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๐Ÿš€ We are hiring! ๐—ฃ๐—ต๐—— ๐—ฆ๐˜๐˜‚๐—ฑ๐—ฒ๐—ป๐˜ ๐—ถ๐—ป ๐—–๐—”๐—ฅ-๐—ง ๐—–๐—ฒ๐—น๐—น๐˜‚๐—น๐—ฎ๐—ฟ ๐—ง๐—ต๐—ฒ๐—ฟ๐—ฎ๐—ฝ๐˜† ๐—ฎ๐—ป๐—ฑ ๐—–๐—ฎ๐—ป๐—ฐ๐—ฒ๐—ฟ ๐—ก๐—ฒ๐˜‚๐—ฟ๐—ผ๐—ถ๐—บ๐—บ๐˜‚๐—ป๐—ผ๐—น๐—ผ๐—ด๐˜† We are looking for a passionate and motivated PhD student to join an exciting project focused on how nerve, immune and cancer cell interactions shape metastatic tumor behavior and resistance to cellular therapies, especially CAR-T cells....

14,771 gรถrรผntรผleme โ€ข 3 ay รถnce โ€ขvia X (Twitter)

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๐Ÿš€ Weโ€™re hiring! Staff Scientist / Postdoc โ€“ Tissue Clearing & 3D Image Analysis (m/f/d) (LMU Munich) Are you a great fit, or do you know someone outstanding, please reach out ๐Ÿ” If you want to at the frontier of whole-organ / whole-body 3D imaging, and help generate truly beautiful datasets that drive major biological discoveries and therapeutic development, see below โœจ Weโ€™re building the next-generation pipeline for tissue clearing + light-sheet microscopy + quantitative 3D analysis in the SyNergy Excellence Cluster (Mesoscale Hub) and weโ€™re looking for someone excited to push this forward with us. ๐Ÿง ๐Ÿ”ฌ๐Ÿ“ˆ ๐ŸŽฅ Iโ€™m also attaching a short video showing the kind of high-quality imaging and datasets youโ€™d be working with. What youโ€™ll do ๐Ÿ› ๏ธ ๐Ÿ”น Lead and evolve tissue clearing + light-sheet workflows across collaborative SyNergy projects ๐Ÿ”น Turn complex 3D datasets into robust quantitative insights (visualization, atlas registration, readouts) ๐Ÿ”น Develop new methods and analysis pipelines together with our AI team ๐Ÿค– ๐Ÿ”น Maintain and optimize cutting-edge light-sheet systems (optional: support animal license writing) What weโ€™re looking for ๐ŸŽฏ โœ… Strong hands-on experience in tissue clearing and/or fluorescence microscopy โœ… Solid experience with light-sheet microscopy and 3D imaging workflows โœ… Familiarity with 3D tools like Imaris / arivis Vision4D, stitching (e.g., BigStitcher), and quantitative analysis in cleared tissues โœ… Service mindset, great organization, and strong scientific English How to apply ๐Ÿ“ฉ Apply via the LMU Klinikum online application form Please also send your application to: [email protected] CC: [email protected] ๐Ÿ“Ž Include one PDF: short cover letter, CV, 2โ€“3 referees, and earliest start date. ๐Ÿ“ Campus GroรŸhadern (Munich) and Helmholtz Munich | ๐Ÿ•’ Full-time | ๐Ÿ“… Start: 01 January 2026 If you love high-quality imaging, cutting-edge biology, and building something that will matter, weโ€™d love to hear from you. ๐ŸŒโœจ #hiring #StaffScientist #Postdoc #TissueClearing #LightSheetMicroscopy #ImageAnalysis #SpatialBiology #Neuroscience #SyNergy #LMU #Munich

