We have developed MouseMapper AI, a deep learning ensemble... for the analysis of whole-body systems, including the nervous and immune systems, to map disease/drug perturbations tissue by tissue, organ by organ, at the cellular level in 3D. MouseMapper uncovered obesity-induced whole-neuronal changes, most notably, a loss of trigeminal nerve endings linked to impaired whisker sensitivity, as well as tissue-specific macrophage clustering across the body. Kaltenecker, Horvath, Al-Maskari, Kolabas, Chen… Ertürk, bioRxiv (2024)show more

A sneak peak of a complex and technically challenging... experiment that my lab developed: Super proud of PhD candidate Hannah Johnson for showcasing our Whole-gut spatial genomic analysis in #zebrafish. This video illustrates one landmark in the protocol after multiple rounds of sequential #HCR and 3D imaging in zebrafish larvae to reveal spatial expression of numerous mRNAs in the same specimen. Data from these imaging data sets are then computationally analyzed for spatial cell groups, spatially variable genes, and differentially expressed genes along 3D. We are leveraging this systems-level SGA to uncover unappreciated mechanistic insight at the cell and tissue levels into #ENS construction. Stay tuned for our work that exploits this pipeline within various mutant and perturbation conditions. Reach out if you are interested in trying this! #fruitypebblesshow more

🚨 REALITY UPDATE Humans may already have hidden regenerative... abilities. Scientists are now discovering that the body’s inability to regrow tissue may not come from missing biological machinery… but from repair systems being “switched” into scar mode instead of regeneration mode. That changes the entire question. Because for decades scientists assumed mammals simply lost regenerative capability entirely. But new research suggests the regenerative programs may still exist underneath normal healing processes. Researchers studying tissue regeneration found they could partially redirect mammalian healing away from scarring and toward structural regrowth using specific signaling pathways. In experiments, scientists regenerated: • bone • ligaments • joint structures • connective tissue inside injured mammalian tissue. The deeper shift: Human biology may contain dormant regenerative instructions that are normally suppressed. That means the future of medicine may not be: “adding artificial replacement parts”… but: reactivating biological repair programs already hidden inside the body. And this is not isolated anymore. Researchers are now uncovering regeneration-related mechanisms across: • skin healing • heart tissue • stem cell systems • cartilage repair • aging biology The line between healing and regeneration is beginning to blur. If this scales: • scar-free healing may become possible • organ repair could accelerate • regenerative medicine may fundamentally change surgery • aging research could shift dramatically • future medicine may focus on “unlocking” dormant repair pathways The deeper implication: Humans may not lack regenerative power. We may simply lack the signals that activate it fully. Question to audience: If dormant regeneration pathways already exist inside the human body… how much hidden biological capability are we still unaware of? Follow if you want to watch the future forming in real time. #RealityUpdate #FutureOfReality #TheNewPhysicsshow more

Stop trading time for rest. Start using light for... recovery. The biggest mistake athletes make in 2026? Thinking "recovery" only happens while you’re asleep. What I’m holding here is a Photobiomodulation (PBM) device—and the data behind it is a total game changer for anyone trying to stay on the field and out of the doctor's office. THE SCIENCE OF THE "BIO-HACK": Most recovery tools just mask pain. PBM actually repairs tissue at the mitochondrial level. Here’s the data-driven truth on how it works: 1️⃣ The Mitochondrial Battery: Red and Near-Infrared light photons are absorbed by cytochrome c oxidase. This triggers a massive spike in ATP production (cellular energy), effectively "supercharging" your body’s ability to repair micro-trauma in half the time. 2️⃣ Inflammation Shutdown: PBM dissociates Nitric Oxide from your mitochondria, allowing oxygen to flood back into the tissue. Result? A 50% reduction in DOMS and faster clearance of metabolic waste. 3️⃣ The Ergogenic Edge: Running this over a non-injured muscle before a workout increases muscle workload capacity and fatigue resistance. It’s essentially a legal "biological cheat code" for endurance. THE DATA 📊: Injury Recovery: Speeds up soft tissue healing by up to 2x. Performance: Studies show a measurable increase in power output and reps to failure when used as a "pre-conditioning" tool. Safety: Non-invasive, drug-free, and now the "Gold Standard" in professional locker rooms from the NFL to Special Forces. Stop waiting for your body to heal itself slowly. Use the light. 💡 Save this for your next rehab session and share with an athlete who is tired of being sidelined.show more

