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Brain cell communication seen in action. Scientists have captured the millisecond fast process of brain cell communication using advanced imaging. Teams in Berlin and the US used rapid freezing techniques on mouse and human neurons to observe neurotransmitter release and vesicle recycling, revealing key steps and proteins involved. This...

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🚨 SCIENTISTS ARE USING AI TO MAP A HIDDEN “CLEANING SYSTEM” INSIDE THE HUMAN BRAIN AND IT COULD CHANGE HOW WE UNDERSTAND SLEEP, AGING, AND NEURODEGENERATIVE DISEASE. It’s called the glymphatic system a vast network of fluid channels that flushes toxic waste from the brain while you sleep. For years it was almost impossible to observe in detail. Now AI-powered imaging is revealing it like a living galaxy of microscopic rivers and pathways inside neural tissue. Why this matters: Your brain produces toxic proteins constantly. The glymphatic system is one of its primary waste-clearance mechanisms clearing the very proteins linked to Alzheimer’s, Parkinson’s, and other neurodegenerative diseases. But here’s the unsettling part: This cleaning system becomes dramatically less efficient with age, poor sleep, stress, and brain injury. Sleep may not just “rest” your mind it may literally wash your brain. The deeper implication is staggering: The brain isn’t just a computer. It’s a dynamic, living network that constantly rebuilds and cleanses itself in real time. The more we map it, the more it looks like an entire universe of connected energy flows inside our skulls. What if some neurological diseases begin when the brain can no longer properly “wash” itself at night? Follow for more frontier neuroscience and future technology.

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E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves. We discovered a new cell barcoding approach exceeding comparable methods by more than 750x. This is the heart of PRISM. We integrated this capability with microscopy and AI image analysis to automatically trace neurons at high resolution and annotate them with molecular features. This is a key advance towards economically viable brain mapping - 95% of costs stem from neuron tracing. It is also an important step towards democratizing neuron tracing for everyday neuroscience. Solving these problems is critical for curing brain disorders, building safer and human-like AI, and even simulating brain function. In our first pilot study, we acquired a unique dataset in mouse hippocampus. Barcodes improved the accuracy of tracing genetically labelled neurons by 8x – with a clear path to 100x or more. They also permit tracing across spatial gaps – essential for mitigating tissue section loss in whole-brain scaling. Using molecular annotation, we uncover an intriguing feature of synaptic organization, demonstrating how PRISM can be used for systematic discovery 🧵
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🚨🇨🇳 Chinese scientists identify previously unknown cause of Alzheimer's disease A substance formed when particles break down — called 6PPD-quinone — may trigger inflammation and oxidative stress, both hallmarks of dementia, the new study suggests 🔸 The chemical is created when microscopic tire rubber reacts with ozone in the air, washing into water, soil, and even our bodies — it has been found in human blood 🔸 The compound can cross the blood-brain barrier — a filter that normally keeps harmful substances out of the brain 🔸 Scientists used databases to map over 100 potential ways this substance could interact with human biology 🔸They found 92 overlaps — including 23 key genes acting as communication hubs. These genes are most active in brain regions critical for memory and movement, such as the cortex and basal ganglia, which are especially vulnerable to Alzheimer's If experimental validation follows, this discovery could significantly improve the effectiveness of Alzheimer's future therapies.

Sputnik

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You’re looking at neurons growing and connecting in real time 🧠. A 65-hour recording of hippocampal activity in a rat brain. The hippocampus plays a crucial role in memory and learning. In this footage, neurons extend their dendrites and axons, building and reshaping connections across days. Capturing this process live offers a rare view into how neural circuits form and reorganize. Why this matters ⬇️ 1️⃣It’s a continuous, multi-day recording of living hippocampal neurons under the microscope 2️⃣You can clearly see dendritic branching and network formation 3️⃣It reveals the dynamic processes that drive brain development and plasticity Observing growth at this resolution helps researchers understand how neurons connect—and how disruptions in these processes might contribute to neurological or psychiatric conditions. Credit to Louis Romet and Dr. Christophe Leterrier for the video
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You’re looking at neurons growing and connecting in real time 🧠. A 65-hour recording of hippocampal activity in a rat brain. The hippocampus plays a crucial role in memory and learning. In this footage, neurons extend their dendrites and axons, building and reshaping connections across days. Capturing this process live offers a rare view into how neural circuits form and reorganize. Why this matters ⬇️ 1️⃣It’s a continuous, multi-day recording of living hippocampal neurons under the microscope 2️⃣You can clearly see dendritic branching and network formation 3️⃣It reveals the dynamic processes that drive brain development and plasticity Observing growth at this resolution helps researchers understand how neurons connect—and how disruptions in these processes might contribute to neurological or psychiatric conditions. Credit to Louis Romet and Dr. Christophe Leterrier for the video

