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Boltz-2 was released recently. It is an Open Source protein-ligand co-folding model, which means it can predict the structure of a protein along with the ligand. It has various applications from drug discovery to protein design. I thought why not make a OSS web app for it.

Ravi Sharma

3,643 subscribers

43,941 görüntüleme • 1 yıl önce •via X (Twitter)

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Ravi Sharma profil fotoğrafı

Ravi Sharma1 yıl önce

I wrote a blog to go with this (finally putting the domain to good use):

Ravi Sharma profil fotoğrafı

Ravi Sharma1 yıl önce

You can run the GUI locally (you're gonna need some GPUs for it) using the repo I made: It is also open source so feel free to modify it as you like. I will try to add support for advanced options like constraints and bulk processing.

Ravi Sharma profil fotoğrafı

Ravi Sharma1 yıl önce

I recommend going through this FAQ from @RowanSci before you use it for something serious to understand the caveats.

Ravi Sharma profil fotoğrafı

Ravi Sharma1 yıl önce

Thank you @GabriCorso and team for the work!

Ravi Sharma profil fotoğrafı

Ravi Sharma1 yıl önce

Special @cursor_ai acknowledgement

Harsh. profil fotoğrafı

Harsh.1 yıl önce

DAMNNNN LETSGOOO RAVI BHAIII THIS IS SOME EPIC STUFF

Ravi Sharma profil fotoğrafı

Ravi Sharma1 yıl önce

Thank you!

Anindyadeep profil fotoğrafı

Anindyadeep1 yıl önce

Cool work

Ravi Sharma profil fotoğrafı

Ravi Sharma1 yıl önce

Thank you!!

clem 🤗 profil fotoğrafı

clem 🤗1 yıl önce

Would be cool to make it a for the community!

Ravi Sharma profil fotoğrafı

Ravi Sharma1 yıl önce

On it🫡 some T4 would be nice!

clem 🤗 profil fotoğrafı

clem 🤗1 yıl önce

cc @cgeorgiaw @reach_vb maybe

Ravi Sharma profil fotoğrafı

Ravi Sharma1 yıl önce

@cgeorgiaw @reach_vb Hey @cgeorgiaw @reach_vb

Vaibhav (VB) Srivastav profil fotoğrafı

Vaibhav (VB) Srivastav1 yıl önce

@ClementDelangue @cgeorgiaw heya! DM me your space, more than happy to add a compute grant

Ravi Sharma profil fotoğrafı

Ravi Sharma1 yıl önce

@ClementDelangue @cgeorgiaw Will reach out in some time as I set it up

Piyush profil fotoğrafı

Piyush1 yıl önce

Nice bro @shinramenDNA

Ravi Sharma profil fotoğrafı

Ravi Sharma1 yıl önce

@shinramenDNA Thank you!!

Mitsu Health profil fotoğrafı

Mitsu Health1 yıl önce

Drug design is no longer just for pharma giants. With Boltz‑2, a browser can fold mutated proteins, dock inhibitors, and visualize where molecules touch. A patient’s unique cancer mutation— now a starting point, not a barrier. Open-source tools. Personal therapies. The future of AI driven research is arriving at pace. #JustShowUp If you like this, follow @mitsumahealth ––– Still here? We’re building something that could change lives at scale. Looking for a full-stack dev + UX designer (gamification a plus). Purpose-driven. Email: health@mitsumamedia.

Sushant profil fotoğrafı

Sushant1 yıl önce

Bro launched finally, less goooo

Ravi Sharma profil fotoğrafı

Ravi Sharma1 yıl önce

Hahha this isn't what I had shown you. That will be coming soon.

himanshu profil fotoğrafı

himanshu1 yıl önce

lesggggo

Ravi Sharma profil fotoğrafı

Ravi Sharma1 yıl önce

Thank you!!!

Vamsi Nimmala— వంశీ profil fotoğrafı

Vamsi Nimmala— వంశీ1 yıl önce

Great:)

Ravi Sharma profil fotoğrafı

Ravi Sharma1 yıl önce

Thank you!!

samyak profil fotoğrafı

samyak1 yıl önce

lfg go ravi

Ravi Sharma profil fotoğrafı

Ravi Sharma1 yıl önce

@Samyak1729 Thank you bro!! Look out for what I'm working on, it's much bigger.