As a gynecologist, one of the most frequently asked... questions is about the ''hymen''. The hymen is not a structure located deep inside the vagina. It is a thin, flexible fold of tissue situated very close to the vaginal opening, anatomically at the entrance of the vaginal canal. It is typically found about 1–2 cm inside the vaginal opening, but in many women, it is almost at the surface. Therefore, the common belief that it is located deep inside is incorrect. One of the most important points is this: The hymen is not a closed membrane. It naturally has openings that allow menstrual blood to pass. Additionally, the structure of the hymen varies from person to person. Its thickness, elasticity, and shape are not standard. In some women, it may be very thin and elastic, while in others, it may be minimal or barely noticeable. This is completely a normal anatomical variation. A common misconception is that changes in the hymen occur only due to sexual intercourse. In reality, factors such as certain physical activities or tampon use can also lead to stretching or changes in this tissue. Therefore, the hymen is not a reliable indicator of a person’s sexual history or “virginity.” In summary, the hymen is a small and variable anatomical structure. The meanings attributed to it are largely shaped by sociocultural beliefs rather than medical facts.show more

🚨 SCIENTISTS MAY HAVE FOUND A WAY TO STOP... BLINDNESS BEFORE VISION IS LOST. Researchers have developed a new laser-based treatment that gently heats the back of the eye not to destroy tissue, but to activate the eye’s own repair systems. The target is dry age-related macular degeneration (AMD) one of the leading causes of blindness worldwide. Around one in three people over 80 develop it, and until now there have been almost no ways to stop it early. Why this matters: Instead of waiting for vision loss and then trying to replace damaged cells, this treatment uses precisely controlled near-infrared laser pulses to raise retinal temperature by just a few degrees. That tiny heat signal triggers: • heat shock proteins • cellular repair mechanisms • autophagy (the cell’s own waste-removal process) In simple terms: the laser may help aging eye cells clean and repair themselves before permanent damage occurs. The deeper implication is enormous: Future medicine may not always work by replacing broken parts. It may work by reactivating the repair systems evolution already built into us. What if many age-related diseases, including blindness, begin when our cells simply lose the ability to clean up after themselves? Follow for more frontier medicine and future science.show more

Today I received my 4th infusion of SGF (Stem... Cell Growth Factors) at Edogawa Hospital in Tokyo, Japan. What is SGF? 🦷 SGF is derived from the dental pulp of children's naturally shed baby teeth. No stem cells are injected. Instead, the infusion contains the signaling molecules, growth factors, cytokines, and regenerative proteins that stem cells naturally produce. These biological messengers help coordinate communication between cells and are believed to support tissue repair, immune regulation, blood vessel health, and nerve regeneration. These growth factors are small enough to cross the blood brain barrier and reach the brain and nervous system directly. For someone like me with confirmed neuroinflammation, white matter atrophy, and small fiber neuropathy destroying my nerves from the inside out, the goal is remyelination. Rebuilding the insulation around my damaged nerve fibers.💯 Researchers have studied SHED (Stem Cells from Human Exfoliated Deciduous Teeth) for their regenerative potential in areas such as nerve repair, neuroinflammation, tissue healing, and age-related degeneration. Some people have nicknamed therapies like this the "Fountain of Youth" because the goal is not to replace damaged tissue, but to activate the body's own repair and regeneration pathways. Whether that nickname is deserved remains to be seen, but the science behind cellular signaling and regeneration is fascinating. Japan has become a global leader in regenerative medicine and allows access to therapies that are not currently available in the United States under its regenerative medicine framework. As Patient #27 in the McCairn–Edogawa Protocol, I am grateful to have the opportunity to experience this emerging science firsthand. 🧬🦷🇯🇵 #SGF #SHED #RegenerativeMedicine #StemCellScience #Neuroinflammation #SmallFiberNeuropathy #EdogawaHospital #Tokyo #MedicalInnovationshow more

