I’m starting a company. An internet-scale dataset is created... every day that can be used to cure diseases. ㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤ Yet decisions for developing new drugs use a tiny fraction of it. ㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤㅤ After years of building and investing in therapeutics companies, I'm convinced that this is about to change. ​ · ​ There are two kinds of knowledge. Facts, and connections. We have an abundance of known facts about biology, but we have barely begun to make all the connections. ㅤ Our company is connecting the world's pharmaceutical data, drawing a coherent understanding from an archipelago of information. ​ Thousands of decisions behind breakthrough drugs—from experimental design to new product planning—can be augmented by this scientific intelligence. ​ · ​ We are partnering with drug developers who’ve dedicated their careers to their craft. ​ We know that engineering tools for those at the pinnacle of human expertise is not going to be easy. ​ But it will change how life-saving discoveries are brought to patients. ​ If this sounds like fun, reach out. We're recruiting founding engineers.show more

World Models are the path for some AI Models... in the future. But how can we efficiently train these models to not only see the world the way humans do but to see the world in a new and unique way. By visualizing, what is normally sequenced audio patterns, we can derive much more insights. Here we see Paganini in a visual form that can than be described and transcribed into a World Model. We can observe connections in a manner that may not have been clear prior to the digitalization of music and sound in this way. The company with the most valuable potential in building a World Model is Tesla. Not that this type of visualization is being used, but that the mechanisms are in place, and the technology is in place for the company to thrive in this new form of AI.show more

"We have had a good run for our money... with this gas chamber story we have been putting about, but don't we run the risk that eventually we are going to be found out? And when we are found out, the collapse of that lie is going to bring the whole of our psychological warfare with it." - Victor Cavendish-Bentinckshow more

"We have had a good run for our money... with this gas chamber story we have been putting about, but don't we run the risk that eventually we are going to be found out? And when we are found out, the collapse of that lie is going to bring the whole of our psychological warfare with it." - Victor Cavendish-Bentinckshow more

There are over 7M Starlink customers today. Yet nearly... ~2.7B people or one-third of Earth’s population still have no internet access. That’s billions of lives disconnected from opportunity. And Starlink is going to change that. We are witnessing the foundation of earth and space’s connectivity being built in real time right now. And I’m proud to be a product owner and investor of this company.show more

The Bitcoin Bookshelf is the corner of the library... where people from all backgrounds can come to discover what Bitcoin is. By taking out the intimidation, we will create an environment for us to strengthen the code, the software, and the network behind it. We have created a place for discovery, for families and friends to learn together and teach one another about the benefits of a decentralized future. I want to thank all the sponsors that helped make this dream a reality, and all the authors who donated all of the books for this project. We are working hard to bringing a bookshelf to all corners of the world, a dedicated section in all libraries so everyone can have access to financial freedom.show more

Big news! Today we are announcing that Shopify is... acquiring the Threads team. There are a million feelings and thoughts from this journey, but nothing more than gratitude to all of our users and customers for building with us, my colleagues (both current and former) for making all of this possible, our investors, especially Mike Vernal, Elad Gil, Avichal - Electric ϟ Capital, and Jessica Verrilli for their unwavering support and guidance, and all of our friends and family who put up with the late nights, canceled plans, and the general roller coaster that is startup life. To our customers and users who have been asking, here’s how we got here: The past several months have been some of the most interesting and intense of my life. It all started with the rise of Instagram Threads, which presented us with the opportunity to sell our domains. Around the same time, a handful of companies approached us, wondering if we would be open to an acquisition. When this happened in the past, we would politely decline. However, this time, things were different. We weren't that excited about the time it would take to invest in a rebrand, and with mind-warping technological advances now being a commodity, we were excited about joining a place where we could tinker at scale. Each company we chatted with was incredible. However, what ultimately led us to choose Shopify over others was their culture; two distinct things in particular: 1) Craft-obsessed. Their obsession with not just building the right thing, but also building it the right way is inspiring. Sacrifice shows priority, and hearing stories about some of the hard decisions they made to ensure that what they ship is robust, scalable, and trustworthy, even at the cost of short-term metric gains, really proved that their obsession with craft was much more than a feel-good slogan. Their discussions and decisions have me truly believing they're going to be around for 100 years. 2) For entrepreneurs, by entrepreneurs. Just about every product and engineering leader I met was an ex-founder who grinded for years to turn nothing into something. They all still had that air of resilience, obsession with the details at every part of the stack, and a compelling vision of the future for whatever they were working on. Threads leadership is also made up of ex-founders, so the entrepreneurial focus at Shopify made it clear that it would be the best environment for us to grow and thrive. Very excited for this next chapter with the team and grateful for all of the support we’ve received over the years from those who believed in us. As always, thanks for (th) reading.show more

