Video wird geladen...

Video konnte nicht geladen werden

Zur Startseite

Anthropic went after the largest bacterium ever found, a single cell you can see with the naked eye, and read the machinery packed inside it. The size was never the interesting part. The question was how one cell keeps millions of copies of its own factory working in sync....

139,859 Aufrufe • vor 1 Tag •via X (Twitter)

25 Kommentare

Profilbild von Jarkko Hietaniemi 🤨
Jarkko Hietaniemi 🤨vor 23 Stunden

"The size was never the interesting part." And you can't even be arsed to clean up your AI slop writing from one of the most common AI tells.

Profilbild von Haroldo O. Pinheiro
Haroldo O. Pinheirovor 23 Stunden

Bacterium cell? This is clearly an eukaryotic, cell.

Profilbild von Crio Songo
Crio Songovor 1 Tag

This completely overturns the traditional cognition of bacterial structure, it's really a cool finding.

Profilbild von shmidt
shmidtvor 1 Tag

fantastic work!

Profilbild von Kotte
Kottevor 1 Tag

Spatial organization turns diffusion from a bottleneck into a routing problem

Profilbild von TechVerser
TechVerservor 1 Tag

Nature refactoring a monolith into microservices just to bypass diffusion latency. Insanely good visualization.

Profilbild von fakin
fakinvor 23 Stunden

For afficionados

Profilbild von Fokki
Fokkivor 1 Tag

i like the ui you doing, how it is being done?

Profilbild von Gloria B-Casareggio🌍 🚨🚨URGENCE 🚨TERRE 🚨🌎
Gloria B-Casareggio🌍 🚨🚨URGENCE 🚨TERRE 🚨🌎vor 20 Stunden

😻😻😻😻😻😻😻

Profilbild von Ace op
Ace opvor 20 Stunden

woah that's sick

Profilbild von Lummox
Lummoxvor 1 Tag

These are worth using

Profilbild von Dekos
Dekosvor 1 Tag

I'm glad they succeeded.

Profilbild von RoB
RoBvor 20 Stunden

I guess they need to change the definition of a prokaryotic cell after these findings!

Profilbild von Gipp 🦅
Gipp 🦅vor 1 Tag

wild breakdown wast, reading the count method right now

Profilbild von beamnxw ./
beamnxw ./vor 1 Tag

looks crazyy

Profilbild von 0xbobaa
0xbobaavor 21 Stunden

This animation looks amazing

Profilbild von Warm Paths
Warm Pathsvor 20 Stunden

Interesting, what else will AI do?

Profilbild von Tedex
Tedexvor 1 Tag

But yeah, all this just randomly happened.

Profilbild von Ridark
Ridarkvor 22 Stunden

Your terminal has that expert configuration look

Profilbild von magsimich
magsimichvor 23 Stunden

That single cell is wild

Profilbild von LaughandKeepMoving
LaughandKeepMovingvor 20 Stunden

Crispr is gonna be ridiculous with this tool.

Profilbild von A.S.I. GOD
A.S.I. GODvor 1 Tag

Possible evolution of organs

Profilbild von V1nT
V1nTvor 1 Tag

Damn this looks so stunning

Profilbild von Nura Kidah ✨
Nura Kidah ✨vor 1 Tag

One cell, yet organized like a tiny city.

