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Dr. David Sinclair said something to Prof Andrew Huberman that left me thinking... "Your cells are forgetting who they are." That is not a metaphor. That is the biological mechanism behind aging itself. Dr. David Sinclair then explained how it works... Every cell in your body carries the same...

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Goku

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32,589 次观看 • 5 个月前 •via X (Twitter)

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When Andrew Huberman asked about the root cause of aging, Dr. David Sinclair gave a surprisingly simple answer: "Aging is a loss of information in the same way you try to copy a cassette tape, or even if you send information across the internet, some of it will get lost." There are two types of information our bodies carry: "There is the genetic information, which is digital — A, T, C, G, the chemical letters of DNA. But there's this other part of the information in the body that's just as important, it's essential, in fact, and that's the systems that control which genes are switched on and off." And when it comes to which one matters more for how long and how well you live, the answer isn't even close: — David Sinclair
2:35

When Andrew Huberman asked about the root cause of aging, Dr. David Sinclair gave a surprisingly simple answer: "Aging is a loss of information in the same way you try to copy a cassette tape, or even if you send information across the internet, some of it will get lost." There are two types of information our bodies carry: "There is the genetic information, which is digital — A, T, C, G, the chemical letters of DNA. But there's this other part of the information in the body that's just as important, it's essential, in fact, and that's the systems that control which genes are switched on and off." And when it comes to which one matters more for how long and how well you live, the answer isn't even close: — David Sinclair

John Cumbers

305,874 次观看 • 5 个月前

🚨David Sinclair: “The first potential human age-reversal technology is in people right now.” ROGAN: “What is the current state of science as applied to longevity treatments?” SINCLAIR: “We have a human clinical trial.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “My colleagues and I found that aging has a root cause that’s the same in pretty much every cell in the body, and that we could control that.” “In 2020, we had a big publication that showed we could actually safely, for the first time, reverse that process, like reinstalling software in the cell to make it work again.” ---- The treatment is ER-100, an experimental epigenetic reprogramming gene therapy being developed by Life Biosciences, a company co-founded by Harvard geneticist Dr. David Sinclair. In the current FDA clinical trial, the therapy is delivered by injection into the eye. If this works in humans, it could be a major step toward actually reversing aspects of biological aging rather than simply slowing them down. Joe Rogan David Sinclair
3:56

🚨David Sinclair: “The first potential human age-reversal technology is in people right now.” ROGAN: “What is the current state of science as applied to longevity treatments?” SINCLAIR: “We have a human clinical trial.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “My colleagues and I found that aging has a root cause that’s the same in pretty much every cell in the body, and that we could control that.” “In 2020, we had a big publication that showed we could actually safely, for the first time, reverse that process, like reinstalling software in the cell to make it work again.” ---- The treatment is ER-100, an experimental epigenetic reprogramming gene therapy being developed by Life Biosciences, a company co-founded by Harvard geneticist Dr. David Sinclair. In the current FDA clinical trial, the therapy is delivered by injection into the eye. If this works in humans, it could be a major step toward actually reversing aspects of biological aging rather than simply slowing them down. Joe Rogan David Sinclair

KanekoaTheGreat

1,231,954 次观看 • 16 天前

David Sinclair's lab just discovered that the same technology that reverses aging also kills cancer cells. His team has been using epigenetic reprogramming to reset old cells back to a younger state. It works. Old cells become young again. But when they tried it on cancer cells, something unexpected happened. The cancer cells didn't get younger. They killed themselves. Sinclair (David Sinclair) explained why. Cancer cells survive by ignoring the DNA damage inside them. They're filled with it. But they've shut down the part of the cell that would normally detect it and trigger self-destruction. Epigenetic reprogramming wakes that system back up. Sinclair put it this way: the cancer cell wakes up from its zombie-like state, looks at its own chromosomes, realizes they're destroyed, and says "I better kill myself." And it does. A normal cell gets reprogrammed and becomes young again. A cancer cell gets reprogrammed and destroys itself. Same technology. Two opposite outcomes. Both exactly what you'd want. His team has shown this works across many types of cancer. Side note: David Sinclair is speaking on May 6th at SynBioBeta this year - discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists who matter in this space will be in the room. Link for tickets below.
1:02

