True, even a two DOF system can exhibit chaotic... behavior, and a single cell is an at least an ~10^7 DOF system (i.e., protein molecules per cell). I still fail to properly convey to others the insane complexity I see in our microscopes, and why successes like AlphaFold only work because of the huge number of unnatural constraints placed on the training data. Case in point (below): lysosome dynamics over 12 min across a 200 x 70 um region in the head of a developing zebrafish embryo, color-coded by depth -- just one of 20k proteins at work. Our Cell Observatory Initiative is more important than ever, but while we have petabytes of the most mind-blowing data ever, we are still hamstrung by insufficient AI talent and compute -- two resources in great demand everywhere. If anyone can help us over this hurdle, we'd be eternally grateful.show more

The most detailed 3D reconstruction of a cell ever... created. Blows my mind every time. But what exactly are we looking at here? The average human cell contains: ~ 15-20 total distinct organelle types, totalling between ~1-10 million working together per cell. All these nano-machines in the cell are made up of proteins. ~ 8,000-10,000 distinct types of unique proteins, adding up to between 40 million - 10 trillion total proteins making up all those cellular systems. ~ 10,000 - 15,000 distinct types of RNA shuttling information around the cell, totalling up to ~10 million RNA molecules moving around the cell simultaneously. ~ Billions of Lipid molecules packed together into the cell membrane, which is also packed tightly with millions more protein-based nano-machines. And let's not forget billions of lines of DNA information to build and run it all. That's TRILLIONS of of individual molecular pieces working together to make a single cell function. That means there is more complexity in a single cell than humanity's largest cities. And people still believe this wasn't Divinely Designed. This is God's Glory on Display. But to make the point. A cell couldn't have evolved from some nebulous simpler "protocell" because even the simplest cells still require massive complexity. The "simplest" cell ever created was engineered by scientists knocking out pieces of a functional cell until it stopped functioning. Here is what they found is the absolute necessary minimal requirements of a cell to function: - Over ~531,000 lines of coded DNA information - 473 total genes to create hundreds of unique protein products (they later added 19 genes back in because the cell was so weak) - Hundreds of thousands of total proteins all working together - Extensive regulatory networks guiding all these interactions If the cell doesn't have all these systems in place, from the start... it doesn't live. Cell rely on an intricate network of complex systems, which are themselves built from complex interconnected pieces woven together into an incomprehensibly complex web of functionilty. Only intelligence has ever been observed creation vast interconnected systems like this. Life was clearly Created. It couldn't happen any other way.show more

Had the opportunity while in London to work with... a quant on one of my models. Fully 100% mechanical edge over 10 years data. We are still making refinements. This was all done in less than 24 hours as well. One of the coolest experiences I ever had. I remember manually backtesting 6 years data on FX Replay years ago a lot has changed. I preach trading with data and I’m a nerd for this stuff excited to continue to make the edge even greater.show more

We took a short drive on the road along... the river by our home this morning. As you can see, a bit overgrown due to cattle! This is exact same land on which we used to be able to see a herd of impala at 200 meters at this time of year, in the days before we began managing holistically. Now we could not see one at one meter. And this is what we are seeing following now over twenty years of poor rainfall. The river this year already drier than ever known. If only…….show more

Opposition in the batters box isn't just a layer... of complexity, an obstacle to overcome, it is the central feature that gives meaning to movement. My sense is that many in the baseball community view the live batter as a linear step to master after mastering other lower complexity pieces, instead of the central feature that we design our training environments around. Part of me understands why this is the case. Pitching is in a challenging place training wise because the behavior of pitches, movements, etc. change so much when you go low effort. In addition we have some limits on volume each day due to throwing being the single fastest movement in sports. Other sports can do unique warmups to work on interpersonal distance (football/basketball/soccer) and tagging games for more of a martial arts context. I simply can't have all 100 throws of a pitchers workload that day be to a live batter. And while I see value in pulling an athlete out of context at times to work on different things, ultimately, the entirety of my paradigm to train pitchers is how to do the real thing MORE, to keep them embedded in a representative environment, rather than treating it as the final step in a linear progression.show more