Profilbild von Dan Hermes
Dan Hermesvor 22 Stunden

Love this. Computational biology always missed the complexity

Ähnliche Videos

Dr. David Sinclair said something to Prof Andrew Huberman that left me thinking... "Your cells are forgetting who they are." That is not a metaphor. That is the biological mechanism behind aging itself. Dr. David Sinclair then explained how it works... Every cell in your body carries the same DNA. A nerve cell and a skin cell are genetically identical. What makes them different is which genes are switched on and which are kept silent. That system of switches is called the epigenome. Think of DNA as a music library. The epigenome is the playlist. Each cell plays a specific set of songs. As long as every cell plays the right playlist, the body works perfectly. Aging is what happens when the playlists get corrupted. Genes that should stay silent start activating in the wrong cells. The cell loses its identity. It forgets what it was built to do. And according to Dr. David Sinclair, that single process is the root cause of heart disease, Alzheimer's, and most cancers. Not separate problems. The same problem, showing up in different places. The part that stopped me cold was what comes after that. If aging is information loss, it can be reversed by restoring the information. Dr. David Sinclair's lab has already done this in animals. When they restored the epigenetic signals, the cells remembered what they were. The aging reversed. Huberman asked whether the diseases go away too. Dr. David Sinclair did not hedge. " If you turn the clock back in tissues, those diseases go away." Every generation inherits assumptions about what the body can and cannot do. This one just changed. Follow @YourDocGoku for the science rewriting what we thought was permanent. David Sinclair

Longevity

32,630 Aufrufe • vor 6 Monaten

Evolution says you can turn anything into anything if you tweak it long enough. But that house of cards collapses immediately when you realize what it takes to make even a single cell. They say new cell types arise one mutation at a time. Is that plausible? Here is the issue: Different cell types are created through a massive coordinated stack of genetic information, and it's not all just about DNA sequences. First you need a whole suite of new genetic systems related to the cell: new genes for the cell’s internal systems, instructions for its specific functional role in the body, the regulators that coordinate everything, markers to tell them where to go and when, and the controls that keep the wrong programs off. But the DNA structure itself must also be manipulated. You see, every cell in your body contains the DNA instructions to make any other cell. So how does a bone cell become a bone cell instead of a skin cell? Because of how the DNA is folded. DNA is folded in certain ways for different cell types, so that only the "bone cell instructions" are able to be read by the "cell construction program." The DNA fold decides which programs are open for each cell type. This is critical. If DNA is not folded properly so that specific cell-type information can be read, catastrophe ensues. Then you need placement blueprints, so the cells form in the right place, in the right number, and lock together to form a functional tissue. These developmental instructions are passed from parent to offspring - but research shows that tweaking these master developmental programs ends badly for the child. One mutation at a time cannot invent that entire programming stack and keep it coordinated. Research has confirmed this. To convert one cell type into another in the lab, researchers have to force many changes to happen at the same time in coordination. And even when directed by the researcher, cell conversion almost always fails. Change the sequence without the fold and you cannot get a new cell type. Fold the DNA without the new systems and you can only rearrange old programs. Make the cell without the map and it shows up in the wrong place. Break one layer in the stack and the others do not patiently wait - they fail. So creating a new cell type is not simply "tweak a gene one at a time." It requires a coordinated stack of entirely new programmed instructions: > New suite of internal systems, programmed into the DNA > New functional DNA fold so only the right systems are activated > New mapping blueprints so everything goes where it's needed Step-by-step mutation does not coordinate those layers. It produces broken cells before it produces new ones. Coordination of this level of complexity has only ever been known to come from one place: Intelligence.

Divinely Designed

22,570 Aufrufe • vor 1 Monat

This is how DNA turns coded information into functional proteins - the building blocks of the nanomachines that keep the cells in your body alive. This complex process highlights the sophisticated interconnected systems of Life which must all exist together from the beginning, or Life doesn't happen. First, an RNA molecule is copied from a short segment of DNA. Without the specifically ordered DNA information, RNA cannot form, proteins cannot be built, cells stop working, and life ceases to exist. Life is information first. Once the RNA Molecule is created, it gets ejected from the Polymerase where it was built, and it travels through a complex molecular machine called a Nuclear Pore Complex (NPC), which is an information recognition device that controls the flow of information in and out of a cell's nucleus. The NPC is highly complex - composed of about 500-1,000 protein subunits, derived from a set of about 35 distinct proteins. Without this molecular machine, there is no regulation for what goes in and out of the cell's nucleus, which would lead to catastrophic death for the cell. It must exist for cells to exist. Once the RNA Molecule passes through the NPC, it travels to the Ribosome, a 2-part chemical factory which reads the information on RNA and uses it to construct functional proteins using a specifically sequenced chain of amino acids. Once complete, this protein will then be sent to the section of the cell it belongs to integrate into another molecular machine and do its job. The Ribosome is another highly complex molecular machine - consisting of between 56-80 proteins. Without this molecular machines, proteins cannot be built. Proteins are the building blocks of every cell in every organism on Earth. Without Ribosomes, Life doesn't exist. If you're paying attention, you'll start to realize that Life relies on a highly sophisticated interdependent network of complex machines, which all rely on each other for the function of the system. DNA requires the cell for stability, but the cell requires the proteins for its structure and function, but those proteins require DNA and RNA to be built - it's a circle of necessary interdependence. Systems like this cannot be built by evolutionary processes, which requires that each piece of the process is built by gradual incremental means over lots of time. Without all the pieces there, from the beginning, none of it works. There is only one known source of complex & interdependent informational systems like those we find in life: and that is from Intelligence. Molecular Biology is the best and most obvious evidence of the Intelligent Design in Life.

