Loading video...

Video Failed to Load

There was a problem loading this video. This could be due to a temporary network issue or the video might be unavailable.

Andy Moore at HHMI | Janelia created this time-lapse video that shows the dynamic structure of the endoplasmic reticulum (ER) within a kidney cell. As you can see, the ER is very densely packed near the nucleus, which is shown in bright orange color at the center of the... show more

HHMI

51,606 subscribers

11,020 views • 1 year ago •via X (Twitter)

Anya Rossi• Live Now

Private livecam show

3 Comments

Amy Farley1 year ago

@HHMIJanelia Wow!

Raffaele Di Giacomo, PhD1 year ago

Nice work, Andy Moore and the team! The endoplasmic reticulum's dynamic structure is indeed an essential part of cellular processes. One curious aspect is how these dense formations might impact protein synthesis efficiency. Do you have any insights or hypotheses on how this density may affect kidney cell functions specifically? For those looking to dive deeper into the cellular mechanisms at play, check out one-stop platform for all your biomedical questions, capable of generating detailed reviews. #BiomedicalScience #CellBiology

Artem Minin1 year ago

@HHMIJanelia The video is great, but I'm pretty sure your scale is off. Vero cells are large, of course, but not that large.

Related Videos

Inside every cell in your body, two metres of DNA is carefully folded into a structure smaller than the width of a human hair. This #DNADay, explore how every fold and twist in the origami of our DNA can affect our bodies and ultimately our health:

Inside every cell in your body, two metres of DNA is carefully folded into a structure smaller than the width of a human hair. This #DNADay, explore how every fold and twist in the origami of our DNA can affect our bodies and ultimately our health:

The Royal Society

18,730 views • 2 years ago

This is a Kinesin Molecule. These little molecular machines are commonly referred to as the "workhorse" of the cell, hauling important cargo like organelles, proteins and other cellular structures to their proper location within the cell. Kinesins are very clear & undeniable evidence of the intelligent design in Life. Kinesins are complex molecular machines, made up of 4 total proteins, each between 500-1,300 amino acids in length. If these aa sequences are not perfectly aligned from the beginning, Kinesin never forms, and cellular life would be unable to survive. Here is how they work: When a new protein, organelle, or other cellular structure is created in the Cytosol of the cell, they are constructed with built-in "binding tags," which are like shipping labels that bind to other protein molecules called Adaptor or Scaffold Proteins. These Adaptor/Scaffold Proteins then attach to the Kinesin's tail, which activates them, and then the Kinesin is guided along the microtubule track to its to its final destination. Kinesin walk on self-assembling tracks of other proteins, called microtubules, moving cargo from the inner area of the cell where they are constructed to the outer edges where they function. This is a complex & sophisticated interdependent network of molecular machines, all relying on one another to function properly for the health of the cell. This Intracellular Transportation system MUST be fully functional from the beginning - with all these working parts, or all of it fails, and the cell dies. Without this entire functioning system, Life could not exist. And the Kinesin is the centerpiece to all of it. Experiments have shown that disrupting Kinesin activity has catastrophic consequences. This type of nano-precision is an obvious example of designed engineering. Blind, unguided evolutionary processes cannot plan ahead and create complex informational highways for precision transportation. The proposed evolutionary explanation is simply "co-option." A nebulous term which basically amounts to, "We don't know how it evolved, but it must have evolved from some other thing that was similar in the past." No observational data supports evolutionary co-option. It's absurd to believe any part of this was built by blind chance. Everything in the cell points to Intelligent Design.

