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Nick Lane — one of the world's leading biochemists on mitochondria and the origin of life — doesn't take supplements. His reasoning: "So if you're thinking about taking supplements or whatever it may be, you've got to think — what are the long-term consequences of doing this? We don't really have any good information on how that's going to work out in the long run. And you don't know what you're missing. So that's why I don't do it personally." Your biology operates as a system. Affect one variable and you affect everything connected to it. Take antioxidants as an example. For decades, health advice pushed them as the fix for aging — on the assumption that free radicals are cellular garbage to be swept away. According to Lane, that assumption is wrong. At normal levels, free radicals act as signals. When mitochondria run into metabolic stress, those signals alter transcription factors in the nucleus — proteins that switch genes on and off. They tell the cell what to do next: build fresh mitochondria, activate its own antioxidant defenses, or trigger apoptosis — programmed cell death — if the damage is beyond repair. Flooding the system with antioxidant supplements mutes that signal. It leaves the cell blind to its own internal state. But there's a second problem — independent of the signaling issue. Researcher Gustavo Barja traced most free radical leakage to one specific subunit inside Complex I — out of more than 40 subunits in that single complex. Free radicals leak directly into the space right next to mitochondrial DNA. There are tens of thousands of complexes per mitochondrion. Hundreds of mitochondria per cell. Roughly 50 trillion cells in the body. Hitting that exact site with enough antioxidant concentration is close to impossible. Antioxidant supplements don't fail only because they mute a signal. They fail because the target is unreachable. You cannot supplement your way out of a systems problem.

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136,644 Aufrufe • vor 29 Tagen

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High dose vitamin D supplementation might be doing more harm than good. Stephanie Seneff, MIT researcher: Vitamin D is a signalling molecule, not a nutrient to megadose. It mobilizes calcium — but doesn't control where calcium goes. High dose vitamin D drives calcium into the arteries, leaching it from bones. A 3-year study comparing 400 IU/day, 4,000 IU/day and 10,000 IU/day found the highest dose group had statistically significantly worse bone mineral density. A 2006 study found that calcitriol supplementation (the active form of vitamin D) in young adults with kidney disease increased artery calcification — because calcitriol is taken up directly by cells in the artery wall. Artery calcification is one of the strongest risk factors for cardiovascular disease. An Indian study compared vitamin D supplementation to 20 minutes of daily sunlight in 100 men with severe deficiency. Remarkably — the supplement group had a larger increase in serum vitamin D than the sunlight group. Yet opposite effects on cholesterol: Sunlight group — cholesterol dropped. Supplement group — cholesterol increased. Why? Sunlight and vitamin D supplements take completely different routes through your body. Vitamin D supplements are fat-soluble. The liver has to synthesize cholesterol and release LDL particles just to transport them through the blood. Sunlight stimulates cholesterol sulfate synthesis directly in the skin. The sulfate component makes the molecule water-soluble — transported freely in the blood without being packaged inside an LDL particle. Because cholesterol sulfate is both water-soluble and fat-soluble, it can transfer from skin cell membranes to HDL particles or red blood cells and deliver cholesterol directly to tissues that need it. No LDL carrier required. When you get vitamin D from a supplement instead of the sun, you don't get the simultaneous increase in cholesterol sulfate. The pill doesn't just fail to replicate sunlight. It uses a completely different biological pathway. Seneff: "Vitamin D wants to be subtle. Get out in the sun." "People answer: oh yeah I know, vitamin D is important." "No. Not vitamin D. The sun.” Vitamin D is a proxy for sunlight exposure. The proxy isn't the mechanism.

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244,075 Aufrufe • vor 5 Monaten

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"I think deuterium is the reason why you have cancer." — Stephanie Seneff, MIT researcher. Deuterium is a heavy form of hydrogen naturally present in water and food. Your mitochondria are extremely sensitive to it — too much deuterium disrupts their ability to produce ATP and triggers excess reactive oxygen species. When deuterium accumulates systemically, every cell in your body starts struggling. Seneff's hypothesis: A cell senses the overload and transforms itself into a cancer cell. Not to harm you. To help you. Cancer cells abandon their normal function and obsess on one thing: duplicating themselves. Their metabolism shifts entirely. They suppress oxidative phosphorylation — the process by which mitochondria generate ATP using oxygen — repurposing them toward anabolic synthesis — to avoid the reactive oxygen species that high deuterium would generate. Instead they run glycolysis. Massive glucose intake. The output: lactate — carrying a deuterium-depleted proton — shipped out into circulation. Low-deuterium fuel delivered to the host. The cancer cell also relocates its V-ATPase pumps — protein pumps embedded in the cell membrane — to the outer surface, pumping deuterium-depleted protons directly into the tumor microenvironment — while hoarding deuterium inside itself. It is self-sacrificial. Taking on the burden so the rest of the body doesn't have to. Immune cells flood the tumor. But they don't attack. The cancer is nourishing them — lactate and deuterium-depleted protons — providing what their damaged mitochondria need to recover. Seneff notes the same lactate and low pH environment also signals immune cells to stand down — suppressing activation and allowing the tumor to survive in the process. Once the immune cells recover, they turn on the tumor and clear it. When deuterium levels drop low enough — the cancer cell's job is done. It undergoes apoptosis. Gabor Somlyai, Hungarian biochemist and cancer researcher showed that when cancer cells are placed in deuterium-depleted water, they stop multiplying and undergo apoptosis. In high-deuterium water — they thrive. He documented patients rejected by mainstream oncology — told to go home and die. They began drinking deuterium-depleted water. Some lived far beyond predicted life expectancy. Some achieved complete recovery. This also might explain why the ketogenic diet works against cancer. Animal fats are the lowest deuterium macronutrient. A ketogenic state naturally lowers systemic deuterium intake. Combined with glucose restriction — cancer cells depend heavily on glucose to run glycolysis — both mechanisms rest on the same biology. Thomas Seyfried, Professor of Biology at Boston College, reached the conclusion that cancer is a mitochondrial metabolic disease, not a genetic one. Seneff goes one step further: deuterium overload is why the mitochondria malfunction in the first place. According to her, cancer isn't a random malfunction. It's a coordinated biological response to a systemic deuterium overload.

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191,309 Aufrufe • vor 5 Monaten