David Sinclair's lab just discovered that the same technology that reverses aging also kills cancer cells. His team has been using epigenetic reprogramming to reset old cells back to a younger state. It works. Old cells become young again. But when they tried it on cancer cells, something unexpected happened. The cancer cells didn't get younger. They killed themselves. Sinclair (David Sinclair) explained why. Cancer cells survive by ignoring the DNA damage inside them. They're filled with it. But they've shut down the part of the cell that would normally detect it and trigger self-destruction. Epigenetic reprogramming wakes that system back up. Sinclair put it this way: the cancer cell wakes up from its zombie-like state, looks at its own chromosomes, realizes they're destroyed, and says "I better kill myself." And it does. A normal cell gets reprogrammed and becomes young again. A cancer cell gets reprogrammed and destroys itself. Same technology. Two opposite outcomes. Both exactly what you'd want. His team has shown this works across many types of cancer. Side note: David Sinclair is speaking on May 6th at SynBioBeta this year - discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists who matter in this space will be in the room. Link for tickets below.

John Cumbers

95,747 次观看 • 4 个月前

Dr. David Sinclair says his lab at Harvard grew a miniature human brain in a dish. Then two small black dots appeared on its surface. They were eyes. These brains are grown from single human cells. They develop the same structures found in a full human brain... They even have measurable brain waves... And under a microscope, you can see calcium signals firing like fireworks. This indicates neurons are communicating with each other in the same way neurons in your brain are firing right now as you read this. After about a year, the firing fades and the brain loses function. Sinclair says when his team treats these aging brains with three "longevity" genes called OSK, the firing comes back on. They have also introduced Alzheimer's disease into these brains. Using the same three genes, it reverses. He says this technology is not limited to brains. His lab has reversed aging in the eye, liver, kidney, and skin. Every tissue responds to the same treatment. Now the first human trial is coming. — David Sinclair (David Sinclair) on Tom Bilyeu's (Tom Bilyeu) podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. Tickets available in the comments below.
1:24

Dr. David Sinclair says his lab at Harvard grew a miniature human brain in a dish. Then two small black dots appeared on its surface. They were eyes. These brains are grown from single human cells. They develop the same structures found in a full human brain... They even have measurable brain waves... And under a microscope, you can see calcium signals firing like fireworks. This indicates neurons are communicating with each other in the same way neurons in your brain are firing right now as you read this. After about a year, the firing fades and the brain loses function. Sinclair says when his team treats these aging brains with three "longevity" genes called OSK, the firing comes back on. They have also introduced Alzheimer's disease into these brains. Using the same three genes, it reverses. He says this technology is not limited to brains. His lab has reversed aging in the eye, liver, kidney, and skin. Every tissue responds to the same treatment. Now the first human trial is coming. — David Sinclair (David Sinclair) on Tom Bilyeu's (Tom Bilyeu) podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. Tickets available in the comments below.

John Cumbers

157,553 次观看 • 4 个月前

David Sinclair's lab just reversed infertility in mice that had been infertile for 6 months. They took 16-month-old mice, the equivalent of a woman well past menopause, and made them produce offspring again. The belief has always been that mammals run out of eggs and that's final. Sinclair's lab proved otherwise. They did it using NMN, a molecule that boosts energy levels in your cells. And it worked. Now his team is working on applying something even more powerful - epigenetic reprogramming - to women's fertility Sinclair was blunt about the problem. After 30, fertility drops dramatically. By the time many women are established in their careers, their window is closing or closed. He called it unfair. Men can have children at 50 without thinking twice. Women face a biological deadline that no one in science has seriously tried to move. His lab is now trying to move it. If this works in humans, it doesn't just extend fertility. It gives women back the choice that biology took away. — David Sinclair (David Sinclair) Side note: David Sinclair is speaking on May 6th at SynBioBeta this year - discussing the science of slowing and reversing aging. If health and longevity is the world you're in, the investors, partners, and scientists important in this space will be in the room. Link for tickets below.
0:27

David Sinclair's lab just reversed infertility in mice that had been infertile for 6 months. They took 16-month-old mice, the equivalent of a woman well past menopause, and made them produce offspring again. The belief has always been that mammals run out of eggs and that's final. Sinclair's lab proved otherwise. They did it using NMN, a molecule that boosts energy levels in your cells. And it worked. Now his team is working on applying something even more powerful - epigenetic reprogramming - to women's fertility Sinclair was blunt about the problem. After 30, fertility drops dramatically. By the time many women are established in their careers, their window is closing or closed. He called it unfair. Men can have children at 50 without thinking twice. Women face a biological deadline that no one in science has seriously tried to move. His lab is now trying to move it. If this works in humans, it doesn't just extend fertility. It gives women back the choice that biology took away. — David Sinclair (David Sinclair) Side note: David Sinclair is speaking on May 6th at SynBioBeta this year - discussing the science of slowing and reversing aging. If health and longevity is the world you're in, the investors, partners, and scientists important in this space will be in the room. Link for tickets below.