Today, we are working in Denmark at the European... Political Community Summit. I began our work by meeting with Prime Minister of Denmark Mette Frederiksen Statsministeriet. The recent incursions into the airspace of Denmark, Poland, Romania, Norway, and Estonia were a key focus. Russia is escalating, and we discussed how we can respond to these threats. We have repeatedly proposed creating a joint, integrated air defense system. The expertise of Ukrainian professionals and Ukrainian technologies must become an important part of the EU’s Drone Wall initiative. Right now, a strong group of Ukrainian servicemembers is in Denmark, helping Danish colleagues. We also discussed the implementation of the PURL initiative and Denmark’s further participation in this program. We value Denmark’s contribution of €90 million. I am grateful to Denmark for a military aid package of more than €360 million to support Ukrainian production under the Danish model. I thank Prime Minister Frederiksen and the people of Denmark for their strong support. 🇺🇦 🇩🇰show more

Hello world A new year has begun and we... are living this genocide We are still being killed and living the worst days of our lives in the shadow of genocide We hope that you will stand by us more than ever We hope that this genocide will end as soon as possible Don't forget that Gaza is being bombed now and the planes are above us and we are waiting at any moment to be bombed Share our voice and we will remain part of your day If you can help us through the link we will be grateful to all of you PP🔗 GFM🔗show more

A team of Ukrainian experts is working in Qatar,... sharing our experience and expertise. I met with our team here today and received a briefing on their work. Our experts have already conducted an overall assessment of the security situation, Qatar’s capabilities to counter aerial threats, and have developed concrete solutions to strengthen the protection of its airspace. And today, during my meeting with the Amir of the State of Qatar, Sheikh Tamim bin Hamad Al Thani, it was important for me to hear such a high assessment of our team’s work and appreciation for their consultations. Ballistic missile and drone attacks are currently the biggest challenge here in the region. And while only air defense systems can effectively counter ballistic threats, in Ukraine, we have developed other, significantly more cost-effective solutions to combat drones. These solutions have already proven their effectiveness against various types of drones, which is why Qatar is so interested in our experience. Ukraine has always said that we are ready to share our expertise and help those who can also help us strengthen our own protection in Ukraine. Qatar is ready for long-term cooperation across various areas. It is important to restore stability in the region so that no one suffers from Iran's terrorist strikes. And we support an approach where, by helping one another, we increase security worldwide.show more

Dear Nigerians, "Patriotism means to stand by the country.... It does not mean to stand by the president." ~Theodore Roosevelt On this national scale, if the mass number of Nigerians are suffering, their lives and properties in jeopardy, it is okay to speak up, call a spade a spade and stop this gov from leading us astray. Now more than ever, we must unite. We must unite against the ruiners of Nigeria before they bury what is left of her. Organization is the first primary weapon of the oppressed. This is the only weapon we are yet to explore, and we can not explore this until we unite. The oppressed Nigerians must organize to form a force against the ruiners of Nigeria and take back our country to have a system that is for the benefit of the Nigerian people and not a few in the position of power. President will come and go, only the people will remain. Don't give those in power today to play politics with your future. Let's unite, not necessary as one but as a team. A team with different skills, languages culture, religion and tradition, but one CAUSE regardless of our tribal differences to stand against the common enemy who have now shown to be a curse on our very own existence as an amazing people of this great nation. ~OIA✊🏿show more

It’s more than a little daunting to set out... to expand and improve the identity system for a company and brand like Stripe. But we knew we had to — the existing one had served us well, but wasn’t up to the task anymore. Our brand system required new and improved tools to scale with our ever growing audiences, new products, global footprint, and more. This update introduces material improvements to infographics, advertising, type styles, and more. While the wordmark remains unchanged, we’re using the dot of the ‘i’ (called the “tittle”), a parallelogram pointing up and to the right, to serve as our identifying symbol. We’re also using it as an ever evolving storytelling device to use when talking about our many great users (you can see the latest brand campaign in SF and NYC doing just that). Anyone who has ever worked on the refresh and expansion of an existing system for a large company knows that it is no small endeavor. Crafting impactful solutions, building alignment, creating extensible guidelines, building toolkits, and orchestrating rollout requires a ton of resilience. Here’s to the team that continually inspires me with their dedication, rigor, taste, and exceptional vibes. Great work and thank you to the Brand Studio folks, and of course our many many amazing and invaluable friends and collaborators across the company who all helped shape the work. And a special thank you to a handful of creative agencies that helped us along the way.show more

During the C8 Summit, I held a bilateral meeting... with Prime Minister of Poland Donald Tusk. Ukraine and Poland are strong neighbors, friends, and partners, and we have one common enemy. Today, above all, we discussed how important it is to maintain our unity and work together to stop this war. I thank Poland for its new aid package. This is an important step in supporting us, and we appreciate it. We also addressed further development of the Carpathian Initiative and the opportunities it can create for all the countries in our Carpathian macro-region. Of course, we are ready to share our experience with Poland and are open to mutually beneficial cooperation. This is how we should continue building relations between our countries.show more