This is a Kinesin Molecule. These little molecular machines are commonly referred to as the "workhorse" of the cell, hauling important cargo like organelles, proteins and other cellular structures to their proper location within the cell. Kinesins are very clear & undeniable evidence of the intelligent design in Life. Kinesins are complex molecular machines, made up of 4 total proteins, each between 500-1,300 amino acids in length. If these aa sequences are not perfectly aligned from the beginning, Kinesin never forms, and cellular life would be unable to survive. Here is how they work: When a new protein, organelle, or other cellular structure is created in the Cytosol of the cell, they are constructed with built-in "binding tags," which are like shipping labels that bind to other protein molecules called Adaptor or Scaffold Proteins. These Adaptor/Scaffold Proteins then attach to the Kinesin's tail, which activates them, and then the Kinesin is guided along the microtubule track to its to its final destination. Kinesin walk on self-assembling tracks of other proteins, called microtubules, moving cargo from the inner area of the cell where they are constructed to the outer edges where they function. This is a complex & sophisticated interdependent network of molecular machines, all relying on one another to function properly for the health of the cell. This Intracellular Transportation system MUST be fully functional from the beginning - with all these working parts, or all of it fails, and the cell dies. Without this entire functioning system, Life could not exist. And the Kinesin is the centerpiece to all of it. Experiments have shown that disrupting Kinesin activity has catastrophic consequences. This type of nano-precision is an obvious example of designed engineering. Blind, unguided evolutionary processes cannot plan ahead and create complex informational highways for precision transportation. The proposed evolutionary explanation is simply "co-option." A nebulous term which basically amounts to, "We don't know how it evolved, but it must have evolved from some other thing that was similar in the past." No observational data supports evolutionary co-option. It's absurd to believe any part of this was built by blind chance. Everything in the cell points to Intelligent Design.

Divinely Designed

15,956 views • 6 months ago

his quirk: cell activation really a healing quirk? bodies recover by cell division... and his quick triggers the cell division the number of times a cell can diving in the human body is fixed so if he did ended up becoming a pro and started 'healing' people he would practically be shrinking the lifespan of his patients?

his quirk: cell activation really a healing quirk? bodies recover by cell division... and his quick triggers the cell division the number of times a cell can diving in the human body is fixed so if he did ended up becoming a pro and started 'healing' people he would practically be shrinking the lifespan of his patients?

weeb sama

508,471 views • 7 months ago

#WATCH | Chandrapur, Maharashtra: On National Sickle Cell Elimination Mission 2047 program, Director of ICMR- CRHCM, Nagpur Dr Manisha Madkaikar says, "The National Sickle Cell Elimination Mission has given the guidelines. One is universal screening. In areas with a very high prevalence of sickle cell disease, the entire population under 40 is screened. Currently, under this mission, it is planned that nearly 7 crore individuals will be screened for sickle cell disease... The other is newborn screening. As soon as a newborn is born, we can test the newborn to determine whether he has sickle cell disease. Newborn screening is important because if you diagnose newborns early, you can give them effective treatment... In antenatal screening, the first visit is an ideal time to screen a pregnant woman. If she is found to be a carrier or affected, we can test her partner. If both are carriers for sickle cell disease, we can counsel them about testing the fetus before 20 weeks' gestational age. If the fetus is affected, the couple can consider options regarding sickle cell disease and the decision about pregnancy termination is left solely to the patients and their family."

#WATCH | Chandrapur, Maharashtra: On National Sickle Cell Elimination Mission 2047 program, Director of ICMR- CRHCM, Nagpur Dr Manisha Madkaikar says, "The National Sickle Cell Elimination Mission has given the guidelines. One is universal screening. In areas with a very high prevalence of sickle cell disease, the entire population under 40 is screened. Currently, under this mission, it is planned that nearly 7 crore individuals will be screened for sickle cell disease... The other is newborn screening. As soon as a newborn is born, we can test the newborn to determine whether he has sickle cell disease. Newborn screening is important because if you diagnose newborns early, you can give them effective treatment... In antenatal screening, the first visit is an ideal time to screen a pregnant woman. If she is found to be a carrier or affected, we can test her partner. If both are carriers for sickle cell disease, we can counsel them about testing the fetus before 20 weeks' gestational age. If the fetus is affected, the couple can consider options regarding sickle cell disease and the decision about pregnancy termination is left solely to the patients and their family."