Ali Max Erturk

14,781 gรถrรผntรผleme โ€ข 8 ay รถnce

๐ŸšจImmunityBioโ€™s Anktiva: A New FDA-Approved Immunotherapy for certain bladder cancer. They are also developing treatments that may reduce the need for strong chemo, for blood cancer, lung cancer, brain cancer, and more. Broader approvals may take time. Someone call the President and fast-track this. Dr. Pat Soon-Shiong leads development beyond typical biotech efforts. Most cancer medicines, like chemotherapy, work by poisoning fast-growing cells to kill the cancer. This also hurts healthy cells, causing side effects like hair loss and weakness. Anktiva is different. It is an immunotherapy that wakes up your bodyโ€™s own immune cells; natural killer cells and T cells to hunt and destroy cancer cells themselves. It acts like a booster shot for your immune system, using a protein called IL-15 to make these cells multiply and remember how to fight cancer long-term. ImmunityBio is different from most companies because of 3 big unique things: 1. They wake up 3 kinds of fighter cells at the same time: โ€ข NK cells (natural killers) โ€ข CD8 T cells (main attackers) โ€ข CD4 T cells (helpers) These three work together like a basketball team. This makes the body remember the cancer for a long time (maybe years). 2. They have a special cell line called NK-92. โ†’ Itโ€™s like buying frozen pizza instead of making dough from scratch every time. Doctors can just thaw it and give it to any patient. No need to take cells from the sick kid, customize them, and make them super weak with hospital chemo (thatโ€™s what normal CAR-T does). 3. Their medicine Anktiva gives a long, steady boost to the immune cells. Older drugs (like IL-2) gave a short, crazy boost that made people very sick. Anktiva is seems safer, so far. Exciting to follow the development. Interview: Chris Cuomo (NewsNation) โ€” โ€œKilling Cancerโ€

Black Panther Capital

40,249 gรถrรผntรผleme โ€ข 6 ay รถnce

Dr. Patrick Soon-Shiong presents a fundamental paradigm shift in the war on cancer: we must stop destroying the immune system to save the body, and start supercharging it to achieve a permanent cure. The critical flaw of conventional chemotherapy and radiation is their inadvertent destruction of the very immune cellsโ€”the lymphocytesโ€”designed to protect us. This often wins a battle but loses the war, leading to metastasis. The solution lies within us. Dr. Soon-Shiongโ€™s work harnesses "God's design": the power of Natural Killer (NK) cells and T-cells. The breakthrough is two-fold: 1. The Activation Key: For the first time, we can effectively activate these cells using a sustained-release form of IL-15, a natural protein. A single injection can create a tenfold increase in the body's innate cancer-killing army. 2. The Army Expansion: We can now draw a patient's blood, grow billions of targeted NK cells in a lab, and reinfuse them, creating a supercharged, augmented immune response. This is not an incremental improvement. It is a move away from the failed strategy of attacking cancer from the inside-outโ€”blocking internal pathways that cancer easily bypassesโ€”to shattering it from the outside-in. The result is data that speaks to a potential cure: patients with metastatic pancreatic cancer alive and disease-free after five years; bladder cancer patients thriving with their organs intact a decade after treatment; long-term remission in aggressive Merkel cell carcinoma. This approach teaches the immune system "T-cell memory," creating a permanent, living surveillance system that stands guard against recurrence. This is the path to long-term survival with quality of life.

