eLife - the journal

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The funder-researcher collaboration and open-access journal for research in the life and biomedical sciences | @eLifeCommunity

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eLife - the journal

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Cells can pass proteins and RNA to each other through tubes that act as a channel between their membranes.

Proteins that allow water to move in and out of cells help shape the development of new blood vessels.

Evidence of artefactual calcium microwaves during calcium imaging of neurons in the hippocampus.

Enhanced single RNA imaging reveals dynamic gene expression in live animals.

Chronic Ca2+ imaging of cortical neurons with long-term expression of GCaMP-X.

Researchers present a platform for cardiac tissue cultivation with 3D ring-shaped cardiac tissues generated from human stem cell-derived cardiomyocytes.

The path we take while walking on rugged terrain can be mathematically predicted. 🔗

Researchers have developed Opto-RhoGEFs, an optimised optogenetic toolbox to reversibly control Rho GTPase activity, advancing the ability to manipulate the barrier between endothelial cells.

Through monitoring a large group of marmosets, researchers have categorised their behaviours to find baselines for typical and atypical responses that can help us study psychiatric disorders.

An imaging system with an ultra-wide field of view allows scientists to track millions of cells at once in large 3D tissues and embryos.

Plant roots can rapidly change the acidity of their cell walls and the root-soil interface to efficiently navigate in the soil environment.

🧵 1/ Female #ReproductiveBiology is, unfortunately, notoriously understudied. So maybe it’s no surprise that a supposedly useless ‘developmental leftover’ in the ovaries could turn out to be...not so useless after all. Meet the rete ovarii 👇

New microscopy technology enables nanoscale imaging of centimetre-scale tissues, making it possible to image the entire expanded mouse brain at cellular and subcellular resolution. #ReviewedPreprint

Controlling the forces needed to move around is pretty complicated for soft-bodied organisms. Researchers have implemented a new technique for measuring these crawling forces with nanonewton precision in fruit fly larvae.

Fibronectin, a key component of the vessel wall, triggers smooth muscle cells to release collagen-rich extracellular vesicles that guide their movement during vessel repair and atherosclerosis.

Calcium and bicarbonate signalling pathways have pivotal, resonating roles in matching ATP production to demand.

New microscopy technology enables nanoscale imaging of centimetre-scale tissues, making it possible to image the entire expanded mouse brain at cellular and subcellular resolution. #ReviewedPreprint

Generating active T1 transitions through mechanochemical feedback.

Ultrastructural reconstructions of T. brucei reveal that the endosomal system in trypanosomes forms a continuous membrane system instead of being compartmentalised.

One protein, two opposing roles: This ‘compelling’ study shows how the same signalling molecule can drive either protrusion or retraction in migrating cells depending on its concentration and activation dynamics.

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For the first time, scientists analysed the connectome for part of the brain in the common octopus involved in long-term memory. Here, they use #ElectronMicroscopy to trace the length of an axon micron by micron.

The centrosome decides which branch extending from the body of microglia will successfully engulf and clear away dead neurons.

Enhanced single RNA imaging reveals dynamic gene expression in live animals.

With three simple steps and in just 48 hr, EZ Clear effectively renders adult mouse organs optically transparent while preserving signals from fluorescent reporters.

Can you infer cause and effect between genes without disturbing the cell? 🧬 This study shows how natural “noise” in gene expression can reveal directed gene–gene interactions.

New microscopy technology enables nanoscale imaging of centimetre-scale tissues, making it possible to image the entire expanded mouse brain at cellular and subcellular resolution. #ReviewedPreprint

A novel method for imaging glutamate receptors in situ via #CryoET.

Structural insights into actin isoforms #CryoEM

“This fundamental work provides a creative and thoughtful analysis of rodent foraging behavior” Mice can take shortcuts to find food, demonstrating their ability to make a mental map of their surroundings.

Retinal motion statistics during natural locomotion.

Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway. #DevBio

What makes one member of the species behave differently from another? It's a core problem in behavioural #neuroscience. This valuable study seeks an answer for the specific case of the fruit fly expressing preferences for one odour over another.