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The #1 AI Engineering podcast & newsletter, now covering AI for Science as well. Over 170,000 daily readers. Technical news today you will use at work tomorrow!

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In this episode, Engram co-founder and CEO Dan Biderman joins allen to cook Mediterranean meatballs with yellow rice and talk about building AI that actually learns from you: why long context, RAG, and compaction eventually break down, how Engram compresses knowledge into cartridges and model weights, what continual learning could unlock for long-horizon agents, why token efficiency is inseparable from intelligence, how personal models could improve like Tamagotchis, and what it takes to build the research and infrastructure for millions of continuously updated AI memories. Timestamps: 0:00 Intro 0:26 Engram’s $98M Launch and Meatballs 1:45 From Naval Special Operations to AI Research 4:32 Israeli Military Culture and Founder Maturity 7:12 Why Engram Is Betting on Context and Continual Learning 9:14 Knowledge Cartridges, Compression, and Model Intuition 14:10 Trillion-Token Company Knowledge and Context Rot 18:05 Long-Context Limits, Compaction, and Neural Memory 22:20 Test-Time Training and “Destroying Prefill” 24:31 Harvey and Holistic Enterprise Queries Beyond RAG 27:02 Personal AI Models and Tamagotchi Weights 30:00 What Belongs in Weights vs. Text 32:25 Autonomous Memory and User-Specific Feedback Loops 34:20 Token Efficiency, Model Routing, and Harder Tasks 38:03 Engram’s Research Team and Product Culture 43:02 Hiring Researchers and Infrastructure Engineers 45:25 Doing More With Less 47:41 Where to Find Engram 48:19 Final Taste Test

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"Projects like the New Deal, the Apollo program pale in comparison to what we're doing right now." 🆕 Greg Brockman (Greg Brockman) joins us to talk GPT-5, GPT-OSS, and what's next on OpenAI's road to crystallizing all of human intelligence! “Energy turns into compute, turns into intelligence… crystallizing compute into potential energy you can release again and again.” 0:00:04 - Introductions 0:01:04 - The Evolution of Reasoning at OpenAI 0:04:01 - Online vs Offline Learning in Language Models 0:06:44 - Sample Efficiency and Human Curation in Reinforcement Learning 0:08:16 - Scaling Compute and Supercritical Learning 0:13:21 - Wall clock time limitations in RL and real-world interactions 0:16:34 - Experience with ARC Institute and DNA neural networks 0:19:33 - Defining the GPT-5 Era 0:22:46 - Evaluating Model Intelligence and Task Difficulty 0:25:06 - Practical Advice for Developers Using GPT-5 0:31:48 - Model Specs 0:37:21 - Challenges in RL Preferences (e.g., try/catch) 0:39:13 - Model Routing and Hybrid Architectures in GPT-5 0:43:58 - GPT-5 pricing and compute efficiency improvements 0:46:04 - Self-Improving Coding Agents and Tool Usage 0:49:11 - On-Device Models and Local vs Remote Agent Systems 0:51:34 - Engineering at OpenAI and Leveraging LLMs 0:54:16 - Structuring Codebases and Teams for AI Optimization 0:55:27 - The Value of Engineers in the Age of AGI 0:58:42 - Current state of AI research and lab diversity 1:01:11 - OpenAI’s Prioritization and Focus Areas 1:03:05 - Advice for Founders - It's Not Too Late 1:04:20 - Future outlook and closing thoughts 1:04:33 - Time Capsule to 2045 - Future of Compute and Abundance 1:07:07 - Time Capsule to 2005 - More Problems Will Emerge

Latent.Space

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