The Sabotaging Practice of Over Supply and Sameness in... the NFT Space. The current zeitgeist of the NFT space is that the same artists are doing the same kind of work five times a year, with project after project leaving a trail of disappointment and discontent among collectors and all of us watching in disbelief as huge resources are extracted from the space over work that feels like it could be left as an "artist study." I understand that you can do what you want with your money as collectors, but we are killing the whole space with this incestuous practice. No artist is that prolific to be able to do 5 collections of 100+ pieces each every year and actually deliver innovation and some kind of creative evolution. Of course, they can pretend play that the work has something new, but there is no precedent nor proof that that has ever happened in the speed that it happens in the NFT space. Again, people are free to through away their resources on whatever they want but with this way of doing things, we more and more are going to start seeing the consequences. Oh! There are consequences? Yes. Maybe unintended, but there are. Let's see. Let's start with the loss of belief in the NFT space as somewhere where emerging artists can come and find support for their experiments. Why even bother to bring experiments, innovation, and new ways to think of art on the blockchain if the same people have all the collectors hypnotized with their magical flutes? Why even try to come to a space where taking risks and challenging the status quo (the mission of art!!!) is overlooked? This makes the NFT space a social club and not a space for art. I guess it is fine, but IMO it is a recipe for disaster. New collectors stay away because the art will slowly but surely become stale and un-challenging. Why even bother to come and see what is happening here if you can't, as a collector, see new weird and up-and-coming artists? The amount of noise emitted by the same artists doing the same art over and over, drowns out any new voices. Again. A recipe for disaster. The NFT space is becoming a space of disappointment and doubt. We think that collections going to zero one after the other, over and over, is not damaging? I feel we are kidding ourselves. Disappointment piles up, and again, the people who will hurt are the emerging artists, the new blood, the ones who are willing to risk the most and, in return, put fire in this cold space of sameness. I love this space—don't get me wrong—it has changed my life, and I believe it has a ton of potential, but things need to change for it to become a beacon of light in art. But we need to support new voices. We need to support new ideas. The challenge is huge. I hope to contribute all I can to this change. I hope more and more see how exciting it is to go out and try to discover what else is out there and move this space forward. But again, I understand the leaps of faith needed, but if there is a space that is based on that, it's the NFT space...so there is hope. We will see. 📺by Boldtronshow more

During a meeting with President of Türkiye Recep Tayyip... Erdoğan in Istanbul, we discussed bilateral relations between our countries, as well as the situation in Europe and the Middle East. It is important that joint and coordinated actions strengthen the protection of life and help deliver greater security to people in every part of the world. We agreed on new steps in security cooperation. This primarily concerns areas where we can support Türkiye – expertise, technology, and experience. There is firm political readiness to work together, and our teams will finalize the details in the coming days. We discussed practical steps to implement joint projects in developing gas infrastructure, as well as opportunities for joint development of gas fields. I am grateful to the President and the people of Türkiye for their consistent support for our independence and territorial integrity. We value our close cooperation over all these years, which enables us to work on truly significant projects that can strengthen our entire region.show more

Inside every cell, there is a transport system that... determines how materials move, signals propagate, and structure is maintained. This video captures that system in motion. The glowing streaks mark the growing ends of microtubules (protein polymers that constantly assemble and disassemble through a process called dynamic instability). Rather than forming permanent tracks, microtubules are rebuilt continuously, allowing cells to reorganize their internal layout in real time. This behavior is essential for life. Cells rely on microtubule dynamics to divide accurately, migrate during development and repair, and maintain long-distance transport in neurons that may span over a meter in length. When this system is altered, the consequences are significant. Certain cancer therapies work by locking microtubules in place, preventing cell division. In contrast, failures in microtubule transport are linked to neurodegenerative conditions (like Alzheimer's) where intracellular delivery breaks down. What appears as abstract motion under a microscope is actually one of the core systems that keeps cells functional, adaptable, and alive. Video Credit: Andy Mooreshow more

