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“Almost everything you learn in biology textbooks is a hallucination.” This week we spoke with Nobel Prize-winning physicist Eric Betzig about one of the biggest challenges in biology: actually seeing what happens inside a living cell. Betzig’s work in super-resolution microscopy revealed a dynamic molecular world that often looks...

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34,593 Aufrufe • vor 11 Tagen •via X (Twitter)

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10 Kommentare

Profilbild von The Fallen Ape-theist
The Fallen Ape-theistvor 10 Tagen

Some people ask “If you admit much of biology and neurology is illusion, then how can you trust it?” But what if illusion and prediction are better than just real-time blank-slate processing of reality as you encounter it? Even if that seems unfathomable to us… what if that’s just how it is?

Profilbild von Superpositionbigbang
Superpositionbigbangvor 10 Tagen

@Eric_Betzig Here is something that could really be useful towards more advanced microscopy. Enjoy!

Profilbild von Joe
Joevor 9 Tagen

@Eric_Betzig

Profilbild von Coban Brundo
Coban Brundovor 10 Tagen

@Eric_Betzig 👍👍

Profilbild von HumanX
HumanXvor 10 Tagen

@Eric_Betzig If so why does it work?

Profilbild von outta boxiano
outta boxianovor 10 Tagen

@Eric_Betzig That’s a real ass academic nigga

Profilbild von karenrivera
karenriveravor 10 Tagen

@Eric_Betzig Can't wait to dive into this episode and learn more about the wonders of super-resolution microscopy!

Profilbild von Ciro
Cirovor 9 Tagen

@Eric_Betzig Everybody has their favorite I’m sure but to me, there’s no question. What a 2 1/2 hour chat! The description of life at Bell Labs alone…

Profilbild von Henning Sittler
Henning Sittlervor 10 Tagen

@Eric_Betzig > trillions 👍

Profilbild von Om Prakash
Om Prakashvor 10 Tagen

@Eric_Betzig Sounds super interesting!

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Lex Fridman

791,661 Aufrufe • vor 2 Jahren

Nobel laureate John Jumper (John Jumper) on AlphaFold and the future of science. At AI Startup School in San Francisco. 01:02 - Journey from Physics to Computational Biology 02:01 - Transition to Machine Learning and AI 02:59 - Joining Google DeepMind 03:47 - The Mission: Accelerating Scientific Discovery 04:54 - Understanding Protein Structures 07:44 - Challenges in Protein Structure Determination 11:21 - The Role of Data, Compute, and Research 13:28 - AlphaFold: A Breakthrough in Protein Prediction 14:09 - The Importance of Research and Ideas 17:48 - Real-World Applications and Impact 18:02 - Open Sourcing AlphaFold 21:07 - Unexpected Uses and Innovations 23:15 - Case Study: Molecular Syringe 25:28 - Future of AI in Science
27:12

Nobel laureate John Jumper (John Jumper) on AlphaFold and the future of science. At AI Startup School in San Francisco. 01:02 - Journey from Physics to Computational Biology 02:01 - Transition to Machine Learning and AI 02:59 - Joining Google DeepMind 03:47 - The Mission: Accelerating Scientific Discovery 04:54 - Understanding Protein Structures 07:44 - Challenges in Protein Structure Determination 11:21 - The Role of Data, Compute, and Research 13:28 - AlphaFold: A Breakthrough in Protein Prediction 14:09 - The Importance of Research and Ideas 17:48 - Real-World Applications and Impact 18:02 - Open Sourcing AlphaFold 21:07 - Unexpected Uses and Innovations 23:15 - Case Study: Molecular Syringe 25:28 - Future of AI in Science