Sadly, many of our traditions are dying! A lot... of people had nobody even show up at their houses for Halloween this year. Of those who did decide to go trick-or-treating, it was widely noticed that a much smaller fraction of houses had their lights on. What is the point of having a country if we lose everything we love? The only way to fix this is to shut down the border and deport every illegal! We can’t be generous unless we are happy and stable. That is step 1. Otherwise, in just a few short years, there won’t be anything left to fight for :(show more

The Sabotaging Practice of Over Supply and Sameness in... the NFT Space. The current zeitgeist of the NFT space is that the same artists are doing the same kind of work five times a year, with project after project leaving a trail of disappointment and discontent among collectors and all of us watching in disbelief as huge resources are extracted from the space over work that feels like it could be left as an "artist study." I understand that you can do what you want with your money as collectors, but we are killing the whole space with this incestuous practice. No artist is that prolific to be able to do 5 collections of 100+ pieces each every year and actually deliver innovation and some kind of creative evolution. Of course, they can pretend play that the work has something new, but there is no precedent nor proof that that has ever happened in the speed that it happens in the NFT space. Again, people are free to through away their resources on whatever they want but with this way of doing things, we more and more are going to start seeing the consequences. Oh! There are consequences? Yes. Maybe unintended, but there are. Let's see. Let's start with the loss of belief in the NFT space as somewhere where emerging artists can come and find support for their experiments. Why even bother to bring experiments, innovation, and new ways to think of art on the blockchain if the same people have all the collectors hypnotized with their magical flutes? Why even try to come to a space where taking risks and challenging the status quo (the mission of art!!!) is overlooked? This makes the NFT space a social club and not a space for art. I guess it is fine, but IMO it is a recipe for disaster. New collectors stay away because the art will slowly but surely become stale and un-challenging. Why even bother to come and see what is happening here if you can't, as a collector, see new weird and up-and-coming artists? The amount of noise emitted by the same artists doing the same art over and over, drowns out any new voices. Again. A recipe for disaster. The NFT space is becoming a space of disappointment and doubt. We think that collections going to zero one after the other, over and over, is not damaging? I feel we are kidding ourselves. Disappointment piles up, and again, the people who will hurt are the emerging artists, the new blood, the ones who are willing to risk the most and, in return, put fire in this cold space of sameness. I love this space—don't get me wrong—it has changed my life, and I believe it has a ton of potential, but things need to change for it to become a beacon of light in art. But we need to support new voices. We need to support new ideas. The challenge is huge. I hope to contribute all I can to this change. I hope more and more see how exciting it is to go out and try to discover what else is out there and move this space forward. But again, I understand the leaps of faith needed, but if there is a space that is based on that, it's the NFT space...so there is hope. We will see. 📺by Boldtronshow more

Lady Gaga says you have committed violence by objecting... to her celebration of Dylan Mulvaney on International Women’s Day. “It's appalling to me that a post about National Women's Day by Dylan Mulvaney and me would be met with such vitriol and hatred. When I see a newspaper reporting on hatred but calling it ‘backlash’ I feel it is important to clarify that hatred is hatred, and this kind of hatred is violence. “Backlash would imply that people who love or respect Dylan and me didn't like something we did. This is not backlash. This is hatred. “But it is not surprising given the immense work that it's obvious we still have to do as a society to make room for transgender lives to be cherished and upheld by all of us. “I feel very protective in this moment, not only of Dylan, but of the trans community who continues to lead the way with their endless grace and inspiration in the face of constant degradation, intolerance, and physical, verbal, and mental violence. I certainly do not speak for this community, but I have something to say. I hope all women will come together to honor us ALL for International Women's Day, and may we do that always until THE DAY that all women are celebrated equally. That all people are celebrated equally. A day where people of all gender identities are celebrated on whichever holiday speaks to them. Because people of all gender identities and races deserve peace and dignity. “May we all come together and be loving, accepting, warm, welcoming. May we all stand and honor the complexity and challenge of trans life-that we do not know, but can seek to understand and have compassion for. I love people too much to allow hatred to be referred to as ‘backlash.’ People deserve better.”show more

