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Aurora B kinase (green) distribution during initial cell divisions of a C elegans embryo relative to plasma membranes and nuclei (red), highlighting apical midbody remnants after cytokinesis. As seen by lattice light sheet microscopy. With Bembenek Lab

Eric Betzig

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24,341 görüntüleme • 2 yıl önce •via X (Twitter)

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The study investigated the dynamics of cytokinesis, which is the final step of cell division, during the development of the nematode Caenorhabditis elegans. Cytokinesis is crucial for tissue formation and organization, but its implementation varies across different cell types and developmental stages. The study revealed several reproducible alterations to cytokinesis during development. For example, the first two mitotic divisions showed asymmetric furrow ingression and specific patterns of midbody inheritance. During the E8-E16 divisions that form the intestine, the midbody migrated to the apical midline, and Aurora B kinase remained localized at the apical surface after the midbody was internalized. Inactivation of Aurora B disrupted cytokinesis and led to defects in epithelial polarization and lumen formation in the gut. Similar patterns of apical midbody migration and Aurora B localization were observed during pharyngeal and sensory neuron development. full paper:

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@BembenekLab Amazing work!!

Breck Yunits profil fotoğrafı

Breck Yunits2 yıl önce

@BembenekLab Woah, this is amazing. Is this simulated or real imaging data? What's the equipment? What's the protocol? Any chance you all could do a macro video showing your setup, something like:

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@BembenekLab Super nice images!!! Kudos to all the authors!

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Jeffrey van Haren2 yıl önce

@BembenekLab 🤩

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Cicero Latin Count Shot and Killed New Years Eve During Facebook Marketplace Robbery Gone Wrong Dec 31, 2025 3:17 pm 13th and 58th Ave Cicero Illinois Months after the incident, surveillance footage has now surfaced showing the moments leading up to the fatal shooting tied to the attempted robbery in Cicero. The video appears to show what investigators originally believed was a setup connected to an online marketplace deal. Two 16-year-old boys met to finalize the sale of a shirt that had been arranged through a social media marketplace. In the footage, a person selling a shirt is seen meeting with another individual to complete the sale. As the two speak, a second person suddenly emerges from a nearby gangway. That individual, later identified as Angel Dominguez, attempted to rob the seller. During the confrontation, a relative of the seller who was sitting in a nearby vehicle got out and intervened. Authorities say Dominguez fired two shots at the relative, who was also armed and returned fire, striking Dominguez once. The relative was transported to Loyola University Medical Center in stable condition. Dominguez later arrived at Rush Oak Park Hospital with a gunshot wound and was pronounced dead. The 16-year-old boy who acted as the buyer was arrested and charged as a juvenile with armed robbery. Investigators concluded the incident was a pre-planned robbery orchestrated by the two teens. Credit chitownwatchandplot and CHICAGO CRITTER #ChicagoScanner #SuburbanScanner

SubX.News®

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THE SUNRISE IS THE MOST POTENT CIRCADIAN STIMULUS. A 2020 paper published in Current Biology identified a previously unknown retinal circuit explaining precisely why the spectral contrast of sunrise so powerfully entrains the circadian system. The key neuron is the M1 intrinsically photosensitive retinal ganglion cell (ipRGC), which projects directly to the suprachiasmatic nucleus (SCN), the brain’s master circadian pacemaker. In primates, M1 ipRGCs are wired to perform a spectral comparison between yellow/red and blue light via two simultaneous pathways. ***This cone-based circuit is just one of several mechanisms by which morning light entrains the circadian system. Going outside after sunrise still delivers meaningful melanopsin stimulation as overall irradiance builds, and that sustained signal remains highly beneficial. The spectral contrast mechanism described here is simply the most precisely tuned and potent stimulus the system has, one that outdoor morning light delivers far more effectively than any indoor environment. As yellow and red wavelengths increase at sunrise, L and M cones drive LM-ON bipolar cells, which directly excite the M1 ipRGC. Simultaneously, the relative decrease in short-wavelength light reduces S-cone activation, quieting S-ON bipolar cells, which reduces drive to a newly identified S-cone amacrine cell, releasing its inhibitory input onto the ipRGC. Disinhibition and excitation converge on the same cell simultaneously. Melanopsin, the ipRGC’s intrinsic photopigment peaking at ~480nm, is slower and requires sustained high irradiance, taking over as morning light intensity builds. The result is a temporal relay: the cone circuit delivers a rapid spectral signal at the horizon transition, then melanopsin sustains entrainment through the morning. No indoor lighting replicates this. The sunrise delivers the exact stimulus this circuit evolved over hundreds of millions of years to detect. #science #circadian #sunrise #neuroscience #biology

