Loading video...

Video Failed to Load

Go Home

"Aging is the process of a complex system slowly falling into its chaotic disequilibrium. And it's not like evolution necessarily even set a lifespan for us. It is merely the result of, once the system has been established, how long its intrinsic property stayed ordered before it became disordered."...

SabrinaHalper's profile picture

Sabrina Halper

12,835 subscribers

20,154 views • 22 days ago •via X (Twitter)

LIVE

Anya Rossi• Live Now

Private livecam show

0 Comments

No comments available

Comments from the original post will appear here

Related Videos

In 2026, it's quite likely that a pill will hit the market which makes dogs live longer. This is a big deal for many reasons. The pill will come from Loyal and Celine Halioua. And they have more therapies in the pipeline. In this episode, we chat about Celine's life and career and Loyal's unique work in the longevity field. The Core Memory podcast - which makes people smarter - is brought to you by the finance wizards at Brex and the genius investors . Enjoy! Timestamps 00:00 – Intro 02:47 – Why Start With Dogs 06:05 – Aging Science Explained 09:12 – Inside FDA Trials 13:18 – Designing a Longevity Drug 17:42 – Metabolism and Aging 22:35 – Lessons From Biotech 26:48 – Building Loyal 31:54 – From Neuroscience to Founder 38:19 – GLP-1 vs Longevity Drugs 43:28 – Ethics of Longer Life 49:44 – What Dog Data Shows 54:59 – Longevity Hype & Peptides 59:47 – Biotech Needs Artists 01:05:20 – Investor Hype vs Reality 01:11:35 – AI in Drug Discovery 01:17:49 – Future of Aging Research 01:23:05 – Dogs and the End of Aging
1:29:44

In 2026, it's quite likely that a pill will hit the market which makes dogs live longer. This is a big deal for many reasons. The pill will come from Loyal and Celine Halioua. And they have more therapies in the pipeline. In this episode, we chat about Celine's life and career and Loyal's unique work in the longevity field. The Core Memory podcast - which makes people smarter - is brought to you by the finance wizards at Brex and the genius investors . Enjoy! Timestamps 00:00 – Intro 02:47 – Why Start With Dogs 06:05 – Aging Science Explained 09:12 – Inside FDA Trials 13:18 – Designing a Longevity Drug 17:42 – Metabolism and Aging 22:35 – Lessons From Biotech 26:48 – Building Loyal 31:54 – From Neuroscience to Founder 38:19 – GLP-1 vs Longevity Drugs 43:28 – Ethics of Longer Life 49:44 – What Dog Data Shows 54:59 – Longevity Hype & Peptides 59:47 – Biotech Needs Artists 01:05:20 – Investor Hype vs Reality 01:11:35 – AI in Drug Discovery 01:17:49 – Future of Aging Research 01:23:05 – Dogs and the End of Aging

Ashlee Vance

63,027 views • 9 months ago

Join my conversation with Elon Musk on AGI timelines, energy, robots, and why abundance is the most likely outcome for humanity's future, alongside my Moonshot Mate NOTDAVID! (00:00) - Navigating the Future of AI and Robotics (04:54) - The Promise of Abundance and Optimism (10:02) - Energy: The Key to a Sustainable Future (15:00) - The Role of Education in a Changing World (41:07) - Health, Longevity, and the Future of Humanity (50:51) - AI's Impact on Labor and Employment (55:05) - Universal High Income: A New Economic Paradigm (57:58) - Navigating the Singularity and AI's Acceleration (01:02:30) - The Role of AI in Healthcare and Surgery (01:08:22) - Ethics and AI: Programming Values into Machines (01:14:18) - The Future of Space Exploration and AI's Role (01:33:30) - The Chip Shortage Crisis (01:42:46) - Simulation Theory and Consciousness (01:48:18) - The Search for Extraterrestrial Life (01:58:28) - The Future of Robotics and AI Integration
2:49:47

Join my conversation with Elon Musk on AGI timelines, energy, robots, and why abundance is the most likely outcome for humanity's future, alongside my Moonshot Mate NOTDAVID! (00:00) - Navigating the Future of AI and Robotics (04:54) - The Promise of Abundance and Optimism (10:02) - Energy: The Key to a Sustainable Future (15:00) - The Role of Education in a Changing World (41:07) - Health, Longevity, and the Future of Humanity (50:51) - AI's Impact on Labor and Employment (55:05) - Universal High Income: A New Economic Paradigm (57:58) - Navigating the Singularity and AI's Acceleration (01:02:30) - The Role of AI in Healthcare and Surgery (01:08:22) - Ethics and AI: Programming Values into Machines (01:14:18) - The Future of Space Exploration and AI's Role (01:33:30) - The Chip Shortage Crisis (01:42:46) - Simulation Theory and Consciousness (01:48:18) - The Search for Extraterrestrial Life (01:58:28) - The Future of Robotics and AI Integration

Peter H. Diamandis, MD

6,232,812 views • 7 months ago

We've got a podcast! In our first episode, Ege, Tamay and Jaime dig into: • What they expect AI to look like by 2030 • Why economists are underestimating the likelihood of explosive growth • The startling regularity in technological trends like Moore's Law • Moravec’s paradox, and how we might overcome it And more more! Timestamps: 00:00:00 Preview 00:00:37 What is Epoch AI? 00:02:32 Scaling Laws 00:08:43 Key Drivers 00:19:20 End of the Decade Predictions 00:21:18 Bottlenecks: Power 00:27:59 Bottlenecks: GPUs 00:32:07 Bottlenecks: Data 00:45:37 Bottlenecks: Latency 00:56:18 Bottlenecks: Failure Rates 01:03:55 AI Investment 01:07:11 Automation 01:12:10 Benchmarks & Moravec’s Paradox 01:19:45 Economic Impact 01:45:48 Open Questions & Takeaways
2:02:21

We've got a podcast! In our first episode, Ege, Tamay and Jaime dig into: • What they expect AI to look like by 2030 • Why economists are underestimating the likelihood of explosive growth • The startling regularity in technological trends like Moore's Law • Moravec’s paradox, and how we might overcome it And more more! Timestamps: 00:00:00 Preview 00:00:37 What is Epoch AI? 00:02:32 Scaling Laws 00:08:43 Key Drivers 00:19:20 End of the Decade Predictions 00:21:18 Bottlenecks: Power 00:27:59 Bottlenecks: GPUs 00:32:07 Bottlenecks: Data 00:45:37 Bottlenecks: Latency 00:56:18 Bottlenecks: Failure Rates 01:03:55 AI Investment 01:07:11 Automation 01:12:10 Benchmarks & Moravec’s Paradox 01:19:45 Economic Impact 01:45:48 Open Questions & Takeaways

Epoch AI

152,591 views • 1 year ago

How does math research change when the cost of trying your first dumb idea goes to zero? Daniel Litt joins Greg Burnham and Anson Ho to discuss what today’s models can and can’t do in math, and how far they are from doing high-quality research. 0:00:00 What's the hardest math problem AI can solve today? 00:16:08 How helpful are today’s AI models for math research? 00:23:36 Junk papers, LLM-generated proofs, and the refereeing crisis 00:27:21 AI enables searching through problems at scale 00:33:49 When will AI be good enough to publish in top math journals? 00:42:15 What are the returns to intelligence? 00:59:50 Will AI solve Millennium problems? 01:11:54 Is math full of low-hanging fruit? 01:18:47 How Daniel has adapted his professional life to AI progress 01:25:28 What do AI math benchmarks actually measure? 01:33:05 Designing the Open Problems benchmark 01:56:35 Do mathematicians believe heuristic arguments about conjectures? 02:01:24 What if FrontierMath: Open Problems gets solved? 02:06:53 Is AI on the cusp of accelerating math progress?
2:10:59

