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6 Things I’ve Changed My Mind On! 1BCAA Supplementation: My PhD research involved BCAAs. I used supplemental BCAAs for 15 years. My 1st supplement company sold a product with BCAA. I stopped recommending them because of evidence & my current company @outworknutritionofficial does not have a BCAA product because...

44,655 görüntüleme • 1 yıl önce •via X (Twitter)

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GrepMed profil fotoğrafı
GrepMed1 yıl önce

Probably been following you for a decade. One of the few honest evidence based influencers out there in a sea of grifters.

Matt Portwood profil fotoğrafı
Matt Portwood1 yıl önce

Respect Layne. I am glad to see someone at your level acknowledging where the research is pointing, and not being dogmatic. I'm also excited and glad to see that the research is pointing to what I've been seeing in coaching practice for many years now, which is that a lot of the "details" don't matter, unless those details help a person find enjoyable and sustainable daily consistency in food intake, activity, and overall lifestyle in alignment with long term health. I hope the entire conversation in the industry continues to shift more and more to focus on sustainability and solving for that at a population level. Good stuff my man.

Craig | Legendary Fatherhood profil fotoğrafı
Craig | Legendary Fatherhood1 yıl önce

Man the normies are not going to like this.

bobbyscaps.eth👺 profil fotoğrafı
bobbyscaps.eth👺1 yıl önce

Research is research and you must evolve.

Alfred profil fotoğrafı
Alfred1 yıl önce

Congrats on always being wrong

finley profil fotoğrafı
finley1 yıl önce

LDL-C is still miles behind apob, triglycerides, A1c, and hs crp in terms of risk factors...

Mike in Woodbridge 🔊🔊 profil fotoğrafı
Mike in Woodbridge 🔊🔊1 yıl önce

@BioLayne the KING of nuanced discussions- thank you!

Darius profil fotoğrafı
Darius1 yıl önce

"strong opinions, loosely held." straight to the point <2 mins, not dogmatic and intellectually honest. bravo Layne!

David Aames profil fotoğrafı
David Aames1 yıl önce

I follow Layne because he is open minded and non biased. He follows the facts and science, rather than pushing his own agenda or defending his own ideas. This is a great example of that. I’d like to see more research and attention into the relationship of blood sugar, insulin sensitivity and the associated nutrient partitioning that goes with it. I think it plays a much bigger part than people give it credit for. Not so much for being anabolic, but for the ability to shift the ratio of fat:muscle gained when bulking. Well timed slow insulin release combined with timing of fat oxidation and prevention of fat accumulation. L-carnitine possibly being a superstar when times correctly with insulin and cardio.

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Casey Means Says Berries Are Going To Make You Fat! Casey means is back on her BS. Honestly, as someone who comes from a conservative household, I am EMBARASSED by the nominations from the republican party, especially Casey Means being nominated as surgeon general because she consistently does NOT understand science In this video she claims that fructose is why bears eat berries because it helps fatten them up for winter & that’s why we should avoid fructose 1Do I need to point out the obvious that we aren’t f***ing bears? 2Do berries & fruit make people fat? Unequivically NO. In research studies where people eat more fruit, they have LESS body fat, BETTER insulin sensitivity, & better overall metabolic health (PMID: 29643151, 26996228, & 31139631) She then claims that high fructose corn syrup is 1000x (she fabricated this number) more potent than regular fructose & is associated with violence WATCH OUT FOR THE FRUCTOSE RAGE! The reality is that people in lower socioeconomic areas are MORE likely to consume more HFCS & people from lower socioeconomic status are 700% MORE likely to engage in violence, but oh yea… it’s the fructose rage Casey 🙄(PMIDs: 19631043 & 25147371). Just for comparison the increase in risk with HFCS consumption is an 11% increase in fighting (PMID: 32150827) meaning that the increase in violent behavior associated with HFCS consumption is COMPLETELY explained by the confounding variable of socioeconomic status Also HFCS is not magically fattening, in studies that replace HFCS of fructose containing sugars with other sources of sugar or carbohydrate but keep calories equal there is no effect on body fat or markers of health (PMIDs: 30463844, 26358358, 28536126, & 22351714) Until you are willing to go back to school to learn how to properly assess scientific research Casey, you need to SIT DOWN