John Cumbers

55,280 次观看 • 4 个月前

David Sinclair said: "You can reverse aging by 75% in 6 weeks… by reinstalling the "software" of the body so that it's young again." This idea sprouted when he proved in his first experiment that you can accelerate aging in mice: "We took two mice born on the same day—same age, same genetics. We "scratched the CD" of one mouse, corrupting its software and accelerating its aging. The result was dramatic. One looked far older than its brother." He believed if you can give aging, you can also take it away. Tomorrow, I'll share his experiment on how he reversed aging in mice (and then Monkeys). — David Sinclair
0:57

David Sinclair said: "You can reverse aging by 75% in 6 weeks… by reinstalling the "software" of the body so that it's young again." This idea sprouted when he proved in his first experiment that you can accelerate aging in mice: "We took two mice born on the same day—same age, same genetics. We "scratched the CD" of one mouse, corrupting its software and accelerating its aging. The result was dramatic. One looked far older than its brother." He believed if you can give aging, you can also take it away. Tomorrow, I'll share his experiment on how he reversed aging in mice (and then Monkeys). — David Sinclair

John Cumbers

417,802 次观看 • 5 个月前

David Sinclair said: "You can reverse aging by 75% in 6 weeks… by reinstalling the "software" of the body so that it's young again." This idea sprouted when he proved in his first experiment that you can accelerate aging in mice: "We took two mice born on the same day—same age, same genetics. We 'scratched the CD' of one mouse, corrupting its software and accelerating its aging. The result was dramatic. One looked far older than its brother." He believed if you can give aging, you can also take it away. Tomorrow, I'll share his experiment on how he reversed aging in mice (and then Monkeys). — David Sinclair
0:57

David Sinclair said: "You can reverse aging by 75% in 6 weeks… by reinstalling the "software" of the body so that it's young again." This idea sprouted when he proved in his first experiment that you can accelerate aging in mice: "We took two mice born on the same day—same age, same genetics. We 'scratched the CD' of one mouse, corrupting its software and accelerating its aging. The result was dramatic. One looked far older than its brother." He believed if you can give aging, you can also take it away. Tomorrow, I'll share his experiment on how he reversed aging in mice (and then Monkeys). — David Sinclair

Goku

985,946 次观看 • 5 个月前

David Sinclair says rapamycin had no measurable effect on slowing or reversing epigenetic aging in humans. This was a drug most of the longevity community supported. He was even a believer of it. It was found to extend lifespan in: • Inbred lab animals • Seemingly in dogs And everyone assumed it would translate to humans. Then a study came out about 6 months ago that compared the effect of different interventions on epigenetic age across multiple clinical trials. The results: • Caloric restriction = worked really well • Acarbose = worked really well • Metformin = "looked better than I thought it would" • Rapamycin = no effect on the age of the epigenome Zero. Nothing. Sinclair now takes rapamycin just four times a year while monitoring whether even that makes a difference. The most hyped longevity drug is being deprioritized by the scientist who is actually reversing aging. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.
1:02

David Sinclair says rapamycin had no measurable effect on slowing or reversing epigenetic aging in humans. This was a drug most of the longevity community supported. He was even a believer of it. It was found to extend lifespan in: • Inbred lab animals • Seemingly in dogs And everyone assumed it would translate to humans. Then a study came out about 6 months ago that compared the effect of different interventions on epigenetic age across multiple clinical trials. The results: • Caloric restriction = worked really well • Acarbose = worked really well • Metformin = "looked better than I thought it would" • Rapamycin = no effect on the age of the epigenome Zero. Nothing. Sinclair now takes rapamycin just four times a year while monitoring whether even that makes a difference. The most hyped longevity drug is being deprioritized by the scientist who is actually reversing aging. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.