How does math research change when the cost of trying your first dumb idea goes to zero? Daniel Litt joins Greg Burnham and Anson Ho to discuss what today’s models can and can’t do in math, and how far they are from doing high-quality research. 0:00:00 What's the hardest math problem AI can solve today? 00:16:08 How helpful are today’s AI models for math research? 00:23:36 Junk papers, LLM-generated proofs, and the refereeing crisis 00:27:21 AI enables searching through problems at scale 00:33:49 When will AI be good enough to publish in top math journals? 00:42:15 What are the returns to intelligence? 00:59:50 Will AI solve Millennium problems? 01:11:54 Is math full of low-hanging fruit? 01:18:47 How Daniel has adapted his professional life to AI progress 01:25:28 What do AI math benchmarks actually measure? 01:33:05 Designing the Open Problems benchmark 01:56:35 Do mathematicians believe heuristic arguments about conjectures? 02:01:24 What if FrontierMath: Open Problems gets solved? 02:06:53 Is AI on the cusp of accelerating math progress?

Epoch AI

178,703 views • 6 months ago

My dear friend, Vlad Tenev, changed the landscape of investing forever! The rise of the retail investor is largely due to Robinhood's success... and in this new Journey Man, we discuss it all... Enjoy! 00:00 - Intro 00:53 - Introducing Vlad Tenev of Robinhood 01:27 - Why Take on Wall Street? 01:54 - Robinhood’s Zero-Fee Origin Story 02:53 - Inspiration from Instagram and Uber 04:24 - Reimagining Trading for Mobile 05:05 - The Challenge of Disrupting Finance 05:42 - Why Everything Is Hard 06:34 - Early Wrong Assumptions 07:42 - Raising Capital with a Small Vision 08:48 - Funding Robinhood on AngelList 09:50 - Early Investors Changed Their Lives 10:38 - The Crypto Explosion Begins 11:07 - Considering a Bitcoin Exchange First 12:17 - Bitcoin’s Early Skepticism and Growth 13:08 - Robinhood Launches Crypto in 2018 14:03 - 2020: Crypto Revenue Surges Overnight 15:04 - The Challenge of Crypto Cyclicality 16:11 - Staffing a Volatile Business 17:10 - Building Robinhood’s Lean Crypto Team 18:46 - Robinhood’s First Crypto Event Coming 19:38 - Where TradFi Meets DeFi 20:34 - Tokenizing Everything 21:09 - Robinhood’s Vision for Crypto + Finance 21:47 - Thoughts on Crypto Options Demand 23:04 - Why Crypto Options Haven’t Taken Off 24:09 - Millennials and the Speculative Economy 25:22 - Democratizing Trading for Everyone 26:08 - Why Buy-and-Hold Doesn’t Work for All 27:15 - Trading vs Investing: A Matter of Wealth 28:01 - Trading as a Skill Anyone Can Build 29:13 - Robinhood’s Role in Onboarding Millions 30:06 - The Fed's Role and Retail Insight 31:03 - The Rise of the Retail Macro Trader 32:17 - Helping Users Succeed with Robinhood Strategies 33:35 - Power of Community and the Hive Mind 34:55 - Will AI Disrupt Community Too? 36:14 - Technological Waves and Investor Opportunity 37:10 - Human Purpose in an AI World 37:52 - Tokenizing Human Connection 38:28 - Creators, Platforms, and Future-Proofing 39:26 - Vlad’s Long-Term View of the Future 40:05 - Financial Services at the Heart of Disruption 41:14 - If AI Replaces Jobs, What Happens to Investing? 42:25 - Entering the Economic Singularity 43:31 - What Happens When AIs Win the Markets? 44:16 - AI's Role in Capital and Markets 45:07 - Will AI Eliminate Human Emotion from Markets? 46:06 - HFT: The Original AI Traders 47:20 - AI and Long-Term Probabilistic Forecasting 48:48 - GPUs, Gaming, and the Origins of AI 50:01 - Nvidia, CUDA, and Wall Street Arms Races 51:04 - Flash Boys and Microwave Trading 51:54 - Will AI Costs Go to Zero? 52:52 - Lower Cost, Higher Usage 53:41 - Robinhood’s UX Won’t Be Just a Chatbox 55:16 - Cortex: AI-Powered Features at Robinhood 56:54 - Tokenization and the Future of Asset Management 57:44 - Crowdsourced, Tokenized Hedge Funds 58:48 - Portability of Tokenized Assets 59:39 - Blockchain as the New Rails of Finance 01:00:09 - The Trump Token and Capital Formation 01:01:00 - Capital Access Unlocks Innovation 01:01:49 - Why Crypto Needs Regulatory Clarity 01:03:17 - From Meme Coins to Real Assets 01:04:17 - Crypto's Path to $100 Trillion? 01:05:15 - The Financial System Will Run on Blockchains 01:06:00 - Platform Layer vs Application Layer Wealth 01:06:29 - AI Raises Money and Launches Tokens 01:07:39 - AIs Creating Software and Capital Formation 01:08:00 - Final Thoughts: A Wild Future Ahead 01:08:20 - When Will Vlad Buy a CryptoPunk? 01:08:51 - Wrapping Up: AI, Crypto, and the Road Ahead
1:09:53