Y Combinator

150,364 Aufrufe • vor 1 Jahr

It's brain versus AI time. Here's our full episode with Sebastian Seung. He's started a new company to reverse engineer the brain and master the intelligence created by nature with the hopes of informing the intelligence we've created with machines. Sebastian has done pioneering AI and neuroscience work and is now blending the two to make a digital brain. Mostly, he's fun to listen to. The Core Memory podcast is made by possible by the intelligent finance powerhouse Brex and the people who back the biggest ideas @e1ventures. Timestamps 00:00:00 - Intro 00:01:42 - Who is Sebastian Seung? 00:03:23 - What is a Connectome? 00:07:08 - The Connectome Winter 00:09:08 - Diamond Knives & AI 00:12:10 - When Will We Map the Human Brain? 00:18:09 - The "Brain Crystal" & Visual Neurons 00:26:31 - New Startup 00:33:55 - Simulating a Mind in Software 00:37:40 - Biology vs. Nvidia 00:44:04 - Is AI a Religious Quest? 00:50:05 - Mind Uploading & Transhumanism 00:59:26 - Brain-Computer Interfaces 01:06:41 - From Physics to Neuroscience 01:12:22 - Will Uploads Be Conscious? 01:19:37 - Neuromorphic Chips & Future Robotics
1:28:39

It's brain versus AI time. Here's our full episode with Sebastian Seung. He's started a new company to reverse engineer the brain and master the intelligence created by nature with the hopes of informing the intelligence we've created with machines. Sebastian has done pioneering AI and neuroscience work and is now blending the two to make a digital brain. Mostly, he's fun to listen to. The Core Memory podcast is made by possible by the intelligent finance powerhouse Brex and the people who back the biggest ideas @e1ventures. Timestamps 00:00:00 - Intro 00:01:42 - Who is Sebastian Seung? 00:03:23 - What is a Connectome? 00:07:08 - The Connectome Winter 00:09:08 - Diamond Knives & AI 00:12:10 - When Will We Map the Human Brain? 00:18:09 - The "Brain Crystal" & Visual Neurons 00:26:31 - New Startup 00:33:55 - Simulating a Mind in Software 00:37:40 - Biology vs. Nvidia 00:44:04 - Is AI a Religious Quest? 00:50:05 - Mind Uploading & Transhumanism 00:59:26 - Brain-Computer Interfaces 01:06:41 - From Physics to Neuroscience 01:12:22 - Will Uploads Be Conscious? 01:19:37 - Neuromorphic Chips & Future Robotics

Ashlee Vance

39,238 Aufrufe • vor 9 Monaten

Ever wonder why we decide to build a new microscope and how we go about it? For the last lecture this semester of the graduate microscopy class Na, Gokul, and I teach at Cal, I spoke on our developing iSOAR microscope, a swept HILO design with adaptive optics and structured illumination. iSOAR is designed to produce the petabytes of high resolution 5D videos of subcellular dynamics in zebrafish we need to train the multimodal vision models at the heart of our Cell Observatory Initiative. We still have some work to do, but the scopes are coming along nicely. It's an exciting time at the Observatory, so if you're experienced and looking for a job in zebrafish transgenics, ultra-high throughput image processing, or the development of 5D spatiotemporal foundation models for interpreting the insane dynamic complexity of living matter, we'd love to hear from you. (sup@berkeley.edu, betzige@janelia.hhmi.org).
1:05:01

Ever wonder why we decide to build a new microscope and how we go about it? For the last lecture this semester of the graduate microscopy class Na, Gokul, and I teach at Cal, I spoke on our developing iSOAR microscope, a swept HILO design with adaptive optics and structured illumination. iSOAR is designed to produce the petabytes of high resolution 5D videos of subcellular dynamics in zebrafish we need to train the multimodal vision models at the heart of our Cell Observatory Initiative. We still have some work to do, but the scopes are coming along nicely. It's an exciting time at the Observatory, so if you're experienced and looking for a job in zebrafish transgenics, ultra-high throughput image processing, or the development of 5D spatiotemporal foundation models for interpreting the insane dynamic complexity of living matter, we'd love to hear from you. ([email protected], [email protected]).