John Cumbers

21,184 次观看 • 4 个月前

Your comfort is aging you. And your biology can prove it. Dr. David Sinclair put it plainly: "People who exercise and eat less have a slower-ticking clock. It's a fact." The longevity genes in your body only activate when your cells perceive adversity. Hunger. Exertion. Cold. The moment your cells sense abundance, they stand down. Defenses off. The clock runs faster. Modern life engineered away every signal the body evolved to receive. Always fed. Always warm. Always sitting. The body was never designed to be comfortable. It was designed to be resilient. And resilience requires pressure to stay active. Skip a meal. Push the muscle. Let the cold in. Every one of those signals tells your cells to tighten up, repair, defend. Without them, the machinery idles. And idle machinery rusts. The uncomfortable truth is that the things most people optimize their lives to avoid are the exact inputs their biology is waiting for. Follow Goku for more on the science of living longer, explained plainly.
3:20

Your comfort is aging you. And your biology can prove it. Dr. David Sinclair put it plainly: "People who exercise and eat less have a slower-ticking clock. It's a fact." The longevity genes in your body only activate when your cells perceive adversity. Hunger. Exertion. Cold. The moment your cells sense abundance, they stand down. Defenses off. The clock runs faster. Modern life engineered away every signal the body evolved to receive. Always fed. Always warm. Always sitting. The body was never designed to be comfortable. It was designed to be resilient. And resilience requires pressure to stay active. Skip a meal. Push the muscle. Let the cold in. Every one of those signals tells your cells to tighten up, repair, defend. Without them, the machinery idles. And idle machinery rusts. The uncomfortable truth is that the things most people optimize their lives to avoid are the exact inputs their biology is waiting for. Follow Goku for more on the science of living longer, explained plainly.

Goku

54,219 次观看 • 4 个月前

The first human age-reversal trial is officially happening. But before the FDA cleared it, Harvard professor David Sinclair had to pull off a mice experiment most scientists thought was impossible: "These mice had their optic nerve regenerated. We were able to show that using [the information theory of aging] method we could cure blindness in animal for the first time." Since then, he also discovered you could treat and reverse diseases like Alzheimer's, multiple sclerosis, ALS, kidney disease and liver disease in mice too: “It's not just the eye that can get reversed and cured of diseases. It's seemingly every part of the body.” It's what he calls "a universal reset of the body." He confirmed his method also worked in monkeys. Now humans are next. The FDA just cleared the first age-reversal trial. Life Biosciences raised $80 million to make it happen. As he put it: "The eye is just the beginning. We believe we can treat every tissue—a whole body reset."
2:55

The first human age-reversal trial is officially happening. But before the FDA cleared it, Harvard professor David Sinclair had to pull off a mice experiment most scientists thought was impossible: "These mice had their optic nerve regenerated. We were able to show that using [the information theory of aging] method we could cure blindness in animal for the first time." Since then, he also discovered you could treat and reverse diseases like Alzheimer's, multiple sclerosis, ALS, kidney disease and liver disease in mice too: “It's not just the eye that can get reversed and cured of diseases. It's seemingly every part of the body.” It's what he calls "a universal reset of the body." He confirmed his method also worked in monkeys. Now humans are next. The FDA just cleared the first age-reversal trial. Life Biosciences raised $80 million to make it happen. As he put it: "The eye is just the beginning. We believe we can treat every tissue—a whole body reset."

John Cumbers

1,162,495 次观看 • 5 个月前

A foreign government attempted to invest over $100 million into one of David Sinclair's age-reversal companies. The US government BLOCKED it. The reason? They classified the technology as too dangerous to fall into foreign hands. Sinclair sits on the board of the company. He confirmed the investment was killed because the US government believed a foreign power would gain too much access to age-reversal research. When asked if it was China, his response: "I won't say more. It's sensitive." But here's what he DID say: Governments around the world are watching this technology closely. Not just for healthcare. The US government has identified what Sinclair calls "so-called super soldier potential" in age-reversal tech. He also said the winner of this race won't just gain economic advantage. There will be "potential for radical change in the pharmaceutical industry, in healthcare" and dramatic social change. Sinclair believes the technology is very powerful and that society should start preparing now. Because as he put it: "It's not an if. It's a when." David Sinclair is at SynBioBeta this year - discussing the science of slowing and reversing aging. Link for tickets below. — David Sinclair
1:45

A foreign government attempted to invest over $100 million into one of David Sinclair's age-reversal companies. The US government BLOCKED it. The reason? They classified the technology as too dangerous to fall into foreign hands. Sinclair sits on the board of the company. He confirmed the investment was killed because the US government believed a foreign power would gain too much access to age-reversal research. When asked if it was China, his response: "I won't say more. It's sensitive." But here's what he DID say: Governments around the world are watching this technology closely. Not just for healthcare. The US government has identified what Sinclair calls "so-called super soldier potential" in age-reversal tech. He also said the winner of this race won't just gain economic advantage. There will be "potential for radical change in the pharmaceutical industry, in healthcare" and dramatic social change. Sinclair believes the technology is very powerful and that society should start preparing now. Because as he put it: "It's not an if. It's a when." David Sinclair is at SynBioBeta this year - discussing the science of slowing and reversing aging. Link for tickets below. — David Sinclair