ANI

10,749 views • 1 year ago

We made an explainer on the power of single cell technology to help understand biology and disease at a single cell level. Thanks Illumina for production support. Clip below and full video at:

We made an explainer on the power of single cell technology to help understand biology and disease at a single cell level. Thanks Illumina for production support. Clip below and full video at:

OzSingleCell Omics

19,797 views • 3 years ago

How small is a proton, really? You already know that atoms and the particles inside them are tiny. But they are SO MUCH SMALLER than most people think... Look at a single strand of your hair. Now imagine that hair is as big across as the entire Earth is wide. The size of a single cell inside your hair would be like the distance from Paris to Rome. A protein inside that cell would be like 6 soccer fields across. An atom inside that protein would be like one school bus across. The nucleus at the center of that atom would be like the width of a grain of rice. And the protons within that nucleus? They’d be like grains of salt. So, a proton compared to the WIDTH OF YOUR HAIR is like a grain of salt compared to the ENTIRE EARTH. And protons are what scientists are send flying around at nearly the speed of light to smash into each other inside particle colliders like the Large Hadron Collider at CERN. It’s incredible we can do this. As humans, we only experience a tiny slice of the full scale of reality. But there is so much more! If you like optimistic science and tech stories, follow for more of our show Huge If True.

How small is a proton, really? You already know that atoms and the particles inside them are tiny. But they are SO MUCH SMALLER than most people think... Look at a single strand of your hair. Now imagine that hair is as big across as the entire Earth is wide. The size of a single cell inside your hair would be like the distance from Paris to Rome. A protein inside that cell would be like 6 soccer fields across. An atom inside that protein would be like one school bus across. The nucleus at the center of that atom would be like the width of a grain of rice. And the protons within that nucleus? They’d be like grains of salt. So, a proton compared to the WIDTH OF YOUR HAIR is like a grain of salt compared to the ENTIRE EARTH. And protons are what scientists are send flying around at nearly the speed of light to smash into each other inside particle colliders like the Large Hadron Collider at CERN. It’s incredible we can do this. As humans, we only experience a tiny slice of the full scale of reality. But there is so much more! If you like optimistic science and tech stories, follow for more of our show Huge If True.

Cleo Abram

13,994 views • 2 years ago

You don't learn this in school. The mother of modern medicine was an African-American woman named Henrietta Lacks, whose cancer cells are the source of the HeLa cell line—the first immortalized human cell line and one of the most important in medical research. Within a decade of her death, HeLa cells were used to test the first polio vaccine, which was instrumental in eradicating polio.

You don't learn this in school. The mother of modern medicine was an African-American woman named Henrietta Lacks, whose cancer cells are the source of the HeLa cell line—the first immortalized human cell line and one of the most important in medical research. Within a decade of her death, HeLa cells were used to test the first polio vaccine, which was instrumental in eradicating polio.

Typical African

12,595 views • 6 months ago

Video of the cell that prompted the tornado warning for parts of Okaloosa and Walton counties a few minutes ago. This was as the cell was crossing the peninsula near Destin and Miramar Beach before it moved over Choctawhatchee Bay. Thanks to Houston Smith for the view! NWS Mobile

Video of the cell that prompted the tornado warning for parts of Okaloosa and Walton counties a few minutes ago. This was as the cell was crossing the peninsula near Destin and Miramar Beach before it moved over Choctawhatchee Bay. Thanks to Houston Smith for the view! NWS Mobile

Spinks Megginson

73,067 views • 2 months ago

This movie is top 5 favourites I've taken: many think of receptors as stagnant entities at the cell membrane. In fact, they are dynamically transported within the cell. Here we simultaneously image 5 receptor types endogenously using multispectral light sheet and protein binders!

This movie is top 5 favourites I've taken: many think of receptors as stagnant entities at the cell membrane. In fact, they are dynamically transported within the cell. Here we simultaneously image 5 receptor types endogenously using multispectral light sheet and protein binders!