Eric Betzig

22,081 Aufrufe • vor 9 Monaten

Aidan Gomez (Aidan Gomez) is a computer scientist, co-author of the seminal paper ‘Attention Is All You Need,’ and the CEO of Cohere. In this episode, we discussed his upbringing in the cabin his grandfather built in Codrington, a small town North of Brighton, and the values that were instilled in him through his family. We explored his path from Codrington to his undergraduate studies at the University of Toronto, emailing Geoffrey Hinton, and joining Google Brain where he co-wrote the paper on transformers. We discussed how he met his co-founders Ivan Zhang and Nick Frosst, and his insights on what it means to build a meaningful, successful company in Canada. Aidan shares his conviction about what is at stake — for Canada and for the world at large. This is a conversation about family, values, and what it means to live with conviction. The Other Stuff is hosted by internetVin — filmmaker, entrepreneur, and possibly the most curious man on Earth. Produced by New. The Other Stuff #29 — Aidan Gomez: Empathy and Conviction — Timestamps 00:00:00 Intro 00:03:10 The Malleability of Toronto 00:11:06 Growing Up in Codrington 00:13:50 The Story of Aidan Gomez’s Family 00:27:23 Introduction to the Internet 00:30:39 Values and Work Ethic 00:35:46 University of Toronto’s AI Scene 00:40:48 Emailing Geoffrey Hinton 00:42:16 Google Brain 00:45:15 Dropout: A Simple Way to Prevent Neural Networks from Overfitting 00:49:48 The Beauty of Research 00:54:24 One Model to Rule Them All 00:59:54 Meeting Ivan Zhang and Nick Frosst 01:04:00 The Birth of Cohere 01:06:56 Twitter Influencers and Alex Friedland 01:11:48 Being the CEO 01:12:51 Building for Canada 01:15:01 Three Fundamental Ingredients of Building a Company 01:21:39 Working with the Canadian Government 01:24:39 Reflexivity in Canada 01:36:22 What Is Evil? 01:42:40 The Role of AI in the World
1:46:27

Aidan Gomez (Aidan Gomez) is a computer scientist, co-author of the seminal paper ‘Attention Is All You Need,’ and the CEO of Cohere. In this episode, we discussed his upbringing in the cabin his grandfather built in Codrington, a small town North of Brighton, and the values that were instilled in him through his family. We explored his path from Codrington to his undergraduate studies at the University of Toronto, emailing Geoffrey Hinton, and joining Google Brain where he co-wrote the paper on transformers. We discussed how he met his co-founders Ivan Zhang and Nick Frosst, and his insights on what it means to build a meaningful, successful company in Canada. Aidan shares his conviction about what is at stake — for Canada and for the world at large. This is a conversation about family, values, and what it means to live with conviction. The Other Stuff is hosted by internetVin — filmmaker, entrepreneur, and possibly the most curious man on Earth. Produced by New. The Other Stuff #29 — Aidan Gomez: Empathy and Conviction — Timestamps 00:00:00 Intro 00:03:10 The Malleability of Toronto 00:11:06 Growing Up in Codrington 00:13:50 The Story of Aidan Gomez’s Family 00:27:23 Introduction to the Internet 00:30:39 Values and Work Ethic 00:35:46 University of Toronto’s AI Scene 00:40:48 Emailing Geoffrey Hinton 00:42:16 Google Brain 00:45:15 Dropout: A Simple Way to Prevent Neural Networks from Overfitting 00:49:48 The Beauty of Research 00:54:24 One Model to Rule Them All 00:59:54 Meeting Ivan Zhang and Nick Frosst 01:04:00 The Birth of Cohere 01:06:56 Twitter Influencers and Alex Friedland 01:11:48 Being the CEO 01:12:51 Building for Canada 01:15:01 Three Fundamental Ingredients of Building a Company 01:21:39 Working with the Canadian Government 01:24:39 Reflexivity in Canada 01:36:22 What Is Evil? 01:42:40 The Role of AI in the World

The Other Stuff Podcast

45,297 Aufrufe • vor 9 Monaten

I sat down with Jordi Visser to discuss the SpaceX IPO, orbital data centers, and the critical minerals powering the AI buildout. We also discuss the AI model wars, why Jordi thinks Sam Altman won't be running OpenAI within a year, and how the New York Knicks playoff run connects to the future of crypto and blockchain in a world of AI and deep fakes. YouTube: Spotify: Apple: TIMESTAMPS: 0:00 - Intro 1:00 - SpaceX IPO, Elon & orbital data centers 12:15 - Critical minerals & the AI supply chain 18:55 - American industrial sovereignty & critical chemicals 22:36 - AI model cost crisis & who wins the model war 37:10 - Knicks NBA Finals & the case for crypto in an AI world 47:48 - Jeff Bezos launches Prometheus 50:34 - AI use case of the week
54:47