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Your every thought, memory, and movement begins here: an electric spark turned chemical message, as one neuron whispers to the next. What you’re seeing This animation captures neurotransmission, the process that allows nerve cells to communicate across microscopic gaps called synapses. When an electrical impulse reaches the end of Cell A (the presynaptic neuron), it triggers the release of neurotransmitters—tiny signaling molecules that cross the synaptic cleft and bind to receptors on Cell B (the postsynaptic neuron). 🟡 Opens ion channels that generate a new electrical signal in the next neuron 🟡 Coordinates how the brain encodes movement, emotion, and thought 🟡 Operates on millisecond precision using hundreds of molecular components 💡 The bigger picture Neurotransmission is the foundation of consciousness, a seamless conversation of electricity and chemistry happening trillions of times each second. Every sensation, decision, and memory depends on this invisible dialogue between your brain’s 86 billion neurons.

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Val Venis™ (The Big Valbowski™)

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Bacteria communicate like us, using electrical signalling similar to how neurones fire in the human brain ⚡️🦠⁠ Researchers at University of Warwick and Politecnico di Milano can control bacteria's electrical signalling with the molecule, Ziapin2 which may have implications for antibiotic resistance
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Bacteria communicate like us, using electrical signalling similar to how neurones fire in the human brain ⚡️🦠⁠ Researchers at University of Warwick and Politecnico di Milano can control bacteria's electrical signalling with the molecule, Ziapin2 which may have implications for antibiotic resistance

New Scientist

65,278 Aufrufe • vor 3 Jahren

BREAKING: Scientists now believe Parkinson's disease may not always start in the brain. In many patients, it may begin in the gut — and travel to the brain via a nerve most people have never heard of. At the same time: → A new drug just reversed brain inflammation in PD patients for the first time in history. → A diabetes drug in the same class as Ozempic slowed Parkinson's motor decline in a New England Journal of Medicine trial. → Fecal transplants are producing lasting motor improvement in randomized controlled trials. None of this is making mainstream news. Here is what is actually happening outside the brain in Parkinson's research right now. 🧵
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BREAKING: Scientists now believe Parkinson's disease may not always start in the brain. In many patients, it may begin in the gut — and travel to the brain via a nerve most people have never heard of. At the same time: → A new drug just reversed brain inflammation in PD patients for the first time in history. → A diabetes drug in the same class as Ozempic slowed Parkinson's motor decline in a New England Journal of Medicine trial. → Fecal transplants are producing lasting motor improvement in randomized controlled trials. None of this is making mainstream news. Here is what is actually happening outside the brain in Parkinson's research right now. 🧵