Jonathan Jarecki

10,637 görüntüleme • 5 ay önce

Anthropic went after the largest bacterium ever found, a single cell you can see with the naked eye, and read the machinery packed inside it. The size was never the interesting part. The question was how one cell keeps millions of copies of its own factory working in sync. > COUNT - every ribosome location in the cell mapped, rather than averaged across it > WRAP - the membrane sacs holding DNA and ribosomes treated as separate rooms > FLOW - what each room produces compared against what sits next to it > SPLIT - rooms with different output flagged as independent units > SCALE - the whole layout tested against how large a normal cell can grow Bacteria are supposed to be simple bags. One compartment, everything mixed, nothing filed away. This one files. Its DNA and its ribosomes sit inside membranes, which textbooks reserve for complex cells. That single arrangement is what lifts the size ceiling. A cell without rooms hits a physical wall long before a centimetre. The rooms are not identical either. Output varies from one to the next, meaning parts of the same cell are doing different jobs. That edges close to what tissue does, inside something that is still one organism by every definition we use. The line between simple and complex life was drawn before anyone had seen this, and it was drawn on compartments. Every room, its output and the size math behind it sit in the breakdown below.

Anthropic went after the largest bacterium ever found, a single cell you can see with the naked eye, and read the machinery packed inside it. The size was never the interesting part. The question was how one cell keeps millions of copies of its own factory working in sync. > COUNT - every ribosome location in the cell mapped, rather than averaged across it > WRAP - the membrane sacs holding DNA and ribosomes treated as separate rooms > FLOW - what each room produces compared against what sits next to it > SPLIT - rooms with different output flagged as independent units > SCALE - the whole layout tested against how large a normal cell can grow Bacteria are supposed to be simple bags. One compartment, everything mixed, nothing filed away. This one files. Its DNA and its ribosomes sit inside membranes, which textbooks reserve for complex cells. That single arrangement is what lifts the size ceiling. A cell without rooms hits a physical wall long before a centimetre. The rooms are not identical either. Output varies from one to the next, meaning parts of the same cell are doing different jobs. That edges close to what tissue does, inside something that is still one organism by every definition we use. The line between simple and complex life was drawn before anyone had seen this, and it was drawn on compartments. Every room, its output and the size math behind it sit in the breakdown below.

