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Artificial intelligence now allows scientists to analyse millions of genomes, comparing younger and older populations to pinpoint where aging occurs in the body. This marks a shift in how aging is studied, from theory to data-driven insight. How could AI change the future of aging research? Dr. Michio Kaku...

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Theoretical physicist Michio Kaku on why aging is simply an accumulation of errors that AI can now identify: He opens with a bold claim about what artificial intelligence might finally make possible: "Artificial intelligence may give us something that the kings and queens of old could never conquer and that is the aging process." For Dr. Michio Kaku, the science behind why we age is no longer a mystery. It comes down to one thing: errors building up inside our cells over time. "We now know why things age. Things get old and die because they accumulate error. Error in the form of DNA mistakes. Accumulation of errors inside cells." The challenge, until now, has been the sheer scale of the problem. Identifying exactly where and how these errors occur across the human genome has been beyond what conventional research could handle. That's where artificial intelligence changes everything: "But now we have artificial intelligence. We can analyze millions of genomes of old people, compare them to millions of genomes of young people, and identify where aging takes place in the body."
0:42

Theoretical physicist Michio Kaku on why aging is simply an accumulation of errors that AI can now identify: He opens with a bold claim about what artificial intelligence might finally make possible: "Artificial intelligence may give us something that the kings and queens of old could never conquer and that is the aging process." For Dr. Michio Kaku, the science behind why we age is no longer a mystery. It comes down to one thing: errors building up inside our cells over time. "We now know why things age. Things get old and die because they accumulate error. Error in the form of DNA mistakes. Accumulation of errors inside cells." The challenge, until now, has been the sheer scale of the problem. Identifying exactly where and how these errors occur across the human genome has been beyond what conventional research could handle. That's where artificial intelligence changes everything: "But now we have artificial intelligence. We can analyze millions of genomes of old people, compare them to millions of genomes of young people, and identify where aging takes place in the body."

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Consistent endurance exercise may be one of the most powerful ways to slow down biological aging. Six months of cycling (about 4.5 hours/week) reduced GrimAge by 7 months relative to the expected trajectory of normal aging. GrimAge is an epigenetic clock tied to mortality risk. Participants also increased VO₂ max by ~20%, and the reduction in GrimAge tracked with those gains in cardiorespiratory fitness, but not with changes in body composition. The anti-aging signal seemed to come more from becoming fitter, not just leaner. To Prof Steve Horvath, this suggests biological aging is, at least to some extent, modifiable. We discuss how exercise may slow biological aging in the latest episode of the podcast. Out now.
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Consistent endurance exercise may be one of the most powerful ways to slow down biological aging. Six months of cycling (about 4.5 hours/week) reduced GrimAge by 7 months relative to the expected trajectory of normal aging. GrimAge is an epigenetic clock tied to mortality risk. Participants also increased VO₂ max by ~20%, and the reduction in GrimAge tracked with those gains in cardiorespiratory fitness, but not with changes in body composition. The anti-aging signal seemed to come more from becoming fitter, not just leaner. To Prof Steve Horvath, this suggests biological aging is, at least to some extent, modifiable. We discuss how exercise may slow biological aging in the latest episode of the podcast. Out now.

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A daily multivitamin can reduce brain aging and modestly slow down epigenetic aging clocks. In the COSMOS trial, older adults who took a standard Centrum Silver multivitamin daily for about 4 years performed better on cognitive tests and showed the equivalent of ~2 years less brain aging compared with those taking a placebo. The multivitamin also slowed epigenetic aging clocks, with an effect equivalent to about 2.7 to 5 months of slowed biological aging. That may sound modest, but I don’t think it’s trivial, and Prof Steve Horvath says that effects from safe, low-cost interventions can matter if they’re sustained over years to decades—2 months of slower biological aging could translate to 2.5 years if a good habit is maintained. These data push back on the idea that multivitamins are “completely useless.” If you’re filling nutritional gaps consistently over time, even a small benefit to cognition and biological aging could become meaningful. From the latest episode of the FoundMyFitness podcast.
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A daily multivitamin can reduce brain aging and modestly slow down epigenetic aging clocks. In the COSMOS trial, older adults who took a standard Centrum Silver multivitamin daily for about 4 years performed better on cognitive tests and showed the equivalent of ~2 years less brain aging compared with those taking a placebo. The multivitamin also slowed epigenetic aging clocks, with an effect equivalent to about 2.7 to 5 months of slowed biological aging. That may sound modest, but I don’t think it’s trivial, and Prof Steve Horvath says that effects from safe, low-cost interventions can matter if they’re sustained over years to decades—2 months of slower biological aging could translate to 2.5 years if a good habit is maintained. These data push back on the idea that multivitamins are “completely useless.” If you’re filling nutritional gaps consistently over time, even a small benefit to cognition and biological aging could become meaningful. From the latest episode of the FoundMyFitness podcast.

