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Andy Moore at HHMI | Janelia created this time-lapse video that shows the dynamic structure of the endoplasmic reticulum (ER) within a kidney cell. As you can see, the ER is very densely packed near the nucleus, which is shown in bright orange color at the center of the... show more

HHMI

52,137 subscribers

11,030 次观看 • 1 年前 •via X (Twitter)

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Amy Farley 的头像

Amy Farley1 年前

@HHMIJanelia Wow!

Raffaele Di Giacomo, PhD 的头像

Raffaele Di Giacomo, PhD1 年前

Nice work, Andy Moore and the team! The endoplasmic reticulum's dynamic structure is indeed an essential part of cellular processes. One curious aspect is how these dense formations might impact protein synthesis efficiency. Do you have any insights or hypotheses on how this density may affect kidney cell functions specifically? For those looking to dive deeper into the cellular mechanisms at play, check out one-stop platform for all your biomedical questions, capable of generating detailed reviews. #BiomedicalScience #CellBiology

Artem Minin 的头像

Artem Minin1 年前

@HHMIJanelia The video is great, but I'm pretty sure your scale is off. Vero cells are large, of course, but not that large.

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Inside every cell in your body, two metres of DNA is carefully folded into a structure smaller than the width of a human hair. This #DNADay, explore how every fold and twist in the origami of our DNA can affect our bodies and ultimately our health:

Inside every cell in your body, two metres of DNA is carefully folded into a structure smaller than the width of a human hair. This #DNADay, explore how every fold and twist in the origami of our DNA can affect our bodies and ultimately our health:

The Royal Society

18,733 次观看 • 2 年前

This is a Kinesin Molecule. These little molecular machines are commonly referred to as the "workhorse" of the cell, hauling important cargo like organelles, proteins and other cellular structures to their proper location within the cell. Kinesins are very clear & undeniable evidence of the intelligent design in Life. Kinesins are complex molecular machines, made up of 4 total proteins, each between 500-1,300 amino acids in length. If these aa sequences are not perfectly aligned from the beginning, Kinesin never forms, and cellular life would be unable to survive. Here is how they work: When a new protein, organelle, or other cellular structure is created in the Cytosol of the cell, they are constructed with built-in "binding tags," which are like shipping labels that bind to other protein molecules called Adaptor or Scaffold Proteins. These Adaptor/Scaffold Proteins then attach to the Kinesin's tail, which activates them, and then the Kinesin is guided along the microtubule track to its to its final destination. Kinesin walk on self-assembling tracks of other proteins, called microtubules, moving cargo from the inner area of the cell where they are constructed to the outer edges where they function. This is a complex & sophisticated interdependent network of molecular machines, all relying on one another to function properly for the health of the cell. This Intracellular Transportation system MUST be fully functional from the beginning - with all these working parts, or all of it fails, and the cell dies. Without this entire functioning system, Life could not exist. And the Kinesin is the centerpiece to all of it. Experiments have shown that disrupting Kinesin activity has catastrophic consequences. This type of nano-precision is an obvious example of designed engineering. Blind, unguided evolutionary processes cannot plan ahead and create complex informational highways for precision transportation. The proposed evolutionary explanation is simply "co-option." A nebulous term which basically amounts to, "We don't know how it evolved, but it must have evolved from some other thing that was similar in the past." No observational data supports evolutionary co-option. It's absurd to believe any part of this was built by blind chance. Everything in the cell points to Intelligent Design.

This is a Kinesin Molecule. These little molecular machines are commonly referred to as the "workhorse" of the cell, hauling important cargo like organelles, proteins and other cellular structures to their proper location within the cell. Kinesins are very clear & undeniable evidence of the intelligent design in Life. Kinesins are complex molecular machines, made up of 4 total proteins, each between 500-1,300 amino acids in length. If these aa sequences are not perfectly aligned from the beginning, Kinesin never forms, and cellular life would be unable to survive. Here is how they work: When a new protein, organelle, or other cellular structure is created in the Cytosol of the cell, they are constructed with built-in "binding tags," which are like shipping labels that bind to other protein molecules called Adaptor or Scaffold Proteins. These Adaptor/Scaffold Proteins then attach to the Kinesin's tail, which activates them, and then the Kinesin is guided along the microtubule track to its to its final destination. Kinesin walk on self-assembling tracks of other proteins, called microtubules, moving cargo from the inner area of the cell where they are constructed to the outer edges where they function. This is a complex & sophisticated interdependent network of molecular machines, all relying on one another to function properly for the health of the cell. This Intracellular Transportation system MUST be fully functional from the beginning - with all these working parts, or all of it fails, and the cell dies. Without this entire functioning system, Life could not exist. And the Kinesin is the centerpiece to all of it. Experiments have shown that disrupting Kinesin activity has catastrophic consequences. This type of nano-precision is an obvious example of designed engineering. Blind, unguided evolutionary processes cannot plan ahead and create complex informational highways for precision transportation. The proposed evolutionary explanation is simply "co-option." A nebulous term which basically amounts to, "We don't know how it evolved, but it must have evolved from some other thing that was similar in the past." No observational data supports evolutionary co-option. It's absurd to believe any part of this was built by blind chance. Everything in the cell points to Intelligent Design.

