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Breakthrough Update: Today, Vertex announced that they are beginning their Phase 3, or pivotal trial for VX-880, a stem cell-derived islet therapy. A pivotal trial gathers the data required for an FDA submission. This therapy is for people with type 1 diabetes (T1D) and hypoglycemia unawareness and severe hypoglycemic...

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Breakthrough T1D

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42,494 просмотров • 1 год назад •via X (Twitter)

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Комментарии: 9

Фото профиля LinnBee🌸
LinnBee🌸1 год назад

Nice. Does this need any immuno suppressants? Stem cell is a very exciting field.

Фото профиля Michael Moraal
Michael Moraal1 год назад

@amsterdamumc @DiabetesNL ik hoop dat VX-264 ook naar Nederland komt na die FDA submission 🙏

Фото профиля john callinan
john callinan1 год назад

@isletbiologylab For the first time a cure in five years may actually be accurate.

Фото профиля L A U R A ... ♥🌼
L A U R A ... ♥🌼1 год назад

This would be so much more heartwarming if it was for ALL T1, not just some. A great effort so far, but can it really be classed as a T1 cure if not all T1s can be cured?

Фото профиля BioBoost
BioBoost1 год назад

Could targeting insulin-degrading enzyme (IDE) hold the key to preventing Type 1 diabetes? A recent study shows that IDE deficiency in mice reduces autoreactive immune cells and insulin-specific immune responses, protecting pancreatic cells from autoimmune destruction and lowering Type 1 diabetes risk. Could IDE be a potential target for autoimmune diabetes therapies?

Фото профиля سعودي ولي الفخر🇸🇦
سعودي ولي الفخر🇸🇦1 год назад

متى نرى هذا العلاج النهائي في الأسواق؟؟

Фото профиля Swati Rights
Swati Rights1 год назад

While it gives a lot of optimism I'm also wondering what impact it will have in terms of side effects that may trigger new autoimmune conditions, affect organs like the kidney, liver and heart, or produce conditions like cancer or bone affliction later Is there any literature ?

Фото профиля Brady Gretch
Brady Gretch1 год назад

@BreakthroughT1D Thank you for sharing this great news with a text and video post!

Фото профиля Rachel Harman
Rachel Harman1 год назад

I would love for my son to be a part of this! He is only 12 and struggling with type one.

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It’s official! We are now Breakthrough T1D UK 🎉 As Breakthrough T1D we’ll continue the journey we started as JDRF: 💙 driving breakthroughs towards a world without type 1 diabetes 💙 helping make every day better for the people who face type 1 💙 working to give everyone with T1D access to the best treatment and support We can’t do any of this without your incredible support. Thank you. Together, let’s make a world where no one lives with T1D. Find out more about our work: #Type1Diabetes #T1D #GBDoc
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It’s official! We are now Breakthrough T1D UK 🎉 As Breakthrough T1D we’ll continue the journey we started as JDRF: 💙 driving breakthroughs towards a world without type 1 diabetes 💙 helping make every day better for the people who face type 1 💙 working to give everyone with T1D access to the best treatment and support We can’t do any of this without your incredible support. Thank you. Together, let’s make a world where no one lives with T1D. Find out more about our work: #Type1Diabetes #T1D #GBDoc

Breakthrough T1D UK

22,975 просмотров • 1 год назад

Same mission, New name. Breakthrough T1D (formerly JDRF) is the world leader in T1D research, advocacy, and community support. Our new brand reflects our bold vision for a world without T1D. We are accelerating breakthroughs and building a movement for change. #BreakthroughT1D
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Same mission, New name. Breakthrough T1D (formerly JDRF) is the world leader in T1D research, advocacy, and community support. Our new brand reflects our bold vision for a world without T1D. We are accelerating breakthroughs and building a movement for change. #BreakthroughT1D

Breakthrough T1D

23,753 просмотров • 2 лет назад

🔊Sound on!🔊 We're excited to introduce our new film, ‘What a cure feels like’, celebrating our transformation to Breakthrough T1D! The film features real people affected by type 1 diabetes (T1D) and captures the relentless nature of living with T1D and the hundreds of extra decisions made each day. We would like to say a special thank you to Tara humphrey and her daughter Tahlia, LiS Warren 💙, Joe and his partner Salman and Jon Peach who shared their experiences and worked alongside us to create this film. Together, let's raise awareness and inspire hope for a future without T1D💙 #BreakthroughT1D #WhatACureFeelsLike #T1D #GBDoc
2:02