Universities and High Schools have not moved rapidly enough... to guide students to have skills for the next decade. THEY HAVE FAILED. It is a massive crisis that can be averted by understanding what AI and Robotics will bring about. Solutions are knowing how to use these tools and new industries that will rise. But this situation is also on ALL OF US. No “job” is safe from founder to entry level in most industries. You and I, by what we do, will be “replaced” ultimately. What to do? AI and Robotics are tools, the next decade is owned by those who know how to use them expertly, but this is also temporary. We have to understand that what we do for “work” will change giving ultimately a greater value to those that are: Creative Flexible Always learning Willing to be wrong Love being human Love being alive Know history Covet wisdom Knowing all tech has downsides Building strong family and friends Realize many institutions have failed The first four are required for you to be able to live through this period with your sanity intact. The rest will allow you to thrive. There are no true careers at this point anymore. There are advocation and vocations which will either earn you money or give life meaning. We will learn that we are not “what we do”, just like we knew for 99% of human existence. Let that sink in. — You and I are far, far ahead of knowing this and we can do two things: 1) Laugh at the “clueless” 2) Help people understand with grace Go to Reddit if you are 1, in fact don’t follow me because you will not like this next decade and what I post. You are 2 and thank you. Even if you and I have not solved this issue, we can help people understand what is ahead and with determination and creativity bound together to solve it locally. Or human family has done this millions of times. The evidence is: you are here. The Neo Luddite movement has not even begun and it will potentially rip apart society even more than all the fashionable moment in the recent past has. These Luddites will have a good point with the wrong answers cooked up by dying academics that cling to labels, “virtues” and victim hood. It will be readymade for some governments to enter in as “big daddy” to “help us”. You will not like what they do, but you will only know when it is too late. It will include YOU “volunteering” to “leave” by 60, to “help out” CanadaPod style. “Brian, I’m 24 what do I do?”. I hope to do much more here to help. But I do know this: 1) Learn a trade or vocation because it’s valuable. It may also be free to low cost if you do it right. 2) Learn everything you can about USING AI and TRAINING YOUR AI. Your expertise will be in the top 1% for a decade. But not forever. 3) Understand Bitcoin and how it will rise while other things sink. This is a short list for now. We will know more moving forward. When you see videos like this posted below, know one thing: Many of these folks had no real family of mental and physical support. Maybe no parent or one parent. Maybe only a broke system to prepare them for—nothing. This was not their doing. Now it is not your “job” to help them, it is your survival to help them if that is what you need. See some day after the dust settles these 20 year olds will be 40 year olds and running YOUR world. And at some point you may need them more than you think you do. You will need them, as they need you now. THIS IS WHAT PAST WISDOM KNEW. The elders of the past never found the need to piss on the youth and hope for the best. THE YOUTH ARE OUR BEST, let us all find ways to change it, even if every aspect of “the system” wants us to berate them into the ground.show more

A football club is more than commercial competition and... sporting rivalry. It is, above all, a platform for things that truly matter - a place where values and principles should be the foundation of everything we do. Today, we chose to stand on the side of values, meritocracy, and the future. We made a decision to prioritise our fans - even at the cost of a sporting result. It was a bold move, and we believe it carries a significance that goes far beyond Poland. In a world where winning is increasingly treated as the only currency that matters, choosing people over points sends a message that the rest of football needs to hear. This decision has the potential not only to change football in Poland, but to prove that there are still places in this world where values come first - before everything else. It has not been an easy week. I am deeply grateful for every word of support you have shared with us. This was one of the hardest decisions of my life. We want to be a club of the future that honours its past. That is who we are - and who we will remain.​​​​​​​​​​​​​​​​ Wisła Kraków 🔵⚪️🔴show more

HOLY COW! Katherine Clark, one of the highest-ranking Democrats... in Congress, just admitted that their strategy with the shutdown is to let Americans SUFFER for their political gain. "Of course, there will be families that are going to suffer... but it is one of the few leverage times we have." At least she's being honest about it.show more