wast3

161,812 görüntüleme • 1 gün önce

Single-cell technologies now let us profile entire transcriptomes in individual cells. But how do we make sense of this complexity in a biologically meaningful way? Many methods summarise cells into a single embedding, but this often comes at the cost of interpretability, especially when multiple gene programs are active at once. We developed Tripso, a self-supervised transformer model that represents cells through multiple gene program-specific embeddings, while also uncovering new programs directly from the data. Instead of collapsing biology into a single vector, Tripso decomposes cell state into multiple representations, each reflecting a different gene program. We explored this across multiple systems. In human hematopoiesis, spanning development to aging, Tripso identified distinct age-associated program activity, including stronger JAK-STAT signalling in early life and dynamic IKZF1-related changes during B cell maturation. By comparing in vitro culture conditions with in vivo hematopoietic stem cell states, Tripso suggested that targeting the SEC61 translocon could enhance stem cell maintenance ex vivo, a prediction that we subsequently validated experimentally. In parallel, we identified a previously uncharacterised tissue-resident memory T-cell program associated with atopic dermatitis and mapped it to distinct spatial immune niches Together, these results show how modelling cells through gene programs can lead to interpretable and experimentally testable insights. More broadly, this work points toward a more interpretable and biologically grounded models of cell state. As single-cell datasets continue to grow, we hope approaches like Tripso will help bridge the gap between data-driven representations and biological insight. This work wouldn’t have been possible without the contributions of an amazing team. Thank you to co-first authors Marie, Tomoya Isobe, Amirhosein Vahidi, Carlo Leonardi, and everyone from roser's Lab, Haniffa Lab, Nicola Wilson and Bertie Gottgens's Lab, bringing together expertise across Cambridge Stem Cell Institute, Open Targets, Wellcome Sanger Institute and Cambridge University. Marie is one of the very best PhD students I have ever supervised. She is truly a force of nature, exceptionally resourceful, deeply innovative, and one of the most impressive scientists I have worked with. I am immensely proud of her and all that she has accomplished. As she begins her internship at Genentech , I have no doubt she will do amazing work there and continue to make her mark. paper: code:

Mo Lotfollahi

22,525 görüntüleme • 6 ay önce

"Every Time You Consume 'Natural Flavors', You Could Be Eating Something Developed By Human Fetal Cells." Deborah Murtagh "The Biggest Food Companies Paid Biotech Labs To Create Flavors Using HEK-293 Human Harvested Kidney Cells." The Food Industry Is A Giant Deceptive Machine. Quotes Taken From..."Human receptors for sweet and umami taste" Peer reviewed submitted article & Senomyx's patent: "HEK-293 Human Embryo Kidney were grown and maintained at 37°C, cells were seeded onto culture plates and stimuli were tested with 24 flavor profiles of sweet and umami taste." "Human cells were generated by transfecting cloned human and rat tissue cells. The response of human cells to all sweet taste stimuli tested was a positive, contrasted with the low limited response of rat cells." Senomyx entered into product discovery & flavor development collaborations with the world’s leading packaged food & beverage companies: Cadbury Schweppes Campbell Soup Coca-Cola Kraft Foods Nestlé SA Halls Dr Pepper Trident Snapple Heinz Kool-Aid Goldfish Prego 'Natural Flavors' Are Anything & Everything Except Natural... Chemical Additives: Up to 100 chemicals, including solvents, emulsifiers, preservatives & carriers, are added to the flavor mixture & are still classified as "natural." Trade Secrets: The exact chemical composition of a natural flavor is considered a trade secret, so manufacturers are not required to list the individual chemicals, notes the Center for Science in the Public Interest. Hidden Additives: "Incidental additives" such as solvents or carriers can be present within the "natural flavor" umbrella term. The Only Difference Between Natural Flavors & Artificial Flavors Is The Origin Of The Initial Flavor Compound... After the initial extraction from a natural source, such as a fruit, root, or animal product, the flavoring undergoes extensive processing in a lab. The final 'natural flavor' product is a complex mixture that includes: Solvents..examples are ethanol & the FDA also permits synthetic solvents like propylene glycol. Preservatives...such as sodium benzoate & potassium sorbate are used. Emulsifiers...like carrageenan that degrade to cancerous poligeenan are used. Carriers...such as maltodextrin & MSG. Both natural & artificial flavors are complex chemical cocktails engineered in a lab by 'flavorists' to create a specific, highly addictive taste. The chemical compositions are so similar that some artificial flavors are chemically identical to their natural flavor counterparts. 👇Senomyx Firmenich Patent To Use HEK-293👇 👇HEK-293 Human Embryo Kidney Harvested👇 👇Sweet Taste Lab Developed Using HEK-293👇 Speaker: Deborah Murtagh