Chaithanya Kumar profil fotoğrafı

Chaithanya Kumar1 yıl önce

Just saw awesome work 👏 😁

Ravi Sharma profil fotoğrafı

Ravi Sharma1 yıl önce

Thank you bro!! More awesome stuff coming soon.

Maz profil fotoğrafı

Maz1 yıl önce

What did you use to screen capture, it looks professional.

Ravi Sharma profil fotoğrafı

Ravi Sharma11 ay önce

It is screenstudio

sparrow profil fotoğrafı

sparrow1 yıl önce

YOOOOOO awesomeeee

Ravi Sharma profil fotoğrafı

Ravi Sharma1 yıl önce

Thank you!!!

atharva ☆ profil fotoğrafı

atharva ☆1 yıl önce

lfglfglflg

Ravi Sharma profil fotoğrafı

Ravi Sharma1 yıl önce

Yoooooo

Kartik profil fotoğrafı

Kartik1 yıl önce

Hey Ravi! 👋 Your work at the intersection of biology and computing is fascinating — especially loved Protein Language Model. Would love to connect and follow your journey at @upsurgelabs!

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Paneer is a great source of protein but it is also high in fat. Please consume it in moderation. Don’t keep paneer the ONLY source of protein in your diet.

Paneer is a great source of protein but it is also high in fat. Please consume it in moderation. Don’t keep paneer the ONLY source of protein in your diet.

Chirag Barjatya

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I was all out of protein coffee, so I decided I would make my own and it turned out really good! The bananas made it sweet and it has a lot of protein in it and some caffeine to give me a little extra energy this morning!

I was all out of protein coffee, so I decided I would make my own and it turned out really good! The bananas made it sweet and it has a lot of protein in it and some caffeine to give me a little extra energy this morning!

Princess Linnea 👸 musclemommtcosplays

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Just because you sprinkle protein on a dog turd doesn’t make it health food. 🙄 Now it’s protein Pop-Tarts, protein Doritos, and Starbucks turning your morning coffee into a 300-calorie milkshake with “protein foam.” Khloé Kardashian says protein popcorn is a diet hack. It’s not. Sugar is still sugar. Grains are still grains. Adding protein to junk just means you're eating protein-fortified junk. Don’t fall for the marketing. 🥩 Stay motivated. #NSNG #DietMyths #RealFood

Just because you sprinkle protein on a dog turd doesn’t make it health food. 🙄 Now it’s protein Pop-Tarts, protein Doritos, and Starbucks turning your morning coffee into a 300-calorie milkshake with “protein foam.” Khloé Kardashian says protein popcorn is a diet hack. It’s not. Sugar is still sugar. Grains are still grains. Adding protein to junk just means you're eating protein-fortified junk. Don’t fall for the marketing. 🥩 Stay motivated. #NSNG #DietMyths #RealFood

Vinnie Tortorich

15,119 görüntüleme • 8 ay önce

We built a website to make it super easy to get started with protein design and participate in the Anthropic x Adaptyv protein design competition ▶️ This week, we're challenging people to design an Ozempic-like drug. You can get started in just a few clicks, using the newly released RFD4 model to design proteins targeting the GLP-1 receptor. We'll synthesize and test 1000+ of these designs in our automated biology lab, including whether they actually activate the cell receptor, and make all the results publicly available

We built a website to make it super easy to get started with protein design and participate in the Anthropic x Adaptyv protein design competition ▶️ This week, we're challenging people to design an Ozempic-like drug. You can get started in just a few clicks, using the newly released RFD4 model to design proteins targeting the GLP-1 receptor. We'll synthesize and test 1000+ of these designs in our automated biology lab, including whether they actually activate the cell receptor, and make all the results publicly available

Julian Englert

23,557 görüntüleme • 15 gün önce

Ex-CDC Director Robert Redfield raises concerns over “significant vaccine injury” from the COVID jab. Says he is no longer an advocate, calls the spike protein “immunotoxic.” “When I give you an mRNA vaccine…” “I turn your body into a spike protein factory.” “I don’t know how much spike protein you make…” “I don’t know how long you make it…” “I don’t know where you make it in your body. And I can’t control any of that.” “And we now know that the spike protein is really an immunotoxic protein that causes a lot of illness.”