Camus

103,022 gรถrรผntรผleme โ€ข 11 ay รถnce

Excited to share our new work on building a multimodal atlas of human skin in health and inflammatory disease โ€” a project Iโ€™m especially proud of, bringing together AI, high-throughput genomics, and clinical science to accelerate discovery. Over the past decade, single-cell genomics has transformed how we map cells in human tissues. But a major challenge remains: can we systematically decode how cells organize into functional niches in situ โ€” including those invisible to standard histopathology? To address this, we integrated large-scale scRNA-seq, spatial transcriptomics, histopathology, and AI-driven modeling frameworks to build an in situ atlas of human skin across health and disease. Led by Lloyd Steele, an MD/PhD student working between Haniffa Lab and my lab at Wellcome Sanger Institute and Cambridge University . Another amazing collaboration with Muzz Haniffa, the mastermind behind the work as part of Human Cell Atlas. A key part of this study is that we didnโ€™t build everything from scratch โ€” we leveraged and combined AI methods that actually work! and showed how they can be used together to extract biological insight at scale. We used: โ€ข scArches to build and map into a reference scRNA-seq atlas of human skin: โ€ข NicheCompass to identify and characterize spatial niches: โ€ข MINT-Flow to extract microenvironment-induced cell states and gene programs: Together, these enabled an end-to-end workflow from atlas construction to spatial mapping, niche discovery, and cell state decoding. At scale, we integrated ~5 million cells and 100+ spatial sections, enabling a systematic view of tissue organization. Using this framework, we identified 26 niches in skin, including known histopathologic structures as well as hidden disease-associated niches not visible on H&E. Among the most striking findings were a resident memory T cell-rich sebaceous gland niche and a plasma cell-rich sweat gland niche, suggesting that appendageal structures act as active immunological microenvironments and may contribute to inflammatory memory and disease persistence. Importantly, this atlas is not just descriptive โ€” it is usable. It can support mapping of new datasets, resolve finer cell types and niches, extract microenvironment-driven programs, and enable predictive analyses at scale. More broadly, this work shows what becomes possible when AI, spatial genomics, and atlas-scale data are integrated end-to-end: not just mapping tissues, but systematically decoding them. This was a massive collaboration, and Iโ€™m very grateful to the amazing scientists April Foster, Kenny Roberts, and Chloe Admane. Lloyd is an amazing scientist, and Iโ€™m especially excited for the community to see more of his work soon โ€” stay tuned. The data and pre-trained models will be released soon. Preprint:

Mo Lotfollahi

11,813 gรถrรผntรผleme โ€ข 4 ay รถnce

A New Dawn in the Cancer War: Pioneering "BioShield" Technology Achieves Long-Term Remission Where Others Failed A stunning revelation from Dr. Patrick Soon-Shiong on the dawn of a new medical era. He details a breakthrough he calls "BioShield," a technology designed to prevent cancer by fundamentally educating the body's own immune system. Forget conventional vaccines. This isn't about antibodies. This is about creating a living, intelligent defense system within you. Hereโ€™s the concept: "BioShield" educates your T-cells to become elite "memory" cells. They then hide in your bone marrow, lying in wait. When a cancerous cell appears, they emerge to seek and destroy itโ€”stopping cancer before it can ever gain a foothold. This isn't science fiction. It's peer-reviewed, published science with the National Cancer Institute (NCI). And the results are nothing short of remarkable: โžก๏ธ Bladder Cancer: Patients who failed all other treatments and faced radical bladder removal have achieved complete remission for nine years after a simple injection. No surgery. Just a functional cure. โžก๏ธ Pancreatic Cancer: A disease with a grim prognosis, now seeing patients disease-free for five years. The late Senator Harry Reid, after being told by others not to pursue it, saw his tumor markers normalize and lived two active, cancer-free years. โžก๏ธ Merkel Cell Carcinoma & Head/Neck Cancer: Stories of complete responses in patients given weeks to live, with one living nine years and another saved from hospice when his ulcerating tumor melted away. Dr. Soon-Shiong is reframing the conversation. This isn't a "vaccine" in the traditional sense. It's Project BioShieldโ€”a proactive, cellular guardian for the body. The takeaway? We are transitioning from toxic, reactive cancer therapies to intelligent, preemptive protection. The age of the immune system as our most powerful shield against cancer has arrived. What are your thoughts on this "BioShield" approach to cancer?