"Every Time You Consume 'Natural Flavors', You Could Be Eating Something Developed By Human Fetal Cells." Deborah Murtagh "The Biggest Food Companies Paid Biotech Labs To Create Flavors Using HEK-293 Human Harvested Kidney Cells." The Food Industry Is A Giant Deceptive Machine. Quotes Taken From..."Human receptors for sweet and umami taste" Peer reviewed submitted article & Senomyx's patent: "HEK-293 Human Embryo Kidney were grown and maintained at 37°C, cells were seeded onto culture plates and stimuli were tested with 24 flavor profiles of sweet and umami taste." "Human cells were generated by transfecting cloned human and rat tissue cells. The response of human cells to all sweet taste stimuli tested was a positive, contrasted with the low limited response of rat cells." Senomyx entered into product discovery & flavor development collaborations with the world’s leading packaged food & beverage companies: Cadbury Schweppes Campbell Soup Coca-Cola Kraft Foods Nestlé SA Halls Dr Pepper Trident Snapple Heinz Kool-Aid Goldfish Prego 'Natural Flavors' Are Anything & Everything Except Natural... Chemical Additives: Up to 100 chemicals, including solvents, emulsifiers, preservatives & carriers, are added to the flavor mixture & are still classified as "natural." Trade Secrets: The exact chemical composition of a natural flavor is considered a trade secret, so manufacturers are not required to list the individual chemicals, notes the Center for Science in the Public Interest. Hidden Additives: "Incidental additives" such as solvents or carriers can be present within the "natural flavor" umbrella term. The Only Difference Between Natural Flavors & Artificial Flavors Is The Origin Of The Initial Flavor Compound... After the initial extraction from a natural source, such as a fruit, root, or animal product, the flavoring undergoes extensive processing in a lab. The final 'natural flavor' product is a complex mixture that includes: Solvents..examples are ethanol & the FDA also permits synthetic solvents like propylene glycol. Preservatives...such as sodium benzoate & potassium sorbate are used. Emulsifiers...like carrageenan that degrade to cancerous poligeenan are used. Carriers...such as maltodextrin & MSG. Both natural & artificial flavors are complex chemical cocktails engineered in a lab by 'flavorists' to create a specific, highly addictive taste. The chemical compositions are so similar that some artificial flavors are chemically identical to their natural flavor counterparts. 👇Senomyx Firmenich Patent To Use HEK-293👇 👇HEK-293 Human Embryo Kidney Harvested👇 👇Sweet Taste Lab Developed Using HEK-293👇 Speaker: Deborah Murtagh

Valerie Anne Smith

119,537 görüntüleme • 11 ay önce

Horrible and the most horrific testimony you will ever hear I have spoken on a space with Motasem A Dalloul, who explained the process of the “Death Traps” the GHF have created…I quote “regularly posts the aid distribution schedule on Facebook. Each time, around 60,000 to 70,000 Palestinians converge at the designated site. Loudspeakers announce that when the green light turns on, people have just 10 minutes to grab between 300 to 400 aid packages—though much of the critical supplies, like flour, sugar, and salt, are snatched up first by gangs and collaborators. After the 10-minute window, the light turns yellow, signaling that only 5 minutes remain to flee before automatic machine guns open fire indiscriminately on anyone still in the area” He described the distribution zones as barren open spaces surrounded by high mounds of sand. There are four such points across southern Gaza, and in some cases, people must walk up to 40 kilometers just to reach them The GHF have created “Hunger Games Area” they play with Palestinians lives like it worth nothing!! Go to their page let them know they were exposed 👇

