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"Aging is the process of a complex system slowly falling into its chaotic disequilibrium. And it's not like evolution necessarily even set a lifespan for us. It is merely the result of, once the system has been established, how long its intrinsic property stayed ordered before it became disordered."...

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Sabrina Halper

12,835 subscribers

20,154 次观看 • 22 天前 •via X (Twitter)

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It's brain versus AI time. Here's our full episode with Sebastian Seung. He's started a new company to reverse engineer the brain and master the intelligence created by nature with the hopes of informing the intelligence we've created with machines. Sebastian has done pioneering AI and neuroscience work and is now blending the two to make a digital brain. Mostly, he's fun to listen to. The Core Memory podcast is made by possible by the intelligent finance powerhouse Brex and the people who back the biggest ideas @e1ventures. Timestamps 00:00:00 - Intro 00:01:42 - Who is Sebastian Seung? 00:03:23 - What is a Connectome? 00:07:08 - The Connectome Winter 00:09:08 - Diamond Knives & AI 00:12:10 - When Will We Map the Human Brain? 00:18:09 - The "Brain Crystal" & Visual Neurons 00:26:31 - New Startup 00:33:55 - Simulating a Mind in Software 00:37:40 - Biology vs. Nvidia 00:44:04 - Is AI a Religious Quest? 00:50:05 - Mind Uploading & Transhumanism 00:59:26 - Brain-Computer Interfaces 01:06:41 - From Physics to Neuroscience 01:12:22 - Will Uploads Be Conscious? 01:19:37 - Neuromorphic Chips & Future Robotics
1:28:39

It's brain versus AI time. Here's our full episode with Sebastian Seung. He's started a new company to reverse engineer the brain and master the intelligence created by nature with the hopes of informing the intelligence we've created with machines. Sebastian has done pioneering AI and neuroscience work and is now blending the two to make a digital brain. Mostly, he's fun to listen to. The Core Memory podcast is made by possible by the intelligent finance powerhouse Brex and the people who back the biggest ideas @e1ventures. Timestamps 00:00:00 - Intro 00:01:42 - Who is Sebastian Seung? 00:03:23 - What is a Connectome? 00:07:08 - The Connectome Winter 00:09:08 - Diamond Knives & AI 00:12:10 - When Will We Map the Human Brain? 00:18:09 - The "Brain Crystal" & Visual Neurons 00:26:31 - New Startup 00:33:55 - Simulating a Mind in Software 00:37:40 - Biology vs. Nvidia 00:44:04 - Is AI a Religious Quest? 00:50:05 - Mind Uploading & Transhumanism 00:59:26 - Brain-Computer Interfaces 01:06:41 - From Physics to Neuroscience 01:12:22 - Will Uploads Be Conscious? 01:19:37 - Neuromorphic Chips & Future Robotics

Ashlee Vance

38,839 次观看 • 7 个月前

Today’s guest on the Free Radicals podcast is José Luis Ricón Fernández de la Puente, head of theory Retro Biosciences and blogger Jose is a prolific blogger, covering a wide breadth of topics across economics, philosophy, progress studies, science funding, much more, and of course longevity. His works have been published by a16z, Works in Progress and Adam Smith Institute. Our conversation is wide ranging, spanning a deep dive on Retro’s work to replace and engineer microglia to rejuvenate the brain and how our cells have the ability to turn back the aging clock but choose not to. We also covered the technological stagnation and why biological engineering is the new frontier of progress, as well as philosophical topics like transhumanism and how a future of total biological control might impact our values and way of life. Be sure to follow me and Eric Dai to stay up to date on the latest news in longevity biotech! And Special thank you to NFX & omri_drory for lending us their beautiful podcasting studio! 0:00 Intro 2:49 What is aging & why cells have a tough choice to make 9:02 When cells choose to reverse aging themselves 12:43 Cellular vs Organismal Aging & the magic wand experiment 18:31 What is reprogramming 22:40 How reprogramming plays a role in DNA damage repair 25:42 Do we already know how to cure aging? FOXO3! 28:37 How to cut through the complexity of interconnected biology 32:32 Why transcription factors are so great for intervening 36:49 Does a rejuvenation program exist already in the genome 38:51 Michael Levin: from thinking in terms of genes to morphogenesis 48:14 Tech stagnation and why physics is cooked 55:03 Why doesn't the world look more futuristic 57:26 Transhumanism & asking ourselves what we want out of life 1:05:34 Do we need war for technological progress 1:09:31 Government role in science funding 1:15:06 How Jose became the Head of Theory at Retro 1:24:53 How AI might put software engineers out of a job, and push them towards biotech 1:27:28 What it takes to get a flywheel in biotech 1:29:04 Rejuvenation vs Prevention 1:34:23 Aging is the coolest hardest problem to work on 1:36:09 What does it take to cure aging 1:42:25 Delivery mechanisms for genetic therapies 1:48:53 Retro's work to replace microglia and engineer them outside the body 1:59:10 Consciousness 2:00:39 Jose's Origin Story
2:05:48