My dear friend, Vlad Tenev, changed the landscape of investing forever! The rise of the retail investor is largely due to Robinhood's success... and in this new Journey Man, we discuss it all... Enjoy! 00:00 - Intro 00:53 - Introducing Vlad Tenev of Robinhood 01:27 - Why Take on Wall Street? 01:54 - Robinhood’s Zero-Fee Origin Story 02:53 - Inspiration from Instagram and Uber 04:24 - Reimagining Trading for Mobile 05:05 - The Challenge of Disrupting Finance 05:42 - Why Everything Is Hard 06:34 - Early Wrong Assumptions 07:42 - Raising Capital with a Small Vision 08:48 - Funding Robinhood on AngelList 09:50 - Early Investors Changed Their Lives 10:38 - The Crypto Explosion Begins 11:07 - Considering a Bitcoin Exchange First 12:17 - Bitcoin’s Early Skepticism and Growth 13:08 - Robinhood Launches Crypto in 2018 14:03 - 2020: Crypto Revenue Surges Overnight 15:04 - The Challenge of Crypto Cyclicality 16:11 - Staffing a Volatile Business 17:10 - Building Robinhood’s Lean Crypto Team 18:46 - Robinhood’s First Crypto Event Coming 19:38 - Where TradFi Meets DeFi 20:34 - Tokenizing Everything 21:09 - Robinhood’s Vision for Crypto + Finance 21:47 - Thoughts on Crypto Options Demand 23:04 - Why Crypto Options Haven’t Taken Off 24:09 - Millennials and the Speculative Economy 25:22 - Democratizing Trading for Everyone 26:08 - Why Buy-and-Hold Doesn’t Work for All 27:15 - Trading vs Investing: A Matter of Wealth 28:01 - Trading as a Skill Anyone Can Build 29:13 - Robinhood’s Role in Onboarding Millions 30:06 - The Fed's Role and Retail Insight 31:03 - The Rise of the Retail Macro Trader 32:17 - Helping Users Succeed with Robinhood Strategies 33:35 - Power of Community and the Hive Mind 34:55 - Will AI Disrupt Community Too? 36:14 - Technological Waves and Investor Opportunity 37:10 - Human Purpose in an AI World 37:52 - Tokenizing Human Connection 38:28 - Creators, Platforms, and Future-Proofing 39:26 - Vlad’s Long-Term View of the Future 40:05 - Financial Services at the Heart of Disruption 41:14 - If AI Replaces Jobs, What Happens to Investing? 42:25 - Entering the Economic Singularity 43:31 - What Happens When AIs Win the Markets? 44:16 - AI's Role in Capital and Markets 45:07 - Will AI Eliminate Human Emotion from Markets? 46:06 - HFT: The Original AI Traders 47:20 - AI and Long-Term Probabilistic Forecasting 48:48 - GPUs, Gaming, and the Origins of AI 50:01 - Nvidia, CUDA, and Wall Street Arms Races 51:04 - Flash Boys and Microwave Trading 51:54 - Will AI Costs Go to Zero? 52:52 - Lower Cost, Higher Usage 53:41 - Robinhood’s UX Won’t Be Just a Chatbox 55:16 - Cortex: AI-Powered Features at Robinhood 56:54 - Tokenization and the Future of Asset Management 57:44 - Crowdsourced, Tokenized Hedge Funds 58:48 - Portability of Tokenized Assets 59:39 - Blockchain as the New Rails of Finance 01:00:09 - The Trump Token and Capital Formation 01:01:00 - Capital Access Unlocks Innovation 01:01:49 - Why Crypto Needs Regulatory Clarity 01:03:17 - From Meme Coins to Real Assets 01:04:17 - Crypto's Path to $100 Trillion? 01:05:15 - The Financial System Will Run on Blockchains 01:06:00 - Platform Layer vs Application Layer Wealth 01:06:29 - AI Raises Money and Launches Tokens 01:07:39 - AIs Creating Software and Capital Formation 01:08:00 - Final Thoughts: A Wild Future Ahead 01:08:20 - When Will Vlad Buy a CryptoPunk? 01:08:51 - Wrapping Up: AI, Crypto, and the Road Ahead

Raoul Pal

172,640 views • 1 year ago

Aidan Gomez (Aidan Gomez) is a computer scientist, co-author of the seminal paper ‘Attention Is All You Need,’ and the CEO of Cohere. In this episode, we discussed his upbringing in the cabin his grandfather built in Codrington, a small town North of Brighton, and the values that were instilled in him through his family. We explored his path from Codrington to his undergraduate studies at the University of Toronto, emailing Geoffrey Hinton, and joining Google Brain where he co-wrote the paper on transformers. We discussed how he met his co-founders Ivan Zhang and Nick Frosst, and his insights on what it means to build a meaningful, successful company in Canada. Aidan shares his conviction about what is at stake — for Canada and for the world at large. This is a conversation about family, values, and what it means to live with conviction. The Other Stuff is hosted by internetVin — filmmaker, entrepreneur, and possibly the most curious man on Earth. Produced by New. The Other Stuff #29 — Aidan Gomez: Empathy and Conviction — Timestamps 00:00:00 Intro 00:03:10 The Malleability of Toronto 00:11:06 Growing Up in Codrington 00:13:50 The Story of Aidan Gomez’s Family 00:27:23 Introduction to the Internet 00:30:39 Values and Work Ethic 00:35:46 University of Toronto’s AI Scene 00:40:48 Emailing Geoffrey Hinton 00:42:16 Google Brain 00:45:15 Dropout: A Simple Way to Prevent Neural Networks from Overfitting 00:49:48 The Beauty of Research 00:54:24 One Model to Rule Them All 00:59:54 Meeting Ivan Zhang and Nick Frosst 01:04:00 The Birth of Cohere 01:06:56 Twitter Influencers and Alex Friedland 01:11:48 Being the CEO 01:12:51 Building for Canada 01:15:01 Three Fundamental Ingredients of Building a Company 01:21:39 Working with the Canadian Government 01:24:39 Reflexivity in Canada 01:36:22 What Is Evil? 01:42:40 The Role of AI in the World
1:46:27

Aidan Gomez (Aidan Gomez) is a computer scientist, co-author of the seminal paper ‘Attention Is All You Need,’ and the CEO of Cohere. In this episode, we discussed his upbringing in the cabin his grandfather built in Codrington, a small town North of Brighton, and the values that were instilled in him through his family. We explored his path from Codrington to his undergraduate studies at the University of Toronto, emailing Geoffrey Hinton, and joining Google Brain where he co-wrote the paper on transformers. We discussed how he met his co-founders Ivan Zhang and Nick Frosst, and his insights on what it means to build a meaningful, successful company in Canada. Aidan shares his conviction about what is at stake — for Canada and for the world at large. This is a conversation about family, values, and what it means to live with conviction. The Other Stuff is hosted by internetVin — filmmaker, entrepreneur, and possibly the most curious man on Earth. Produced by New. The Other Stuff #29 — Aidan Gomez: Empathy and Conviction — Timestamps 00:00:00 Intro 00:03:10 The Malleability of Toronto 00:11:06 Growing Up in Codrington 00:13:50 The Story of Aidan Gomez’s Family 00:27:23 Introduction to the Internet 00:30:39 Values and Work Ethic 00:35:46 University of Toronto’s AI Scene 00:40:48 Emailing Geoffrey Hinton 00:42:16 Google Brain 00:45:15 Dropout: A Simple Way to Prevent Neural Networks from Overfitting 00:49:48 The Beauty of Research 00:54:24 One Model to Rule Them All 00:59:54 Meeting Ivan Zhang and Nick Frosst 01:04:00 The Birth of Cohere 01:06:56 Twitter Influencers and Alex Friedland 01:11:48 Being the CEO 01:12:51 Building for Canada 01:15:01 Three Fundamental Ingredients of Building a Company 01:21:39 Working with the Canadian Government 01:24:39 Reflexivity in Canada 01:36:22 What Is Evil? 01:42:40 The Role of AI in the World

The Other Stuff Podcast

45,297 views • 7 months ago

New Journey Man episode with my dear friend Alex Gurevich—please enjoy! 00:00 – Welcome to The Journeyman 01:12 – Meet Alex Gurevich 02:08 – Alex’s Macro Framework 04:47 – Five Key Forces Driving Markets 07:00 – Rate Cuts & Central Bank Cycles 08:18 – Fiscal Dominance & Inflation Risks 09:37 – Demographics and Deflation 10:07 – Geopolitics and Trade Shifts 12:32 – The Rise of the Singularity 14:05 – Why Rates Remain Sticky 16:17 – Tariffs and the Bond Market 18:03 – Basel, Regulation & Forced Buying 20:26 – Stocks, Bonds & Mispriced Narratives 22:45 – Why Crises Always End in Liquidity 25:15 – 2022’s Puzzle: Real Rates & Liquidity 27:08 – Will the Fed Cut Soon? 28:37 – Favorite Macro Trades 30:25 – Currency Plays: Yen & Yuan 32:18 – Gold, Silver & Hard Assets 35:16 – Patience in Commodities 36:08 – Bitcoin, Crypto & Long-Term Views 37:00 – Copper & Industrial Demand 38:14 – Bearish on Equities… For Now 41:03 – Crises Create Opportunity 43:01 – The Buy-the-Dip Mindset 44:48 – The AI Singularity is Here 47:11 – Kurzweil Was Right 49:21 – End of the Exponential Age 51:14 – Energy as the True Constraint 55:15 – Can AI Solve Its Energy Crisis? 58:15 – Kardashev Scale & Solar Limits 01:02:37 – What Happens to the Economy? 01:04:34 – UBI and the End of Work 01:06:53 – Energy as the New Macro Constraint 01:07:29 – Why 2030 Could Be a Turning Point 01:10:12 – Can AI Run a Macro Fund? 01:14:29 – A Future Dominated by AGI 01:16:13 – This Changes Everything 01:18:44 – Final Thoughts & Takeaways
1:20:22