I sat down with Jordi Visser to discuss the SpaceX IPO, orbital data centers, and the critical minerals powering the AI buildout. We also discuss the AI model wars, why Jordi thinks Sam Altman won't be running OpenAI within a year, and how the New York Knicks playoff run connects to the future of crypto and blockchain in a world of AI and deep fakes. YouTube: Spotify: Apple: TIMESTAMPS: 0:00 - Intro 1:00 - SpaceX IPO, Elon & orbital data centers 12:15 - Critical minerals & the AI supply chain 18:55 - American industrial sovereignty & critical chemicals 22:36 - AI model cost crisis & who wins the model war 37:10 - Knicks NBA Finals & the case for crypto in an AI world 47:48 - Jeff Bezos launches Prometheus 50:34 - AI use case of the week

Anthony Pompliano 🌪

133,301 Aufrufe • vor 3 Monaten

Here's my conversation with historian Lars Brownworth all about the Vikings, from the start of the Vikings Age to the conquest of Europe and beyond. This was an epic & mind-blowing conversation. It's here on X in full and is up everywhere else (see comment). Timestamps: 0:00 - Episode highlight 1:17 - Introduction 2:37 - The start of the Viking Age 12:30 - Viking military strategy, tactics & technology 26:13 - Ragnar Lothbrok 35:40 - The Great Heathen Army 40:23 - Rollo and Normandy 50:34 - Viking religion and Valhalla 1:01:06 - Viking explorers 1:06:13 - Vikings in North America 1:19:35 - Vikings in the East 1:39:14 - Byzantine Empire 1:47:57 - History and human nature
2:03:23

Here's my conversation with historian Lars Brownworth all about the Vikings, from the start of the Vikings Age to the conquest of Europe and beyond. This was an epic & mind-blowing conversation. It's here on X in full and is up everywhere else (see comment). Timestamps: 0:00 - Episode highlight 1:17 - Introduction 2:37 - The start of the Viking Age 12:30 - Viking military strategy, tactics & technology 26:13 - Ragnar Lothbrok 35:40 - The Great Heathen Army 40:23 - Rollo and Normandy 50:34 - Viking religion and Valhalla 1:01:06 - Viking explorers 1:06:13 - Vikings in North America 1:19:35 - Vikings in the East 1:39:14 - Byzantine Empire 1:47:57 - History and human nature

Lex Fridman

277,031 Aufrufe • vor 5 Monaten

Judea Pearl (Judea Pearl) is a Turing Award winner famous for his contributions to artificial intelligence and causal reasoning. We talked about the greatest scientist of all time, his major breakthroughs and his predictions for AI today. Full conversation also on my YouTube, Spotify, and Apple Podcasts. Timestamps: 00:00 Intro 00:54 How he got into AI 11:17 Greatest scientist of all time 20:15 What people thought of AI in the 80s 26:23 Entering academia and researching AI 34:52 The invention of Bayesian networks 46:28 Pioneering work in causality 55:38 The causal hierarchy 59:34 LLMs and predictions 01:20:12 A restless mind pays 01:24:36 Advice for his younger self 01:26:37 Outro
1:27:33

Judea Pearl (Judea Pearl) is a Turing Award winner famous for his contributions to artificial intelligence and causal reasoning. We talked about the greatest scientist of all time, his major breakthroughs and his predictions for AI today. Full conversation also on my YouTube, Spotify, and Apple Podcasts. Timestamps: 00:00 Intro 00:54 How he got into AI 11:17 Greatest scientist of all time 20:15 What people thought of AI in the 80s 26:23 Entering academia and researching AI 34:52 The invention of Bayesian networks 46:28 Pioneering work in causality 55:38 The causal hierarchy 59:34 LLMs and predictions 01:20:12 A restless mind pays 01:24:36 Advice for his younger self 01:26:37 Outro