Layne Norton, PhD

39,427 görüntüleme • 1 yıl önce

There is NO BEST DIET for Everyone There are so many diet wars out there. Low carb vs. vegetarian. Carnivore vs. vegan. Intermittent fasting vs. eat every 2 hours to stoke your ‘metabolic furnace. ‘Clean’ eating vs. flexible dieting. What do you choose? Which one is best? The reality is there is NO one best diet out there. In research studies, no diets are superior for long term weight loss compared to other diets when calories & protein are equated between diets (PMIDs: 32238384, 29466592, & 28193517). However, when you stratify diets by adherence, there is a LINEAR relationship between diet adherence and weight loss REGARDLESS of the type of diet used (PMIDs: 25182101 & 37931749). Diet type doesn’t matter for fat loss nearly as much as being consistently adherent to a calorie deficit. But to induce a deficit to lose fat, you must follow some form of restriction. Whether its a tracking restriction (tracking calories, macros, portion sizes, exchange system, etc), a diet restriction (low carb, low fat, etc), or a time restriction (various versions of intermittent fasting), any of these approaches can work. Still, they all require a form of cognitive restraint. So if you want something to work, you should choose the form of restriction that FEELS the LEAST restrictive to YOU And don’t assume that because it feels easiest to you, it will feel the easiest for everyone else, too Consistency>perfection DATA>feelings

Layne Norton, PhD

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Intermittent Fasting Destroys Your Gains?! A new study (PMID: 40241374) on intermittent fasting (IF) out of Grant Tinsley, PhD lab in collaboration with other colleagues of mine on social media like Menno Henselmans & Andy Galpin, PhD looked to examine the effects of continuous meal feeding pattern (CMF) vs. IF on body composition, strength, & performance, in well-trained men & women over 8 weeks. Several other studies have examined CMF vs. IF but this was the first study to have people eat in a calorie surplus (10% above maintenance calories) & eat a high protein diet (2.2g/kg body weight). The people in the IF group performed their exercise fasted & then ate their first meal after training & kept all their meals within an 8 hour feeding window The results of the study were mixed in favor of CMF & IF. There were no differences between the groups in the amount of fat free mass added, but there were differences in various other measures. The IF group did not gain as much strength on the squat as people following CMF. The group following IF also was not able to complete as many repetitions overall through the course of study, which makes sense because the IF group also reported feeling more fatigued that the CMF group. However, the IF group also gained less body fat than the CMF group The difference in fat mass is in opposition to other studies examining IF vs. CMF that equate calories & protein showing no difference in fat mass changes (PMID: 31614992) however, none of those studies were looking at resistance training in a calorie surplus. So does that mean IF magically reduces fat gain in these conditions? I spoke to Menno about this & his take was the same as mine: it is likely that the people in the IF group ate less without realizing it Overall this study adds to the body of literature that demonstrates normal IF like 16:8 produces similar outcomes in muscle gain compared to CMF. Other more extreme forms of IF like alternate day fasting do show worse lean mass outcomes compared to CMF (PMID: 34135111). The differences in performance & body fat are interesting but we need more research before drawing strong conclusions