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The most detailed 3D reconstruction of a cell ever created. Blows my mind every time. But what exactly are we looking at here? The average human cell contains: ~ 15-20 total distinct organelle types, totalling between ~1-10 million working together per cell. All these nano-machines in the cell are made up of proteins. ~ 8,000-10,000 distinct types of unique proteins, adding up to between 40 million - 10 trillion total proteins making up all those cellular systems. ~ 10,000 - 15,000 distinct types of RNA shuttling information around the cell, totalling up to ~10 million RNA molecules moving around the cell simultaneously. ~ Billions of Lipid molecules packed together into the cell membrane, which is also packed tightly with millions more protein-based nano-machines. And let's not forget billions of lines of DNA information to build and run it all. That's TRILLIONS of of individual molecular pieces working together to make a single cell function. That means there is more complexity in a single cell than humanity's largest cities. And people still believe this wasn't Divinely Designed. This is God's Glory on Display. But to make the point. A cell couldn't have evolved from some nebulous simpler "protocell" because even the simplest cells still require massive complexity. The "simplest" cell ever created was engineered by scientists knocking out pieces of a functional cell until it stopped functioning. Here is what they found is the absolute necessary minimal requirements of a cell to function: - Over ~531,000 lines of coded DNA information - 473 total genes to create hundreds of unique protein products (they later added 19 genes back in because the cell was so weak) - Hundreds of thousands of total proteins all working together - Extensive regulatory networks guiding all these interactions If the cell doesn't have all these systems in place, from the start... it doesn't live. Cell rely on an intricate network of complex systems, which are themselves built from complex interconnected pieces woven together into an incomprehensibly complex web of functionilty. Only intelligence has ever been observed creation vast interconnected systems like this. Life was clearly Created. It couldn't happen any other way.
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The most detailed 3D reconstruction of a cell ever created. Blows my mind every time. But what exactly are we looking at here? The average human cell contains: ~ 15-20 total distinct organelle types, totalling between ~1-10 million working together per cell. All these nano-machines in the cell are made up of proteins. ~ 8,000-10,000 distinct types of unique proteins, adding up to between 40 million - 10 trillion total proteins making up all those cellular systems. ~ 10,000 - 15,000 distinct types of RNA shuttling information around the cell, totalling up to ~10 million RNA molecules moving around the cell simultaneously. ~ Billions of Lipid molecules packed together into the cell membrane, which is also packed tightly with millions more protein-based nano-machines. And let's not forget billions of lines of DNA information to build and run it all. That's TRILLIONS of of individual molecular pieces working together to make a single cell function. That means there is more complexity in a single cell than humanity's largest cities. And people still believe this wasn't Divinely Designed. This is God's Glory on Display. But to make the point. A cell couldn't have evolved from some nebulous simpler "protocell" because even the simplest cells still require massive complexity. The "simplest" cell ever created was engineered by scientists knocking out pieces of a functional cell until it stopped functioning. Here is what they found is the absolute necessary minimal requirements of a cell to function: - Over ~531,000 lines of coded DNA information - 473 total genes to create hundreds of unique protein products (they later added 19 genes back in because the cell was so weak) - Hundreds of thousands of total proteins all working together - Extensive regulatory networks guiding all these interactions If the cell doesn't have all these systems in place, from the start... it doesn't live. Cell rely on an intricate network of complex systems, which are themselves built from complex interconnected pieces woven together into an incomprehensibly complex web of functionilty. Only intelligence has ever been observed creation vast interconnected systems like this. Life was clearly Created. It couldn't happen any other way.

Divinely Designed

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Did you know about 21 million people worldwide are diagnosed with #epilepsy in 2021? Epilepsy’s pathophysiology involves the aberrant electrical activity of neurons in the brain. This typically stems from an imbalance between excitatory and inhibitory neurotransmitters, with increased excitation or reduced inhibition leading to hyperactive neural networks. These abnormal electrical discharges manifest as seizures, which can vary in intensity and impact depending on the specific regions of the brain affected by this pathophysiological imbalance.🧠 . Video credit silvan_haber_ #scientissimum #neurology #neurologia #MedTwitter #Worlds2023
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Did you know about 21 million people worldwide are diagnosed with #epilepsy in 2021? Epilepsy’s pathophysiology involves the aberrant electrical activity of neurons in the brain. This typically stems from an imbalance between excitatory and inhibitory neurotransmitters, with increased excitation or reduced inhibition leading to hyperactive neural networks. These abnormal electrical discharges manifest as seizures, which can vary in intensity and impact depending on the specific regions of the brain affected by this pathophysiological imbalance.🧠 . Video credit silvan_haber_ #scientissimum #neurology #neurologia #MedTwitter #Worlds2023