John Cumbers

203,250 次观看 • 5 个月前

🚨Here's what a lot of people misunderstand about cancer treatment, says drpaulmarik: "Cancer is not homogeneous. The somatic mutation theory—which is the current theory in which treatment is based—posits that you have a mutation in a single cell, and that gives rise to a whole population of cells that look the same and have the same mutation. But the Cancer Genome Atlas has shown that that theory is completely wrong. The cancer cells are very heterogeneous, so they're made up of very different populations of cells with different mutations, and one of the populations is the cancer stem cell. It's a sub-population of the cancer. These are generally slow-growing, but they're distinct in that they have the ability to divide indefinitely and grow indefinitely, and can change their characteristics. Basically, if you get rid of the fast-dividing cells, which is the cancer, you're left with the stem cells, which then become the roots, which grow back to form the tumor" sometimes years later. Conventional chemotherapy gets rid of the fast-dividing regular cancer cells but *NOT* the stem cells. So the key question is: how do you get rid of the stem cells? “There are a number of repurposed drugs that do it, and this has been well-established in scientific medical literature. One of the most effective treatments to knock out the stem cell is the famous horse deworming medicine," says drpaulmarik. Yes, ivermectin. Independent Medical Alliance
6:30

🚨Here's what a lot of people misunderstand about cancer treatment, says drpaulmarik: "Cancer is not homogeneous. The somatic mutation theory—which is the current theory in which treatment is based—posits that you have a mutation in a single cell, and that gives rise to a whole population of cells that look the same and have the same mutation. But the Cancer Genome Atlas has shown that that theory is completely wrong. The cancer cells are very heterogeneous, so they're made up of very different populations of cells with different mutations, and one of the populations is the cancer stem cell. It's a sub-population of the cancer. These are generally slow-growing, but they're distinct in that they have the ability to divide indefinitely and grow indefinitely, and can change their characteristics. Basically, if you get rid of the fast-dividing cells, which is the cancer, you're left with the stem cells, which then become the roots, which grow back to form the tumor" sometimes years later. Conventional chemotherapy gets rid of the fast-dividing regular cancer cells but *NOT* the stem cells. So the key question is: how do you get rid of the stem cells? “There are a number of repurposed drugs that do it, and this has been well-established in scientific medical literature. One of the most effective treatments to knock out the stem cell is the famous horse deworming medicine," says drpaulmarik. Yes, ivermectin. Independent Medical Alliance

Jan Jekielek

96,002 次观看 • 1 年前

Science Corner: David Friedberg Explains Recent Mitotherapy Breakthroughs ⚡️ On E224, david friedberg broke down what mitotherapy is and how recent discoveries could unleash this treatment for many diseases: "So mitochondria are the powerhouse of the cell." "Every cell in our body gets its energy, which is what it uses to function, from the mitochondria." "And so there's been a lot of research into the relationship between mitochondria and aging, and that dysfunctional mitochondria may actually be a key driver for many diseases." "Including many cancers, Alzheimer's, Parkinson's, ALS, features of autism, muscle tissues being weak, etc." " So, as the cells get older and the mitochondria stop working, we make new mitochondria." "But over time, the DNA degrades and the mitochondria become less effective and there are fewer functional mitochondria per cell." Friedberg highlighted three recent papers: 1) "The power and potential of mitochondria transfer" (nature) -- "these folks identified and demonstrated that mitochondria can actually transfer from one cell to another" -- " So, if you've got a cell that's got damaged, or dysfunctional mitochondria, they've identified three mechanisms by which mitochondria can move into a cell that needs more mitochondria that are working and are more functional." -- "And as a result, it can rejuvenate or provide energy to a dysfunctional cell, which might improve dysfunctional tissue or improve disease." 2) "A human brain map of mitochondrial respiratory capacity and diversity" (nature) -- " this was the first mapping of the mitochondria in the human brain" -- " what it showed was that different parts of the brain, different cells, had different amounts of mitochondria and different mitochondrial function." -- "(This) starts to highlight how that difference in energy production in different cells in different parts of the brain may actually cause some of the things like memory loss or speech impairment," -- "the mitochondrial dysfunction in the brain might actually be the key driver of that aging symptomology." 3) "Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration" (nature | Bone Research) -- " (the researchers) figured out a way to treat stem cells so that (they) would start to make an excess amount of mitochondria than they normally would make" -- " So they created highly energetic mitochondria and they made a lot of them." -- " the idea that we can put mitochondria into our body or into tissue in our body to heal it or repair it has been something that folks have been trying to do research around for a long time" -- " but the limiting factor is access to enough mitochondria" -- " so this mechanism that they developed opens up the door to this whole new therapeutic modality, a new type of therapy called mitotherapy" Conclusion: " ... based on the series of papers that we're seeing coming out recently, I believe (this) could end up becoming a really incredible new therapy that may ultimately lead to the treatment for many diseases that we're dealing with right now."
2:46