🔊Sound on!🔊 We're excited to introduce our new film, ‘What a cure feels like’, celebrating our transformation to Breakthrough T1D! The film features real people affected by type 1 diabetes (T1D) and captures the relentless nature of living with T1D and the hundreds of extra decisions made each day. We would like to say a special thank you to Tara humphrey and her daughter Tahlia, LiS Warren 💙, Joe and his partner Salman and Jon Peach who shared their experiences and worked alongside us to create this film. Together, let's raise awareness and inspire hope for a future without T1D💙 #BreakthroughT1D #WhatACureFeelsLike #T1D #GBDoc

Breakthrough T1D UK

109,551 просмотров • 1 год назад

Earlier today at the ADA Scientific Sessions, Sana Biotechnology gave an exciting 6-month update on the first person who received transplanted donor-derived pancreatic islet cells modified with hypo-immune (HIP) technology, a cell therapy that does NOT require immunosuppression. Breakthrough T1D’s Vice President of Research, Esther Latres, Ph.D., gives an update on this incredibly exciting step toward cures for type 1 diabetes (T1D).
2:38

Earlier today at the ADA Scientific Sessions, Sana Biotechnology gave an exciting 6-month update on the first person who received transplanted donor-derived pancreatic islet cells modified with hypo-immune (HIP) technology, a cell therapy that does NOT require immunosuppression. Breakthrough T1D’s Vice President of Research, Esther Latres, Ph.D., gives an update on this incredibly exciting step toward cures for type 1 diabetes (T1D).

Breakthrough T1D

14,103 просмотров • 1 год назад

It's been a decade of leading in #t1diabetes care for NHS England 😃 And finally? It's time to hand the mantle over regards technology in the world of #t1diabetes A YouTube video on my channel- for those living with #T1D and their carers Thank you for all the support, love and help- YOU have been the reason we have come so far. I will still be around -yet the technology journey comes to a close- as all things must. It's been a swashbucklingly fun decade. We made some progress, didn't we? x Much love Partha Breakthrough T1D UK Diabetes UK Getting It Right First Time (GIRFT) (Link for whole video: )
1:30

It's been a decade of leading in #t1diabetes care for NHS England 😃 And finally? It's time to hand the mantle over regards technology in the world of #t1diabetes A YouTube video on my channel- for those living with #T1D and their carers Thank you for all the support, love and help- YOU have been the reason we have come so far. I will still be around -yet the technology journey comes to a close- as all things must. It's been a swashbucklingly fun decade. We made some progress, didn't we? x Much love Partha Breakthrough T1D UK Diabetes UK Getting It Right First Time (GIRFT) (Link for whole video: )

Partha S Kar 🇮🇳🇬🇧🏏🎥

11,549 просмотров • 4 месяцев назад

🚨🚨🚨🚨 LOW CARB IS FINALLY THE LAW OF THE LAND FOR TYPE 1 DIABETES! New publication details the first major medical society endorsement of therapeutic carb reduction (TCR) for T1D! Here's coauthor Dave Dikeman with a two-minute summary of the revolution in T1D care from SMHP. ALL people with Type 1 deserve the choice to normalize their blood glucose and avoid the complications from high blood glucose. Dr. Eric Westman, MD, MHS Robert Cywes MD Laura Buchanan MD, MHP Matt Calkins MD MHP T1D Nutrition Miriam Kalamian Ian Lake Dr Evelyne Bourdua-Roy Doug Reynolds, MHP Michael Fitzpatrick Dr. Ryan Attar Andrew Koutnik, Ph.D.
2:20

🚨🚨🚨🚨 LOW CARB IS FINALLY THE LAW OF THE LAND FOR TYPE 1 DIABETES! New publication details the first major medical society endorsement of therapeutic carb reduction (TCR) for T1D! Here's coauthor Dave Dikeman with a two-minute summary of the revolution in T1D care from SMHP. ALL people with Type 1 deserve the choice to normalize their blood glucose and avoid the complications from high blood glucose. Dr. Eric Westman, MD, MHS Robert Cywes MD Laura Buchanan MD, MHP Matt Calkins MD MHP T1D Nutrition Miriam Kalamian Ian Lake Dr Evelyne Bourdua-Roy Doug Reynolds, MHP Michael Fitzpatrick Dr. Ryan Attar Andrew Koutnik, Ph.D.

RD, Ph.D.