New Journey Man episode with my dear friend Alex Gurevich—please enjoy! 00:00 – Welcome to The Journeyman 01:12 – Meet Alex Gurevich 02:08 – Alex’s Macro Framework 04:47 – Five Key Forces Driving Markets 07:00 – Rate Cuts & Central Bank Cycles 08:18 – Fiscal Dominance & Inflation Risks 09:37 – Demographics and Deflation 10:07 – Geopolitics and Trade Shifts 12:32 – The Rise of the Singularity 14:05 – Why Rates Remain Sticky 16:17 – Tariffs and the Bond Market 18:03 – Basel, Regulation & Forced Buying 20:26 – Stocks, Bonds & Mispriced Narratives 22:45 – Why Crises Always End in Liquidity 25:15 – 2022’s Puzzle: Real Rates & Liquidity 27:08 – Will the Fed Cut Soon? 28:37 – Favorite Macro Trades 30:25 – Currency Plays: Yen & Yuan 32:18 – Gold, Silver & Hard Assets 35:16 – Patience in Commodities 36:08 – Bitcoin, Crypto & Long-Term Views 37:00 – Copper & Industrial Demand 38:14 – Bearish on Equities… For Now 41:03 – Crises Create Opportunity 43:01 – The Buy-the-Dip Mindset 44:48 – The AI Singularity is Here 47:11 – Kurzweil Was Right 49:21 – End of the Exponential Age 51:14 – Energy as the True Constraint 55:15 – Can AI Solve Its Energy Crisis? 58:15 – Kardashev Scale & Solar Limits 01:02:37 – What Happens to the Economy? 01:04:34 – UBI and the End of Work 01:06:53 – Energy as the New Macro Constraint 01:07:29 – Why 2030 Could Be a Turning Point 01:10:12 – Can AI Run a Macro Fund? 01:14:29 – A Future Dominated by AGI 01:16:13 – This Changes Everything 01:18:44 – Final Thoughts & Takeaways

Raoul Pal

136,948 views • 1 year ago

The one and only Nikita Bier is today's guest on Out of Office. He's X's head of product, a Lightspeed venture partner, and the world's leading expert on consumer product growth. He and I recently had a long conversation in Los Angeles where we covered the evolution of the X product, how he mastered growth by hacking and learning to "think like an adversary", and what it's like to work with Elon Musk. Enjoy. Chapters: 00:00 No Silver Bullet to Growth 00:18 The Evolution of X: From PayPal to Financial Network 01:25 A Tour of South Bay 01:56 Growing Up in South Bay: Internet Adventures 03:11 From Hacking to Growth Hacking 06:57 Joining X: The Journey and Challenges 09:14 Revolutionizing X: Growth and Product Development 15:44 The Role of a Product Head at X 29:13 Balancing Free Speech and Authenticity on X 34:58 The Future of X: AI, Links, and User Engagement 37:22 Solving Engagement Issues on X 40:42 Working with Elon Musk 50:13 Building Viral Apps: TBH and Gas 01:02:35 Consulting and Angel Investing 01:10:09 AI's Impact on App Development 01:12:49 Personal Anecdotes and Reflections
1:15:17

The one and only Nikita Bier is today's guest on Out of Office. He's X's head of product, a Lightspeed venture partner, and the world's leading expert on consumer product growth. He and I recently had a long conversation in Los Angeles where we covered the evolution of the X product, how he mastered growth by hacking and learning to "think like an adversary", and what it's like to work with Elon Musk. Enjoy. Chapters: 00:00 No Silver Bullet to Growth 00:18 The Evolution of X: From PayPal to Financial Network 01:25 A Tour of South Bay 01:56 Growing Up in South Bay: Internet Adventures 03:11 From Hacking to Growth Hacking 06:57 Joining X: The Journey and Challenges 09:14 Revolutionizing X: Growth and Product Development 15:44 The Role of a Product Head at X 29:13 Balancing Free Speech and Authenticity on X 34:58 The Future of X: AI, Links, and User Engagement 37:22 Solving Engagement Issues on X 40:42 Working with Elon Musk 50:13 Building Viral Apps: TBH and Gas 01:02:35 Consulting and Angel Investing 01:10:09 AI's Impact on App Development 01:12:49 Personal Anecdotes and Reflections

Michael Mignano

583,302 views • 5 months ago

Netflix pays AI PMs up to $900K/year. How do you become (and succeed) as one? Marily Nika Marily Nika is an AI PM at Google, and was an AI PM at Meta. In today's episode, she breaks it down: How AI PM Roles Differ at Big Tech Companies – 06:56 How Technical an AI PM Needs to Be – 08:08 Data Handling Responsibilities for AI PMs – 13:10 How PMs Can Improve Collaboration with Researchers – 18:06 Interviewing for AI PM Roles at Big Tech Companies – 22:08 The Role of a PhD in AI Product Management – 26:03 Optimizing LinkedIn for Aspiring AI PMs – 31:55 Roadmap to Becoming an AI PM – 37:05 Transitioning into AI Product Management – 40:52 The Process of Boomeranging Back to a Company – 44:00 AI Tools Every PM Should Know – 48:08 What It’s Like to Be an AI PM at Google – 57:46 How to Develop a Strong Product Strategy – 01:01:21 The Evolution of PM Roles in the Age of AI – 01:05:11 How PMs Can Stay Relevant in an AI-Driven World – 01:08:12 Balancing a Side Business with a Full-Time Job – 01:13:42 The Process of Creating a Course – 01:17:12 LinkedIn Tips for Aspiring AI PM Creators – 01:21:21 Lessons from Product Failures – 01:25:27 Paid promotions included
1:27:33

Netflix pays AI PMs up to $900K/year. How do you become (and succeed) as one? Marily Nika Marily Nika is an AI PM at Google, and was an AI PM at Meta. In today's episode, she breaks it down: How AI PM Roles Differ at Big Tech Companies – 06:56 How Technical an AI PM Needs to Be – 08:08 Data Handling Responsibilities for AI PMs – 13:10 How PMs Can Improve Collaboration with Researchers – 18:06 Interviewing for AI PM Roles at Big Tech Companies – 22:08 The Role of a PhD in AI Product Management – 26:03 Optimizing LinkedIn for Aspiring AI PMs – 31:55 Roadmap to Becoming an AI PM – 37:05 Transitioning into AI Product Management – 40:52 The Process of Boomeranging Back to a Company – 44:00 AI Tools Every PM Should Know – 48:08 What It’s Like to Be an AI PM at Google – 57:46 How to Develop a Strong Product Strategy – 01:01:21 The Evolution of PM Roles in the Age of AI – 01:05:11 How PMs Can Stay Relevant in an AI-Driven World – 01:08:12 Balancing a Side Business with a Full-Time Job – 01:13:42 The Process of Creating a Course – 01:17:12 LinkedIn Tips for Aspiring AI PM Creators – 01:21:21 Lessons from Product Failures – 01:25:27 Paid promotions included