Camus

31,209 gรถrรผntรผleme โ€ข 9 ay รถnce

Weโ€™re thrilled to share that our MERFISH+ preprint is now live on bioRxiv!๐Ÿ‘‰ In this work, the Bintu and Zhu labs (UCSD) developed MERFISH+, a next-generation spatial genomics platform that combines genome-wide RNA and epigenetic imaging over a large field of view. By introducing acrydite-modified probes covalently anchored to hydrogels, MERFISH+ achieves remarkable imaging stability and enables >1,800-gene, multi-modal, and multi-month experiments. With this platform, they, together with the Chi lab at UCSD, profiled a whole developing human heart at 12 post-conception week with merely two slides, resulting in a total of 53 slides, 3.1 million single cells and more than 30 cell types. Building upon our previous 3D reconstruction and modeling framework, Spateo ( we reconstruct the 3D human heart that nicely captures the anatomical structure of the heart, including the intricate vasculature network. Sophisticated analyses provide a holistic view of an entire organ and enable systematic characterization of 3D cellular neighborhoods and transcriptional gradients of substructures such as the descending arteries. Furthermore, using a generative integration framework for spatial multimodal data (Spateo-VI), we harmonized these MERFISH+ transcriptomic and chromatin data to reconstruct a 3D spatially-resolved multi-omics atlas of the developing human heart, shared at and MERFISH+ thus sets a new standard for large-format, multi-omic spatial profiling, enabling holistic, 3D characterization of organs at subcellular resolution. Huge congratulations to first authors Colin Kern, qingquan Zhang, @YifanLu2024 , and Jacqueline Eschbach, and to all collaborators from the Bintu, Zhu, Chi, and Qiu labs for this amazing team effort. Thanks for your diligence, creativity, and hard work on this project. Weโ€™re grateful for support from Arc Institute and our generous donors. Our lab is expandingโ€”if youโ€™re excited about building the next generation of single-cell and spatial genomics techniques and predictive single cell and spatial foundation models, weโ€™re hiring! If you are interested, please reach out to me via direct message or email at [email protected]. We are excited for any potential collaborations along this line of research in Stanford, UCSF and Berkeley and other labs as well.

evo-devo

42,268 gรถrรผntรผleme โ€ข 9 ay รถnce

The Chemotherapy Paradox โ€“ A "Cure" That Preserves the Root of Cancer? You've been told chemotherapy is a cornerstone of cancer care. But what if the standard of care is fundamentally flawed, suppressing the very system designed to heal you while protecting the engine that drives the disease? In a stunning exposition, Dr. Paul Marik pulls back the curtain on oncology's biggest dilemma. Here's the shocking truth: - Chemotherapy annihilates your immune army. It wipes out your natural killer cells and T-cellsโ€”the very soldiers your body needs to fight cancer. You are immune-suppressed, allowing the tumor a clearer path to proliferate. - Chemotherapy preserves the cancer stem cell. This is the root of the tumor. While chemo kills rapidly dividing cells, it often leaves the stem cellโ€”the queen beeโ€”untouched. From this root, the cancer indefinitely divides, mutates, and regrows. - Some chemo drugs may even STIMULATE the stem cell. That's right. The very treatment intended to kill cancer can, in some cases, fuel its source. "So you can't cure the patient unless you get rid of the cancer stem cell," states Dr. Marik. "Interestingly, chemotherapy doesn't kill the stem cell." This explains why "remission" is not a "cure." The cancer can return 7, 8, or 10 years later because the root was never addressed. You are in remission, not cured. The conclusion? The high-dose, "burn-and-cut" approach of traditional oncology is not holistic. It weakens the host and empowers the enemy's most resilient forces. Dr. Marik confirms: The efficacy depends on the tumor type. Cancers with a low percentage of stem cells can see long-term remission. But for many, it's a ticking time bomb. This isn't an opinion; it's a biological reality. Itโ€™s time for a paradigm shift. Share this to spark a crucial conversation. The future of oncology depends on it.