Akaash Kumar

16,798 views • 1 year ago

This video is one of the first times I thought biology was “cool.” It shows a neutrophil cell chasing a bacterium. Originally recorded in the 1950s by David Rogers at Vanderbilt University, the video gave me a deeper appreciation for life, even at the level of a single cell, because the neutrophil's movements seem so intentful, purposeful, aware. It wasn’t until recently, though, that I actually tried to demystify the neutrophil’s movements and understand how they happen. Here's what I learned: 1. The neutrophil's surface has thousands of protein receptors. Molecules secreted by the bacteria collide with these receptors. When that happens, the proteins change shape, slightly, and initiate a signaling cascade. 2. The neutrophil “knows” where to go because of a discrepancy in bound vs. unbound receptors. The side of the cell closest to the microbe will, probabilistically, have more "bound" receptors than the other side (because the molecules secreted by the microbe have a concentration gradient). This is how the neutrophil figures out which way to move. 3. Each bound receptor activates several G proteins located inside the cell membrane. Each G protein, in turn, switches on PI3K enzymes. In this way, the original signal is amplified; a single "activated" receptor might cause ~100 copies of PI3K to get switched on downstream. 4. The PI3K enzymes stick phosphates onto lipids in the cell membrane. The side of the neutrophil facing the bacterium now has more phosphates than the "back" side. Phosphate-binding proteins, such as GEF, accumulate and then recruit Rac, thus activating it. Rac, in turn, acts like a molecular switch, ultimately recruiting Arp2/3. (TL;DR: A bunch of proteins get activated, and the high phosphate concentration at the leading edge is the key signal for all this.) 5. At any given moment, the neutrophil has millions of actin molecules. These are the proteins used to build the cytoskeleton. Half of the actins are already “assembled” into filaments, but the other half are just floating around. Arp2/3 acts as a nucleator, grabbing onto actin and then starting a new cytoskeletal branch. More actin is assembled at the leading edge (where the Arp2/3 has accumulated), where they each push on the cell membrane with ~2 piconewtons of force. Hundreds of actin chains, pushing together, causes the cell to form protrusions. 6. The assembling actin chains push the cell at a speed of ~20 micrometers per minute (the length of about ten E. coli cells placed end-to-end.) As all of this is happening, another signaling cascade, nucleated at the back end of the cell, is dismantling actin filaments and recycling them. All this happens over a span of about 30 seconds. Much of this process is invisible; what we see, instead, is "just" a cell chasing its prey. But that's the wonderful thing about biology: A singular observation is usually more than enough fodder for a lifetime of work. The well is deep. There is always more to learn.

This video is one of the first times I thought biology was “cool.” It shows a neutrophil cell chasing a bacterium. Originally recorded in the 1950s by David Rogers at Vanderbilt University, the video gave me a deeper appreciation for life, even at the level of a single cell, because the neutrophil's movements seem so intentful, purposeful, aware. It wasn’t until recently, though, that I actually tried to demystify the neutrophil’s movements and understand how they happen. Here's what I learned: 1. The neutrophil's surface has thousands of protein receptors. Molecules secreted by the bacteria collide with these receptors. When that happens, the proteins change shape, slightly, and initiate a signaling cascade. 2. The neutrophil “knows” where to go because of a discrepancy in bound vs. unbound receptors. The side of the cell closest to the microbe will, probabilistically, have more "bound" receptors than the other side (because the molecules secreted by the microbe have a concentration gradient). This is how the neutrophil figures out which way to move. 3. Each bound receptor activates several G proteins located inside the cell membrane. Each G protein, in turn, switches on PI3K enzymes. In this way, the original signal is amplified; a single "activated" receptor might cause ~100 copies of PI3K to get switched on downstream. 4. The PI3K enzymes stick phosphates onto lipids in the cell membrane. The side of the neutrophil facing the bacterium now has more phosphates than the "back" side. Phosphate-binding proteins, such as GEF, accumulate and then recruit Rac, thus activating it. Rac, in turn, acts like a molecular switch, ultimately recruiting Arp2/3. (TL;DR: A bunch of proteins get activated, and the high phosphate concentration at the leading edge is the key signal for all this.) 5. At any given moment, the neutrophil has millions of actin molecules. These are the proteins used to build the cytoskeleton. Half of the actins are already “assembled” into filaments, but the other half are just floating around. Arp2/3 acts as a nucleator, grabbing onto actin and then starting a new cytoskeletal branch. More actin is assembled at the leading edge (where the Arp2/3 has accumulated), where they each push on the cell membrane with ~2 piconewtons of force. Hundreds of actin chains, pushing together, causes the cell to form protrusions. 6. The assembling actin chains push the cell at a speed of ~20 micrometers per minute (the length of about ten E. coli cells placed end-to-end.) As all of this is happening, another signaling cascade, nucleated at the back end of the cell, is dismantling actin filaments and recycling them. All this happens over a span of about 30 seconds. Much of this process is invisible; what we see, instead, is "just" a cell chasing its prey. But that's the wonderful thing about biology: A singular observation is usually more than enough fodder for a lifetime of work. The well is deep. There is always more to learn.