There is only one reason to share truth. And... no it has nothing to do with money- and everything to do about helping God move. Peace is the prize- a better world for everyone is the prize. We make SACRIFICES for things we want most in this world. Christ made the ultimate sacrifice If He can do that for us FREE of charge- we owe it to each other to work TOGETHER to make the world a better place- despite the toll and sacrifice. A level playing field- where we can all work hard and do our best to succeed- that is the payout. A better world for all We’re not here for just ourselves- otherwise the second commandment wouldn’t be like the first- love your neighbor as yourself. This world gets better the sooner we all wake up. Information is free- we collect and share it for free in hopes that it keeps spreading. Only working TOGETHER can we win. We are meant to move these messages for God so that humanity can wake up- this plan is designed that way- working together The Lord is ONE. We are bound as a family by Our Father in Heaven. We are apart of Him and He is apart of all of us. We are billions of little pieces of the Lords gift of life. We’ve been separated and pushed apart because it makes us weak. We were designed to be powerful by the love we draw from Creator and push through creation. We are ONE with Our Holy Father 🙏💗 Be EXCELLENT to each other frensshow more

Beauty should be a core pursuit of biotechnology. There... should be companies and nonprofits that engineer organisms solely for the sake of crafting beautiful things. A few reasons why: 1/ Biotechnology has historically worked in reductionist ways, but many useful functions only emerge at the systems level. By engineering a systems-level outcome, like beauty, we will get much better at engineering organisms in predictable ways. When I say "reductionist," I mean that most useful things in biotechnology (drugs and tools) were discovered by stripping molecules from their natural contexts. Scientists collect organisms from soil or wherever and then study their molecules in isolation. This basic approach has yielded everything from rapamycin to antibiotics and CRISPR. This reductionism, though, means that that we know disturbingly little about how life actually works at a systems-level. My core argument is that, by studying beauty, we can remedy this. Beauty has persisted through tens of millions of years of evolution because it is functional; bright colors help attract pollinators to a plant, for example, which helps the plant breed. If evolution has created all of this beauty for functional reasons, then it stands to reason that by trying to create **new** forms of beauty, we'll be able to discover and understand how these systems-level functions work! Indeed, we may even be able to create entirely new functions that biology hasn't evolved yet. These functions will not possible to understand via isolated molecules or reductionism. Therefore, a company pursuing engineered beauty for the sake of beauty will probably make many fundamental discoveries about how organisms develop, interact, adapt to their surroundings, and so on. 2/ Beauty is a way to grow the field and bring more people into biotechnology. Nick Desnoyer’s flower design work, for example, has probably reached hundreds of thousands of people. The glowing plants from Light Bio, too, were featured in the mainstream press. You may not think that these examples are “important” for the universe relative to, say, an incrementally better cancer therapeutic, but there’s no question that they are way more popular to mainstream audiences and good, overall, for the field. 3/ The market is huge! Breeding is already widely used to engineer beauty, or at least to select for aesthetic preferences. Pugs are evolutionarily suboptimal, but they've been bred precisely to satisfy a certain aesthetic desire are now a multi-billion dollar industry. The Juliet Rose, developed via breeding over a 15-year period, debuted at the 2006 Chelsea Flower Show and is enormously profitable today. Why should deliberately engineered forms of beauty be any different? If you are building a biotech company or nonprofit that is pursuing beauty, please reach out! I’d love to help.show more

Kedarnath is a tremendous space. The utterance of the... sound “Shiva” attains a completely new dimension and significance in Kedar. It is a space which has been specially prepared for this particular sound. When we utter the word “Shiva,” it is the freedom of the uncreated, the liberation of one who is not created. It is almost like on this planet, the sound “Shiva” emanates from this place. For thousands of years, people have experienced that space as a reverberation of that sound. This is also a place that has witnessed thousands of Yogis and mystics of every kind. When I say every kind, you cannot imagine those kinds. These are people who made no attempt to teach anything to anyone. Their way of making an offering to the world was by leaving their energies, their path, their work – everything – in a certain way in these spaces.show more

We are already at war. Not with rifles or... tanks, but with replacement. This is conquest by other means, through the slow erasure of a people who no longer recognize they are being conquered. That is why I write—to remind my people that we are not living in peace, but in the midst of a war waged without banners. The invasion is not declared with armies but with flights and boats, birthrates and welfare rolls. It is demographic warfare, calculated, continuous, and increasingly irreversible. A people, and a civilization, does not need to be burned to the ground to fall. It only needs to be replaced. Throughout the Western world, we are witnessing not mere immigration but a deliberate population transformation, one that has been rationalized by moral cowardice and enforced by political elites who have long since abandoned the idea that their nations belong to their people. What you mock as conquest is already underway, and unlike the conquests of old, it comes with the full consent of those in power. But I do not write in surrender. I write as a warning, as an act of resistance. My writing is meant to exhort and to enliven, to reawaken what has been buried beneath shame and silence. It is a summons to remember, to reclaim, and to rebuild. We are in an existential struggle, not only for our land, but for our survival, and thus for the future itself. Those who sneer at the loss will one day find there is nothing left to sneer at. A people who forget that they exist will be replaced by those who do not. You may call this natural. So be it. Then let nature return, red in tooth and claw, and let the sons of Europe remember who they are.show more