Camus

69,662 gรถrรผntรผleme โ€ข 9 ay รถnce

How does an embryo reliably "compute" its form - "cell by cell" - using only local interactions and mechanics, yet produce a precise global body plan? Iโ€™m excited to share our Nature Methods paper "MultiCell: geometric learning in multicellular development", presenting #AIxBiology research led by Haiqian Yang and the result of a great collaboration with Ming Guo, George Roy, Tomer Stern, Anh Nguyen and Dapeng Bi. A long-standing challenge in developmental biology is to predict how thousands of cells collectively self-organize as tissues fold, divide, and rearrange. In MultiCell, we represent a developing embryo as a dual graph that unifies two complementary views of tissue mechanics with single-cell resolution: cells as moving points (granular) and cells as a connected foam (junction network). This lets the model learn dynamics from both geometry and cellโ€“cell connectivity. On whole-embryo 4D light-sheet movies of Drosophila gastrulation (~5,000 cells), our model predicts key cell behaviors and the timing of events, including junction loss, rearrangements, and divisions with high accuracy, at single-cell resolution. Beyond prediction, the same representation supports robust time alignment across embryos and offers interpretable activation maps that highlight the morphogenetic "drivers" of development. The broader goal is a foundation for cell-by-cell forecasting in more complex tissues, and eventually for detecting subtle dynamical signatures of disease. Kudos to the team for this inspiring collaboration with brilliant researchers to push the boundary of AI for biology! Citation: Yang, H., Roy, G., Nguyen, A.Q., Buehler, M.J., et al. MultiCell: geometric learning in multicellular development. Nature Methods (2025), DOI: 10.1038/s41592-025-02983-x Code/data links are in the manuscript.

Markus J. Buehler

388,177 gรถrรผntรผleme โ€ข 8 ay รถnce

Chemotherapy kills the very cells the body uses to fight cancer. A surgeon and cancer researcher just said it out loud to a national audience, and the science backing him up is growing fast. Jefferey Jaxen opens with Dr. Patrick Soon-Shiong, who told Tucker Carlson that 99.9% of oncologists pay no attention to lymphocytes, the natural killer cells and T cells that are the immune system's actual weapon against cancer, and that chemotherapy's brief response is followed by metastasis because the treatment eliminates the body's protection. The research community is beginning to build in a different direction. Researchers at Trinity College Dublin have demonstrated that interferon gamma, a naturally occurring signaling protein that activates T cells and macrophages, can be used to train immune cells before they encounter a pathogen, thereby enhancing the killing of drug-resistant tuberculosis and MRSA staph infections in both healthy and genetically vulnerable individuals. The implications reach beyond antibiotic resistance: the same principle suggests that targeted immune training for immunosuppressed individuals could replace the current practice of blanket vaccination of entire populations to protect a few. Also reported last month, a UCLA study and subsequent meta-analysis found that honeybee venom and its primary protein, melittin, induced massive cell death in triple-negative and HER2-enriched breast cancer cell lines within 60 minutes of treatment, disrupting receptor pathways that aggressive breast cancers depend on. Melittin is globally available, cost-effective, and accessible in remote regions. None of these treatments are available off the shelf yet, but the direction of the research, working with the immune system and drawing from natural environments rather than suppressing the body's own defenses, represents a genuine paradigm shift that would have been unlikely to receive funding a decade ago.