Niko McCarty.

127,178 views • 6 months ago

made a big breakthrough on tinynodes! this is a huge .blend file with 679 nodes, running 100% in the browser... and it's fully dynamic! at the end of the video, you can see the raw geometry and the node graph that describes how to turn it into this complex wooden structure

made a big breakthrough on tinynodes! this is a huge .blend file with 679 nodes, running 100% in the browser... and it's fully dynamic! at the end of the video, you can see the raw geometry and the node graph that describes how to turn it into this complex wooden structure

Seth Thompson

36,271 views • 2 months ago

This is how DNA turns coded information into functional proteins - the building blocks of the nanomachines that keep the cells in your body alive. This complex process highlights the sophisticated interconnected systems of Life which must all exist together from the beginning, or Life doesn't happen. First, an RNA molecule is copied from a short segment of DNA. Without the specifically ordered DNA information, RNA cannot form, proteins cannot be built, cells stop working, and life ceases to exist. Life is information first. Once the RNA Molecule is created, it gets ejected from the Polymerase where it was built, and it travels through a complex molecular machine called a Nuclear Pore Complex (NPC), which is an information recognition device that controls the flow of information in and out of a cell's nucleus. The NPC is highly complex - composed of about 500-1,000 protein subunits, derived from a set of about 35 distinct proteins. Without this molecular machine, there is no regulation for what goes in and out of the cell's nucleus, which would lead to catastrophic death for the cell. It must exist for cells to exist. Once the RNA Molecule passes through the NPC, it travels to the Ribosome, a 2-part chemical factory which reads the information on RNA and uses it to construct functional proteins using a specifically sequenced chain of amino acids. Once complete, this protein will then be sent to the section of the cell it belongs to integrate into another molecular machine and do its job. The Ribosome is another highly complex molecular machine - consisting of between 56-80 proteins. Without this molecular machines, proteins cannot be built. Proteins are the building blocks of every cell in every organism on Earth. Without Ribosomes, Life doesn't exist. If you're paying attention, you'll start to realize that Life relies on a highly sophisticated interdependent network of complex machines, which all rely on each other for the function of the system. DNA requires the cell for stability, but the cell requires the proteins for its structure and function, but those proteins require DNA and RNA to be built - it's a circle of necessary interdependence. Systems like this cannot be built by evolutionary processes, which requires that each piece of the process is built by gradual incremental means over lots of time. Without all the pieces there, from the beginning, none of it works. There is only one known source of complex & interdependent informational systems like those we find in life: and that is from Intelligence. Molecular Biology is the best and most obvious evidence of the Intelligent Design in Life.

This is how DNA turns coded information into functional proteins - the building blocks of the nanomachines that keep the cells in your body alive. This complex process highlights the sophisticated interconnected systems of Life which must all exist together from the beginning, or Life doesn't happen. First, an RNA molecule is copied from a short segment of DNA. Without the specifically ordered DNA information, RNA cannot form, proteins cannot be built, cells stop working, and life ceases to exist. Life is information first. Once the RNA Molecule is created, it gets ejected from the Polymerase where it was built, and it travels through a complex molecular machine called a Nuclear Pore Complex (NPC), which is an information recognition device that controls the flow of information in and out of a cell's nucleus. The NPC is highly complex - composed of about 500-1,000 protein subunits, derived from a set of about 35 distinct proteins. Without this molecular machine, there is no regulation for what goes in and out of the cell's nucleus, which would lead to catastrophic death for the cell. It must exist for cells to exist. Once the RNA Molecule passes through the NPC, it travels to the Ribosome, a 2-part chemical factory which reads the information on RNA and uses it to construct functional proteins using a specifically sequenced chain of amino acids. Once complete, this protein will then be sent to the section of the cell it belongs to integrate into another molecular machine and do its job. The Ribosome is another highly complex molecular machine - consisting of between 56-80 proteins. Without this molecular machines, proteins cannot be built. Proteins are the building blocks of every cell in every organism on Earth. Without Ribosomes, Life doesn't exist. If you're paying attention, you'll start to realize that Life relies on a highly sophisticated interdependent network of complex machines, which all rely on each other for the function of the system. DNA requires the cell for stability, but the cell requires the proteins for its structure and function, but those proteins require DNA and RNA to be built - it's a circle of necessary interdependence. Systems like this cannot be built by evolutionary processes, which requires that each piece of the process is built by gradual incremental means over lots of time. Without all the pieces there, from the beginning, none of it works. There is only one known source of complex & interdependent informational systems like those we find in life: and that is from Intelligence. Molecular Biology is the best and most obvious evidence of the Intelligent Design in Life.