Today’s guest on the Free Radicals podcast is José Luis Ricón Fernández de la Puente, head of theory Retro Biosciences and blogger Jose is a prolific blogger, covering a wide breadth of topics across economics, philosophy, progress studies, science funding, much more, and of course longevity. His works have been published by a16z, Works in Progress and Adam Smith Institute. Our conversation is wide ranging, spanning a deep dive on Retro’s work to replace and engineer microglia to rejuvenate the brain and how our cells have the ability to turn back the aging clock but choose not to. We also covered the technological stagnation and why biological engineering is the new frontier of progress, as well as philosophical topics like transhumanism and how a future of total biological control might impact our values and way of life. Be sure to follow me and Eric Dai to stay up to date on the latest news in longevity biotech! And Special thank you to NFX & omri_drory for lending us their beautiful podcasting studio! 0:00 Intro 2:49 What is aging & why cells have a tough choice to make 9:02 When cells choose to reverse aging themselves 12:43 Cellular vs Organismal Aging & the magic wand experiment 18:31 What is reprogramming 22:40 How reprogramming plays a role in DNA damage repair 25:42 Do we already know how to cure aging? FOXO3! 28:37 How to cut through the complexity of interconnected biology 32:32 Why transcription factors are so great for intervening 36:49 Does a rejuvenation program exist already in the genome 38:51 Michael Levin: from thinking in terms of genes to morphogenesis 48:14 Tech stagnation and why physics is cooked 55:03 Why doesn't the world look more futuristic 57:26 Transhumanism & asking ourselves what we want out of life 1:05:34 Do we need war for technological progress 1:09:31 Government role in science funding 1:15:06 How Jose became the Head of Theory at Retro 1:24:53 How AI might put software engineers out of a job, and push them towards biotech 1:27:28 What it takes to get a flywheel in biotech 1:29:04 Rejuvenation vs Prevention 1:34:23 Aging is the coolest hardest problem to work on 1:36:09 What does it take to cure aging 1:42:25 Delivery mechanisms for genetic therapies 1:48:53 Retro's work to replace microglia and engineer them outside the body 1:59:10 Consciousness 2:00:39 Jose's Origin Story

Daniel Shur

13,616 次观看 • 4 个月前

Allie Beth Stuckey has never been afraid to speak truth in a world that often rewards silence. In this conversation, we talked about faith, conviction, and what it means to stand firm when culture pushes you to conform. Allie opened up about her journey into broadcasting, how motherhood reshaped her worldview, and why she believes women today are desperate for truth, not validation. We also talked about the cost of conviction, how to disagree without dehumanizing, and why faith must come before fear, especially in media and leadership. We discussed the state of Christianity in America, the pressure many young people face to compromise, and how social media has changed the way we share and live out our beliefs. Allie’s perspective is strong but full of grace, rooted in both intellect and compassion. This conversation was about more than faith or influence. It was about courage, clarity, and holding fast to what is true even when it is unpopular. Chapters: 0:00:00 - Intro 00:03:02: Allie Beth’s Personal Life 00:15:25: Allie Beth’s Thoughts on Marriage 00:21:20: Advice to Young Women on Finding the Right Partner 00:27:10: Lessons from Allie Beth’s Life 00:32:44: Dealing with Shame 00:41:32: Are Eating Disorders Considered Sinful? 00:46:16: Differences Between Southern Baptist, Reformed Christian, and Catholicism 00:52:19: Faith 01:12:45: Allie Beth’s Best Quotes 01:13:08: “It’s Easy to Be a Progressive” 01:14:16: “The Last Thing a Woman Wants Is to Be Excluded” 01:15:34: “I Am for the Death Penalty for the Same Reason I Am Against Abortion. I Value Innocent Life.” 01:19:19: “Your Daughters Should Not Be Listening to Taylor Swift. She Is Not a Role Model.” 01:26:24: How Allie Beth Manages Friendships That Disagree with the Bible 01:30:22: How Allie Beth Balances Sharing God’s Word Without Sounding Judgmental 01:32:56: Dealing with the Loss of Charlie Kirk BTS on Patreon:
1:46:38