13,593 просмотров • 1 год назад

Today, more than 170 delegates from all 50 states and five countries were in Washington for the 2025 Breakthrough Type 1 Diabetes Children’s Congress. I was proud to chair a Senate Appropriations Committee hearing to welcome the delegates and focus on the importance of federal investment in Type 1 diabetes research. Senator Jeanne Shaheen and I — the founding co-chairs of the bipartisan Senate Diabetes Caucus — introduced legislation this week to reauthorize the Special Diabetes Program, a federal initiative that provides $160 million annually for Type 1 diabetes research and prevention. Thanks to this program and the tireless advocacy of Breakthrough T1D and its Children’s Congress Delegates, we are seeing life changing breakthroughs in the fight against this terrible disease. Some of these developments include the now widely used continuous glucose monitors, the first FDA-approved artificial pancreas, and a groundbreaking clinical trial in which 10 of the 12 participants no longer need insulin to manage their diabetes because of a stem cell-based therapy. Since the founding of the Senate Diabetes Caucus in 1997, federal funding for diabetes research has increased from $319 million to more than $2.3 billion annually. I want to thank our outstanding witnesses for today’s hearing: Ruby Whitmore of Old Town, Maine, Rachel White of North Hampton, New Hampshire, Katie Bone of Bernalillo, New Mexico, and Dr. Griffin Rodgers, Director of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Their passionate testimony highlighted both the daily realities of living with type 1 diabetes and the vital role of continued federal research through agencies like the NIDDK. Finding a cure for Type 1 diabetes remains our ultimate goal and has been one of my highest priorities since the very beginning of my Senate service. With continued advocacy, bipartisan support, and strong federal investment, I am confident that day will come.
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Today, more than 170 delegates from all 50 states and five countries were in Washington for the 2025 Breakthrough Type 1 Diabetes Children’s Congress. I was proud to chair a Senate Appropriations Committee hearing to welcome the delegates and focus on the importance of federal investment in Type 1 diabetes research. Senator Jeanne Shaheen and I — the founding co-chairs of the bipartisan Senate Diabetes Caucus — introduced legislation this week to reauthorize the Special Diabetes Program, a federal initiative that provides $160 million annually for Type 1 diabetes research and prevention. Thanks to this program and the tireless advocacy of Breakthrough T1D and its Children’s Congress Delegates, we are seeing life changing breakthroughs in the fight against this terrible disease. Some of these developments include the now widely used continuous glucose monitors, the first FDA-approved artificial pancreas, and a groundbreaking clinical trial in which 10 of the 12 participants no longer need insulin to manage their diabetes because of a stem cell-based therapy. Since the founding of the Senate Diabetes Caucus in 1997, federal funding for diabetes research has increased from $319 million to more than $2.3 billion annually. I want to thank our outstanding witnesses for today’s hearing: Ruby Whitmore of Old Town, Maine, Rachel White of North Hampton, New Hampshire, Katie Bone of Bernalillo, New Mexico, and Dr. Griffin Rodgers, Director of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Their passionate testimony highlighted both the daily realities of living with type 1 diabetes and the vital role of continued federal research through agencies like the NIDDK. Finding a cure for Type 1 diabetes remains our ultimate goal and has been one of my highest priorities since the very beginning of my Senate service. With continued advocacy, bipartisan support, and strong federal investment, I am confident that day will come.

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We are thrilled to share positive topline data from our ELEVATE IPF Phase 2b trial evaluating deupirfenidone (LYT-100) for the treatment of idiopathic pulmonary fibrosis (#IPF), a progressive and fatal lung disease. Our trial met the primary and key secondary endpoints, with deupirfenidone demonstrating the potential to serve as a new standard of care. Over 26 weeks, the highest dose of deupirfenidone studied was generally well-tolerated and reduced lung function decline to levels that approach natural lung function decline in healthy adults over sixty—a first for any investigational or approved treatment for IPF. We’re incredibly excited for what deupirfenidone could offer the IPF community, which urgently needs new treatment options with better efficacy that don’t compromise on tolerability. A heartfelt thank you to everyone who participated in the ELEVATE IPF trial, including patients, caregivers, clinical trial sites, and advocacy groups. Your courage, dedication and expertise make progress possible, and we are grateful for your trust and partnership. Read more in today’s press release:

PureTech

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#BREAKING It is a big day for the Liver Community! Madrigal is proud to announce the first and only U.S. FDA-approved therapy in NASH/MASH. Learn more here: #FDAApproval #NASH
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#BREAKING It is a big day for the Liver Community! Madrigal is proud to announce the first and only U.S. FDA-approved therapy in NASH/MASH. Learn more here: #FDAApproval #NASH