Aakash Gupta

42,853 views • 1 year ago

It's brain versus AI time. Here's our full episode with Sebastian Seung. He's started a new company to reverse engineer the brain and master the intelligence created by nature with the hopes of informing the intelligence we've created with machines. Sebastian has done pioneering AI and neuroscience work and is now blending the two to make a digital brain. Mostly, he's fun to listen to. The Core Memory podcast is made by possible by the intelligent finance powerhouse Brex and the people who back the biggest ideas @e1ventures. Timestamps 00:00:00 - Intro 00:01:42 - Who is Sebastian Seung? 00:03:23 - What is a Connectome? 00:07:08 - The Connectome Winter 00:09:08 - Diamond Knives & AI 00:12:10 - When Will We Map the Human Brain? 00:18:09 - The "Brain Crystal" & Visual Neurons 00:26:31 - New Startup 00:33:55 - Simulating a Mind in Software 00:37:40 - Biology vs. Nvidia 00:44:04 - Is AI a Religious Quest? 00:50:05 - Mind Uploading & Transhumanism 00:59:26 - Brain-Computer Interfaces 01:06:41 - From Physics to Neuroscience 01:12:22 - Will Uploads Be Conscious? 01:19:37 - Neuromorphic Chips & Future Robotics
1:28:39

It's brain versus AI time. Here's our full episode with Sebastian Seung. He's started a new company to reverse engineer the brain and master the intelligence created by nature with the hopes of informing the intelligence we've created with machines. Sebastian has done pioneering AI and neuroscience work and is now blending the two to make a digital brain. Mostly, he's fun to listen to. The Core Memory podcast is made by possible by the intelligent finance powerhouse Brex and the people who back the biggest ideas @e1ventures. Timestamps 00:00:00 - Intro 00:01:42 - Who is Sebastian Seung? 00:03:23 - What is a Connectome? 00:07:08 - The Connectome Winter 00:09:08 - Diamond Knives & AI 00:12:10 - When Will We Map the Human Brain? 00:18:09 - The "Brain Crystal" & Visual Neurons 00:26:31 - New Startup 00:33:55 - Simulating a Mind in Software 00:37:40 - Biology vs. Nvidia 00:44:04 - Is AI a Religious Quest? 00:50:05 - Mind Uploading & Transhumanism 00:59:26 - Brain-Computer Interfaces 01:06:41 - From Physics to Neuroscience 01:12:22 - Will Uploads Be Conscious? 01:19:37 - Neuromorphic Chips & Future Robotics

Ashlee Vance

38,839 views • 7 months ago

Today’s guest on the Free Radicals podcast is José Luis Ricón Fernández de la Puente, head of theory Retro Biosciences and blogger Jose is a prolific blogger, covering a wide breadth of topics across economics, philosophy, progress studies, science funding, much more, and of course longevity. His works have been published by a16z, Works in Progress and Adam Smith Institute. Our conversation is wide ranging, spanning a deep dive on Retro’s work to replace and engineer microglia to rejuvenate the brain and how our cells have the ability to turn back the aging clock but choose not to. We also covered the technological stagnation and why biological engineering is the new frontier of progress, as well as philosophical topics like transhumanism and how a future of total biological control might impact our values and way of life. Be sure to follow me and Eric Dai to stay up to date on the latest news in longevity biotech! And Special thank you to NFX & omri_drory for lending us their beautiful podcasting studio! 0:00 Intro 2:49 What is aging & why cells have a tough choice to make 9:02 When cells choose to reverse aging themselves 12:43 Cellular vs Organismal Aging & the magic wand experiment 18:31 What is reprogramming 22:40 How reprogramming plays a role in DNA damage repair 25:42 Do we already know how to cure aging? FOXO3! 28:37 How to cut through the complexity of interconnected biology 32:32 Why transcription factors are so great for intervening 36:49 Does a rejuvenation program exist already in the genome 38:51 Michael Levin: from thinking in terms of genes to morphogenesis 48:14 Tech stagnation and why physics is cooked 55:03 Why doesn't the world look more futuristic 57:26 Transhumanism & asking ourselves what we want out of life 1:05:34 Do we need war for technological progress 1:09:31 Government role in science funding 1:15:06 How Jose became the Head of Theory at Retro 1:24:53 How AI might put software engineers out of a job, and push them towards biotech 1:27:28 What it takes to get a flywheel in biotech 1:29:04 Rejuvenation vs Prevention 1:34:23 Aging is the coolest hardest problem to work on 1:36:09 What does it take to cure aging 1:42:25 Delivery mechanisms for genetic therapies 1:48:53 Retro's work to replace microglia and engineer them outside the body 1:59:10 Consciousness 2:00:39 Jose's Origin Story
2:05:48

Today’s guest on the Free Radicals podcast is José Luis Ricón Fernández de la Puente, head of theory Retro Biosciences and blogger Jose is a prolific blogger, covering a wide breadth of topics across economics, philosophy, progress studies, science funding, much more, and of course longevity. His works have been published by a16z, Works in Progress and Adam Smith Institute. Our conversation is wide ranging, spanning a deep dive on Retro’s work to replace and engineer microglia to rejuvenate the brain and how our cells have the ability to turn back the aging clock but choose not to. We also covered the technological stagnation and why biological engineering is the new frontier of progress, as well as philosophical topics like transhumanism and how a future of total biological control might impact our values and way of life. Be sure to follow me and Eric Dai to stay up to date on the latest news in longevity biotech! And Special thank you to NFX & omri_drory for lending us their beautiful podcasting studio! 0:00 Intro 2:49 What is aging & why cells have a tough choice to make 9:02 When cells choose to reverse aging themselves 12:43 Cellular vs Organismal Aging & the magic wand experiment 18:31 What is reprogramming 22:40 How reprogramming plays a role in DNA damage repair 25:42 Do we already know how to cure aging? FOXO3! 28:37 How to cut through the complexity of interconnected biology 32:32 Why transcription factors are so great for intervening 36:49 Does a rejuvenation program exist already in the genome 38:51 Michael Levin: from thinking in terms of genes to morphogenesis 48:14 Tech stagnation and why physics is cooked 55:03 Why doesn't the world look more futuristic 57:26 Transhumanism & asking ourselves what we want out of life 1:05:34 Do we need war for technological progress 1:09:31 Government role in science funding 1:15:06 How Jose became the Head of Theory at Retro 1:24:53 How AI might put software engineers out of a job, and push them towards biotech 1:27:28 What it takes to get a flywheel in biotech 1:29:04 Rejuvenation vs Prevention 1:34:23 Aging is the coolest hardest problem to work on 1:36:09 What does it take to cure aging 1:42:25 Delivery mechanisms for genetic therapies 1:48:53 Retro's work to replace microglia and engineer them outside the body 1:59:10 Consciousness 2:00:39 Jose's Origin Story