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Everyone over 30 blames their genes for aging faster. But research proves genetics is only 10% of the equation. Here are 7 rules from Harvard's top anti-aging scientist to slow aging in your 30s, 40s, and beyond: 1) Sauna use is one of the most proven longevity habits

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Everyone over 30 blames their genes for aging faster. But research proves genetics is only 10% of the equation. Here are 7 rules from Harvard's top anti-aging scientist to slow aging in your 30s, 40s, and beyond: 1) If you're not hungry in the morning, don't eat...
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Everyone over 30 blames their genes for aging faster. But research proves genetics is only 10% of the equation. Here are 7 rules from Harvard's top anti-aging scientist to slow aging in your 30s, 40s, and beyond: 1) If you're not hungry in the morning, don't eat...

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Aubrey de Grey says defeating age-related diseases ultimately means treating aging itself. - We need to make aging the new COVID. - Mark Zuckerberg said the CCI is going to cure all diseases. - The real challenge is curing the biological damage that causes aging. - Scientific breakthroughs often arrive much faster than expected once the right technologies emerge. - AI is already accelerating biology, from protein structure prediction to drug discovery. - Aging is fundamentally a resource allocation problem. - COVID proved that when governments remove bureaucracy and invest at scale, medical progress can happen in record time. - Aging research has been chronically underfunded. If it became a global priority, progress could accelerate dramatically. Aubrey's message is clear: Don't plan to die from aging. Do everything possible to stay healthy long enough to benefit from future breakthroughs.

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A run-of-the-mill multivitamin can measurably change how your brain ages In three large randomized controlled trials of older adults (65+), daily Centrum Silver led to about 2 years less brain aging versus placebo Even more striking, episodic memory aging (remembering experiences, people, and events) looked roughly 5 years “younger” in the multivitamin group On top of that, it acts as basic insurance, filling micronutrient gaps that most diets simply don’t cover
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A run-of-the-mill multivitamin can measurably change how your brain ages In three large randomized controlled trials of older adults (65+), daily Centrum Silver led to about 2 years less brain aging versus placebo Even more striking, episodic memory aging (remembering experiences, people, and events) looked roughly 5 years “younger” in the multivitamin group On top of that, it acts as basic insurance, filling micronutrient gaps that most diets simply don’t cover

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I’m so tired of people being scared of aging. My mom is 55, in Cancun right now on a girls trip, and she’s the reason I’m not worried. Fill your life and social media with older people you admire. Aging will happen to us all.

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Yann LeCun addressing the UN Security Council says AI will profoundly transform the world in the coming years, amplifying human intelligence, accelerating progress in science, solving aging and decreasing populations, surpassing human intellectual capabilities to become superintelligent and leading to a new Renaissance and a period of enlightenment for humanity

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Omega-3s may be one of the most powerful dietary tools for resolving inflammation and slowing biological aging In a 3-year randomized trial of healthy older adults, omega-3 alone slowed epigenetic aging, while vitamin D and resistance training alone did not But the biggest effect came when all three were combined: omega-3, vitamin D, and resistance training slowed biological aging by about 3.8 months That may sound small, but it reflects a slower pace of aging that could compound over time The combo was also linked to ~40% lower pre-frailty and 61% lower invasive cancer incidence

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As AI becomes part of everyday life, we need to understand how these tools affect older Americans. AI has the potential to make a difference for seniors, families, and caregivers, but research hasn’t kept up. We need real data on the benefits and risks so we can make smarter policies. My Aging with AI Act will do just that.
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As AI becomes part of everyday life, we need to understand how these tools affect older Americans. AI has the potential to make a difference for seniors, families, and caregivers, but research hasn’t kept up. We need real data on the benefits and risks so we can make smarter policies. My Aging with AI Act will do just that.

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5 supplements that give you big bang for your buck: • Omega-3 — a high omega-3 index is linked to 5 extra years of life expectancy, 66% lower Alzheimer’s risk, and slower epigenetic aging • Vitamin D — regulates over 5% of your genome, including genes for viral defense, neurotransmitter synthesis, and longevity; correcting deficiency can reverse epigenetic age by ~2 years • Multivitamin — daily use in older adults was linked to 2.1 years less global brain aging, nearly 5 years less episodic memory aging, and modestly slower epigenetic aging • Magnesium — supports 300+ enzymes involved in DNA repair and sleep, and low intake has been linked to higher cancer risk • Creatine monohydrate — one of the most studied supplements for strength and performance, with 10 grams as a baseline for brain benefits

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5 high-impact supplements worth taking daily: • Omega-3s — 2 g/day is a strong starting point; a high omega-3 index is linked to 5 extra years of life expectancy, slower epigenetic aging, and may lower Alzheimer’s risk • Multivitamin — daily use in older adults has been linked to ~2 years less global brain aging, nearly 5 years less episodic memory aging • Vitamin D — regulates over 5% of your genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity • Magnesium — a cofactor for 300+ biological processes, including DNA repair, energy production, and sleep regulation • Creatine monohydrate — one of the most studied supplements for strength and performance; 10 g/day is a baseline for brain benefits, with higher-dose research showing benefits under sleep deprivation

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A shift to robot soldiers could change war in profound ways. Brook Silva-Braga took a trip in an autonomous Black Hawk helicopter to see how artificial intelligence is reshaping the battlefield.
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A shift to robot soldiers could change war in profound ways. Brook Silva-Braga took a trip in an autonomous Black Hawk helicopter to see how artificial intelligence is reshaping the battlefield.

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