Divinely Designed

62,517 views • 7 months ago

Sebastien Beauzile is the first person in New York to be cured of sickle cell anemia. For too long, research and treatment for sickle cell disease, which disproportionately affects Black people, have taken a back seat. It's my honor to support Cohen Children’s Medical Center with a $100K donation to invest in their cutting-edge sickle cell treatment and research.

Sebastien Beauzile is the first person in New York to be cured of sickle cell anemia. For too long, research and treatment for sickle cell disease, which disproportionately affects Black people, have taken a back seat. It's my honor to support Cohen Children’s Medical Center with a $100K donation to invest in their cutting-edge sickle cell treatment and research.

Ben Crump

60,631 views • 1 year ago

🚨 FBI Director Kash Patel unveils on Rogan that the footage of Epstein's cell will be RELEASED to the public: "You're going to get the video, of the cell, and you're going to see for yourself."

🚨 FBI Director Kash Patel unveils on Rogan that the footage of Epstein's cell will be RELEASED to the public: "You're going to get the video, of the cell, and you're going to see for yourself."

Benny Johnson

1,109,215 views • 1 year ago

Science Corner: David Friedberg Explains Recent Mitotherapy Breakthroughs ⚡️ On E224, david friedberg broke down what mitotherapy is and how recent discoveries could unleash this treatment for many diseases: "So mitochondria are the powerhouse of the cell." "Every cell in our body gets its energy, which is what it uses to function, from the mitochondria." "And so there's been a lot of research into the relationship between mitochondria and aging, and that dysfunctional mitochondria may actually be a key driver for many diseases." "Including many cancers, Alzheimer's, Parkinson's, ALS, features of autism, muscle tissues being weak, etc." " So, as the cells get older and the mitochondria stop working, we make new mitochondria." "But over time, the DNA degrades and the mitochondria become less effective and there are fewer functional mitochondria per cell." Friedberg highlighted three recent papers: 1) "The power and potential of mitochondria transfer" (nature) -- "these folks identified and demonstrated that mitochondria can actually transfer from one cell to another" -- " So, if you've got a cell that's got damaged, or dysfunctional mitochondria, they've identified three mechanisms by which mitochondria can move into a cell that needs more mitochondria that are working and are more functional." -- "And as a result, it can rejuvenate or provide energy to a dysfunctional cell, which might improve dysfunctional tissue or improve disease." 2) "A human brain map of mitochondrial respiratory capacity and diversity" (nature) -- " this was the first mapping of the mitochondria in the human brain" -- " what it showed was that different parts of the brain, different cells, had different amounts of mitochondria and different mitochondrial function." -- "(This) starts to highlight how that difference in energy production in different cells in different parts of the brain may actually cause some of the things like memory loss or speech impairment," -- "the mitochondrial dysfunction in the brain might actually be the key driver of that aging symptomology." 3) "Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration" (nature | Bone Research) -- " (the researchers) figured out a way to treat stem cells so that (they) would start to make an excess amount of mitochondria than they normally would make" -- " So they created highly energetic mitochondria and they made a lot of them." -- " the idea that we can put mitochondria into our body or into tissue in our body to heal it or repair it has been something that folks have been trying to do research around for a long time" -- " but the limiting factor is access to enough mitochondria" -- " so this mechanism that they developed opens up the door to this whole new therapeutic modality, a new type of therapy called mitotherapy" Conclusion: " ... based on the series of papers that we're seeing coming out recently, I believe (this) could end up becoming a really incredible new therapy that may ultimately lead to the treatment for many diseases that we're dealing with right now."