Allie Beth Stuckey has never been afraid to speak truth in a world that often rewards silence. In this conversation, we talked about faith, conviction, and what it means to stand firm when culture pushes you to conform. Allie opened up about her journey into broadcasting, how motherhood reshaped her worldview, and why she believes women today are desperate for truth, not validation. We also talked about the cost of conviction, how to disagree without dehumanizing, and why faith must come before fear, especially in media and leadership. We discussed the state of Christianity in America, the pressure many young people face to compromise, and how social media has changed the way we share and live out our beliefs. Allie’s perspective is strong but full of grace, rooted in both intellect and compassion. This conversation was about more than faith or influence. It was about courage, clarity, and holding fast to what is true even when it is unpopular. Chapters: 0:00:00 - Intro 00:03:02: Allie Beth’s Personal Life 00:15:25: Allie Beth’s Thoughts on Marriage 00:21:20: Advice to Young Women on Finding the Right Partner 00:27:10: Lessons from Allie Beth’s Life 00:32:44: Dealing with Shame 00:41:32: Are Eating Disorders Considered Sinful? 00:46:16: Differences Between Southern Baptist, Reformed Christian, and Catholicism 00:52:19: Faith 01:12:45: Allie Beth’s Best Quotes 01:13:08: “It’s Easy to Be a Progressive” 01:14:16: “The Last Thing a Woman Wants Is to Be Excluded” 01:15:34: “I Am for the Death Penalty for the Same Reason I Am Against Abortion. I Value Innocent Life.” 01:19:19: “Your Daughters Should Not Be Listening to Taylor Swift. She Is Not a Role Model.” 01:26:24: How Allie Beth Manages Friendships That Disagree with the Bible 01:30:22: How Allie Beth Balances Sharing God’s Word Without Sounding Judgmental 01:32:56: Dealing with the Loss of Charlie Kirk BTS on Patreon:

Sage Steele

46,033 次观看 • 9 个月前

A Physics That Could Finally Unify Reality (Part 2/2) - James Ellias, DemystifySci #385 A quiet tremor sounds beneath the floorboards of physics, the still-living heartbeat of the forgotten search for the hidden substance that carries every wave and whisper of the universe. We walk through the fog of equations and theories of fundamental physics with James Ellias of James Ellias, and ask if there is a material truth lies beneath the symbols, or if we have to be satisfied with the short-sighted vision of mathematics alone. 00:00 Go! 00:04:37 Central Equations in Physics 00:08:20 The Importance of a Medium in Physics 00:10:00 Empowerment Through Understanding Physics 00:12:36 Rationality and Truth in Society 00:16:31 Existence vs Consciousness 00:20:30 Discussion on Existence and Consciousness 00:24:25 Role of Imagination in Existence 00:28:10 Properties and Entities in Physics 00:30:15 The Nature of Aether and Physical Mediums 00:36:08 Clarity and Understanding in Physics 00:40:26 Discussion on Force and Aether 00:44:57 Relationship of Entities and Actions 00:49:30 Theoretical Framework for Aether 00:58:04 Exploration of Aether Theories 01:00:40 Importance of Conciseness in Communication 01:02:00 Understanding Physics Before Proposing Hypotheses 01:05:15 Reevaluation of Flawed Theories 01:09:35 The Evolution of Key Physics Concepts 01:15:19 Context-Specific Nature of Constants 01:19:43 Historical Context in Physics 01:21:36 The Nature of Electrons 01:25:53 J.J. Thomson’s Evolving Perspective 01:29:24 Upcoming Work and Philosophical Frameworks 01:32:11 Collaborations
1:33:44

