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#FluorescenceFriday #cellbiology #bioart The interior of the cell is a busy place, as seen by grazing incidence structured illumination microscopy at 30 frames per minute: Lysosomes (green) can become corralled by the endoplasmic reticulum (ER, magenta), but can also remodel the ER when they are actively transported at high speed along microtubules (MTs, yellow). ER tubules are also remodeled directly when they associate with the growing or shrinking ends of MTs.

#FluorescenceFriday #cellbiology #bioart The interior of the cell is a busy place, as seen by grazing incidence structured illumination microscopy at 30 frames per minute: Lysosomes (green) can become corralled by the endoplasmic reticulum (ER, magenta), but can also remodel the ER when they are actively transported at high speed along microtubules (MTs, yellow). ER tubules are also remodeled directly when they associate with the growing or shrinking ends of MTs.

41,991 görüntüleme • 2 yıl önce

#FluorescenceFriday #cellbiology #bioart A neutrophilic cell migrating through a 3D collagen mesh at 1.3 sec intervals for 5.5 min, as seen by lattice light sheet microscopy.

#FluorescenceFriday #cellbiology #bioart A neutrophilic cell migrating through a 3D collagen mesh at 1.3 sec intervals for 5.5 min, as seen by lattice light sheet microscopy.

37,610 görüntüleme • 2 yıl önce

#FluorescenceFriday #zebrafish #bioart To see cells as they really are, it's necessary to see them in the native multicellular environment in which they evolved. However, the deeper we peer into living tissue, the more our view is obscured by optical aberrations. Here, take a trip as we dive 200 um down from the optic tectum to the hindbrain in a living zebrafish, turning on adaptive optics to correct these aberrations as we go, to see oligodendrocytes (orange) and neural nuclei (green).

#FluorescenceFriday #zebrafish #bioart To see cells as they really are, it's necessary to see them in the native multicellular environment in which they evolved. However, the deeper we peer into living tissue, the more our view is obscured by optical aberrations. Here, take a trip as we dive 200 um down from the optic tectum to the hindbrain in a living zebrafish, turning on adaptive optics to correct these aberrations as we go, to see oligodendrocytes (orange) and neural nuclei (green).

26,336 görüntüleme • 2 yıl önce

#FluorescenceFriday #cellbiology #bioart Three examples of mitochondrial remodeling by lysosomes/late endosomes actively transported along microtubules, as seen by grazing incidence structured illumination microscopy at 1-2 frames/sec.

#FluorescenceFriday #cellbiology #bioart Three examples of mitochondrial remodeling by lysosomes/late endosomes actively transported along microtubules, as seen by grazing incidence structured illumination microscopy at 1-2 frames/sec.

23,085 görüntüleme • 2 yıl önce

#FluorescenceFriday #neuroscience #bioart A minute sliver of some of the most complex matter in the known universe: a small subset of neurons (yellow) and pre- (blue) and post- (magenta) synaptic markers over 75 x 100 x 125 um in layers IV-V of the mouse primary somatosensory cortex, as seen by combined expansion and lattice light sheet microscopy (ExLLSM): The first six seconds show all pre/post synaptic pairs, the remainder shows only those pairs associated with the small subset of labeled dendritic spines. An insanely complicated computational machine.

#FluorescenceFriday #neuroscience #bioart A minute sliver of some of the most complex matter in the known universe: a small subset of neurons (yellow) and pre- (blue) and post- (magenta) synaptic markers over 75 x 100 x 125 um in layers IV-V of the mouse primary somatosensory cortex, as seen by combined expansion and lattice light sheet microscopy (ExLLSM): The first six seconds show all pre/post synaptic pairs, the remainder shows only those pairs associated with the small subset of labeled dendritic spines. An insanely complicated computational machine.

17,476 görüntüleme • 2 yıl önce

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