The HighWire

12,121 gรถrรผntรผleme โ€ข 2 ay รถnce

Can people in power/ authority kindly stop with this absolute BS on "fasting killing cancer cells" and citing religious nonsense to appeal to peoples emotions? Fasting is really quite dangerous for cancer patients in real life. Let me explain and bury this myth once and for all, especially for science illiterates like this guy. [1] The most common argument is that fasting "starves" cancer by cutting off its sugar (glucose) supply. While it is true that cancer cells consume vast amounts of glucose, they are biologically aggressive survivalists. If you stop eating, your body eventually switches to burning fat and breaking down muscle for energy. Cancer cells are highly adaptable; when glucose is low, many types of cancer can mutate to feed on other fuel sources, such as lactate, amino acids (from your muscles), or fatty acids. You cannot simply "starve" a tumor without starving the patient first. [2] Fasting is dangerous for cancer patients because of cancer cachexia - a wasting syndrome where the body loses muscle and fat rapidly. Cachexia is responsible for up to 30% of cancer deaths. Cancer puts the body in a hyper-metabolic state (burning energy fast). If a patient fasts, they risk accelerating muscle loss and weakening their immune system. A weak body cannot tolerate life-saving treatments like chemotherapy or radiation, nor can it fight off infections. [3] Most claims about fasting curing cancer come from studies on mice or cells in a petri dish. In a dish: You can kill cancer cells with almost anything (lemon juice, bleach, starvation, even shooting a bullet at it at close point or using a grenade to destroy the entire lab) because they have no immune system or body to protect them. In a human: The biology is infinitely more complex. Human metabolism, hormonal fluctuations, and tumor micro-environments mean that what shrinks a tumor in a mouse often fails completely in human trials. [4] Proponents often cite "autophagy" (the body's cellular recycling process triggered by fasting) as the cure. They claim it cleans out cancerous cells. Science shows that autophagy is a double-edged sword. -In all people, autophagy is a normal physiological process - whether fasting or not, which help in cleaning up damaged cells. -But in patients with cancer, once a tumor exists, cancer cells can actually hijack autophagy to survive stress (like chemotherapy) and repair themselves. In this context, fasting could theoretically help the cancer survive the treatment intended to kill it. [5] "Cancer" is not one disease; it is over 200 different diseases characterized by uncontrolled cell growth. Some cancers are driven by hormones, some by genetic mutations, and some by viruses. A fasting protocol that slows down one specific type of breast cancer might have zero effect on pancreatic cancer, or worse, accelerate a different type. The most lethal aspect of this misinformation is the delay in treatment. Cancer is a time-sensitive disease. While a patient spends months trying to fast the cancer away based on religious or alternative advice, the cancer often metastasizes (spreads) to other organs. Once cancer spreads, it often moves from being curable to being terminal. Relying solely on fasting wastes the critical window where medical intervention could have saved a life. Suggesting a single "ancient cure" for 200 complex genetic diseases is scientifically illogical... ...and generally stupid, as this video proves.

TheLiverDocโ„ข

193,453 gรถrรผntรผleme โ€ข 7 ay รถnce

A new Nature paper from Johns Hopkins (by Prof. Lin Dingchang Lin ) just solved one of the hardest problems in biology: how do you record what every cell in a tissue experienced over time, not just what it looks like right now? The answer: GEMINI โ€” Granularly Expanding Memory for Intracellular Narrative Integration. It works exactly like tree rings. Cells are genetically engineered to express a computationally designed protein assembly. As the assembly grows inside the cell, it captures cellular activity as fluorescent ring patterns โ€” each ring a timestamp, each ring's properties encoding signal intensity. Look at a cross-section under a microscope and you can read the cell's history backward, with ~15-minute resolution. The key: cells build the recorder themselves. GEMINI doesn't interfere with normal function โ€” it just quietly writes. What they demonstrated: In a full tumor xenograft, GEMINI captured every cancer cell's activity history across the entire tumor while it continued to grow normally. For the first time, researchers can look back and see how different regions of the same tumor responded differently to therapy over time โ€” not snapshots, but film. In a mouse brain, GEMINI recorded neural activity dynamics without disrupting behavior, coordination, or memory. It could temporally resolve the history of a brain seizure. Why this matters: Every tool we have in biology gives you state โ€” what the cell looks like now. Sequencing, imaging, proteomics โ€” all snapshots. GEMINI gives you trajectory. It's the difference between a photograph and a video, applied to every cell in an organ simultaneously. The team is explicit that AI-based decoding tools will be central to reading GEMINI's output at whole-brain scale. This is the data layer that makes temporal single-cell atlases possible. Paper: Congratulations Dingchang Lin

Bo Wang

85,182 gรถrรผntรผleme โ€ข 5 ay รถnce