Layne Norton, PhD

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Your Kids Don’t Eat too Many Calories… IT’S THE CARBS! This video is from Jason Whittrock where he is demonstrating that continuous glucose monitor shows a glucose increase in response to eating chicken nuggets In the least shocking news of 2025 thus far… they chicken nuggets increase blood glucose Big deal He claims kids aren’t eating too many calories, implying that it is the carbs that are the problem. He claims that kids aren’t eating too many calories because obesity affects poor families more, trying to imply that poor kids must eat less calories because they have less money… BUT WHAT DOES THE DATA ACTUALLY SAY????? Oh well look at that, poor families actually eat MORE calories compared to middle class & upper class families (PMIDs: 26809142, 27994148, & 31082447) OOPSIE! Guess he either didn’t bother to look up the actual research data or knew about it & didn’t care As for carbs causing obesity, this has been debunked many times over. In a large meta-analysis of controlled feeding studies that equated calories & protein but varied carbohydrate & fat intake, researchers found that people in high carb/low fat diets actually lost slightly MORE body fat than people following low carb high fat diets (about 16g more body fat loss per day… not a huge difference) PMID: 28193517. These results have even been demonstrated with huge differences in carb intake (over 300g per day vs. ketogenic diet) & insulin release (PMID: 27385608) While I agree with Jason that chicken nuggets probably aren’t the best nutritional choice, it’s not because they have breading, it’s because they tend to be high in calories overall. Sorry Jason, calories mattercise Makes You Smarter It seems like every day, new data is emerging demonstrating that the benefits of exercise extend far beyond the physical & go well into the mental space of the brain. Research has shown exercise can improve symptoms of depression, schizophrenia, bi-polar, & anxiety but more research is also demonstrating that exercise can enhance cognitive performance in healthy people This is highlighted by a new meta-analysis demonstrating that exercise of various forms improved academic performance in college students (PMID: 39310016). While the mechanisms behind the way this works still need to be further elucidated, we are starting to discover more & more that what happens in the body affects the mind & what happens in the mind affects the body. In the reverse direction, we see psychological stress associated with greater pain sensitivity, autoimmune disorders, cardiovascular disease, cancer, and all cause mortality (PMIDs: 31568044, 32983091, 18371552, 34830968, & 27407085) E]]] want to take care of your body, take care of your mind.]

Layne Norton, PhD

26,140 görüntüleme • 1 yıl önce

Plant Protein is as Good as Animal Protein for Building Muscle? New Study Breakdown! A new study just dropped demonstrating that a plent blend was as good as whey protein at building muscle over 12 weeks in untrained men undergoing a resistance training program. The headline may surprise some of you, but when I read the full study, I was not surprised at all… why? Because the plant blend was matched to whey in leucine and total EAAs. When you equalize the actual anabolic signals, the gap closes — which is exactly what my PhD thesis showed nearly 20 years ago. Study details (PMID: 41059835) • Randomized, controlled trial in untrained men • Whey vs. plant blend (pea + soy + added leucine) • 12-week supervised resistance-training program • Outcomes: quadriceps cross-sectional area (ultrasound), DEXA, lower-body strength • Result: Both groups improved significantly, with no between-group differences in hypertrophy or strength. This is in line with my PhD research which demonstrated that wheat (a poor protein for stimulating muscle protein synthesis) was as good as whey at stimulating MPS when leucine was added to wheat protein to match the leucine content of whey (PMID: 22818257) Important nuance: The plant blend used in this study is not commercially available, and appears that it was formulated + fortified to match whey’s leucine/EAA profile. That’s why it performed similarly, not because all plant proteins are inherently equivalent to whey for anabolism If your plant protein is low in leucine or EAAs… the results won’t look like this. That said, a plant protein sources can still be as anabolic as animal protein sources if their leucine/EAA content is high enough or if you consume enough protein overall

Layne Norton, PhD

27,233 görüntüleme • 7 ay önce

Fasting is NOT Superior for Autophagy Autophagy has become the biggest buzzword in nutrition in the last 5 years & whenever I do videos or posts on intermittent fasting & why it is a useful tool for fat loss, but NOT superior to other calorie equated diets, people invariably say that ‘tHeSe StUdIeS dOn’T aCcOuNt FoR aUtoPhAgY!’ When I cite studies showing that normal calorie restriction gets the same benefits as calorie equated fasting diets, people often say that fasting gets you the benefits WITHOUT calorie restriction. Well, a very highly controlled study showed that this is NOT the case Well this study did (PMID: 34135111). They had people follow one of 3 diets: 1) Alternate day fasting without calorie restriction where they ate 200% of their maintenance calories on feeding days, & 0% the next day (200:0) & continued to alternate them throughout the course of the study 2) Alternate day fasting with 25% calorie restriction where they ate 150% of their maintenance calories on feeding days & 0% the next day (150:0) & continued to alternate those throughout the course of the study or 3) Continuous calorie restriction where they had people eat 75% of their maintenance calories every day for the duration of the study (75:75) Both the 150:0 & 75:75 diets reduced body weight to the same extent, but the 75:75 group lost slightly more fat mass & retained slightly more lean mass than the 150:0 fasting group. Both restricted groups lost more body fat & weight than the 200:0 group which did not lose weight or fat. Markers of autophagy were also equivalent between the 150:0 & 75:75 groups as well as other adipose tissue genes, gut hormones, and markers of cardiometabolic health This study demonstrates that it is the caloric restriction that drives these improvements in health & the changes in autophagy, NOT because fasting has some magical effect on autophagy that exists outside of the caloric restriction it imposes I am NOT saying fasting is bad. I’m not saying it’s not a useful tool or that you can’t lose fat with it. You can & it can be a great tool for many people… it’s just not magic like many proponents of fasting try to make it out to be Tired of the diet wars & not knowing how to make sense of all the contradictory information out there? Comment ‘FRAMEWORK’ and I’ll send you my simplified guide on how to lose fat & build muscle for FREE