A Physics That Could Finally Unify Reality (Part 2/2) - James Ellias, DemystifySci #385 A quiet tremor sounds beneath the floorboards of physics, the still-living heartbeat of the forgotten search for the hidden substance that carries every wave and whisper of the universe. We walk through the fog of equations and theories of fundamental physics with James Ellias of James Ellias, and ask if there is a material truth lies beneath the symbols, or if we have to be satisfied with the short-sighted vision of mathematics alone. 00:00 Go! 00:04:37 Central Equations in Physics 00:08:20 The Importance of a Medium in Physics 00:10:00 Empowerment Through Understanding Physics 00:12:36 Rationality and Truth in Society 00:16:31 Existence vs Consciousness 00:20:30 Discussion on Existence and Consciousness 00:24:25 Role of Imagination in Existence 00:28:10 Properties and Entities in Physics 00:30:15 The Nature of Aether and Physical Mediums 00:36:08 Clarity and Understanding in Physics 00:40:26 Discussion on Force and Aether 00:44:57 Relationship of Entities and Actions 00:49:30 Theoretical Framework for Aether 00:58:04 Exploration of Aether Theories 01:00:40 Importance of Conciseness in Communication 01:02:00 Understanding Physics Before Proposing Hypotheses 01:05:15 Reevaluation of Flawed Theories 01:09:35 The Evolution of Key Physics Concepts 01:15:19 Context-Specific Nature of Constants 01:19:43 Historical Context in Physics 01:21:36 The Nature of Electrons 01:25:53 J.J. Thomson’s Evolving Perspective 01:29:24 Upcoming Work and Philosophical Frameworks 01:32:11 Collaborations

Anastasia

13,618 次观看 • 8 个月前

Just after Gemini 3 was released, OpenAI's research chief Mark Chen stopped by to chat. Here's our full Core Memory pod with Mark. We start with the Great Recruitment Wars and then get into Mark's career and how OpenAI's research arm works and the tricks the company thinks it has up its sleeve. Think you'll learn more about Mark's personality than ever before. This pod is brought to you by Brex. We run our company on Brex, and you should too. It's also made possible by the investing gurus E1 Ventures 🇺🇸. Timestamps 00:00:00 Intro 00:05:02 Allocating Compute and Priorities 00:08:36 Finding the Next AI Paradigm 00:14:14 Research vs. Engineering Dichotomy 00:16:25 Gemini 3 and Math Puzzles 00:20:07 AI’s "Move 37" Moment 00:28:42 ChatGPT Replacing Technical Interviews 00:35:58 From Wall Street to AI 00:44:26 Joining Early OpenAI in 2018 00:48:08 Inside the OpenAI Coup 00:53:46 Impact of Losing Top Researchers 01:00:10 Is AI Scaling Dead? 01:09:29 Automating Nobel Prize Discoveries 01:13:43 Automating Research 01:15:35 The Insatiable Demand for Compute 01:18:23 Jony Ive and AI Hardware 01:27:50 Reaction to China’s DeepSeek 01:34:03 Preventing Scheming AI Models
1:38:17

Just after Gemini 3 was released, OpenAI's research chief Mark Chen stopped by to chat. Here's our full Core Memory pod with Mark. We start with the Great Recruitment Wars and then get into Mark's career and how OpenAI's research arm works and the tricks the company thinks it has up its sleeve. Think you'll learn more about Mark's personality than ever before. This pod is brought to you by Brex. We run our company on Brex, and you should too. It's also made possible by the investing gurus E1 Ventures 🇺🇸. Timestamps 00:00:00 Intro 00:05:02 Allocating Compute and Priorities 00:08:36 Finding the Next AI Paradigm 00:14:14 Research vs. Engineering Dichotomy 00:16:25 Gemini 3 and Math Puzzles 00:20:07 AI’s "Move 37" Moment 00:28:42 ChatGPT Replacing Technical Interviews 00:35:58 From Wall Street to AI 00:44:26 Joining Early OpenAI in 2018 00:48:08 Inside the OpenAI Coup 00:53:46 Impact of Losing Top Researchers 01:00:10 Is AI Scaling Dead? 01:09:29 Automating Nobel Prize Discoveries 01:13:43 Automating Research 01:15:35 The Insatiable Demand for Compute 01:18:23 Jony Ive and AI Hardware 01:27:50 Reaction to China’s DeepSeek 01:34:03 Preventing Scheming AI Models