Science Corner: David Friedberg Explains Recent Mitotherapy Breakthroughs ⚡️ On E224, david friedberg broke down what mitotherapy is and how recent discoveries could unleash this treatment for many diseases: "So mitochondria are the powerhouse of the cell." "Every cell in our body gets its energy, which is what it uses to function, from the mitochondria." "And so there's been a lot of research into the relationship between mitochondria and aging, and that dysfunctional mitochondria may actually be a key driver for many diseases." "Including many cancers, Alzheimer's, Parkinson's, ALS, features of autism, muscle tissues being weak, etc." " So, as the cells get older and the mitochondria stop working, we make new mitochondria." "But over time, the DNA degrades and the mitochondria become less effective and there are fewer functional mitochondria per cell." Friedberg highlighted three recent papers: 1) "The power and potential of mitochondria transfer" (nature) -- "these folks identified and demonstrated that mitochondria can actually transfer from one cell to another" -- " So, if you've got a cell that's got damaged, or dysfunctional mitochondria, they've identified three mechanisms by which mitochondria can move into a cell that needs more mitochondria that are working and are more functional." -- "And as a result, it can rejuvenate or provide energy to a dysfunctional cell, which might improve dysfunctional tissue or improve disease." 2) "A human brain map of mitochondrial respiratory capacity and diversity" (nature) -- " this was the first mapping of the mitochondria in the human brain" -- " what it showed was that different parts of the brain, different cells, had different amounts of mitochondria and different mitochondrial function." -- "(This) starts to highlight how that difference in energy production in different cells in different parts of the brain may actually cause some of the things like memory loss or speech impairment," -- "the mitochondrial dysfunction in the brain might actually be the key driver of that aging symptomology." 3) "Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration" (nature | Bone Research) -- " (the researchers) figured out a way to treat stem cells so that (they) would start to make an excess amount of mitochondria than they normally would make" -- " So they created highly energetic mitochondria and they made a lot of them." -- " the idea that we can put mitochondria into our body or into tissue in our body to heal it or repair it has been something that folks have been trying to do research around for a long time" -- " but the limiting factor is access to enough mitochondria" -- " so this mechanism that they developed opens up the door to this whole new therapeutic modality, a new type of therapy called mitotherapy" Conclusion: " ... based on the series of papers that we're seeing coming out recently, I believe (this) could end up becoming a really incredible new therapy that may ultimately lead to the treatment for many diseases that we're dealing with right now."

The All-In Podcast

58,532 次观看 • 1 年前

Dr. Zach Bush reframed the soul in a way that bridges science and mystery: What if your "soul" is the electromagnetic field that reorganizes your entire body every millionth of a second? He explains: You start as one cell that divides like a tumor — until around replication #260, when cells suddenly know exactly what to become (kidney, neuron, etc.) and where to migrate in 3D space. No biological map explains this. The blueprint appears to live in the physics — in the electromagnetic field, the "space between everything." Your body is 99.999% vacuum, yet that vacuum is super-dense with electromagnetic information that keeps manifesting "you" every millionth of a second. You disappear and reappear constantly — and keep coming back as the same coherent self. So perhaps the soul is not something separate that leaves after death… but the organizing field that holds the original blueprint of who you are. Mind-bending or profound? Which part hits hardest — the science of constant re-manifestation, or the idea that "you" are held together by an invisible field?
1:26

Dr. Zach Bush reframed the soul in a way that bridges science and mystery: What if your "soul" is the electromagnetic field that reorganizes your entire body every millionth of a second? He explains: You start as one cell that divides like a tumor — until around replication #260, when cells suddenly know exactly what to become (kidney, neuron, etc.) and where to migrate in 3D space. No biological map explains this. The blueprint appears to live in the physics — in the electromagnetic field, the "space between everything." Your body is 99.999% vacuum, yet that vacuum is super-dense with electromagnetic information that keeps manifesting "you" every millionth of a second. You disappear and reappear constantly — and keep coming back as the same coherent self. So perhaps the soul is not something separate that leaves after death… but the organizing field that holds the original blueprint of who you are. Mind-bending or profound? Which part hits hardest — the science of constant re-manifestation, or the idea that "you" are held together by an invisible field?