Horrible and the most horrific testimony you will ever hear I have spoken on a space with Motasem A Dalloul, who explained the process of the “Death Traps” the GHF have created…I quote “regularly posts the aid distribution schedule on Facebook. Each time, around 60,000 to 70,000 Palestinians converge at the designated site. Loudspeakers announce that when the green light turns on, people have just 10 minutes to grab between 300 to 400 aid packages—though much of the critical supplies, like flour, sugar, and salt, are snatched up first by gangs and collaborators. After the 10-minute window, the light turns yellow, signaling that only 5 minutes remain to flee before automatic machine guns open fire indiscriminately on anyone still in the area” He described the distribution zones as barren open spaces surrounded by high mounds of sand. There are four such points across southern Gaza, and in some cases, people must walk up to 40 kilometers just to reach them The GHF have created “Hunger Games Area” they play with Palestinians lives like it worth nothing!! Go to their page let them know they were exposed 👇

Stories From Palestine 🇵🇸

1,414,978 görüntüleme • 1 yıl önce

#WATCH | On the morning of May 10, even as we were gathering to war-game the events of the previous night, a routine exercise, I received a message on the hotline from my counterpart in Pakistan, seeking my willingness to communicate. Since our initial aim was to strike at terror camps, and all our subsequent actions were in response to the intrusions and violations by the Pakistan Air Force and its army, it was decided that I would indeed speak with my counterpart. As you are already aware, I have seen it covered on national television. My communication with the Pakistani DGMO was conducted at 15:35 hours yesterday and resulted in the cessation of cross-border firing and air intrusions by either side, with effect from 17:00 hours on May 10, after he proposed that we cease hostilities. We also agreed to speak again on May 12, that is tomorrow, at 12:00 hours, to discuss modalities that would ensure the longevity of this understanding. However, disappointingly and, I must add, expectedly, it took only a few hours for the Pakistan Army to violate these arrangements through cross-border and Line of Control firing, followed by drone intrusions across the expanse of the Western Front during the last night and into the early hours of this morning. These violations were met with robust responses and dealt with as they must be. Earlier today, we sent another hotline message to my counterpart, highlighting these violations of the May 10 understanding between the DGMOs and conveying our firm and clear intent to respond fiercely and punitively if such actions are repeated, tonight, subsequently, or later: DGMO Lieutenant General Rajiv Ghai Indian Air Force SpokespersonNavy ADG PI - INDIAN ARMY रक्षा मंत्री कार्यालय/ RMO India Ministry of Defence, Government of India #IndianArmy #IndianAirForce #IndianNavy #IndianArmedForces #IndiaPakistan #IndiaPakistanTensions

#WATCH | On the morning of May 10, even as we were gathering to war-game the events of the previous night, a routine exercise, I received a message on the hotline from my counterpart in Pakistan, seeking my willingness to communicate. Since our initial aim was to strike at terror camps, and all our subsequent actions were in response to the intrusions and violations by the Pakistan Air Force and its army, it was decided that I would indeed speak with my counterpart. As you are already aware, I have seen it covered on national television. My communication with the Pakistani DGMO was conducted at 15:35 hours yesterday and resulted in the cessation of cross-border firing and air intrusions by either side, with effect from 17:00 hours on May 10, after he proposed that we cease hostilities. We also agreed to speak again on May 12, that is tomorrow, at 12:00 hours, to discuss modalities that would ensure the longevity of this understanding. However, disappointingly and, I must add, expectedly, it took only a few hours for the Pakistan Army to violate these arrangements through cross-border and Line of Control firing, followed by drone intrusions across the expanse of the Western Front during the last night and into the early hours of this morning. These violations were met with robust responses and dealt with as they must be. Earlier today, we sent another hotline message to my counterpart, highlighting these violations of the May 10 understanding between the DGMOs and conveying our firm and clear intent to respond fiercely and punitively if such actions are repeated, tonight, subsequently, or later: DGMO Lieutenant General Rajiv Ghai Indian Air Force SpokespersonNavy ADG PI - INDIAN ARMY रक्षा मंत्री कार्यालय/ RMO India Ministry of Defence, Government of India #IndianArmy #IndianAirForce #IndianNavy #IndianArmedForces #IndiaPakistan #IndiaPakistanTensions

DD News

21,648 görüntüleme • 1 yıl önce