Science Corner: David Friedberg Explains Recent Mitotherapy Breakthroughs ⚡️ On E224, david friedberg broke down what mitotherapy is and how recent discoveries could unleash this treatment for many diseases: "So mitochondria are the powerhouse of the cell." "Every cell in our body gets its energy, which is what it uses to function, from the mitochondria." "And so there's been a lot of research into the relationship between mitochondria and aging, and that dysfunctional mitochondria may actually be a key driver for many diseases." "Including many cancers, Alzheimer's, Parkinson's, ALS, features of autism, muscle tissues being weak, etc." " So, as the cells get older and the mitochondria stop working, we make new mitochondria." "But over time, the DNA degrades and the mitochondria become less effective and there are fewer functional mitochondria per cell." Friedberg highlighted three recent papers: 1) "The power and potential of mitochondria transfer" (nature) -- "these folks identified and demonstrated that mitochondria can actually transfer from one cell to another" -- " So, if you've got a cell that's got damaged, or dysfunctional mitochondria, they've identified three mechanisms by which mitochondria can move into a cell that needs more mitochondria that are working and are more functional." -- "And as a result, it can rejuvenate or provide energy to a dysfunctional cell, which might improve dysfunctional tissue or improve disease." 2) "A human brain map of mitochondrial respiratory capacity and diversity" (nature) -- " this was the first mapping of the mitochondria in the human brain" -- " what it showed was that different parts of the brain, different cells, had different amounts of mitochondria and different mitochondrial function." -- "(This) starts to highlight how that difference in energy production in different cells in different parts of the brain may actually cause some of the things like memory loss or speech impairment," -- "the mitochondrial dysfunction in the brain might actually be the key driver of that aging symptomology." 3) "Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration" (nature | Bone Research) -- " (the researchers) figured out a way to treat stem cells so that (they) would start to make an excess amount of mitochondria than they normally would make" -- " So they created highly energetic mitochondria and they made a lot of them." -- " the idea that we can put mitochondria into our body or into tissue in our body to heal it or repair it has been something that folks have been trying to do research around for a long time" -- " but the limiting factor is access to enough mitochondria" -- " so this mechanism that they developed opens up the door to this whole new therapeutic modality, a new type of therapy called mitotherapy" Conclusion: " ... based on the series of papers that we're seeing coming out recently, I believe (this) could end up becoming a really incredible new therapy that may ultimately lead to the treatment for many diseases that we're dealing with right now."

The All-In Podcast

58,412 views • 1 year ago

Quinton Smith's stem cell engineering is "on the cusp of changing the world," says Popular Science. His research aims to find cures for preeclampsia and liver diseases which affect Black and Latino people at higher rates. Quinton Smith #stemcell #BlackHistoryMonth2024

Quinton Smith's stem cell engineering is "on the cusp of changing the world," says Popular Science. His research aims to find cures for preeclampsia and liver diseases which affect Black and Latino people at higher rates. Quinton Smith #stemcell #BlackHistoryMonth2024