Divinely Designed

15,956 次观看 • 9 个月前

his quirk: cell activation really a healing quirk? bodies recover by cell division... and his quick triggers the cell division the number of times a cell can diving in the human body is fixed so if he did ended up becoming a pro and started 'healing' people he would practically be shrinking the lifespan of his patients?

his quirk: cell activation really a healing quirk? bodies recover by cell division... and his quick triggers the cell division the number of times a cell can diving in the human body is fixed so if he did ended up becoming a pro and started 'healing' people he would practically be shrinking the lifespan of his patients?

weeb sama

508,496 次观看 • 10 个月前

How small is a proton, really? You already know that atoms and the particles inside them are tiny. But they are SO MUCH SMALLER than most people think... Look at a single strand of your hair. Now imagine that hair is as big across as the entire Earth is wide. The size of a single cell inside your hair would be like the distance from Paris to Rome. A protein inside that cell would be like 6 soccer fields across. An atom inside that protein would be like one school bus across. The nucleus at the center of that atom would be like the width of a grain of rice. And the protons within that nucleus? They’d be like grains of salt. So, a proton compared to the WIDTH OF YOUR HAIR is like a grain of salt compared to the ENTIRE EARTH. And protons are what scientists are send flying around at nearly the speed of light to smash into each other inside particle colliders like the Large Hadron Collider at CERN. It’s incredible we can do this. As humans, we only experience a tiny slice of the full scale of reality. But there is so much more! If you like optimistic science and tech stories, follow for more of our show Huge If True.

How small is a proton, really? You already know that atoms and the particles inside them are tiny. But they are SO MUCH SMALLER than most people think... Look at a single strand of your hair. Now imagine that hair is as big across as the entire Earth is wide. The size of a single cell inside your hair would be like the distance from Paris to Rome. A protein inside that cell would be like 6 soccer fields across. An atom inside that protein would be like one school bus across. The nucleus at the center of that atom would be like the width of a grain of rice. And the protons within that nucleus? They’d be like grains of salt. So, a proton compared to the WIDTH OF YOUR HAIR is like a grain of salt compared to the ENTIRE EARTH. And protons are what scientists are send flying around at nearly the speed of light to smash into each other inside particle colliders like the Large Hadron Collider at CERN. It’s incredible we can do this. As humans, we only experience a tiny slice of the full scale of reality. But there is so much more! If you like optimistic science and tech stories, follow for more of our show Huge If True.

Cleo Abram

13,994 次观看 • 2 年前

We made an explainer on the power of single cell technology to help understand biology and disease at a single cell level. Thanks Illumina for production support. Clip below and full video at:

We made an explainer on the power of single cell technology to help understand biology and disease at a single cell level. Thanks Illumina for production support. Clip below and full video at:

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19,797 次观看 • 3 年前

You don't learn this in school. The mother of modern medicine was an African-American woman named Henrietta Lacks, whose cancer cells are the source of the HeLa cell line—the first immortalized human cell line and one of the most important in medical research. Within a decade of her death, HeLa cells were used to test the first polio vaccine, which was instrumental in eradicating polio.

You don't learn this in school. The mother of modern medicine was an African-American woman named Henrietta Lacks, whose cancer cells are the source of the HeLa cell line—the first immortalized human cell line and one of the most important in medical research. Within a decade of her death, HeLa cells were used to test the first polio vaccine, which was instrumental in eradicating polio.