Divinely Designed

62,517 Aufrufe • vor 8 Monaten

This is how DNA is organized in a cell. And it's more evidence that Life was intelligently designed. Each human cell contains about 6.5ft (2m) of DNA packed into a dense microscopic structure. But it's not packed into a random pile. It's packed into precise loops scientists call 'cohesin loops.' DNA is wound up around spool-like proteins called histones, which are then further wound together into clusters called nucleosomes, which are then organized into shapes called chromatins, which are then folded into large structures called chromosomes. Four levels of very specific, complex organization. Without a specific & controlled organization system, DNA would be an unreadable, useless mess. Which means DNA would have to be organized immediately upon creation, or Life couldn't arise. And this is the craziest part... The way DNA is organized in a eukaryotic cell directly controls which genes are turned on or off. This organization is what determines cell-type. Every cell in your body contains the exact same DNA blueprint. The only reason a heart cell beats and a skin cell protects you is due to DNA organization. A heart cell packs away all "skin genes" into tight, unreadable section that doesn't get activated, while keeping "heart genes" open & active. If a cell doesn't have specific DNA organization, it loses its identity. When that happens, it results in cancer. Which means DNA organization must be specifically planned out from the start to prevent catastrophe. Life doesn't have time to tinker and figure this out via evolution. DNA requires organization from the start, or it's useless. DNA organizarion requires multiple systems all working together to function. Without them, it fails. Only intelligence has ever been shown to engineer specifically organized, complex informational systems with obvious signs of preplanning and intentionality. Life was Divinely Designed. Biology proves it over & over again.

Divinely Designed

14,875 Aufrufe • vor 2 Monaten

A new Nature paper from Johns Hopkins (by Prof. Lin Dingchang Lin ) just solved one of the hardest problems in biology: how do you record what every cell in a tissue experienced over time, not just what it looks like right now? The answer: GEMINI — Granularly Expanding Memory for Intracellular Narrative Integration. It works exactly like tree rings. Cells are genetically engineered to express a computationally designed protein assembly. As the assembly grows inside the cell, it captures cellular activity as fluorescent ring patterns — each ring a timestamp, each ring's properties encoding signal intensity. Look at a cross-section under a microscope and you can read the cell's history backward, with ~15-minute resolution. The key: cells build the recorder themselves. GEMINI doesn't interfere with normal function — it just quietly writes. What they demonstrated: In a full tumor xenograft, GEMINI captured every cancer cell's activity history across the entire tumor while it continued to grow normally. For the first time, researchers can look back and see how different regions of the same tumor responded differently to therapy over time — not snapshots, but film. In a mouse brain, GEMINI recorded neural activity dynamics without disrupting behavior, coordination, or memory. It could temporally resolve the history of a brain seizure. Why this matters: Every tool we have in biology gives you state — what the cell looks like now. Sequencing, imaging, proteomics — all snapshots. GEMINI gives you trajectory. It's the difference between a photograph and a video, applied to every cell in an organ simultaneously. The team is explicit that AI-based decoding tools will be central to reading GEMINI's output at whole-brain scale. This is the data layer that makes temporal single-cell atlases possible. Paper: Congratulations Dingchang Lin