The three-body problem is a classic and notoriously difficult... question in physics and mathematics. It asks: How do three objects, such as stars, planets, or moons, move under the influence of each other’s gravity? Unlike the simpler two-body problem, which has precise and predictable analytical solutions (like the Earth orbiting the Sun in an ellipse), the three-body problem quickly becomes chaotic and unpredictable. This complexity arises because each object's motion constantly affects, and is affected by, the other two. These gravitational interactions form a tangled and unstable system. In fact, there's no general formula that can solve all three-body scenarios exactly. This was first demonstrated in the 19th century by Henri Poincaré, whose work laid the foundations for chaos theory. While exact solutions remain elusive, scientists have discovered certain special cases where the motion is stable or periodic. One well-known example is the Lagrange points, where three bodies can maintain a stable triangular configuration. However, such neat solutions are rare. Today, thanks to powerful computers, researchers can simulate three-body systems with remarkable accuracy, helping us study triple-star systems, exoplanets, and asteroid dynamics. Yet even small changes in the starting conditions can lead to dramatically different outcomes, highlighting the sensitive dependence on initial conditions that defines chaotic systems. The three-body problem is actually a specific case of the broader n-body problem, where n can be any number of interacting bodies. As n increases, the complexity and unpredictability rise even further. The three-body problem serves as a vivid example of how simple laws of nature, like Newton’s law of gravity, can produce behavior that is intricate, unexpected, and profoundly difficult to predict.show more

as a former professional skater, I can say the... technique here immediately reminds me of upper body positioning in speed skating. specifically the way the arms move across the body while the hips and torso rotate underneath them In skating that goofy motion helps manage the lateral shift of the center of mass and counter the angular momentum created by each leg it’s interesting is that the robot wasn’t explicitly taught to run this way the gait emerged through reinforcement learning as it searched for a faster, more stable and less thermally demanding way to move. yet it is not copying a speed skater It seems like two very different systems arrived at a similar solution to the same basic dynamics problem Convergent biomechanics ™ lol video is of an old competitor of mine who is currently crushing everyone in skating at the moment GUZMANshow more

As a newly appointed 𝗔𝘀𝘀𝗶𝘀𝘁𝗮𝗻𝘁 𝗣𝗿𝗼𝗳𝗲𝘀𝘀𝗼𝗿 at Imperial College... London, I'm thrilled to announce the 𝗦𝗮𝗳𝗲 𝗪𝗵𝗼𝗹𝗲-𝗯𝗼𝗱𝘆 𝗜𝗻𝘁𝗲𝗹𝗹𝗶𝗴𝗲𝗻𝘁 𝗥𝗼𝗯𝗼𝘁𝗶𝗰𝘀 𝗟𝗮𝗯 (𝗦𝗪𝗜𝗥𝗟) at 𝗜𝗺𝗽𝗲𝗿𝗶𝗮𝗹 𝗖𝗼𝗹𝗹𝗲𝗴𝗲 𝗟𝗼𝗻𝗱𝗼𝗻. 𝗦𝗮𝗳𝗲 𝗪𝗵𝗼𝗹𝗲-𝗯𝗼𝗱𝘆 𝗜𝗻𝘁𝗲𝗹𝗹𝗶𝗴𝗲𝗻𝘁 𝗥𝗼𝗯𝗼𝘁𝗶𝗰𝘀 𝗟𝗮𝗯 (𝗦𝗪𝗜𝗥𝗟) ( is a new research lab focused on the intersection of safety and intelligence in next-generation robotics. We're hiring exceptional PhD students who are passionate about pushing the boundaries of robot learning. 𝗪𝗵𝗮𝘁 𝗺𝗮𝗸𝗲𝘀 𝗦𝗪𝗜𝗥𝗟 𝘂𝗻𝗶𝗾𝘂𝗲? We operate at the exciting convergence of: • Online & offline reinforcement learning • Imitation learning & human demonstrations • Sample-efficient learning methods • Whole-body and soft robotics systems We're 𝗹𝗼𝗼𝗸𝗶𝗻𝗴 𝗳𝗼𝗿 𝗽𝗿𝗼𝘀𝗽𝗲𝗰𝘁𝗶𝘃𝗲 𝗣𝗵𝗗 𝘀𝘁𝘂𝗱𝗲𝗻𝘁𝘀 interested in: • Developing safe exploration algorithms for robotic systems • Creating sample-efficient learning methods that minimize real-world trials • Building foundation models for robotics with safety guarantees • Advancing soft robotics and compliant human-robot interaction • Bridging theory and practice in embodied AI Why now? As robots become more capable and work closer with humans, we need systems that are both intelligent enough to handle complex tasks 𝗔𝗡𝗗 safe enough for real-world deployment. Traditional approaches treat safety and intelligence as competing priorities, we believe they're synergistic. If you're a motivated researcher who wants to develop the theoretical foundations and practical algorithms for tomorrow's safe, intelligent robots, I'd love to hear from you. Want to join? Apply viashow more