Layne Norton, PhD

29,887 görüntüleme • 1 yıl önce

Everyone keeps telling her to eat less fat so her body will burn stored fat. But it is not working. And there is a reason for that. When you come from a background of insulin resistance your body has literally lost the ability to tap into stored fat. Elevated insulin for extended periods shoves glucose into your fat cells and locks it behind closed doors. Your liver is still running around looking for glucose because that is all it has ever known. You cannot fix that by eating less fat. You fix it by flooding your body with fat. I am talking 150 to 200 grams a day. You have to force your liver to stop looking for glucose and finally accept fat as its fuel source. That is not maintenance eating. That is metabolic retraining. And before you close this post let me remind you what fat actually does for your body. Your brain is nearly 60% fat. Every single one of your hormones is made from fat. Your cell membranes are made from fat. Fat carries your fat soluble vitamins, A, D, E and K, without fat you cannot absorb them at all. Fat keeps you satiated, stabilizes your mood, gives you steady energy, and keeps your hormones balanced. Fat is not the enemy. Fat is literally the building material your body runs on. About 70% of your calories should be coming from fat. That is not a typo. Once your liver concedes and fat becomes the rule of the land that is fat adaptation. And THAT is when you can start pulling back on dietary fat slightly and let your body tap into its own stores. That is when the weight really starts moving. I know it sounds completely backwards. I lived on low fat my entire life and ballooned to 330 pounds eating way too many carbohydrates. It took me months to unlearn everything I had been taught. The answer has always been fat. It will always be fat.👑

Queen of Carni

18,088 görüntüleme • 4 ay önce

Gary Brecka Gets REKT… AGAIN @Garybrecka is the king of making claims with zero real evidence to back it up. He is now making claims about jose david because he sells his own protein bar so of course he has to go after a popular bar. Full disclosure, I am an investor in David Protein because I believe in the product and think it will be a great option for a lot of people. But do I think protein bars are better than real, minimally processed, single ingredient foods? No. Do I think a low calorie, high protein bar is a great option for people who might otherwise choose junk food when they are on the go? I absolutely do But let’s look at his false claims: Whey is inflammatory? No, in fact the data from numerous studies shows the opposite (PMID: 35706399) I don’t know what Gary means by ‘insulin confusion but I assume it’s the trope that artificial sweeteners cause an insulin response & affect glycemia but again, the research clearly shows that is not the case (PMID: 36839408) He says Palm Kernel Oil (PKO) is inflammatory & it promotes ‘cellular stress.’ How do you define cellular stress Gary? What objective measurement are you using to diagnose this? Oh wait, you made it up. There isn’t really much data on PKO, but it actually has more saturated fat in it than palm oil which is confusing because Gary says saturated fat is ok? EPG is what makes the product so low calorie by making the fat in the product not absorbable. It has NOT been banned in Europe. Any food ingredient needs to be approved by the EU & has to go through the bureaucratic procedures to do so. It has been approved by the FDA as generally recognized as safe & has numerous studies demonstrating safety (PMID: 25497999). Some will compare it to Olestra, but EPG is different. Olestra is solid at room temperature but liquid at body temp, hence the nasty side effects like anal leakage. EPG is solid at body temperature, so it passes through as normal stool Also taking this moment to point out Gary has agreed to & reneged on 2 different debates with me so any time he’s ready I’d love to have the debate on any of the claims I’ve called him out for

Layne Norton, PhD

18,711 görüntüleme • 1 yıl önce