Camus

42,958 次观看 • 5 个月前

This is how DNA is organized in a cell. And it's more evidence that Life was intelligently designed. Each human cell contains about 6.5ft (2m) of DNA packed into a dense microscopic structure. But it's not packed into a random pile. It's packed into precise loops scientists call 'cohesin loops.' DNA is wound up around spool-like proteins called histones, which are then further wound together into clusters called nucleosomes, which are then organized into shapes called chromatins, which are then folded into large structures called chromosomes. Four levels of very specific, complex organization. Without a specific & controlled organization system, DNA would be an unreadable, useless mess. Which means DNA would have to be organized immediately upon creation, or Life couldn't arise. And this is the craziest part... The way DNA is organized in a eukaryotic cell directly controls which genes are turned on or off. This organization is what determines cell-type. Every cell in your body contains the exact same DNA blueprint. The only reason a heart cell beats and a skin cell protects you is due to DNA organization. A heart cell packs away all "skin genes" into tight, unreadable section that doesn't get activated, while keeping "heart genes" open & active. If a cell doesn't have specific DNA organization, it loses its identity. When that happens, it results in cancer. Which means DNA organization must be specifically planned out from the start to prevent catastrophe. Life doesn't have time to tinker and figure this out via evolution. DNA requires organization from the start, or it's useless. DNA organizarion requires multiple systems all working together to function. Without them, it fails. Only intelligence has ever been shown to engineer specifically organized, complex informational systems with obvious signs of preplanning and intentionality. Life was Divinely Designed. Biology proves it over & over again.
0:47

This is how DNA is organized in a cell. And it's more evidence that Life was intelligently designed. Each human cell contains about 6.5ft (2m) of DNA packed into a dense microscopic structure. But it's not packed into a random pile. It's packed into precise loops scientists call 'cohesin loops.' DNA is wound up around spool-like proteins called histones, which are then further wound together into clusters called nucleosomes, which are then organized into shapes called chromatins, which are then folded into large structures called chromosomes. Four levels of very specific, complex organization. Without a specific & controlled organization system, DNA would be an unreadable, useless mess. Which means DNA would have to be organized immediately upon creation, or Life couldn't arise. And this is the craziest part... The way DNA is organized in a eukaryotic cell directly controls which genes are turned on or off. This organization is what determines cell-type. Every cell in your body contains the exact same DNA blueprint. The only reason a heart cell beats and a skin cell protects you is due to DNA organization. A heart cell packs away all "skin genes" into tight, unreadable section that doesn't get activated, while keeping "heart genes" open & active. If a cell doesn't have specific DNA organization, it loses its identity. When that happens, it results in cancer. Which means DNA organization must be specifically planned out from the start to prevent catastrophe. Life doesn't have time to tinker and figure this out via evolution. DNA requires organization from the start, or it's useless. DNA organizarion requires multiple systems all working together to function. Without them, it fails. Only intelligence has ever been shown to engineer specifically organized, complex informational systems with obvious signs of preplanning and intentionality. Life was Divinely Designed. Biology proves it over & over again.

Divinely Designed

14,657 次观看 • 1 个月前

THE CELLS IN YOUR BODY REACT TO EVERYTHING THAT YOUR MIND SAYS. Negativity brings down your immune system. Unprocessed emotions are the cause of all diseases. Every time we have a negative life experience, the memory of that life experience gets stored in our cells. And if we don't process the emotions surrounding the experience, it can manifest itself into a disease. Heal the emotion and heal the disease. Once you learn what the disease or physical block has to teach you and you finally let go of the emotional issues stored in the cells then, and only then, can real healing begin on all levels - emotional, spiritual and physical. Whatever you believe about your body, your cells believe too. They don't question anything you think, feel, or believe. In fact, they hear every thought, feeling, and belief you have. Imagine that every cell in your body is dancing to your favorite song moving in perfect harmony to the uplifting melody that makes your body come alive and frees you of all worries and fears releasing all illness and pain as healing, energy, hope & peace become the rhythm of you heart and breath. © rathelightbearer ✨🙌🏽💫
0:40