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12,595 次观看 • 8 个月前

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Video of the cell that prompted the tornado warning for parts of Okaloosa and Walton counties a few minutes ago. This was as the cell was crossing the peninsula near Destin and Miramar Beach before it moved over Choctawhatchee Bay. Thanks to Houston Smith for the view! NWS Mobile

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73,922 次观看 • 4 个月前

This movie is top 5 favourites I've taken: many think of receptors as stagnant entities at the cell membrane. In fact, they are dynamically transported within the cell. Here we simultaneously image 5 receptor types endogenously using multispectral light sheet and protein binders!

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Niko McCarty.

127,486 次观看 • 9 个月前

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This is how DNA turns coded information into functional proteins - the building blocks of the nanomachines that keep the cells in your body alive. This complex process highlights the sophisticated interconnected systems of Life which must all exist together from the beginning, or Life doesn't happen. First, an RNA molecule is copied from a short segment of DNA. Without the specifically ordered DNA information, RNA cannot form, proteins cannot be built, cells stop working, and life ceases to exist. Life is information first. Once the RNA Molecule is created, it gets ejected from the Polymerase where it was built, and it travels through a complex molecular machine called a Nuclear Pore Complex (NPC), which is an information recognition device that controls the flow of information in and out of a cell's nucleus. The NPC is highly complex - composed of about 500-1,000 protein subunits, derived from a set of about 35 distinct proteins. Without this molecular machine, there is no regulation for what goes in and out of the cell's nucleus, which would lead to catastrophic death for the cell. It must exist for cells to exist. Once the RNA Molecule passes through the NPC, it travels to the Ribosome, a 2-part chemical factory which reads the information on RNA and uses it to construct functional proteins using a specifically sequenced chain of amino acids. Once complete, this protein will then be sent to the section of the cell it belongs to integrate into another molecular machine and do its job. The Ribosome is another highly complex molecular machine - consisting of between 56-80 proteins. Without this molecular machines, proteins cannot be built. Proteins are the building blocks of every cell in every organism on Earth. Without Ribosomes, Life doesn't exist. If you're paying attention, you'll start to realize that Life relies on a highly sophisticated interdependent network of complex machines, which all rely on each other for the function of the system. DNA requires the cell for stability, but the cell requires the proteins for its structure and function, but those proteins require DNA and RNA to be built - it's a circle of necessary interdependence. Systems like this cannot be built by evolutionary processes, which requires that each piece of the process is built by gradual incremental means over lots of time. Without all the pieces there, from the beginning, none of it works. There is only one known source of complex & interdependent informational systems like those we find in life: and that is from Intelligence. Molecular Biology is the best and most obvious evidence of the Intelligent Design in Life.

Divinely Designed

62,743 次观看 • 9 个月前

Sebastien Beauzile is the first person in New York to be cured of sickle cell anemia. For too long, research and treatment for sickle cell disease, which disproportionately affects Black people, have taken a back seat. It's my honor to support Cohen Children’s Medical Center with a $100K donation to invest in their cutting-edge sickle cell treatment and research.

Sebastien Beauzile is the first person in New York to be cured of sickle cell anemia. For too long, research and treatment for sickle cell disease, which disproportionately affects Black people, have taken a back seat. It's my honor to support Cohen Children’s Medical Center with a $100K donation to invest in their cutting-edge sickle cell treatment and research.

Ben Crump

60,631 次观看 • 1 年前

made a big breakthrough on tinynodes! this is a huge .blend file with 679 nodes, running 100% in the browser... and it's fully dynamic! at the end of the video, you can see the raw geometry and the node graph that describes how to turn it into this complex wooden structure

made a big breakthrough on tinynodes! this is a huge .blend file with 679 nodes, running 100% in the browser... and it's fully dynamic! at the end of the video, you can see the raw geometry and the node graph that describes how to turn it into this complex wooden structure

Seth Thompson

36,436 次观看 • 4 个月前

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THE STILL POINT Does the TORUS provide us with a way to conceptualise TIME? Within the æther, MAGNETISM provides structure - the toroidal FIELD gives that structure FLOW and within that flow we find INFINITY. The same figure is traced by the SUN in the ANALEMMA over the course of a YEAR - movement through TIME, cycling and returning. And at the CENTRE of that movement is the STILL POINT. The PRESENT. The eternal NOW. ⚪️ Our MIND creates its own infinity loop - memories of the PAST and projections of the FUTURE. What WAS and what MIGHT BE. What we HAD and what we WANT. Yet NEITHER can be inhabited. PAST and FUTURE are movements of the MIND. LIFE can only be experienced at the CENTRE. HERE... and NOW.