It is important that the Mark Rutte is with... us in Ukraine at such a brutal moment of this war, when the Russians have once again disregarded the efforts of the American side. Today, Russia carried out a record strike in terms of the use of ballistic missiles. There were 28 cruise missiles, as well as 43 missiles of various types that approach their targets along a ballistic trajectory and can be intercepted only by Patriot systems. This means that missiles for these systems are needed and that deliveries must be prompt. I discussed this with Mark today, and I hope we will be able to implement everything we agreed on. Thank you, Mark, for your support.show more

RULE #18 OF THE PRIMAL DIET Drink raw milkshakes.... The raw milkshake is a recipe and one of the most important items on the Primal Diet. It reinforces the body, in particular the mucous linings, which are essential to protect bodily tissues from toxin damage. It strengthens parts of the body that other foods cannot, most of the time, as it is the best combination of foods to help the body restore mucus. Mucus protects the mucous membranes in the intestines, kidney, etc. Contrary to certain beliefs, mucus is not toxic. It is part of the body and remains internally. When mucus is expelled, is during detoxification, as a vessel that contains the toxins, but it is not a toxin itself, it protects from them. Toxins can deplete the mucus lining in the body, exposing tissues and organs to damage. This manifests in heartburn, being constantly drained, and other ways. So it is important to reconstitute the mucus layers that buffer those toxins, with milkshakes. Eating raw meat, raw fat, etc., should in theory give everything the body needs to make anything it needs. However, for most people, because of limitations induced by toxicity and long-term deficiencies, it often takes the combination of foods in raw milkshakes to let the body generate the appropriate amounts of mucus. It takes a whole raw egg, raw milk, and extra raw cream (that extra fat is necessary), with a bit of unheated honey to facilitate the digestion of this complex mix. Blend them together. Milkshake recipe with measurements:show more

💜 One Last Update! 💜 Last week when we... were in Minnesota for Clark’s 6-month follow-up for his clinical trial, of all the tests they ran, the one we were both most anxious and most eager to see results from was his brain MRI. For children with untreated Sanfilippo Type A, it’s typical to see 2–5% loss of brain volume each year, along with enlargement of the ventricles (the fluid-filled spaces in the brain). This is one of the most heartbreaking parts of the disease — watching the brain slowly lose tissue and function over time. We were so nervous that Clark’s MRI might show some loss compared to his baseline scan 6 months ago. But the results came back and… ✨ ZERO change. ✨ His brain volume and ventricle size were completely stable — no loss at all. This is such an incredible sign that the treatment may be doing exactly what it’s meant to: clearing the toxic waste from his brain cells and protecting his brain from further damage. If feel that it is SO important for us to share these results as they come because people need to be FULLY aware that these treatments that are out there WORK. These children with Sanfilippo do not need to regress and they DEFINITELY do not have to have their lives cut short. We just need the FDA to say yes. We are so close to a reality where Sanfilippo syndrome is as manageable as a disease like diabetes. P.S. Enjoy this video of our little sunshine having the best time singing!show more