Ashlee Vance

80,718 次观看 • 8 个月前

New episode with Dr. Konrad Kording (Kording Lab 🦖), professor of bioengineering and neuroscience at the University of Pennsylvania (Penn) and co-director of CIFAR's Learning in Machines & Brains program (CIFAR). Konrad works at the intersection of causality, machine learning, and neuroscience, building rigorous methods for causal reasoning when experiments aren't possible — and challenging how researchers interpret neural data and build AI. Konrad argues the most promising path to understanding how the brain works is to read the brain’s wiring directly, down to the molecular detail of each connection, and to build compilers and simulations to understand the brain’s computation directly. In this episode we go deep into how neurons work, how neurons wire together, and how organic and artificial neural networks differ. We discuss why organic neurons are doing much more; how a model of a single organic neuron can solve MNIST — computing more like a 3-layer artificial neural network; how the brain might learn by solving credit assignment with only local signals; how to approximate backprop without a global algorithm; why AI and humans are intelligent along different dimensions; why Konrad isn’t very worried about AI replacing us; economic models of intelligence and physical work; and much more. Konrad is a brilliant, contrarian thinker who explains complex concepts very intuitively. It is a solid computational neuroscience primer. I hope you enjoy this conversation as much as I did! Other links to this episode and references below. Chapters 00:00:00 Introduction 00:01:01 How organic neurons work 00:24:13 How the brain learns: circuits and credit assignment 00:45:29 Recording the brain 00:52:47 Why simulating brains is hard 01:05:00 A new approach: connectomes and compilers 01:21:00 Why simulate brains? 01:29:50 How AI and human intelligence differ 01:41:04 Evolution, intelligence and AI risk 01:52:42 Robotics, causality, and the roots of intelligence 02:05:53 AI for science and scientific rigor 02:13:05 The economics of intelligence 02:27:50 A hopeful future
2:29:40

New episode with Dr. Konrad Kording (Kording Lab 🦖), professor of bioengineering and neuroscience at the University of Pennsylvania (Penn) and co-director of CIFAR's Learning in Machines & Brains program (CIFAR). Konrad works at the intersection of causality, machine learning, and neuroscience, building rigorous methods for causal reasoning when experiments aren't possible — and challenging how researchers interpret neural data and build AI. Konrad argues the most promising path to understanding how the brain works is to read the brain’s wiring directly, down to the molecular detail of each connection, and to build compilers and simulations to understand the brain’s computation directly. In this episode we go deep into how neurons work, how neurons wire together, and how organic and artificial neural networks differ. We discuss why organic neurons are doing much more; how a model of a single organic neuron can solve MNIST — computing more like a 3-layer artificial neural network; how the brain might learn by solving credit assignment with only local signals; how to approximate backprop without a global algorithm; why AI and humans are intelligent along different dimensions; why Konrad isn’t very worried about AI replacing us; economic models of intelligence and physical work; and much more. Konrad is a brilliant, contrarian thinker who explains complex concepts very intuitively. It is a solid computational neuroscience primer. I hope you enjoy this conversation as much as I did! Other links to this episode and references below. Chapters 00:00:00 Introduction 00:01:01 How organic neurons work 00:24:13 How the brain learns: circuits and credit assignment 00:45:29 Recording the brain 00:52:47 Why simulating brains is hard 01:05:00 A new approach: connectomes and compilers 01:21:00 Why simulate brains? 01:29:50 How AI and human intelligence differ 01:41:04 Evolution, intelligence and AI risk 01:52:42 Robotics, causality, and the roots of intelligence 02:05:53 AI for science and scientific rigor 02:13:05 The economics of intelligence 02:27:50 A hopeful future

Juan Benet

49,297 次观看 • 1 个月前

This one was personal in a way I didn’t expect. I sat down with Vivek Ramaswamy —not just to talk politics—but to talk about faith, family, and what drives him as a man. We got into what it was like growing up as the child of Indian immigrants, how his faith shapes the way he sees the world, and why he’s more interested in speaking the truth than winning approval. (00:06:54) – Milwaukee Debate (00:14:25) – What Vivek Learned from His Presidential Campaign (00:18:42) – Who Is Vivek? (00:27:20) – Apoorva Ramaswamy (00:31:37) – Breaking News! (00:34:44) – Having Children (00:38:54) – Vivek’s Parents (00:42:53) – What Vivek Has Done by Age 40 (01:01:10) – Top 3 Priorities as Governor of Ohio (01:04:57) – DOGE (01:11:24) – Epstein Files (01:19:32) – Vivek in 10 Years
1:28:05