WhatdoIknow

14,918 次观看 • 26 天前

Meet Professor Sarah A. Teichmann, laureate for Europe of the 2026 L'Oréal-UNESCO #ForWomenInScience International Awards. Her pioneering research is deepening our understanding of the human body, one cell at a time, opening new possibilities for biomedical research and medicine. Watch her story. 🎥 → Cambridge University Fondation L'Oréal

Meet Professor Sarah A. Teichmann, laureate for Europe of the 2026 L'Oréal-UNESCO #ForWomenInScience International Awards. Her pioneering research is deepening our understanding of the human body, one cell at a time, opening new possibilities for biomedical research and medicine. Watch her story. 🎥 → Cambridge University Fondation L'Oréal

UNESCO

52,257 次观看 • 1 个月前

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𝗜𝗻𝗱𝗶𝗮’𝘀 𝗦𝗶𝗰𝗸𝗹𝗲 𝗖𝗲𝗹𝗹 𝗷𝗼𝘂𝗿𝗻𝗲𝘆: 𝗙𝗿𝗼𝗺 𝗮 𝗻𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝗺𝗶𝘀𝘀𝗶𝗼𝗻 𝘁𝗼 𝗴𝗹𝗼𝗯𝗮𝗹 𝗿𝗲𝗰𝗼𝗴𝗻𝗶𝘁𝗶𝗼𝗻 Launched by PM Shri Narendra Modi on 1st July 2023 in Shahdol, Madhya Pradesh, the National Sickle Cell Anaemia Elimination Mission is transforming the fight against Sickle Cell Disease through screening, counselling, early diagnosis, treatment and specialised care. With 7.29 crore+ people screened, 20 lakh+ carriers identified, 2.5 lakh people diagnosed and 4.93 crore+ Sickle Cell Cards distributed, India is advancing towards its goal of eliminating Sickle Cell Disease as a public health problem by 2047. At the launch of OneSCD on the sidelines of #UNGA81, Ms. Lea Kilinga Masamo, Founder & Executive Director, Africa Sickle Cell Organisation, highlighted the positive change being witnessed in the lives of people living with Sickle Cell Disease in India. India remains committed to a Sickle Cell-free future through strengthened prevention, early detection and comprehensive care. World Health Organization (WHO) UNICEF India St. Jude Africa CDC Federal Ministry of Health, NIGERIA India at UN, NY #SickleCellAnaemia #SickleCellElimination #UNGA81

Ministry of Health

17,493 次观看 • 7 天前

🚨 FBI Director Kash Patel unveils on Rogan that the footage of Epstein's cell will be RELEASED to the public: "You're going to get the video, of the cell, and you're going to see for yourself."

🚨 FBI Director Kash Patel unveils on Rogan that the footage of Epstein's cell will be RELEASED to the public: "You're going to get the video, of the cell, and you're going to see for yourself."

Benny Johnson

1,109,215 次观看 • 1 年前

Twenty-five years of working with RNA taught one medical biochemist three things you should never do with it: modify it, stabilize it, or inject it. The mRNA COVID vaccine did all three, and I asked him to walk me through why that's important. He described RNA as the blueprint of a cell, the instructions it uses to translate into proteins that do the actual work. If that blueprint is modified mid-construction, you don't get the protein you designed. You get fragments, and he said that's what is being produced in the majority of cases after the modification and injection of the spike protein RNA. The greater danger is reverse transcription. When the RNA template persists in the cell long enough, it can be converted back into DNA. A cell with more DNA than it should have is something every physician recognizes. It's called aneuploidy, and it's a transformed cell. It's cancer. He told me that, in his assessment as someone who has spent his career studying exactly this biology, the impact of all of this is beyond a disaster.

Twenty-five years of working with RNA taught one medical biochemist three things you should never do with it: modify it, stabilize it, or inject it. The mRNA COVID vaccine did all three, and I asked him to walk me through why that's important. He described RNA as the blueprint of a cell, the instructions it uses to translate into proteins that do the actual work. If that blueprint is modified mid-construction, you don't get the protein you designed. You get fragments, and he said that's what is being produced in the majority of cases after the modification and injection of the spike protein RNA. The greater danger is reverse transcription. When the RNA template persists in the cell long enough, it can be converted back into DNA. A cell with more DNA than it should have is something every physician recognizes. It's called aneuploidy, and it's a transformed cell. It's cancer. He told me that, in his assessment as someone who has spent his career studying exactly this biology, the impact of all of this is beyond a disaster.

Del Bigtree

163,421 次观看 • 2 个月前