you've never actually seen your own app. you've seen... one build. in english. logged in as you. on your phone. at Uber, that was the whole problem. no one knew what the app actually looked like. every week a room of designers would sit down and check, screen by screen, that the build matched the figma. and that was one language. the app shipped in 50+, across thousands of a/b tests, on hundreds of devices. thousands of versions of the same app, and nobody had seen most of them. we built atlas to map what users actually see.show more

Facial reconstruction of a likely 5,500-year-old man from Chiatura,... Darkveti, Georgia The “Chiatura man” is well known in anthropological literature for his massive cranial dimensions. Without soft tissue, the skull, first described by Alexandre Javakhishvili, exhibits a massive cheek breadth of 153 mm, a very large cranial width of 156 mm, and a very long cranial length of 199 mm. Most notably, it stands out among contemporaneous Caucasian crania for its overall size and massiveness, showing a closer affinity to the Caucasionic type, which is otherwise thought to have first appeared in the Caucasus during the Middle Ages. The Caucasionic type, which now dominates the Greater Caucasus region, is characterized by very large cheek width and very large cranial breadth. This Caucasionic-like morphology led some anthropologists -- most notably Malkhaz Abdushelishvili -- to describe the Chiatura man as proto-Caucasionic, using him as evidence for a much earlier presence of Caucasionic morphology in the Caucasus. Other anthropologists, such as Ilya Gokhman, questioned this interpretation, expressing doubts about the proposed dating of the individual and suggesting that he may instead belong to a period much closer to modernity. The individual is attributed to the Kura-Araxes culture, whose languages are generally associated with Northeast Caucasian speakers. The Upper Imeretian variant of the Kura-Araxes culture (to which the Chiatura man belonged), however, differs from other Kura-Araxes groups. Genetically, it was likely influenced by local Darkveti populations, while culturally it is distinguished by the presence of kurgan burials and by rich metal assemblages, such as those found in the Sachkhere kurgans, setting it apart from most other Kura-Araxes communities. Middle Bronze Age individuals from Imereti, such as the sample from Sagvarjile, can be genetically modeled as a mixture of Proto-Kartvelian-like/ancient Svan-like profile and Kura-Araxes ancestry, likely reflecting mutual interaction and admixture between Imeretian Kura-Araxes populations and local Kartvelians. The Chiatura individual also exhibits artificial cranial deformation, a practice well documented within the Kura-Araxes cultural horizon. Such practice is also observed among Kura-Araxes populations in Armenia and Dagestan. This custom may have been transmitted by Kura-Araxes groups to the Catacomb culture. Crania from Chiatura dating to Late Antiquity also display artificial cranial deformation.show more