Daniel Shur

13,616 views • 4 months ago

Allie Beth Stuckey has never been afraid to speak truth in a world that often rewards silence. In this conversation, we talked about faith, conviction, and what it means to stand firm when culture pushes you to conform. Allie opened up about her journey into broadcasting, how motherhood reshaped her worldview, and why she believes women today are desperate for truth, not validation. We also talked about the cost of conviction, how to disagree without dehumanizing, and why faith must come before fear, especially in media and leadership. We discussed the state of Christianity in America, the pressure many young people face to compromise, and how social media has changed the way we share and live out our beliefs. Allie’s perspective is strong but full of grace, rooted in both intellect and compassion. This conversation was about more than faith or influence. It was about courage, clarity, and holding fast to what is true even when it is unpopular. Chapters: 0:00:00 - Intro 00:03:02: Allie Beth’s Personal Life 00:15:25: Allie Beth’s Thoughts on Marriage 00:21:20: Advice to Young Women on Finding the Right Partner 00:27:10: Lessons from Allie Beth’s Life 00:32:44: Dealing with Shame 00:41:32: Are Eating Disorders Considered Sinful? 00:46:16: Differences Between Southern Baptist, Reformed Christian, and Catholicism 00:52:19: Faith 01:12:45: Allie Beth’s Best Quotes 01:13:08: “It’s Easy to Be a Progressive” 01:14:16: “The Last Thing a Woman Wants Is to Be Excluded” 01:15:34: “I Am for the Death Penalty for the Same Reason I Am Against Abortion. I Value Innocent Life.” 01:19:19: “Your Daughters Should Not Be Listening to Taylor Swift. She Is Not a Role Model.” 01:26:24: How Allie Beth Manages Friendships That Disagree with the Bible 01:30:22: How Allie Beth Balances Sharing God’s Word Without Sounding Judgmental 01:32:56: Dealing with the Loss of Charlie Kirk BTS on Patreon:
1:46:38

Allie Beth Stuckey has never been afraid to speak truth in a world that often rewards silence. In this conversation, we talked about faith, conviction, and what it means to stand firm when culture pushes you to conform. Allie opened up about her journey into broadcasting, how motherhood reshaped her worldview, and why she believes women today are desperate for truth, not validation. We also talked about the cost of conviction, how to disagree without dehumanizing, and why faith must come before fear, especially in media and leadership. We discussed the state of Christianity in America, the pressure many young people face to compromise, and how social media has changed the way we share and live out our beliefs. Allie’s perspective is strong but full of grace, rooted in both intellect and compassion. This conversation was about more than faith or influence. It was about courage, clarity, and holding fast to what is true even when it is unpopular. Chapters: 0:00:00 - Intro 00:03:02: Allie Beth’s Personal Life 00:15:25: Allie Beth’s Thoughts on Marriage 00:21:20: Advice to Young Women on Finding the Right Partner 00:27:10: Lessons from Allie Beth’s Life 00:32:44: Dealing with Shame 00:41:32: Are Eating Disorders Considered Sinful? 00:46:16: Differences Between Southern Baptist, Reformed Christian, and Catholicism 00:52:19: Faith 01:12:45: Allie Beth’s Best Quotes 01:13:08: “It’s Easy to Be a Progressive” 01:14:16: “The Last Thing a Woman Wants Is to Be Excluded” 01:15:34: “I Am for the Death Penalty for the Same Reason I Am Against Abortion. I Value Innocent Life.” 01:19:19: “Your Daughters Should Not Be Listening to Taylor Swift. She Is Not a Role Model.” 01:26:24: How Allie Beth Manages Friendships That Disagree with the Bible 01:30:22: How Allie Beth Balances Sharing God’s Word Without Sounding Judgmental 01:32:56: Dealing with the Loss of Charlie Kirk BTS on Patreon:

Sage Steele

46,033 views • 9 months ago

A Physics That Could Finally Unify Reality (Part 2/2) - James Ellias, DemystifySci #385 A quiet tremor sounds beneath the floorboards of physics, the still-living heartbeat of the forgotten search for the hidden substance that carries every wave and whisper of the universe. We walk through the fog of equations and theories of fundamental physics with James Ellias of James Ellias, and ask if there is a material truth lies beneath the symbols, or if we have to be satisfied with the short-sighted vision of mathematics alone. 00:00 Go! 00:04:37 Central Equations in Physics 00:08:20 The Importance of a Medium in Physics 00:10:00 Empowerment Through Understanding Physics 00:12:36 Rationality and Truth in Society 00:16:31 Existence vs Consciousness 00:20:30 Discussion on Existence and Consciousness 00:24:25 Role of Imagination in Existence 00:28:10 Properties and Entities in Physics 00:30:15 The Nature of Aether and Physical Mediums 00:36:08 Clarity and Understanding in Physics 00:40:26 Discussion on Force and Aether 00:44:57 Relationship of Entities and Actions 00:49:30 Theoretical Framework for Aether 00:58:04 Exploration of Aether Theories 01:00:40 Importance of Conciseness in Communication 01:02:00 Understanding Physics Before Proposing Hypotheses 01:05:15 Reevaluation of Flawed Theories 01:09:35 The Evolution of Key Physics Concepts 01:15:19 Context-Specific Nature of Constants 01:19:43 Historical Context in Physics 01:21:36 The Nature of Electrons 01:25:53 J.J. Thomson’s Evolving Perspective 01:29:24 Upcoming Work and Philosophical Frameworks 01:32:11 Collaborations
1:33:44

A Physics That Could Finally Unify Reality (Part 2/2) - James Ellias, DemystifySci #385 A quiet tremor sounds beneath the floorboards of physics, the still-living heartbeat of the forgotten search for the hidden substance that carries every wave and whisper of the universe. We walk through the fog of equations and theories of fundamental physics with James Ellias of James Ellias, and ask if there is a material truth lies beneath the symbols, or if we have to be satisfied with the short-sighted vision of mathematics alone. 00:00 Go! 00:04:37 Central Equations in Physics 00:08:20 The Importance of a Medium in Physics 00:10:00 Empowerment Through Understanding Physics 00:12:36 Rationality and Truth in Society 00:16:31 Existence vs Consciousness 00:20:30 Discussion on Existence and Consciousness 00:24:25 Role of Imagination in Existence 00:28:10 Properties and Entities in Physics 00:30:15 The Nature of Aether and Physical Mediums 00:36:08 Clarity and Understanding in Physics 00:40:26 Discussion on Force and Aether 00:44:57 Relationship of Entities and Actions 00:49:30 Theoretical Framework for Aether 00:58:04 Exploration of Aether Theories 01:00:40 Importance of Conciseness in Communication 01:02:00 Understanding Physics Before Proposing Hypotheses 01:05:15 Reevaluation of Flawed Theories 01:09:35 The Evolution of Key Physics Concepts 01:15:19 Context-Specific Nature of Constants 01:19:43 Historical Context in Physics 01:21:36 The Nature of Electrons 01:25:53 J.J. Thomson’s Evolving Perspective 01:29:24 Upcoming Work and Philosophical Frameworks 01:32:11 Collaborations

Anastasia

13,618 views • 8 months ago

Just after Gemini 3 was released, OpenAI's research chief Mark Chen stopped by to chat. Here's our full Core Memory pod with Mark. We start with the Great Recruitment Wars and then get into Mark's career and how OpenAI's research arm works and the tricks the company thinks it has up its sleeve. Think you'll learn more about Mark's personality than ever before. This pod is brought to you by Brex. We run our company on Brex, and you should too. It's also made possible by the investing gurus E1 Ventures 🇺🇸. Timestamps 00:00:00 Intro 00:05:02 Allocating Compute and Priorities 00:08:36 Finding the Next AI Paradigm 00:14:14 Research vs. Engineering Dichotomy 00:16:25 Gemini 3 and Math Puzzles 00:20:07 AI’s "Move 37" Moment 00:28:42 ChatGPT Replacing Technical Interviews 00:35:58 From Wall Street to AI 00:44:26 Joining Early OpenAI in 2018 00:48:08 Inside the OpenAI Coup 00:53:46 Impact of Losing Top Researchers 01:00:10 Is AI Scaling Dead? 01:09:29 Automating Nobel Prize Discoveries 01:13:43 Automating Research 01:15:35 The Insatiable Demand for Compute 01:18:23 Jony Ive and AI Hardware 01:27:50 Reaction to China’s DeepSeek 01:34:03 Preventing Scheming AI Models
1:38:17

