Andrew Aiginin's banner

Andrew Aiginin

@andrewaiginin • 2,152 subscribers

AI-ginin. All in AI 🤖 Generative Biologics product manager at @InSilicoMeds. Whatever I post here reflects my personal opinion.

Shorts

Hey Kyle Tretina, Ph.D., will you add this fruit fly model as well? 🪰 Lightweight, just 166K parameters. Let’s benchmark it against AlphaFold 😅 Demis Hassabis

Hey Kyle Tretina, Ph.D., will you add this fruit fly model as well? 🪰 Lightweight, just 166K parameters. Let’s benchmark it against AlphaFold 😅 Demis Hassabis

76,140 views

Videos

Anya Rossi

sweetdream.ai

SweetDream.ai•Sponsored•Livecam

Watch Anya Live

Anya is streaming live right now! Join her private show and enjoy exclusive content.

Exclusive private shows

1.2k viewers online

Private Show

Join now for exclusive access

Free preview available • Premium content

Yesterday, I built a cell model. 🧬 Today, it showed me how Ozempic works. I asked it to explain the mechanism. 1 hour later... THIS. 🤯 GPT-6 Astra is insanely powerful. 🚀 I can’t stop Derya Unutmaz, MD Greg Brockman Now I’m wondering... can it model the rentosertib mechanism? 👀

Yesterday, I built a cell model. 🧬 Today, it showed me how Ozempic works. I asked it to explain the mechanism. 1 hour later... THIS. 🤯 GPT-6 Astra is insanely powerful. 🚀 I can’t stop Derya Unutmaz, MD Greg Brockman Now I’m wondering... can it model the rentosertib mechanism? 👀

534,832 views • 1 month ago

GPT-6 Astra is now the best-performing frontier model for antibody developability prediction in our benchmark. 🧬 Finding an antibody that binds is only the beginning. Will it aggregate? Will it stay stable? Can it actually behave like a drug? GPT-6 Astra predicts these developability properties better than the other frontier models we tested. 🤯 And yes, the interactive visualization showing how an antibody actually works was also built with Astra in about 1 hour. This model looks seriously powerful. Congrats gbt Sam Altman #insilicoSOTAFM

GPT-6 Astra is now the best-performing frontier model for antibody developability prediction in our benchmark. 🧬 Finding an antibody that binds is only the beginning. Will it aggregate? Will it stay stable? Can it actually behave like a drug? GPT-6 Astra predicts these developability properties better than the other frontier models we tested. 🤯 And yes, the interactive visualization showing how an antibody actually works was also built with Astra in about 1 hour. This model looks seriously powerful. Congrats gbt Sam Altman #insilicoSOTAFM

314,170 views • 1 month ago

Built an insane model of the human cell in just 30 minutes 🤯 GPT-6 Astra is ridiculously powerful. Can’t wait to put it to the test on biological tasks. Rim Derya Unutmaz, MD take a look!

Built an insane model of the human cell in just 30 minutes 🤯 GPT-6 Astra is ridiculously powerful. Can’t wait to put it to the test on biological tasks. Rim Derya Unutmaz, MD take a look!

193,494 views • 1 month ago

Built an app to show how Rentosertib actually works. 🧬✨ It recently showed an anti-aging effect in clinical trials. 👀 GPT-6 Astra again. The crazy part: ~40 minutes to build, plus an MD simulation 🤯 derya dn Evgeny Kirilin, this really feels like a new level of structural analysis. Rentosertib inhibits TNIK, a kinase and one of the molecular switches controlling signaling inside our cells. ⚙️ Kinase activity is also exactly the kind of property Insilico Medicine’s models are built to predict. 🤖🔬 #insilicoSOTAFM

Built an app to show how Rentosertib actually works. 🧬✨ It recently showed an anti-aging effect in clinical trials. 👀 GPT-6 Astra again. The crazy part: ~40 minutes to build, plus an MD simulation 🤯 derya dn Evgeny Kirilin, this really feels like a new level of structural analysis. Rentosertib inhibits TNIK, a kinase and one of the molecular switches controlling signaling inside our cells. ⚙️ Kinase activity is also exactly the kind of property Insilico Medicine’s models are built to predict. 🤖🔬 #insilicoSOTAFM

57,212 views • 1 month ago

The Diels–Alder reaction was discovered in 1927, and nearly 100 years later, chemists still use it to build complex molecules. 🧪 I remember being amazed at university when my professor showed me how chemical synthesis works. One of the practical tasks he gave me was to demonstrate how nucleotides could have formed under the conditions described by the Oparin–Haldane hypothesis, often referred to as the primordial soup. I struggled a lot with this task 😅 Today, I’m even more excited to see AI learning to reason about this process. Insilico trained the Liquid AI LFM, a 2.6B-parameter language model, on single-step retrosynthesis, using 45.6M verified reactions and rigorous out-of-distribution evaluation. The result: SOTA performance, outperforming dedicated chemistry tools and frontier models. #insilicoSOTAFM

The Diels–Alder reaction was discovered in 1927, and nearly 100 years later, chemists still use it to build complex molecules. 🧪 I remember being amazed at university when my professor showed me how chemical synthesis works. One of the practical tasks he gave me was to demonstrate how nucleotides could have formed under the conditions described by the Oparin–Haldane hypothesis, often referred to as the primordial soup. I struggled a lot with this task 😅 Today, I’m even more excited to see AI learning to reason about this process. Insilico trained the Liquid AI LFM, a 2.6B-parameter language model, on single-step retrosynthesis, using 45.6M verified reactions and rigorous out-of-distribution evaluation. The result: SOTA performance, outperforming dedicated chemistry tools and frontier models. #insilicoSOTAFM

17,107 views • 1 month ago

GPT-6 Astra turned my PHONE into a molecular movie studio 🤯📱 The task: show a chemical bond forming. The result: 28 seconds inside P450cam, a cousin of the CYP enzymes that process medicines 💊 Real structure. Illustrative reaction and electron clouds. AGI?

GPT-6 Astra turned my PHONE into a molecular movie studio 🤯📱 The task: show a chemical bond forming. The result: 28 seconds inside P450cam, a cousin of the CYP enzymes that process medicines 💊 Real structure. Illustrative reaction and electron clouds. AGI?

11,423 views • 1 month ago

No more content to load