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The Vigilant Fox 🦊

127,826 görüntüleme • 6 ay önce

Guess which country this national dish Is from? I added a protein component to it 🤝

Guess which country this national dish Is from? I added a protein component to it 🤝

PrincessFromBabylon

73,657 görüntüleme • 2 yıl önce

Bro called it a "source of protein" and meant it literally 🤣

Bro called it a "source of protein" and meant it literally 🤣

Claire Morgan

19,219 görüntüleme • 23 gün önce

Sattu vs Protein Powder? Only idiots like Sonal Mehrotra Kapoor can compare food items with supplements and say supplement is better. Never seen anyone drinking multiple glasses of Sattu for Protein. Sattu is good source of protein, it also has daily requirements of fibre, iron, magnesium and Potassium. Sattu is good for digestion, doesn't have bloating effect like Protein Powder. Sattu has more calories but it also keeps you full for long, so you consume less calories in total. Sattu is zero cholesterol, so good for heart. Most protein powders have cholesterol. Sattu is wholefood, it can be taken as a meal. Protein powder is supplement, you will need meal. Also Sattu is much much cheaper. Even your hifi branded organic sattu is not even 5% cost of protein supplements. Also Sattu is super tasty, no need of added flavours like in Protein Powder. Compare food with Food, supplements with Supplements Consume Sattu Daily, take protein powder when you are short of your daily protein intake. If your aim is to promote Protein Powders, do it. Nothing wrong with Protein Powders. But Comparison with Sattu is stupidity.

Sattu vs Protein Powder? Only idiots like Sonal Mehrotra Kapoor can compare food items with supplements and say supplement is better. Never seen anyone drinking multiple glasses of Sattu for Protein. Sattu is good source of protein, it also has daily requirements of fibre, iron, magnesium and Potassium. Sattu is good for digestion, doesn't have bloating effect like Protein Powder. Sattu has more calories but it also keeps you full for long, so you consume less calories in total. Sattu is zero cholesterol, so good for heart. Most protein powders have cholesterol. Sattu is wholefood, it can be taken as a meal. Protein powder is supplement, you will need meal. Also Sattu is much much cheaper. Even your hifi branded organic sattu is not even 5% cost of protein supplements. Also Sattu is super tasty, no need of added flavours like in Protein Powder. Compare food with Food, supplements with Supplements Consume Sattu Daily, take protein powder when you are short of your daily protein intake. If your aim is to promote Protein Powders, do it. Nothing wrong with Protein Powders. But Comparison with Sattu is stupidity.

Ankur Singh

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Still incredible that the DeepMind documentary has footage of exact moment Demis is told that AlphaFold can “easily” predict all known (1-2B) protein sequences “in a month” and he says to do it. Then, it shows the moment AlphaFold is released to the world.

Still incredible that the DeepMind documentary has footage of exact moment Demis is told that AlphaFold can “easily” predict all known (1-2B) protein sequences “in a month” and he says to do it. Then, it shows the moment AlphaFold is released to the world.

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We're thrilled to present ESM3 in Science Magazine. ESM3 is a generative language model that reasons over the three fundamental properties of proteins: sequence, structure, and function. Today we're making ESM3 available free to researchers worldwide via the public beta of an API for biological intelligence. Trained with over a trillion teraflops of compute, this is the first time a model of this scale has been trained for biology, pushing the frontier of AI for biological discovery and engineering. ESM3 learns to represent the immense complexity of protein biology, learning from billions of natural proteins. From this training it developed the capability to design proteins, responding to complex prompts combining atomic level details and high level instructions to generate new proteins. ESM3 can explore protein space far beyond natural evolution. We prompted ESM3 to generate a fluorescent protein at a far distance from any known fluorescent proteins, searching an unknown region of protein space, to discover a new fluorescent protein. We estimate this is equivalent to simulating five hundred million years of evolution.

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We've been tinkering with protein structure design. Our (new?) method works like a language model, but instead of a discrete token, it samples the placement of the next amino acid backbone from a continuous distribution. Meet the Generative Invariant Angle Transformer (GIAT):

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🚩 Fmr. CDC Director Robert Redfield Makes a Series of Stunning Admissions That Were Once Deemed 'Misinformation' "There was a decision not to do anything that made the vaccine sound like it didn't work." "Two thirds of the people that I'm seeing infected in Maryland have been vaccinated." "If you came down and visited me and interviewed my patients...you'd interview patient after patient after patient that did not have COVID but are very sick. You would say very sick, long COVID patients. And it's all from the vaccine." "The spike protein is immunotoxic. You get infected, it's immunotoxic. But when you give the vaccine, we make the spike protein." "When I give you an mRNA vaccine...I don't know how much spike protein you make because I give you mRNA and then your body goes and makes it...You may make it for a week...You may make it for a month." "I use the protein vaccine so I know exactly how much spike protein you get. Your body's not becoming a [spike protein] manufacturing plant."