Just after Gemini 3 was released, OpenAI's research chief Mark Chen stopped by to chat. Here's our full Core Memory pod with Mark. We start with the Great Recruitment Wars and then get into Mark's career and how OpenAI's research arm works and the tricks the company thinks it has up its sleeve. Think you'll learn more about Mark's personality than ever before. This pod is brought to you by Brex. We run our company on Brex, and you should too. It's also made possible by the investing gurus E1 Ventures 🇺🇸. Timestamps 00:00:00 Intro 00:05:02 Allocating Compute and Priorities 00:08:36 Finding the Next AI Paradigm 00:14:14 Research vs. Engineering Dichotomy 00:16:25 Gemini 3 and Math Puzzles 00:20:07 AI’s "Move 37" Moment 00:28:42 ChatGPT Replacing Technical Interviews 00:35:58 From Wall Street to AI 00:44:26 Joining Early OpenAI in 2018 00:48:08 Inside the OpenAI Coup 00:53:46 Impact of Losing Top Researchers 01:00:10 Is AI Scaling Dead? 01:09:29 Automating Nobel Prize Discoveries 01:13:43 Automating Research 01:15:35 The Insatiable Demand for Compute 01:18:23 Jony Ive and AI Hardware 01:27:50 Reaction to China’s DeepSeek 01:34:03 Preventing Scheming AI Models

Ashlee Vance

80,718 views • 8 months ago

New episode with Dr. Konrad Kording (Kording Lab 🦖), professor of bioengineering and neuroscience at the University of Pennsylvania (Penn) and co-director of CIFAR's Learning in Machines & Brains program (CIFAR). Konrad works at the intersection of causality, machine learning, and neuroscience, building rigorous methods for causal reasoning when experiments aren't possible — and challenging how researchers interpret neural data and build AI. Konrad argues the most promising path to understanding how the brain works is to read the brain’s wiring directly, down to the molecular detail of each connection, and to build compilers and simulations to understand the brain’s computation directly. In this episode we go deep into how neurons work, how neurons wire together, and how organic and artificial neural networks differ. We discuss why organic neurons are doing much more; how a model of a single organic neuron can solve MNIST — computing more like a 3-layer artificial neural network; how the brain might learn by solving credit assignment with only local signals; how to approximate backprop without a global algorithm; why AI and humans are intelligent along different dimensions; why Konrad isn’t very worried about AI replacing us; economic models of intelligence and physical work; and much more. Konrad is a brilliant, contrarian thinker who explains complex concepts very intuitively. It is a solid computational neuroscience primer. I hope you enjoy this conversation as much as I did! Other links to this episode and references below. Chapters 00:00:00 Introduction 00:01:01 How organic neurons work 00:24:13 How the brain learns: circuits and credit assignment 00:45:29 Recording the brain 00:52:47 Why simulating brains is hard 01:05:00 A new approach: connectomes and compilers 01:21:00 Why simulate brains? 01:29:50 How AI and human intelligence differ 01:41:04 Evolution, intelligence and AI risk 01:52:42 Robotics, causality, and the roots of intelligence 02:05:53 AI for science and scientific rigor 02:13:05 The economics of intelligence 02:27:50 A hopeful future
2:29:40

New episode with Dr. Konrad Kording (Kording Lab 🦖), professor of bioengineering and neuroscience at the University of Pennsylvania (Penn) and co-director of CIFAR's Learning in Machines & Brains program (CIFAR). Konrad works at the intersection of causality, machine learning, and neuroscience, building rigorous methods for causal reasoning when experiments aren't possible — and challenging how researchers interpret neural data and build AI. Konrad argues the most promising path to understanding how the brain works is to read the brain’s wiring directly, down to the molecular detail of each connection, and to build compilers and simulations to understand the brain’s computation directly. In this episode we go deep into how neurons work, how neurons wire together, and how organic and artificial neural networks differ. We discuss why organic neurons are doing much more; how a model of a single organic neuron can solve MNIST — computing more like a 3-layer artificial neural network; how the brain might learn by solving credit assignment with only local signals; how to approximate backprop without a global algorithm; why AI and humans are intelligent along different dimensions; why Konrad isn’t very worried about AI replacing us; economic models of intelligence and physical work; and much more. Konrad is a brilliant, contrarian thinker who explains complex concepts very intuitively. It is a solid computational neuroscience primer. I hope you enjoy this conversation as much as I did! Other links to this episode and references below. Chapters 00:00:00 Introduction 00:01:01 How organic neurons work 00:24:13 How the brain learns: circuits and credit assignment 00:45:29 Recording the brain 00:52:47 Why simulating brains is hard 01:05:00 A new approach: connectomes and compilers 01:21:00 Why simulate brains? 01:29:50 How AI and human intelligence differ 01:41:04 Evolution, intelligence and AI risk 01:52:42 Robotics, causality, and the roots of intelligence 02:05:53 AI for science and scientific rigor 02:13:05 The economics of intelligence 02:27:50 A hopeful future

Juan Benet

49,297 views • 1 month ago

This one was personal in a way I didn’t expect. I sat down with Vivek Ramaswamy —not just to talk politics—but to talk about faith, family, and what drives him as a man. We got into what it was like growing up as the child of Indian immigrants, how his faith shapes the way he sees the world, and why he’s more interested in speaking the truth than winning approval. (00:06:54) – Milwaukee Debate (00:14:25) – What Vivek Learned from His Presidential Campaign (00:18:42) – Who Is Vivek? (00:27:20) – Apoorva Ramaswamy (00:31:37) – Breaking News! (00:34:44) – Having Children (00:38:54) – Vivek’s Parents (00:42:53) – What Vivek Has Done by Age 40 (01:01:10) – Top 3 Priorities as Governor of Ohio (01:04:57) – DOGE (01:11:24) – Epstein Files (01:19:32) – Vivek in 10 Years
1:28:05

This one was personal in a way I didn’t expect. I sat down with Vivek Ramaswamy —not just to talk politics—but to talk about faith, family, and what drives him as a man. We got into what it was like growing up as the child of Indian immigrants, how his faith shapes the way he sees the world, and why he’s more interested in speaking the truth than winning approval. (00:06:54) – Milwaukee Debate (00:14:25) – What Vivek Learned from His Presidential Campaign (00:18:42) – Who Is Vivek? (00:27:20) – Apoorva Ramaswamy (00:31:37) – Breaking News! (00:34:44) – Having Children (00:38:54) – Vivek’s Parents (00:42:53) – What Vivek Has Done by Age 40 (01:01:10) – Top 3 Priorities as Governor of Ohio (01:04:57) – DOGE (01:11:24) – Epstein Files (01:19:32) – Vivek in 10 Years