Bo Wang

85,261 Aufrufe • vor 6 Monaten

Intelligence was the one thing that never scaled. We scaled everything else. Steel. Energy. Compute. The one resource that built all of it never left the skull. Musk: “People thought defeating Go was either never or 20 years away.” Twelve months later it was over. Musk: “Now that same AlphaGo system can defeat the top 50 players simultaneously with 0% chance of them winning. And that’s one year later.” Fifty lifetimes of mastery against a system that does not know it is playing a game. Zero percent chance. That was not a competition. That was a preview. Musk: “The degrees of freedom to which artificial intelligence is able to apply itself are really increasing by 10 orders of magnitude a year.” Ten billion times. Every twelve months. No brain alive can visualize that number. By design. Every hard problem that ever defeated us did it for the same reason. Not complexity. Scarcity. The only mind capable of solving it was biological and there was never enough of it. Cancer. Fusion. Climate. The physics we cannot even see yet. Not waiting on more data. Waiting on something that can think at a scale biology never allowed. That just arrived. Most people hear this and reduce it to a question about their paycheck. They are watching the single largest expansion of capability in the history of life on this planet and worrying about a job title. For ten thousand years intelligence had one speed. One brain. One lifetime. Every civilization on earth throttled by the same biological ceiling. That ceiling just shattered. We are the only species that ever hit its own limit and built what breaks through it. That is not an ending. That is the point of everything we ever built.

Dustin

24,426 Aufrufe • vor 3 Monaten

Elon Musk, absolute leader of the AI race with Grok Bot, and it's not a joke anymore. Ultimate guide on god-mode setup of Grok Bot, the org chart that runs while you sleep, step by step: A Chief of Staff sits in the middle with no tools of its own, BUT it reads the outcome you gave it, picks who does what, and never does the work itself. That one rule is why it never turns into the bottleneck you hired it to remove. → Researcher pulls real sources and tracks what's actually moving, not what sounds true → Writer turns that into finished copy while the research is still in the room → Visualiser gets three reference visuals once, then ships everything in that style forever → Analyst reads what performed and tells the rest of the team what to stop doing → Scheduler owns timing and holds the queue → Publisher actually ships What makes it different from every AI tool you've used: each bot gets its own computer in the cloud, its own browser, its own files, and they all share one memory. So the research is already sitting inside the draft before the draft starts. Nothing gets copy-pasted between tabs, nothing waits on you to approve step four of nine. And you never write a workflow for it. You hit record, do the job once the way you actually do it, stop. It pulls out the steps, saves them as a skill, and puts it on a schedule. The shape you're aiming for on every bot: everything reversible finished, nothing sent. 36 drafts queued, 0 published. It does all the work and stops dead at the one line only you can cross. You stop prompting. You start assigning. Full charter blocks, the approval line and the routines are in the article below ↓

Miraqle

87,098 Aufrufe • vor 1 Monat

This is a Kinesin Molecule. These little molecular machines are commonly referred to as the "workhorse" of the cell, hauling important cargo like organelles, proteins and other cellular structures to their proper location within the cell. Kinesins are very clear & undeniable evidence of the intelligent design in Life. Kinesins are complex molecular machines, made up of 4 total proteins, each between 500-1,300 amino acids in length. If these aa sequences are not perfectly aligned from the beginning, Kinesin never forms, and cellular life would be unable to survive. Here is how they work: When a new protein, organelle, or other cellular structure is created in the Cytosol of the cell, they are constructed with built-in "binding tags," which are like shipping labels that bind to other protein molecules called Adaptor or Scaffold Proteins. These Adaptor/Scaffold Proteins then attach to the Kinesin's tail, which activates them, and then the Kinesin is guided along the microtubule track to its to its final destination. Kinesin walk on self-assembling tracks of other proteins, called microtubules, moving cargo from the inner area of the cell where they are constructed to the outer edges where they function. This is a complex & sophisticated interdependent network of molecular machines, all relying on one another to function properly for the health of the cell. This Intracellular Transportation system MUST be fully functional from the beginning - with all these working parts, or all of it fails, and the cell dies. Without this entire functioning system, Life could not exist. And the Kinesin is the centerpiece to all of it. Experiments have shown that disrupting Kinesin activity has catastrophic consequences. This type of nano-precision is an obvious example of designed engineering. Blind, unguided evolutionary processes cannot plan ahead and create complex informational highways for precision transportation. The proposed evolutionary explanation is simply "co-option." A nebulous term which basically amounts to, "We don't know how it evolved, but it must have evolved from some other thing that was similar in the past." No observational data supports evolutionary co-option. It's absurd to believe any part of this was built by blind chance. Everything in the cell points to Intelligent Design.