THE CELLS IN YOUR BODY REACT TO EVERYTHING THAT YOUR MIND SAYS. Negativity brings down your immune system. Unprocessed emotions are the cause of all diseases. Every time we have a negative life experience, the memory of that life experience gets stored in our cells. And if we don't process the emotions surrounding the experience, it can manifest itself into a disease. Heal the emotion and heal the disease. Once you learn what the disease or physical block has to teach you and you finally let go of the emotional issues stored in the cells then, and only then, can real healing begin on all levels - emotional, spiritual and physical. Whatever you believe about your body, your cells believe too. They don't question anything you think, feel, or believe. In fact, they hear every thought, feeling, and belief you have. Imagine that every cell in your body is dancing to your favorite song moving in perfect harmony to the uplifting melody that makes your body come alive and frees you of all worries and fears releasing all illness and pain as healing, energy, hope & peace become the rhythm of you heart and breath. © rathelightbearer ✨🙌🏽💫

🧬Maxpein🧬

205,866 次观看 • 1 年前

How Yoga Nidra puts you in "edit mode" for the unconscious mind: "In Yoga Nidra, you're in a trance, and in that trance you're in the edit mode for your unconscious mind." "A sankalpa is a resolve that you put in there, and that's where the rewriting comes in." "A being statement is the pluripotent stem cell of where you want to go." "Willpower is necessary when you are trying to not be narcissistic. It is not necessary when you are no longer narcissistic." "Why not just change the tendency? That's literally what we do in psychotherapy every day." Dr. Alok Kanojia MD MPH on Andrew D. Huberman, Ph.D.
9:33

How Yoga Nidra puts you in "edit mode" for the unconscious mind: "In Yoga Nidra, you're in a trance, and in that trance you're in the edit mode for your unconscious mind." "A sankalpa is a resolve that you put in there, and that's where the rewriting comes in." "A being statement is the pluripotent stem cell of where you want to go." "Willpower is necessary when you are trying to not be narcissistic. It is not necessary when you are no longer narcissistic." "Why not just change the tendency? That's literally what we do in psychotherapy every day." Dr. Alok Kanojia MD MPH on Andrew D. Huberman, Ph.D.

Huberman Lab Clips

214,393 次观看 • 20 天前

A Harvard professor who's studied aging for 30 years says one of the most powerful longevity tools on Earth is free. Fasting. David Sinclair explained what happens at the cellular level when you stop eating food for long periods of time: Your body has proteins called sirtuins. They're the conductors of your cellular orchestra - telling each gene when to turn on and off, keeping every cell's identity intact. But sirtuins need fuel called NAD to function. By age 50, your NAD levels drop by HALF. Your conductors are running on empty. Your cells start losing their identity. Fasting raises NAD back up. It reactivates the sirtuins and preserves the epigenome. Sinclair mentions it's only useful if you're already meeting nutrient and micronutrient intake as well. He himself skips breakfast daily and tries to go until late afternoon before eating. Once a month, he fasts for 3 full days because deep cellular recycling - called chaperone-mediated autophagy - only kicks in after about 2 and a half to 3 days. He called three meals a day "craziness" and said the idea that breakfast is the most important meal of the day was "marketing from the early 20th century" by cereal companies. Fasting is just one of the strategies he uses for optimal health. — David Sinclair
1:36

A Harvard professor who's studied aging for 30 years says one of the most powerful longevity tools on Earth is free. Fasting. David Sinclair explained what happens at the cellular level when you stop eating food for long periods of time: Your body has proteins called sirtuins. They're the conductors of your cellular orchestra - telling each gene when to turn on and off, keeping every cell's identity intact. But sirtuins need fuel called NAD to function. By age 50, your NAD levels drop by HALF. Your conductors are running on empty. Your cells start losing their identity. Fasting raises NAD back up. It reactivates the sirtuins and preserves the epigenome. Sinclair mentions it's only useful if you're already meeting nutrient and micronutrient intake as well. He himself skips breakfast daily and tries to go until late afternoon before eating. Once a month, he fasts for 3 full days because deep cellular recycling - called chaperone-mediated autophagy - only kicks in after about 2 and a half to 3 days. He called three meals a day "craziness" and said the idea that breakfast is the most important meal of the day was "marketing from the early 20th century" by cereal companies. Fasting is just one of the strategies he uses for optimal health. — David Sinclair

John Cumbers

231,590 次观看 • 4 个月前