Sage Steele

243,044 views • 1 year ago

My full conversation with Spencer, founder of Orange Cap Games & new CEO of Moonbirds. The first ever upload of Max Abstraction. Enjoy! Chapters: 00:00 – Intro & Spencer joins Max Abstraction 06:45 – Spencer’s Web3 & gaming background 17:08 – Vibes: early challenges & lessons 27:14 – Crypto vs traditional gamer culture 34:08 – Korea’s impact on crypto & NFTs 39:04 – Sneak peek: Legend of the Littles 42:42 – Vibes’ evolving art & quality focus 46:27 – Breaking silhouette fatigue 50:51 – Art integrity & QC obsession 56:34 – How the Moonbirds deal happened 57:32 – Why OCG bought Moonbirds, not SV 58:53 – Mythics art: the hidden gem 01:01:49 – Moonbirds vs Mythics 01:02:41 – Market reacts to the acquisition 01:04:30 – Why Moonbirds needed new hands 01:06:18 – Vibes proves what OCG can do 01:07:42 – Set 3 is already in motion 01:09:13 – Doing it right vs fast 01:10:44 – Product-first mindset 01:12:15 – The future of Moonbirds
2:25:25

My full conversation with Spencer, founder of Orange Cap Games & new CEO of Moonbirds. The first ever upload of Max Abstraction. Enjoy! Chapters: 00:00 – Intro & Spencer joins Max Abstraction 06:45 – Spencer’s Web3 & gaming background 17:08 – Vibes: early challenges & lessons 27:14 – Crypto vs traditional gamer culture 34:08 – Korea’s impact on crypto & NFTs 39:04 – Sneak peek: Legend of the Littles 42:42 – Vibes’ evolving art & quality focus 46:27 – Breaking silhouette fatigue 50:51 – Art integrity & QC obsession 56:34 – How the Moonbirds deal happened 57:32 – Why OCG bought Moonbirds, not SV 58:53 – Mythics art: the hidden gem 01:01:49 – Moonbirds vs Mythics 01:02:41 – Market reacts to the acquisition 01:04:30 – Why Moonbirds needed new hands 01:06:18 – Vibes proves what OCG can do 01:07:42 – Set 3 is already in motion 01:09:13 – Doing it right vs fast 01:10:44 – Product-first mindset 01:12:15 – The future of Moonbirds

Ely

24,802 views • 1 year ago

Today’s guest on the Free Radicals podcast is Michael Ringel, JD PhD, COO Life Biosciences and former Managing Director at Boston Consulting Group. Michael is a leader in longevity and pharma who spent 25+ years advising top pharma companies on their R&D strategy. He is now COO at Life Biosciences where he is bringing the first ever partial epigenetic reprogramming therapy to human clinical trials - a major milestone for the longevity industry. In this episode, we discuss Michael’s insightful paper on why aging is an optimization by evolution, why that means it’s malleable, and how to push the longevity field forward. Michael also sits on the US board of Hevolution Foundation and on the board of the AFAR. Be sure to follow me and Eric Dai to stay up to date on the latest news in longevity biotech! 0:00 Intro 2:30 Why aging is an optimization by evolution 15:10 Why scientists miss the role of evolution in aging 19:31 Evidence that aging is a regulated process 24:40 Hormesis and adaptive stress responses 28:55 The promise of partial epigenetic reprogramming in humans 35:08 Life Bio's first therapy proceeding to clinical trials 47:47 Why targeting the eye, particularly glaucoma and NION, is a strategic choice 52:03 The pharma industry's perspective on anti-aging research 56:39 The importance of public engagement for funding and policy change 1:05:42 Reasons for optimism in longevity 1:08:26 Advice on how to have an impactful and interdisciplinary career 1:11:54 The ethical case for longevity 1:17:34 Concrete steps for audience members to support longevity research
1:20:44

Today’s guest on the Free Radicals podcast is Michael Ringel, JD PhD, COO Life Biosciences and former Managing Director at Boston Consulting Group. Michael is a leader in longevity and pharma who spent 25+ years advising top pharma companies on their R&D strategy. He is now COO at Life Biosciences where he is bringing the first ever partial epigenetic reprogramming therapy to human clinical trials - a major milestone for the longevity industry. In this episode, we discuss Michael’s insightful paper on why aging is an optimization by evolution, why that means it’s malleable, and how to push the longevity field forward. Michael also sits on the US board of Hevolution Foundation and on the board of the AFAR. Be sure to follow me and Eric Dai to stay up to date on the latest news in longevity biotech! 0:00 Intro 2:30 Why aging is an optimization by evolution 15:10 Why scientists miss the role of evolution in aging 19:31 Evidence that aging is a regulated process 24:40 Hormesis and adaptive stress responses 28:55 The promise of partial epigenetic reprogramming in humans 35:08 Life Bio's first therapy proceeding to clinical trials 47:47 Why targeting the eye, particularly glaucoma and NION, is a strategic choice 52:03 The pharma industry's perspective on anti-aging research 56:39 The importance of public engagement for funding and policy change 1:05:42 Reasons for optimism in longevity 1:08:26 Advice on how to have an impactful and interdisciplinary career 1:11:54 The ethical case for longevity 1:17:34 Concrete steps for audience members to support longevity research

Daniel Shur

16,967 views • 4 months ago

Today I am launching the Free Radicals podcast with Eric Dai . Every Tuesday, we’ll be releasing long form conversations with the visionaries giving humanity control over biology and working to dramatically extend human lifespan. We’re thrilled to host Celine Halioua, Founder + CEO Loyal, for our inaugural episode. Celine is building the world’s first lifespan extension drugs for dogs. Follow me, Eric Dai and Free Radicals for new episodes every Tuesday. 00:00:00 - Intro 00:01:51 - Celine’s background 00:05:00 - Dropping out of academia 00:07:50 - Finding ways to increase free will 00:09:36 - How to align financial incentives with longevity 00:14:52 - Longevity drugs should be boring 00:21:24 - Celine’s leadership style 00:24:08 - Advice on fundraising and constructing feedback loops 00:26:52 - Loyal’s fundraising history 00:27:57 - Building for Zero Billion Dollar Markets 00:29:11 - How to succeed in biotech 00:30:21 - How to find blockbuster opportunities 00:33:25 - How to create a gold rush in longevity 00:35:25 - The problem with the aging field 00:39:32 - How to identify signal from noise 00:41:54 - AI applications to biology 00:45:15 - Importance of naiveté 00:47:24 - FREE RADICALS
47:57

Today I am launching the Free Radicals podcast with Eric Dai . Every Tuesday, we’ll be releasing long form conversations with the visionaries giving humanity control over biology and working to dramatically extend human lifespan. We’re thrilled to host Celine Halioua, Founder + CEO Loyal, for our inaugural episode. Celine is building the world’s first lifespan extension drugs for dogs. Follow me, Eric Dai and Free Radicals for new episodes every Tuesday. 00:00:00 - Intro 00:01:51 - Celine’s background 00:05:00 - Dropping out of academia 00:07:50 - Finding ways to increase free will 00:09:36 - How to align financial incentives with longevity 00:14:52 - Longevity drugs should be boring 00:21:24 - Celine’s leadership style 00:24:08 - Advice on fundraising and constructing feedback loops 00:26:52 - Loyal’s fundraising history 00:27:57 - Building for Zero Billion Dollar Markets 00:29:11 - How to succeed in biotech 00:30:21 - How to find blockbuster opportunities 00:33:25 - How to create a gold rush in longevity 00:35:25 - The problem with the aging field 00:39:32 - How to identify signal from noise 00:41:54 - AI applications to biology 00:45:15 - Importance of naiveté 00:47:24 - FREE RADICALS

Daniel Shur

29,498 views • 8 months ago