A somatic therapist who worked with elite performers for... 20 years said frequency isn't raised by thinking. It's raised by giving the nervous system a signal it can't ignore. Here are 8 bizarre rituals that do it. 1. THE DOORWAY HANG Hang from a doorframe for 30 seconds. Decompression and grip load flood the system with physical feedback — the fastest route out of your head. 2. THE COLD SPOON Hold something cold against the back of your neck. Cold at the neck reaches the vagus nerve faster than anywhere else on the body. 3. THE WALL PRESS Press both palms flat to a wall and push hard for 20 seconds. Isometric effort with nowhere to go discharges tension the body has been storing. 4. THE VOICE DROP Say one full sentence a whole octave lower than usual. Your pitch feeds back into your nervous system. Lower reads as calmer — and the body believes it. 5. THE SOUND CUP Hum into a cupped glass and feel it vibrate against your hand. Feeling your voice as a physical object turns an abstract practice into something real. 6. THE BACKWARDS NAME Say your name backwards, out loud, once. Absurd effort interrupts a mental loop far faster than trying to stop it. 7. THE CEILING MINUTE Lie flat on a hard floor and look at the ceiling for 60 seconds. A hard surface is the one position the body cannot brace against so it stops trying. 8. THE SET DOWN Carry something heavy across the room, then put it down on purpose. The body learns release by doing it never by deciding to. THE PATTERN NO ONE TALKS ABOUT All 8 rituals share one thing: they give the nervous system a signal it cannot argue with. Not a thought. A physical fact. Frequency doesn't rise from affirmations. It rises when the body exits survival mode and the vagus nerve tells every cell: it is safe now. That's when manifestation actually starts working not because the universe changed, but because your signal did.show more

🚨 Scientists discover wisdom teeth contain stem cells capable... of repairing the heart, brain, and bones. Wisdom teeth contain dental pulp, a soft connective tissue threaded with blood vessels and nerves. Inside that pulp lives a dense population of mesenchymal stem cells, a class of undifferentiated cells that researchers classify as among the most therapeutically valuable biological material a human body produces. These are not ordinary cells maintaining routine tissue. They are blueprint cells, capable of receiving chemical signals from damaged environments and reshaping themselves into whatever the body needs most, neurons, cardiomyocytes, osteoblasts, even hepatic cells under the right conditions. The brain operates under a brutal rule: most of its neurons do not regenerate after damage. A stroke, a traumatic injury, a neurodegenerative disease removes cells the brain cannot replace through normal biological processes. Researchers have spent decades attempting to solve this through synthetic means, engineered cell therapies, growth factor injections, gene editing approaches that cost extraordinary resources and produce inconsistent results. What dental pulp stem cells demonstrated in laboratory conditions is that they can migrate toward neural damage sites, integrate with existing tissue architecture, and begin producing neurons and glial support cells. The mechanism involves neurotrophic factor secretion, essentially the cells releasing signaling proteins that stimulate the surrounding neural environment to repair itself from within. Cardiac muscle operates under a similarly unforgiving rule. After a heart attack, the dead muscle tissue becomes fibrotic scar material. The heart compensates by making surviving muscle work harder, a process that gradually leads to enlargement, weakening, and eventual failure. Dental pulp stem cells introduced into cardiac tissue in multiple studies produced measurable reductions in scar formation and demonstrated the ability to differentiate into functional cardiomyocytes, beating in synchrony with native heart cells. Some studies recorded improved ejection fraction in animal models, the core measurement of how effectively the heart pumps blood. Bone regeneration represents the most clinically advanced application already moving toward human trials. Dental pulp stem cells express high levels of osteogenic markers and respond rapidly to bone morphogenetic proteins, the chemical messengers that trigger skeletal repair. Their application in craniofacial reconstruction, spinal fusion, and long bone defect repair is being studied across multiple institutions simultaneously. What separates these cells from other stem cell sources is the combination of accessibility and biological youth. Bone marrow aspiration requires sedation and produces significant post procedure pain. Umbilical cord blood requires planning around birth. Wisdom teeth emerge between 17 and 25, during peak cellular vitality, and come out during a procedure most people already schedule. The extraction window is permanent. Once the teeth are gone and the pulp degrades, that specific population of young, highly potent cells is irretrievable from that individual. Cryogenic preservation protocols now exist that maintain dental pulp stem cell viability for over two decades. Several countries have commercial dental stem cell banks operating with the same institutional model as cord blood banking, long term frozen storage, indexed against future therapeutic need. The science supporting the value of preservation is no longer speculative. What lags behind is public awareness and clinical infrastructure in markets where this remains obscure. The wider pattern is worth recognizing. Medicine has repeatedly discovered that profound biological tools were present in tissues it previously categorized as vestigial, unnecessary, or inconvenient. The appendix was considered evolutionary junk for over a century before researchers identified its role in gut microbiome preservation. Wisdom teeth carried the same dismissal, a developmental relic from ancestors who needed extra molars for coarse diets, relevant only in their capacity to cause orthodontic problems. The pulp inside them was never junk. It was a repair system the body built during youth and stored in one of the most protected anatomical locations, surrounded by enamel, the hardest substance the human body produces. Evolution rarely wastes that kind of architecture.show more

