A method for imaging massive quantities of cell populations... in centimetre-wide tissue and embryo. #ReviewedPreprintshow more

New microscopy technology enables nanoscale imaging of centimetre-scale tissues,... making it possible to image the entire expanded mouse brain at cellular and subcellular resolution. #ReviewedPreprintshow more

New microscopy technology enables nanoscale imaging of centimetre-scale tissues,... making it possible to image the entire expanded mouse brain at cellular and subcellular resolution. #ReviewedPreprintshow more

Imaging the endocardium of the heart in a two-day-old... zebrafish embryo. Credit to Dr Anjalie Schlaeppi. #ZebrafishZundayshow more

📢 Submissions are now open for the CellMap Segmentation... Challenge. Build the best method for segmenting cellular organelles in vEM using our 289 annotated volumes, 40 organelle classes, and 22 diverse cell and tissue types. 🔗show more

A sneak peak of a complex and technically challenging... experiment that my lab developed: Super proud of PhD candidate Hannah Johnson for showcasing our Whole-gut spatial genomic analysis in #zebrafish. This video illustrates one landmark in the protocol after multiple rounds of sequential #HCR and 3D imaging in zebrafish larvae to reveal spatial expression of numerous mRNAs in the same specimen. Data from these imaging data sets are then computationally analyzed for spatial cell groups, spatially variable genes, and differentially expressed genes along 3D. We are leveraging this systems-level SGA to uncover unappreciated mechanistic insight at the cell and tissue levels into #ENS construction. Stay tuned for our work that exploits this pipeline within various mutant and perturbation conditions. Reach out if you are interested in trying this! #fruitypebblesshow more

Since long time we tried to achieve “permanent” labelling... of plasma membranes. Now it become possible with MemGraft probes, which exploit a new principle of lipid-directed covalent fluorescent labeling of membrane proteins. The MemGraft probes are compatible with fixation, permeabilization, trypsinization, presence of serum in the medium and enable long-term cell imaging, co-culture of cells and their imaging in multiple colors, cell barcoding and cell manipulation. Congrats and thanks to co-authors: Nathan Aknine Nathan Aknine & Remi Pelletier. - CNRS 🌍 CNRS 🌍_Alsace LBP UMR 7021 Just out in biorXiv:show more

@gunsnrosesgirl3 Ducks are an effective and natural method for... pest control in gardens and farms. They consume a wide variety of pests, including slugs, snails, grubs, mosquito larvae, damaging beetles, and grasshoppers.show more

NIST researchers and their colleagues have demonstrated a method... to distinguish century-old coins from fakes by imaging antique coins with beams of low-energy neutrons.show more

A 3D map of mRNA transcripts in a zebrafish... embryo. This video was not made using a microscope. Researchers tag nucleotides with barcodes, which then "link" together in the tissue. Sequencing those links can then be used to computationally infer the 3D positions of genes.show more

mScarlet3-H (aka mYongHong) makes a great pair with mBaoJin... ( for long-term live cell imaging. All plasmids can be requested for free from WeKwikGeneshow more

🎉Congratulations to Janelia Research Scientist Andy Moore (Andy Moore)... on 2 honorable mentions in the 2024 #NikonSmallWorldInMotion competition for videos of a crawling tissue culture cell & a time-lapse of culture cells crawling & exploring. Nikon Small Worldshow more

Brain cell communication seen in action. Scientists have captured... the millisecond fast process of brain cell communication using advanced imaging. Teams in Berlin and the US used rapid freezing techniques on mouse and human neurons to observe neurotransmitter release and vesicle recycling, revealing key steps and proteins involved. This could help understand brain diseases.show more

Scientists just recreated a 100-year-old Nobel Prize experiment in... one of Earth's oldest animals, and the result is wild... In the 1920s, researchers discovered that a tiny cluster of embryo cells can "organize" an entire body plan, head to tail, back to belly. Now they've found that same switch in comb jellies, creatures that split from us around 700 million years ago. Transplant that tissue into another embryo and it still triggers a second body axis, even across wildly distant species. The takeaway: the instructions for building a body may be almost as old as animal life itself. Writers: Lynn, Danielshow more

New Raid Quest "vs Cell Max" is now underway... in #DBXV2 ! Cell Max has appeared as a raid boss! Beware of high power and wide range of attacks, and let's all work together to face them! From March 23th (Thu) 8PM to 29th (Wed) 10PM PST/CET Learn more here:show more

I am thrilled that our work on MemGraft probes... for “permanent” fluorescent labelling of plasma membranes is out in JACS Au! We established a concept of lipid-directed covalent labeling of plasma membranes. Open access: MemGraft probes allow cell fixation, permeabilization, trypsinization, presence of serum, long-term imaging, co-culture, cell barcoding and magnetic manipulation. Congratulations and thanks to co-authors: Nathan Aknine and Rémi Pelletier. -, CNRS 🌍, CNRS 🌍_Alsace, LBP UMR 7021, ANR - Agence nationale de la rechercheshow more

Introducing GoalPillars - Put in your goal and get... your own 64-cell Harada Method inspired dream sheet in seconds. Very cool way to map goals.show more

Update! We outline AIVE, an AI method for volume... EM data. We show the benefits of AIVE for reconstructing your FIB-SEM data, reveal some fascinating cell biology, and define intrusions as a new form of mitochondrial contact. Muscle mito nanotunnels 1/3🧵show more

📍Khan Yunis IDF troops from the Paratroopers Brigade encountered... an armed terrorist cell and thwarted it. The soldiers also located large quantities of weapons including AK-47 rifles, grenades and explosive devices.show more