UCI Engineering

22,796 views • 2 years ago

🚨🚨🚨 Dutch Cancer Researcher and Erasmus Medical Centre Assc Prof Maarten Fornerod discusses DNA contamination in COVID Vaccines. ---------------------------- ...for last 35 years or so I've been working uh in the areas of molecular biology, gene expression, biology, cancer biology and recently in the last years, maybe last 10 years in the context of big data and computational biology... ...when we use genetic vaccines what we do essentially is we're making a complex intervention in a very complex system. It's impossible to predict what happens if you combine these two complex systems, and you get unpredictable effects. .. And the only way to go about this is to do genotoxic research, when you want to introduce a genetic medicine into a human being and that genetotic research has to be independent, it has to be double blind, has to be long lasting. AND ALL THESE HAVE NOT BEEN DONE WITH THE GENETIC CORONA VACCINES! if there's a vaccine, there's a little bit of DNA in there upon injection that is very, very rapidly degraded by the human body. However if it's protected and in a lipid nanoarticle it can very efficiently be transduced in the cell... I've been doing this this many, many times. This is called lipofection and it's a very efficient way to introduce DNA into a cell. ...Many people think that this is not possible. But I've been working in nuclear transport for many years, I think more than 10 years. So I've been exposed to a lot of molecular cell biology of nuclear cytoplasmic transport. And it's clear that the DNA can enter the nucleus. Now to make things worse, the mRNA vaccine doesn't stay in the arm but it's detected in , in all different organs including the reproductive system. And so partly this is based on animal models, of course we know from Michael Morz that he has detected uh the spike protein in brain, in the heart and it's for sure it's detected in the blood and even in breast milk. ..So there's NO DOUBT that this mRNA vaccine spreads widely in the human body. ..Now from a genetic point of view, there are possible consequences uh of this and the consequences could be a 1. long term disruption of cellular processes that could lead to disease. 2. there's a risk of insertional mutageenesis in somatic cells that can lead to cancer. 3. the insertion mutogenesis takes place in a germ cell which would be a hereditary burden uh on the human population. 4. And you could also think that these um DNAs, could transfect the microbiome and it could possibly lead to bacterial resistance. So these are all possible..the consequences of these genetic vaccines in my view, the shortcomings in this rollout of these vaccines were there was no genotoxic research performed at all. There was no safety studies, on carcinogenic potential of these vaccines. My personal opinion is that it's now not a question of whether, it will integrate in recipient's DNA, but how often it occurs... It's just a numbers game. If you do this in many cells, many persons it will no doubt integrate in cells in human recipients. So the question does it affect the human genome? I would say it probably, I think it most certainly does. And you see Kevin McKernan here and he represented ah a preliminary data where he detected a possible Pfizer DNA in colon cancer biopsy one year after vaccination.

🚨🚨🚨 Dutch Cancer Researcher and Erasmus Medical Centre Assc Prof Maarten Fornerod discusses DNA contamination in COVID Vaccines. ---------------------------- ...for last 35 years or so I've been working uh in the areas of molecular biology, gene expression, biology, cancer biology and recently in the last years, maybe last 10 years in the context of big data and computational biology... ...when we use genetic vaccines what we do essentially is we're making a complex intervention in a very complex system. It's impossible to predict what happens if you combine these two complex systems, and you get unpredictable effects. .. And the only way to go about this is to do genotoxic research, when you want to introduce a genetic medicine into a human being and that genetotic research has to be independent, it has to be double blind, has to be long lasting. AND ALL THESE HAVE NOT BEEN DONE WITH THE GENETIC CORONA VACCINES! if there's a vaccine, there's a little bit of DNA in there upon injection that is very, very rapidly degraded by the human body. However if it's protected and in a lipid nanoarticle it can very efficiently be transduced in the cell... I've been doing this this many, many times. This is called lipofection and it's a very efficient way to introduce DNA into a cell. ...Many people think that this is not possible. But I've been working in nuclear transport for many years, I think more than 10 years. So I've been exposed to a lot of molecular cell biology of nuclear cytoplasmic transport. And it's clear that the DNA can enter the nucleus. Now to make things worse, the mRNA vaccine doesn't stay in the arm but it's detected in , in all different organs including the reproductive system. And so partly this is based on animal models, of course we know from Michael Morz that he has detected uh the spike protein in brain, in the heart and it's for sure it's detected in the blood and even in breast milk. ..So there's NO DOUBT that this mRNA vaccine spreads widely in the human body. ..Now from a genetic point of view, there are possible consequences uh of this and the consequences could be a 1. long term disruption of cellular processes that could lead to disease. 2. there's a risk of insertional mutageenesis in somatic cells that can lead to cancer. 3. the insertion mutogenesis takes place in a germ cell which would be a hereditary burden uh on the human population. 4. And you could also think that these um DNAs, could transfect the microbiome and it could possibly lead to bacterial resistance. So these are all possible..the consequences of these genetic vaccines in my view, the shortcomings in this rollout of these vaccines were there was no genotoxic research performed at all. There was no safety studies, on carcinogenic potential of these vaccines. My personal opinion is that it's now not a question of whether, it will integrate in recipient's DNA, but how often it occurs... It's just a numbers game. If you do this in many cells, many persons it will no doubt integrate in cells in human recipients. So the question does it affect the human genome? I would say it probably, I think it most certainly does. And you see Kevin McKernan here and he represented ah a preliminary data where he detected a possible Pfizer DNA in colon cancer biopsy one year after vaccination.

aussie17

126,273 views • 1 year ago