🚩 Fmr. CDC Director Robert Redfield Makes a Series of Stunning Admissions That Were Once Deemed 'Misinformation' "There was a decision not to do anything that made the vaccine sound like it didn't work." "Two thirds of the people that I'm seeing infected in Maryland have been vaccinated." "If you came down and visited me and interviewed my patients...you'd interview patient after patient after patient that did not have COVID but are very sick. You would say very sick, long COVID patients. And it's all from the vaccine." "The spike protein is immunotoxic. You get infected, it's immunotoxic. But when you give the vaccine, we make the spike protein." "When I give you an mRNA vaccine...I don't know how much spike protein you make because I give you mRNA and then your body goes and makes it...You may make it for a week...You may make it for a month." "I use the protein vaccine so I know exactly how much spike protein you get. Your body's not becoming a [spike protein] manufacturing plant."

Chief Nerd

2,627,162 görüntüleme • 2 yıl önce

Brett Weinstein, Professor of Evolutionary Biology. Host of the DarkHorse podcast. "The mRNA platform is brilliant. But it has a giant gaping flaw in it, which is ; Any cell of yours that produces a foreign protein, will be targetted by your immune system and destroyed. You will create an autoimmune disorder. When it works. How do you keep it out of your heart. Not by coding it in a lipid nanoparticle. So, they had no way to deliver it safely to market. So then they had a pandemic, the emergency allowed them to do it. This technology, in my opinion, was at least 3 decades out from being usefully and safely deployed at all, if at all. They did not want to wait, this crisis gave them the opportunity not to wait. And now, they will blame the spike protein, we picked the wrong protein. When in actual fact there are 2 problems, the spike protein and the platform itself."

Brett Weinstein, Professor of Evolutionary Biology. Host of the DarkHorse podcast. "The mRNA platform is brilliant. But it has a giant gaping flaw in it, which is ; Any cell of yours that produces a foreign protein, will be targetted by your immune system and destroyed. You will create an autoimmune disorder. When it works. How do you keep it out of your heart. Not by coding it in a lipid nanoparticle. So, they had no way to deliver it safely to market. So then they had a pandemic, the emergency allowed them to do it. This technology, in my opinion, was at least 3 decades out from being usefully and safely deployed at all, if at all. They did not want to wait, this crisis gave them the opportunity not to wait. And now, they will blame the spike protein, we picked the wrong protein. When in actual fact there are 2 problems, the spike protein and the platform itself."

RefugeOfSinners (ROS)

1,204,884 görüntüleme • 3 yıl önce

They're putting PROTEIN in EVERYTHING now. Cookies. Chips. Cereal. Candy. Ice cream. Look, I'm a HUGE believer in eating 1g of protein per pound of body weight. But putting 15g of protein in a cookie doesn't magically make it HEALTHY. The problem isn't protein. It's the ridiculous marketing convincing people that anything labeled HIGH PROTEIN is automatically good for you. This craze has gotten completely OUT OF CONTROL. I break it all down in my new video. WATCH THIS! 👇

They're putting PROTEIN in EVERYTHING now. Cookies. Chips. Cereal. Candy. Ice cream. Look, I'm a HUGE believer in eating 1g of protein per pound of body weight. But putting 15g of protein in a cookie doesn't magically make it HEALTHY. The problem isn't protein. It's the ridiculous marketing convincing people that anything labeled HIGH PROTEIN is automatically good for you. This craze has gotten completely OUT OF CONTROL. I break it all down in my new video. WATCH THIS! 👇

Marc Lobliner - IFBB Pro

47,476 görüntüleme • 5 gün önce

This is a Kinesin protein. It transports vital cargo from the cell nucleus. I don't have enough faith to be an Atheist.

This is a Kinesin protein. It transports vital cargo from the cell nucleus. I don't have enough faith to be an Atheist.

Against Atheism

200,775 görüntüleme • 1 yıl önce