Ola recently announced that they are bringing affordable AI... to Indian developers. 𝐉𝐚𝐫𝐯𝐢𝐬𝐥𝐚𝐛𝐬 an Indian company has been providing affordable GPUs for developers across the globe since 2020. We are a little known, so I want to share our story here. 𝐖𝐡𝐨 𝐰𝐞 𝐚𝐫𝐞 We are bootstrapped, building from the outskirts of Coimbatore. Started as a small team of 4, from humble backgrounds none from IITs/IIMs. Currently, we are a team of 12+. 𝐖𝐡𝐚𝐭 𝐰𝐞 𝐚𝐜𝐡𝐢𝐞𝐯𝐞𝐝 The cost of hosting GPU servers 4 years back in India was insanely high. We got 2 quotes which charged us Rs. 1.5L for a single server per month. At that cost, it was not practical for us to do the business. So we went to the first principle to build an MVP for a mini data center/server room. For the first few years, we ran all our servers from a room fitted with ACs, a UPS, and a Generator, which experts claimed would not work. As we scaled, we faced the heat of our setup, but by then we accumulated more money than we had. So last year we moved it to a tier 3+ DC near Bangalore. This helped us boost the confidence of our users, as we have redundancy for power, internet, and networking which gives us and our customers a lot of peaceful nights. 𝐖𝐡𝐨 𝐮𝐬𝐞𝐬 𝐉𝐚𝐫𝐯𝐢𝐬𝐥𝐚𝐛𝐬 Developers and artists from across the world have supported us in our journey. Some prominent companies are ZOHO (My inspiration), Weights and Biases, UNC, UpGrad, and many more. 𝐑𝐞𝐯𝐞𝐧𝐮𝐞 We crossed 580K USD in the last financial year, the highest ever in our history. Being bootstrapped, the only way for us to grow is to put all the money back. Our customers are our investors, as a founder I have hardly taken a paycheck for the last 4+ years, since the team also believes in our vision they are happy not taking a fancy cheque. 𝐕𝐢𝐬𝐢𝐨𝐧 As AI evolves, we want to bring the capabilities of AI to users at the lowest prices possible. Being bootstrapped, the only way to survive is to be frugal and disciplined. 𝐇𝐢𝐫𝐢𝐧𝐠 I am proud of our hiring strategy. We hired only freshers to date, and most of our hires do not have a formal degree. They come from rural areas and economically challenged backgrounds. The average age of our new team is 19. They have played an active role in building our V2 of Jarvislabs and improving the product daily. I love to thank everyone for supporting us in our journey. Thanks to Analytics India Magazine, INDIAai, fastai for recognizing us in our early years. If our story resonates with you, Please share our story to inspire others & support our mission. #StartupIndiashow more

A single E. coli cell, placed on a dish,... will become 70 billion cells in just 12 hours. That’s exponential growth. But a new preprint shows that it's possible to engineer E. coli to grow linearly instead, where only one daughter cell continues dividing and the other stops. First, some context. In nature, there is a bacterium called Mycobacterium smegmatis (initially discovered in 1884 in ulcers scraped from syphilis patients.) M. smegmatis is weird because it divides asymmetrically. These cells grow only from one end, and all their cell wall biosynthesis machinery is located on that one end. So when the cell divides, one daughter gets this machinery and the other gets nothing. The daughter that gets the machinery can keep dividing immediately, but the other daughter has to remake all that machinery from scratch, so its growth is delayed. E. coli doesn’t grow like this. When it divides, it pinches in the middle and splits everything evenly. Enzymes, metabolites, and proteins get partitioned more or less randomly between the two daughters. For the new preprint, though, researchers engineered E. coli to behave more like M. smegmatis. Here is how they did it: First, they deleted a gene called cyaA, which encodes an enzyme (adenylate cyclase) that makes a molecule called cAMP. cAMP is SUPER IMPORTANT! It is a nutrient sensor that instructs E. coli to switch on genes that help it digest non-glucose carbon sources when glucose is scarce. Without cAMP, E. coli cells growing on alternative carbon sources will starve; they won’t know how to eat the food. Next, they added back a “split” version of the cyaA gene into the cells. In other words, they split the gene in two so that each half of the enzyme is made separately. Cells can only make cAMP, and thus eat non-glucose carbon sources, if these two halves come together. To facilitate that “coming together,” the researchers also fused the split cyaA proteins to sticky proteins that clump together, and to a fluorescent protein (to make it easy to track these molecules in the cell.) So now some interesting things start to happen if you grow E. coli on a growth medium lacking glucose. As the cell grows, its cyaA “halves” start clumping together into a giant ball. Inside the aggregate, the two enzyme halves come together and make cAMP. And when the cell gets big enough and divides, the clump of cyaA RANDOMLY goes to either daughter cell #1 or #2. The daughter that gets the aggregate (called PA+ in this paper) can keep dividing. The daughter that doesn’t (PA–) cannot. It still grows a few times — about four divisions — because it inherits some leftover cAMP from its mother. But after that, the metabolite is diluted away, and the cell stops growing. PA+ cells went through about 23 divisions on average before their aggregate decayed. And the population of cells, as a whole, grew linearly. This paper is cool because there are many applications where exponential growth is too unpredictable and, perhaps, unsafe. If you want to engineer bacteria to deliver drugs, clean up waste, or live in the gut, you don’t want them to double uncontrollably. This paper shows you can make them expand in a controlled, linear way. Alas, mutations could break this whole engineered system. A mutation that restores cyaA, for example, would give cells a new way to make cAMP. Mutations that make the aggregates split between daughters would break the asymmetry, too. But still, I really enjoy proof-of-concept engineering papers like this.show more