Divinely Designed

15,956 Aufrufe • vor 8 Monaten

Agents vs. Graphs, clearly explained! spawning more agents is great, but it has a ceiling nobody says out loud: five agents is a count. a graph is a shape. only one of them changes the answer. point five agents at the same pile with the same window and they converge. the first one writes a finding, the rest read it, and all five reports centre on the same thing. you paid five times for one opinion with four echoes. Graph engineering fixes this by moving the decision up a layer: not how many agents, but who is allowed to look at what. you need both. here's how it works: ↳ the count buys you throughput. five things happening instead of one ↳ the shape buys you coverage. five different things happening instead of the same one five times Prompts → Context → Harness → Agents → Graphs the node that does this is the splitter, and it decides more than any other node in the system. cut a repository by folder and four workers audit the same three files. cut it by blast radius and each one sees something the others cannot. the trick is being selective about what each lane is allowed to see. separate contexts are not a nice-to-have, they are the mechanism. if two agents are meant to produce different things, they must not share a window. if they are meant to produce the same thing, you did not need two agents. one thing to know before you scale it. a branch that throws does not reject the batch. it resolves to null, and that is the containment. which means your merge quietly receives a short list. ↳ filter the nulls before the merge, or one dead lane poisons the whole result ↳ never index a merge by position. eight good branches and one failure will shift everything by one, silently skip that and the run looks like it worked. the output is just missing a lane, and nothing errored. and the one that eats whole nights: multi-agent setups can use up to fifteen times the total tokens of a single chat, because every lane reloads its own core. you are trading total tokens for a clean main window. usually the right trade, always a choice. below i have quoted my full guide on graph engineering. it covers the three topologies, the verifier patterns, and where the gate should actually open. save this and read it below ↓

Hanako

97,154 Aufrufe • vor 1 Monat

🚨Here's what a lot of people misunderstand about cancer treatment, says drpaulmarik: "Cancer is not homogeneous. The somatic mutation theory—which is the current theory in which treatment is based—posits that you have a mutation in a single cell, and that gives rise to a whole population of cells that look the same and have the same mutation. But the Cancer Genome Atlas has shown that that theory is completely wrong. The cancer cells are very heterogeneous, so they're made up of very different populations of cells with different mutations, and one of the populations is the cancer stem cell. It's a sub-population of the cancer. These are generally slow-growing, but they're distinct in that they have the ability to divide indefinitely and grow indefinitely, and can change their characteristics. Basically, if you get rid of the fast-dividing cells, which is the cancer, you're left with the stem cells, which then become the roots, which grow back to form the tumor" sometimes years later. Conventional chemotherapy gets rid of the fast-dividing regular cancer cells but *NOT* the stem cells. So the key question is: how do you get rid of the stem cells? “There are a number of repurposed drugs that do it, and this has been well-established in scientific medical literature. One of the most effective treatments to knock out the stem cell is the famous horse deworming medicine," says drpaulmarik. Yes, ivermectin. Independent Medical Alliance