This one was personal in a way I didn’t expect. I sat down with Vivek Ramaswamy —not just to talk politics—but to talk about faith, family, and what drives him as a man. We got into what it was like growing up as the child of Indian immigrants, how his faith shapes the way he sees the world, and why he’s more interested in speaking the truth than winning approval. (00:06:54) – Milwaukee Debate (00:14:25) – What Vivek Learned from His Presidential Campaign (00:18:42) – Who Is Vivek? (00:27:20) – Apoorva Ramaswamy (00:31:37) – Breaking News! (00:34:44) – Having Children (00:38:54) – Vivek’s Parents (00:42:53) – What Vivek Has Done by Age 40 (01:01:10) – Top 3 Priorities as Governor of Ohio (01:04:57) – DOGE (01:11:24) – Epstein Files (01:19:32) – Vivek in 10 Years

Sage Steele

243,044 次观看 • 1 年前

My full conversation with Spencer, founder of Orange Cap Games & new CEO of Moonbirds. The first ever upload of Max Abstraction. Enjoy! Chapters: 00:00 – Intro & Spencer joins Max Abstraction 06:45 – Spencer’s Web3 & gaming background 17:08 – Vibes: early challenges & lessons 27:14 – Crypto vs traditional gamer culture 34:08 – Korea’s impact on crypto & NFTs 39:04 – Sneak peek: Legend of the Littles 42:42 – Vibes’ evolving art & quality focus 46:27 – Breaking silhouette fatigue 50:51 – Art integrity & QC obsession 56:34 – How the Moonbirds deal happened 57:32 – Why OCG bought Moonbirds, not SV 58:53 – Mythics art: the hidden gem 01:01:49 – Moonbirds vs Mythics 01:02:41 – Market reacts to the acquisition 01:04:30 – Why Moonbirds needed new hands 01:06:18 – Vibes proves what OCG can do 01:07:42 – Set 3 is already in motion 01:09:13 – Doing it right vs fast 01:10:44 – Product-first mindset 01:12:15 – The future of Moonbirds
2:25:25

My full conversation with Spencer, founder of Orange Cap Games & new CEO of Moonbirds. The first ever upload of Max Abstraction. Enjoy! Chapters: 00:00 – Intro & Spencer joins Max Abstraction 06:45 – Spencer’s Web3 & gaming background 17:08 – Vibes: early challenges & lessons 27:14 – Crypto vs traditional gamer culture 34:08 – Korea’s impact on crypto & NFTs 39:04 – Sneak peek: Legend of the Littles 42:42 – Vibes’ evolving art & quality focus 46:27 – Breaking silhouette fatigue 50:51 – Art integrity & QC obsession 56:34 – How the Moonbirds deal happened 57:32 – Why OCG bought Moonbirds, not SV 58:53 – Mythics art: the hidden gem 01:01:49 – Moonbirds vs Mythics 01:02:41 – Market reacts to the acquisition 01:04:30 – Why Moonbirds needed new hands 01:06:18 – Vibes proves what OCG can do 01:07:42 – Set 3 is already in motion 01:09:13 – Doing it right vs fast 01:10:44 – Product-first mindset 01:12:15 – The future of Moonbirds

Ely

24,802 次观看 • 1 年前

Today’s guest on the Free Radicals podcast is Michael Ringel, JD PhD, COO Life Biosciences and former Managing Director at Boston Consulting Group. Michael is a leader in longevity and pharma who spent 25+ years advising top pharma companies on their R&D strategy. He is now COO at Life Biosciences where he is bringing the first ever partial epigenetic reprogramming therapy to human clinical trials - a major milestone for the longevity industry. In this episode, we discuss Michael’s insightful paper on why aging is an optimization by evolution, why that means it’s malleable, and how to push the longevity field forward. Michael also sits on the US board of Hevolution Foundation and on the board of the AFAR. Be sure to follow me and Eric Dai to stay up to date on the latest news in longevity biotech! 0:00 Intro 2:30 Why aging is an optimization by evolution 15:10 Why scientists miss the role of evolution in aging 19:31 Evidence that aging is a regulated process 24:40 Hormesis and adaptive stress responses 28:55 The promise of partial epigenetic reprogramming in humans 35:08 Life Bio's first therapy proceeding to clinical trials 47:47 Why targeting the eye, particularly glaucoma and NION, is a strategic choice 52:03 The pharma industry's perspective on anti-aging research 56:39 The importance of public engagement for funding and policy change 1:05:42 Reasons for optimism in longevity 1:08:26 Advice on how to have an impactful and interdisciplinary career 1:11:54 The ethical case for longevity 1:17:34 Concrete steps for audience members to support longevity research
1:20:44