Our long-range responses make the aggressor feel the war... every day. Over the past 24 hours, two enterprises of Russia’s chemical industry were hit in the Perm and Samara regions. A target was hit in the Black Sea. In Taganrog, our SSU warriors hit an FPV drone production facility and UAV storage sites, an oil products tank, a radar station, and a Pantsir-S2 system. I thank our warriors for their precision. We also have confirmation of our warriors’ successful work this week. In particular, a Su-33 aircraft and two Mi-8 helicopters were destroyed in the Krasnodar and Rostov regions. An oil facility was hit in Perm. I am grateful to everyone who delivers a just response to the Russians for all their terrorist strikes against our people. The war must hit home. This is important.show more

Getting from $1M to $100M in ARR took us... 18 months. The second hundred took less than six. Last week Legora passed $200M. 130,000 lawyers now use Legora on a monthly basis, across 2,100 firms and legal teams in more than 80 countries. Two things from this year I would not have predicted: The first is how fast the US moved. 18 months ago we had no office in North America. Today over half of the AmLaw 50 work with us, out of our offices in New York, Denver, Chicago, Houston, San Francisco and Toronto. The US is our largest market by revenue. The second is where the demand is coming from. More than 40% of our new customers are now in-house legal teams, including Air Canada, Salesforce and Palo Alto Networks. Two thank-yous, before we get back to work. To our customers, who backed a small company from Stockholm with a lot to prove, and who still tell us plainly when we get something wrong. And to the team, engineers and lawyers sitting next to each other, who turn that into something better, faster than any group I have worked with.show more

🇺🇬Leadership isn't defined by the suits we wear or... the halls we sit in, it’s defined by the work we do on the ground. While others focus on high level politics, I remain rooted in the service of our people and the protection of our national heritage. A true Speaker must be a guardian. Just as I stand here watching over this herd, I am ready to stand in the August House to guard the dignity of our Parliament and the resources of every Ugandan taxpayer. My Independent ticket is my promise, I am a leader of the people, for the people, and I am ready to lead with the same care and firmness I show here in the field. For God and My Country 🇺🇬. "The 12th Parliament needs a Speaker who stays grounded. Ready to serve! 🇺🇬" #PersisPrincess #IndependentVoice #NamuganzaForSpeakershow more

Dear Pioneers 🌏 We are living in a decisive... moment! Pi Network has the potential to become a true revolution in the global financial landscape, but for that to happen, we must act wisely and united. We are millions of Pioneers around the world, driven by the same purpose: to create a decentralized, accessible, and fair financial system for all. The real value of Pi is not determined by the traditional market but by our confidence and engagement. The GCV of $314,159 represents much more than just a number – it symbolizes our conviction about Pi's potential. Our Strength Lies in the Community For Pi to reach its true value, we need to act strategically and with commitment. No great project can sustain itself without the support of its participants. If we want to see Pi shine, we must: ✅ Avoid having our Pi traded on exchanges prematurely, creating scarcity and strengthening its value ✅ Not accept selling it for prices lower than it truly deserves ✅ Acquire and withdraw Pi from exchanges, consolidating its strength in the market ✅ Use it in real transactions, promoting its growth as a global digital currency ✅ Spread awareness and encourage its daily use, expanding its acceptance Each Pioneer plays a crucial role in this process. The more we use and value Pi within the ecosystem, the more it will establish itself as an asset of great global impact. The Future Is in Our Hands We can allow speculators to dictate the value of Pi, or we can take control of our own destiny and ensure that it reaches its true potential. The decision is ours! If we act together, with strategy and determination, nothing can stop us from making Pi Network a milestone in cryptocurrency history. The time is now, and each of us is a fundamental part of this revolution. Let's strengthen Pi together and make the GCV of $314,159 an undeniable reality! Sérgio Cruz, Portugal GCV Ambassador 🇵🇹show more