Ukrainian engineers, at a UAE-registered company, are co-developing a... submarine vessel that is capable of firing torpedo rockets. It can travel silently at a speed of 50km/h, is able to carry 10 passengers and can carry a payload. It already has undergone tests for warfare use. Wether Ukraine will be granted access to use this vessel is not yet known.show more

Today a group of Muslims prayed next to the... Ministry of Defence, facing the Iraq and Afghanistan memorial. As I have said before, choosing to pray in this way in public is a political act. It is a social statement and, yes, it is an act of domination. Anybody who understands Islamism understands that the domination of public spaces is part of the modus operandi. It is done so Islamists can show who is in charge - and to show other Muslims and the wider public that the authorities will bend to their will. There is quite obviously no need to pray here. The decision to do so is symbolic and pointed. It is not welcome. We have freedom of religion in this country, which is why there are mosques. But we are not a Muslim country and this is not welcome. It should be stopped.show more

LLM Artifacts Connected to Andrej Karpathy's LLM Knowledge base... idea, I've been building out a fun way to generate dynamic artifacts from these knowledge bases with the goal of discovering and revealing meaningful and deeper insights. LLM KBs are hard to consume for humans, as I think they are more built for agents. So the question is, what form would be useful for humans to take actions and make important decisions? That's what I am trying to figure out with these artifacts. The artifact example shows a pulse on HN discussions around AI-related stories. The insights can go deeper, of course, but this is already super fun and thought-provoking, like some of my favorite podcasts. The format and depth matter a lot. The aggregation skills of agents are outstanding if you tune the prompts and skill carefully. I built this artifact generator in a few minutes through an agent skill, but I feel like there are so many ways that LLM-generated information can be used and consumed. Like generating deeper insights and analysis, and things that are just not feasible for humans today. The generated artifact (including its data and design) serves as reusable templates or can be updated in real-time via auomations, which is something I am also working on. It is truly an insane way to monitor and track information. Better than a newsletter. Better than newspapers. There is something about this that gets me really excited about the future of AI agents for knowledge generation and discovery. Lots of hidden gems everywhere just waiting to be discovered and acted on if the information is presented correctly. This is not perfect. The format, style/prose can be improved, but this is easy to customize via skill. You can personalize it to your liking. I feel like these dynamic artifacts are going to emerge as a strong new medium to stay on the cutting edge of things, both for agents and humans. My target is research, of course. This was just a basic example. Besides animation, I am also targeting other components like voice, videos, images, slides, etc. This space is full of opportunities to explore. Skill for this coming soon.show more

It's 2030 and you are reviewing humanoid robots. A... Tesla. A Google. An Apple. An OpenAI. A Meta. A Figure. And a bunch of Chinese-made ones. Which one is best, and why? I think the Tesla understands the world much better. Why? There were eight Teslas around me on the freeway today. Start there. No other robot company has that data. But my robot is parked at the local high school twice a day. Its cameras see humans in all of our weirdness. How we move. Where we go. Where we walk. Who we talk with. What you are wearing. Whether your hair was combed this morning. That data will lead to robotics breakthroughs. Apple might keep up with its Vision Pro data, but it is too freaked out by the privacy implications of using said data. (On the front are six cameras and a couple of TOF -- Time Of Flight -- sensors that can see everything in your home in great detail). Google has a lot of data, for sure. All my: 1. Email. 2. Calendars. 3. Photos. 4. TV watching behavior. 5. Contacts. 6. Documents and spreadsheets. 7. Files. 8. Location data. So I expect Google's robot will be attractive to many. But how do you see the others shake out over the next five years? Make some guesses. But remember what an AI pioneer told me years ago about AI: it's all about the data. The Chinese ones have huge advantages: the Chinese have more data on their citizens, and many more citizens to boot AND they can make robots cheaper than we can. But now that you know OpenAI is building its own robot you have caught wind of what I've heard from many in San Francisco and Silicon Valley: that humanoid robots are the real prize of AI and will be highly profitable for those that can make them and find customers willing to buy them. Here, too, I learned long ago never to bet against Elon Musk. Will you?show more