Scientissimum

165,358 Aufrufe • vor 2 Jahren

🚨 SCIENTISTS JUST BUILT AN ARTIFICIAL RETINA THAT RESTORES VISION AND ADDS INFRARED SIGHT. Researchers at Yonsei University in South Korea have developed a flexible, three-layer implant that bypasses dead photoreceptors and directly stimulates healthy retinal ganglion cells. The device not only helps restore vision in cases of retinal degeneration (like retinitis pigmentosa) but also gives the eye the ability to detect near-infrared light that humans normally cannot see. The key innovation is a soft 3D array of liquid metal micropillars (gallium-indium alloy) that gently conform to the curved retina without causing damage or inflammation a major improvement over rigid electrodes used in earlier implants. Why this matters: • Retinal diseases destroy light-sensing cells, but the neurons deeper in the eye often remain healthy and capable of sending signals to the brain • The implant uses an ultrathin filter + phototransistor array to convert near-infrared light into electrical signals the ganglion cells can understand • In mouse tests, blind animals regained visual responses, while healthy mice gained infrared sensitivity on top of their normal vision • The liquid metal electrodes are soft and biocompatible, dramatically reducing the risk of scarring or tissue damage The deeper implication: This isn’t just about restoring lost vision it’s about augmenting human sight. If it reaches human trials and proves safe long-term, people with partial vision loss could keep their remaining natural sight while gaining an entirely new sensory channel (infrared). The biggest open question is how the human brain would interpret this new stream of information whether it would feel like a new color, an overlay, or something else entirely. We’re moving from “fixing blindness” to “expanding what it means to see.” How do you think gaining the ability to see infrared light would change daily life or human perception? Follow for more frontier neurotechnology and bionic vision breakthroughs.
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🚨 SCIENTISTS JUST BUILT AN ARTIFICIAL RETINA THAT RESTORES VISION AND ADDS INFRARED SIGHT. Researchers at Yonsei University in South Korea have developed a flexible, three-layer implant that bypasses dead photoreceptors and directly stimulates healthy retinal ganglion cells. The device not only helps restore vision in cases of retinal degeneration (like retinitis pigmentosa) but also gives the eye the ability to detect near-infrared light that humans normally cannot see. The key innovation is a soft 3D array of liquid metal micropillars (gallium-indium alloy) that gently conform to the curved retina without causing damage or inflammation a major improvement over rigid electrodes used in earlier implants. Why this matters: • Retinal diseases destroy light-sensing cells, but the neurons deeper in the eye often remain healthy and capable of sending signals to the brain • The implant uses an ultrathin filter + phototransistor array to convert near-infrared light into electrical signals the ganglion cells can understand • In mouse tests, blind animals regained visual responses, while healthy mice gained infrared sensitivity on top of their normal vision • The liquid metal electrodes are soft and biocompatible, dramatically reducing the risk of scarring or tissue damage The deeper implication: This isn’t just about restoring lost vision it’s about augmenting human sight. If it reaches human trials and proves safe long-term, people with partial vision loss could keep their remaining natural sight while gaining an entirely new sensory channel (infrared). The biggest open question is how the human brain would interpret this new stream of information whether it would feel like a new color, an overlay, or something else entirely. We’re moving from “fixing blindness” to “expanding what it means to see.” How do you think gaining the ability to see infrared light would change daily life or human perception? Follow for more frontier neurotechnology and bionic vision breakthroughs.

TheNewPhysics

34,362 Aufrufe • vor 1 Monat

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🚨SPACEX NAILS LAUNCH OF REVOLUTIONARY DIRECT-TO-CELL STARLINK SATELLITES SpaceX just successfully deployed 20 next-generation Starlink satellites to orbit - including 13 equipped with groundbreaking Direct to Cell capabilities. The Falcon 9 lifted off from Vandenberg, lighting up the California coast. The veteran booster, on its eighth flight, stuck another perfect landing on the "Of Course I Still Love You" droneship in the Pacific Ocean. This marks another milestone in SpaceX's march toward global connectivity, with these new satellites set to enable direct communication between standard cell phones and space. Source: SpaceX

Mario Nawfal

82,653 Aufrufe • vor 1 Jahr

Hey everyone, I’m proud to share my first-ever submission to 'The Memes by 6529'. I have seen this collection of meme cards stand as a living record of the incredible artists involved in the culture in this space! I'm honored to contribute to that story, and I’d truly appreciate your support and vote. “Pixel Party” Pixel party on the chain. JPEGs dancing in my brain. ETH in my left hand, BTC in my right. I’m buying up the night, buying up the night. 🎥⬇️: Sound On:🔉⬇️
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Hey everyone, I’m proud to share my first-ever submission to 'The Memes by 6529'. I have seen this collection of meme cards stand as a living record of the incredible artists involved in the culture in this space! I'm honored to contribute to that story, and I’d truly appreciate your support and vote. “Pixel Party” Pixel party on the chain. JPEGs dancing in my brain. ETH in my left hand, BTC in my right. I’m buying up the night, buying up the night. 🎥⬇️: Sound On:🔉⬇️

Abrahanny.eth

12,326 Aufrufe • vor 4 Monaten

Like a stadium full of sports fans doing the wave, neurons coordinate their electrical signals in rhythmic patterns that sweep across the cortex, the brain’s outermost layer. Recent studies in humans and animals have shown these patterns, called traveling waves, can take on complex shapes, among them a rotating spiral that has been observed during deep sleep, memory retrieval, and other brain processes. A new study has now captured the fast-spinning waves spanning whole brains, offering clues to how they’re organized and what they might do. Learn more: News from Science
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Like a stadium full of sports fans doing the wave, neurons coordinate their electrical signals in rhythmic patterns that sweep across the cortex, the brain’s outermost layer. Recent studies in humans and animals have shown these patterns, called traveling waves, can take on complex shapes, among them a rotating spiral that has been observed during deep sleep, memory retrieval, and other brain processes. A new study has now captured the fast-spinning waves spanning whole brains, offering clues to how they’re organized and what they might do. Learn more: News from Science

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