Ryan Peterman

11,509 Aufrufe • vor 1 Monat

Here's my conversation with Jensen Huang, CEO of NVIDIA, the most valuable & one of the most influential companies in the history of human civilization. It is the engine powering the AI revolution. This was a fascinating & inspiring conversation, in parts super-technical on engineering of every part of the AI stack, memory, power, supply chain (TSMC, ASML, etc), in parts about leadership & psychology, and in parts personal & philosophical about life, consciousness, mortality, and human nature. It's here on X in full and is up everywhere else (see comment). Timestamps: 0:00 - Introduction 0:33 - Extreme co-design and rack-scale engineering 3:18 - How Jensen runs NVIDIA 22:40 - AI scaling laws 37:40 - Biggest blockers to AI scaling laws 39:23 - Supply chain 41:18 - Memory 47:24 - Power 52:43 - Elon and Colossus 56:11 - Jensen's approach to engineering and leadership 1:01:37 - China 1:09:50 - TSMC and Taiwan 1:15:04 - NVIDIA's moat 1:20:41 - AI data centers in space 1:24:30 - Will NVIDIA be worth $10 trillion? 1:34:39 - Leadership under pressure 1:48:25 - Video games 1:55:16 - AGI timeline 1:57:29 - Future of programming 2:11:01 - Consciousness 2:17:22 - Mortality
2:25:58

Here's my conversation with Jensen Huang, CEO of NVIDIA, the most valuable & one of the most influential companies in the history of human civilization. It is the engine powering the AI revolution. This was a fascinating & inspiring conversation, in parts super-technical on engineering of every part of the AI stack, memory, power, supply chain (TSMC, ASML, etc), in parts about leadership & psychology, and in parts personal & philosophical about life, consciousness, mortality, and human nature. It's here on X in full and is up everywhere else (see comment). Timestamps: 0:00 - Introduction 0:33 - Extreme co-design and rack-scale engineering 3:18 - How Jensen runs NVIDIA 22:40 - AI scaling laws 37:40 - Biggest blockers to AI scaling laws 39:23 - Supply chain 41:18 - Memory 47:24 - Power 52:43 - Elon and Colossus 56:11 - Jensen's approach to engineering and leadership 1:01:37 - China 1:09:50 - TSMC and Taiwan 1:15:04 - NVIDIA's moat 1:20:41 - AI data centers in space 1:24:30 - Will NVIDIA be worth $10 trillion? 1:34:39 - Leadership under pressure 1:48:25 - Video games 1:55:16 - AGI timeline 1:57:29 - Future of programming 2:11:01 - Consciousness 2:17:22 - Mortality

Lex Fridman

2,537,941 Aufrufe • vor 5 Monaten

After decades of lethargy, we are back and in the midst of a nuclear boom. And so we went out and found the sharpest mind in the nuclear industry for a 2.5-hour masterclass on the past, present and future of nuclear reactors. We do it all. SMRs. China. France. Fusion. Fission. What's real. What's not. James Krellenstein is legend. The Core Memory podcast is on Spotify, Apple, YouTube, all the things. Timestamps 00:00 Intro 05:30 Why America Stopped Building 12:00 China's Rise 21:00 France's Surprising Playbook 28:30 What Really Killed U.S. Nuclear 38:30 The Hippies Ruined Everything 43:00 The Almost 2005 Comeback 51:00 A Reactor Crash Course 57:00 The $30 Billion Vogtle Lesson 1:04:30 Why SMRs Won't Save Us 1:14:30 Alva Energy's Contrarian Bet 1:40:30 TRISO, Valar, and TerraPower 1:55:30 Fusion, Uranium, and the Waste Problem 2:21:00 Can America Out-Build China?
2:34:55

After decades of lethargy, we are back and in the midst of a nuclear boom. And so we went out and found the sharpest mind in the nuclear industry for a 2.5-hour masterclass on the past, present and future of nuclear reactors. We do it all. SMRs. China. France. Fusion. Fission. What's real. What's not. James Krellenstein is legend. The Core Memory podcast is on Spotify, Apple, YouTube, all the things. Timestamps 00:00 Intro 05:30 Why America Stopped Building 12:00 China's Rise 21:00 France's Surprising Playbook 28:30 What Really Killed U.S. Nuclear 38:30 The Hippies Ruined Everything 43:00 The Almost 2005 Comeback 51:00 A Reactor Crash Course 57:00 The $30 Billion Vogtle Lesson 1:04:30 Why SMRs Won't Save Us 1:14:30 Alva Energy's Contrarian Bet 1:40:30 TRISO, Valar, and TerraPower 1:55:30 Fusion, Uranium, and the Waste Problem 2:21:00 Can America Out-Build China?

Ashlee Vance

21,860 Aufrufe • vor 4 Monaten