First Corps Azov Launches Its Own Job Search Platform... Vacancies in Ukraine’s Defense Forces have become one of the most in-demand segments on job platforms. But how do you find the role that truly fits your calling? From now on, vacancies within the units of the First Corps Azov of the National Guard of Ukraine can be found easily and conveniently through a dedicated platform that provides everything you need in one place: The platform allows you to browse vacancies across four categories: combat, support, medical, and unmanned systems. Looking for something more specific? You can choose from 35 specialties, including infantry, artillery, intelligence/analysis, maintenance, engineering, and more. Additional filters are also available: • by unit (select a brigade within the Corps) • by rank (enlisted, NCO, or officer positions) • by citizenship (Ukrainian or foreign applicants) • by availability of the "18–24 Contract." • Everything is transparent. Each vacancy includes a brief role description, as well as detailed information on conditions of service, candidate requirements, and responsibilities. If you do not find the right position today, you can subscribe to a weekly email digest to stay updated on current openings. You can also contact a recruiter directly via the chatbot. Be the First. Find your calling and join the ranks of the First Corps Azov of the National Guard of Ukraine.show more

E11 Bio is excited to unveil PRISM technology for... mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. We discovered a new cell barcoding approach exceeding comparable methods by more than 750x. This is the heart of PRISM. We integrated this capability with microscopy and AI image analysis to automatically trace neurons at high resolution and annotate them with molecular features. This is a key advance towards economically viable brain mapping - 95% of costs stem from neuron tracing. It is also an important step towards democratizing neuron tracing for everyday neuroscience. Solving these problems is critical for curing brain disorders, building safer and human-like AI, and even simulating brain function. In our first pilot study, we acquired a unique dataset in mouse hippocampus. Barcodes improved the accuracy of tracing genetically labelled neurons by 8x – with a clear path to 100x or more. They also permit tracing across spatial gaps – essential for mitigating tissue section loss in whole-brain scaling. Using molecular annotation, we uncover an intriguing feature of synaptic organization, demonstrating how PRISM can be used for systematic discovery 🧵show more

Only comment on this Non-Tropical vs Sub-Tropical vs Tropical... debate for the Nor'easter, but I don't know of many purely Non-Tropical systems over 25-26C SSTs that generate their own convection by dynamics of a well structured LLC and warm SSTs. I'm not saying the system is tropical, but it's clearly acquiring some Sub-Tropical characteristics and it's broadly ignored. By the agency who should be giving this more evaluation than it is... Let's also not pretend that we haven't seen dozens of these Non-Tropical to Sub-Tropical transitions marked well away from land over the years as at least having the potential to transition, if not fully having done so. That's the continued issue. The goal posts are always moving for systems like these, and for some reason it's the storms that make US impact that tend to have less leniency in classification. Which you would think it would be the opposite. It's not November, it's September and Non-Tropical systems FREQUENTLY acquire Sub-Tropical characteristics at this latitude. Why is it only when it's actually going to impact the CONUS that we go full classroom mode and err on the side of fully NT. This goes to the same issue of not having a recon in a borderline rapidly intensifying TS Edouard earlier this month along the the most susceptible coastline in the country for our energy industry. We have more resources, more data accessibility than ever to modernize the process of tracking these systems, yet the industry still behaves like its 2000. Why isn't there a recon in this system? It will be the most impact storm for the Northeast since probably Sandy(And to be clear I'm not saying this is Sandy). IMO it's a shortcoming that does the industry no good whatsoever.show more