Today’s guest on the Free Radicals podcast is Michael Ringel, JD PhD, COO Life Biosciences and former Managing Director at Boston Consulting Group. Michael is a leader in longevity and pharma who spent 25+ years advising top pharma companies on their R&D strategy. He is now COO at Life Biosciences where he is bringing the first ever partial epigenetic reprogramming therapy to human clinical trials - a major milestone for the longevity industry. In this episode, we discuss Michael’s insightful paper on why aging is an optimization by evolution, why that means it’s malleable, and how to push the longevity field forward. Michael also sits on the US board of Hevolution Foundation and on the board of the AFAR. Be sure to follow me and Eric Dai to stay up to date on the latest news in longevity biotech! 0:00 Intro 2:30 Why aging is an optimization by evolution 15:10 Why scientists miss the role of evolution in aging 19:31 Evidence that aging is a regulated process 24:40 Hormesis and adaptive stress responses 28:55 The promise of partial epigenetic reprogramming in humans 35:08 Life Bio's first therapy proceeding to clinical trials 47:47 Why targeting the eye, particularly glaucoma and NION, is a strategic choice 52:03 The pharma industry's perspective on anti-aging research 56:39 The importance of public engagement for funding and policy change 1:05:42 Reasons for optimism in longevity 1:08:26 Advice on how to have an impactful and interdisciplinary career 1:11:54 The ethical case for longevity 1:17:34 Concrete steps for audience members to support longevity research

Daniel Shur

16,967 次观看 • 4 个月前

Today I am launching the Free Radicals podcast with Eric Dai . Every Tuesday, we’ll be releasing long form conversations with the visionaries giving humanity control over biology and working to dramatically extend human lifespan. We’re thrilled to host Celine Halioua, Founder + CEO Loyal, for our inaugural episode. Celine is building the world’s first lifespan extension drugs for dogs. Follow me, Eric Dai and Free Radicals for new episodes every Tuesday. 00:00:00 - Intro 00:01:51 - Celine’s background 00:05:00 - Dropping out of academia 00:07:50 - Finding ways to increase free will 00:09:36 - How to align financial incentives with longevity 00:14:52 - Longevity drugs should be boring 00:21:24 - Celine’s leadership style 00:24:08 - Advice on fundraising and constructing feedback loops 00:26:52 - Loyal’s fundraising history 00:27:57 - Building for Zero Billion Dollar Markets 00:29:11 - How to succeed in biotech 00:30:21 - How to find blockbuster opportunities 00:33:25 - How to create a gold rush in longevity 00:35:25 - The problem with the aging field 00:39:32 - How to identify signal from noise 00:41:54 - AI applications to biology 00:45:15 - Importance of naiveté 00:47:24 - FREE RADICALS
47:57

Today I am launching the Free Radicals podcast with Eric Dai . Every Tuesday, we’ll be releasing long form conversations with the visionaries giving humanity control over biology and working to dramatically extend human lifespan. We’re thrilled to host Celine Halioua, Founder + CEO Loyal, for our inaugural episode. Celine is building the world’s first lifespan extension drugs for dogs. Follow me, Eric Dai and Free Radicals for new episodes every Tuesday. 00:00:00 - Intro 00:01:51 - Celine’s background 00:05:00 - Dropping out of academia 00:07:50 - Finding ways to increase free will 00:09:36 - How to align financial incentives with longevity 00:14:52 - Longevity drugs should be boring 00:21:24 - Celine’s leadership style 00:24:08 - Advice on fundraising and constructing feedback loops 00:26:52 - Loyal’s fundraising history 00:27:57 - Building for Zero Billion Dollar Markets 00:29:11 - How to succeed in biotech 00:30:21 - How to find blockbuster opportunities 00:33:25 - How to create a gold rush in longevity 00:35:25 - The problem with the aging field 00:39:32 - How to identify signal from noise 00:41:54 - AI applications to biology 00:45:15 - Importance of naiveté 00:47:24 - FREE RADICALS

Daniel Shur

29,498 次观看 • 8 个月前