Jan Jekielek

96,002 Aufrufe • vor 1 Jahr

Workflows vs. Graphs, clearly explained! workflows are great, and almost everyone has one. here is the ceiling: a workflow decides every step before it runs. you drew eight boxes in March. six months later the same three fire, every single time, and the other five have never once been reached. then a case arrives that nobody drew, and it goes to the closest wrong box. quietly, with a green status, because from the inside that looks exactly like success. Graph engineering fixes this by moving the decision: not what the steps do, but when the steps get chosen. you need both, and here is the sentence that resolves the whole confusion: a workflow decides the steps before it runs. a graph decides them while it runs. ↳ drawn in advance: the boxes, the branches, the order, the error path ↳ decided at runtime: how many units exist, what each one is allowed to see, which ones get created at all Prompts → Context → Harness → Loops → Graphs branches do not make it a graph. the branches were drawn in advance too, which means every one of them is a case you already thought of. the trick is knowing which part is allowed to be fixed. the node kinds are fixed. a splitter is a splitter, a gate is a gate, a merge is code. what is not fixed is how many of them exist this run, and that is decided after something has been read. one thing to know before you scale it. a workflow fails in a way that never pages anyone. ↳ the wrong branch ran, every check inside it passed, and the output is well formed ↳ nothing errored, because routing to the wrong box is not an error, it is a route that last one catches careful people. you cannot test your way out of it either, because the test suite was written from the same diagram that has the gap in it. and the one that eats whole nights: a workflow that has never surprised you is not stable, it is narrow. if it has run four hundred times and produced the same three shapes, it is not handling your work. it is handling the part of your work that fits it, and you have quietly stopped sending it the rest. below i have quoted my full guide on graph engineering. it covers the three topologies, the verifier patterns, and where the gate should actually open. save this and read it below ↓

Hanako

16,810 Aufrufe • vor 13 Tagen

Gilbert Strang, the legendary mathematician who taught linear algebra for 61 years and became the most watched math professor in history: "I used to think a matrix was just a grid of numbers, until I proved that its rows and columns always agree on one number no matter how you look at them. That fact still feels like magic to me after sixty years." this is the exact proof sitting quietly underneath every factor model a risk desk trusts with real capital, and almost nobody outside a math department has ever seen it. strip away the notation and the idea is almost absurdly simple. take any matrix, any grid of numbers, and count how many of its rows are truly independent, meaning none of them can be built out of the others. now count the independent columns instead, a completely different question on the surface. those two numbers, row independence and column independence, always turn out exactly equal, no matter how large or lopsided the matrix is. nobody presenting a clean risk model out loud credits a decades old proof for the reason the math even holds together. zoom out to what this means for anything built on a grid of numbers today. a portfolio, a covariance matrix, a neural network's weights, all of them hide a true dimension smaller than their size suggests, and that hidden number is exactly what this proof pins down. the industry sells complexity as scale, more assets, more parameters, more rows and columns. but the real question was never how big the matrix is. it's how many independent directions are actually hiding inside it. the size of the grid was never the real story. it was the one number both sides of it were quietly agreeing on the whole time.

MindArch

18,494 Aufrufe • vor 1 Monat

This is mind ATP Synthase The energy pump that powers every cell in every lifeform on Earth, slowed down by over 1,000x. Without ATP Synthase, life cannot exist. This little nano-machine is made up of a minimum of 8 distinct proteins, all designed perfectly to fit together and operate in a coordinated system that takes in ADP and turns it into ATP, which the cell uses to power metabolic processes. It's designed to only allow certain molecules in & out. Any mistakes, and it could flood the cell with toxic waste in a matter of seconds, killing everything. Each protein building block must fit perfectly together, much like all the pieces inside your phone. Without all the proteins fit & working together from the start, ATP Synthase cannot function, and Life cannot exist. But making things even more complex, ATP Synthase doesn't operate alone. It's located inside the cell membrane, where it actively works with other molecules to ensure the ATP it creates gets to the right place. It's a whole integrated network of energy movement within each cell, without which, Life could not exist. All these pieces must exist together, from the beginning, for Life to be possible. Which means it can't arise piece by piece through evolution - because the very process of evolution requires the whole system. Life requires this system in order to produce the energy it needs to replicate & evolve - but replication & evolution is supposed to have created it. You can't have one without the other. There are no simpler versions - it's literally all or nothing. This is clear evidence of an intelligently designed system. What more evidence do you need?

Divinely Designed

28,434 Aufrufe • vor 4 Monaten