters free credits = astra access without living on the invoice the constraint moved from "can i afford the model" to "did i route the job to the right model" ▹ the take single-model stacks die on bills and on boredom multi-agent + dual routing is the new default factory grok for the grind astra for the cut free credits for the spikes that used to empty the wallet bookmark this before everyone copies the route map comments: what % of your tasks actually deserve astra

cryptopsihoz

44,187 次观看 • 5 天前

GPT-6 Astra can already plan, code, and build. The more interesting question is what happens when it can call a dedicated 3D tool at the exact moment a project needs an asset. So we connected Hyper3D Rodin MCP and asked Astra to build an interactive Solar System Explorer. Astra handled the app logic and integration. When it needed 3D models, it called Hyper3D Rodin directly. Hyper3D Rodin generated the required assets, and Astra brought them back into the project and continued building from there. That is where the workflow gets useful. Instead of stopping to search for assets or creating them manually, Astra can keep moving while Hyper3D handles the specialized 3D generation, with more control over the output and assets that are easier to integrate into the final project. The result is a browser-based solar system where the generated 3D models are part of the actual experience, not just outputs sitting in a model viewer.

GPT-6 Astra can already plan, code, and build. The more interesting question is what happens when it can call a dedicated 3D tool at the exact moment a project needs an asset. So we connected Hyper3D Rodin MCP and asked Astra to build an interactive Solar System Explorer. Astra handled the app logic and integration. When it needed 3D models, it called Hyper3D Rodin directly. Hyper3D Rodin generated the required assets, and Astra brought them back into the project and continued building from there. That is where the workflow gets useful. Instead of stopping to search for assets or creating them manually, Astra can keep moving while Hyper3D handles the specialized 3D generation, with more control over the output and assets that are easier to integrate into the final project. The result is a browser-based solar system where the generated 3D models are part of the actual experience, not just outputs sitting in a model viewer.

GitHub Projects Community

11,097 次观看 • 4 天前

GPT-6 Astra is a beast. Give it a Zillow listing. It can 3D model the house based on the listing photos and create a cool promotion video. The video was just created in one shot and there are still some wrong details. But I am sure it will be much better if I ask it to polish further. OpenAI is so back.

GPT-6 Astra is a beast. Give it a Zillow listing. It can 3D model the house based on the listing photos and create a cool promotion video. The video was just created in one shot and there are still some wrong details. But I am sure it will be much better if I ask it to polish further. OpenAI is so back.

Yunfan Ye

2,036,729 次观看 • 11 天前

GPT-6 Astra recreated the Palace of Fine arts in Blender. This is favorite building in San Francisco because it was built for the World's Fair in 1914 where the steam locomotive and telephone were showed off. It was a time when technology gave us all a deep sense of optimism for the future. I feel like some of that sense has been lost since, but I hope models like astra can help restore it, and push us towards a more hopeful future.

GPT-6 Astra recreated the Palace of Fine arts in Blender. This is favorite building in San Francisco because it was built for the World's Fair in 1914 where the steam locomotive and telephone were showed off. It was a time when technology gave us all a deep sense of optimism for the future. I feel like some of that sense has been lost since, but I hope models like astra can help restore it, and push us towards a more hopeful future.

Sharif Shameem

2,602,540 次观看 • 10 天前

The interesting part isn't just generating a product. Turns out GPT-6 Astra + Dreamina Seedance 2.5 is an actual pipeline. It's going from a draft → real-looking product → product page in one continuous workflow. I started with a simple product concept in Dreamina. Then GPT-6 Astra interpreted the draft, built out the actual product, and used it to create the final product detail page. Dreamina's pricing also makes it practical to generate a bunch of early concepts instead of overthinking the first one. This workflow is definitely worth experimenting with. #Dreamina #DreaminaPartner

The interesting part isn't just generating a product. Turns out GPT-6 Astra + Dreamina Seedance 2.5 is an actual pipeline. It's going from a draft → real-looking product → product page in one continuous workflow. I started with a simple product concept in Dreamina. Then GPT-6 Astra interpreted the draft, built out the actual product, and used it to create the final product detail page. Dreamina's pricing also makes it practical to generate a bunch of early concepts instead of overthinking the first one. This workflow is definitely worth experimenting with. #Dreamina #DreaminaPartner

Md Riyazuddin

61,601 次观看 • 3 天前