Madrigal Pharmaceuticals

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This is a truly historic moment. The results from this pivotal trial evaluating a fully percutaneous transcatheter mitral valve replacement technology has opened a new treatment option for patients who are not good candidates for surgery or TEER. This is a remarkable milestone that will not only transform the field of interventional cardiology but, most importantly, will change the lives of countless patients who have been waiting for a viable treatment option. Slides presented as LBCT #TCT2025 today and link to our manuscript published The Lancet today are included. Thank you to all the people who worked with us for a decade to make this happen! Dave Daniels Mayo Clinic CV

Mayra Guerrero, MD

20,941 просмотров • 10 месяцев назад

Today, we celebrate a milestone that reminds us that every great journey starts with a single step. From working with a rake and a shovel to proudly owning our own bus, this achievement is a testament to hard work, consistency, faith, and the incredible support we've received from our viewers and community. What once seemed like a distant dream has become a reality, and we are deeply grateful to everyone who has supported the Buz Stop Boys movement along the way. This bus is not just ours it belongs to every person who believed in us, encouraged us, and followed our journey. We are excited for this new chapter and the opportunities it brings. If you or your organization need a bus for transportation services, we are pleased to recommend Uncle Prince, who is known for his honest, reliable, and professional service. Thank you for being part of our story. The journey continues, and this is only the beginning.
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Today, we celebrate a milestone that reminds us that every great journey starts with a single step. From working with a rake and a shovel to proudly owning our own bus, this achievement is a testament to hard work, consistency, faith, and the incredible support we've received from our viewers and community. What once seemed like a distant dream has become a reality, and we are deeply grateful to everyone who has supported the Buz Stop Boys movement along the way. This bus is not just ours it belongs to every person who believed in us, encouraged us, and followed our journey. We are excited for this new chapter and the opportunities it brings. If you or your organization need a bus for transportation services, we are pleased to recommend Uncle Prince, who is known for his honest, reliable, and professional service. Thank you for being part of our story. The journey continues, and this is only the beginning.

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8:55

We are in trouble. We are surrounded by people who seek to curb our free speech and our right to assemble and they have weaponised antisemitism to do it. The problem is, our top cop, Prime Minister and an assortment of compromised politicians, media outlets and bought 'patriots' all support it. Even typing this could find the police at my door for the second time in a week. They are dangerously over-zealous in their obedience to Israel and our citizens are paying the price. It is not antisemitic to say Israel is 'running the UK'. It is anti-Zionism and that is protected in UK law. Don't conflate the two, that's antisemitic. British people are not a priority in our own country. Our politicians, police and media are compromised. These people are Israel First and they are harming us.

Sonia Poulton

38,393 просмотров • 3 месяцев назад

Among all the European nations that have already joined the European Union or see such a prospect for themselves, Ukraine is the one making the greatest sacrifices for Europe. We are not simply carrying out internal reforms, nor are we simply going through a transformation. We are fighting for our state, for our independence, and for our right to choose our own path and to be Europe. And this right of ours is at the same time the right of every nation in our region. We are fighting for our freedom and theirs, for Europe for ourselves and for them – for the Baltic states and for Poland, for Hungary and Slovakia, for Romania and Moldova, and for the peoples of the Caucasus. That is why the fate of Europe is being decided here – it is being decided in Ukraine, in this war, and in how this war ends – and whether Russia will still have the strength and the desire after this war to threaten the existence of Ukraine and its other neighbors, and the entirety of Europe. That is why we must end this war with dignity and with guaranteed security. And this is what we will discuss with our partners during the G7 Summit in France, and later at the European Council Summit and at the NATO Summit in Ankara.
5:35

Among all the European nations that have already joined the European Union or see such a prospect for themselves, Ukraine is the one making the greatest sacrifices for Europe. We are not simply carrying out internal reforms, nor are we simply going through a transformation. We are fighting for our state, for our independence, and for our right to choose our own path and to be Europe. And this right of ours is at the same time the right of every nation in our region. We are fighting for our freedom and theirs, for Europe for ourselves and for them – for the Baltic states and for Poland, for Hungary and Slovakia, for Romania and Moldova, and for the peoples of the Caucasus. That is why the fate of Europe is being decided here – it is being decided in Ukraine, in this war, and in how this war ends – and whether Russia will still have the strength and the desire after this war to threaten the existence of Ukraine and its other neighbors, and the entirety of Europe. That is why we must end this war with dignity and with guaranteed security. And this is what we will discuss with our partners during the G7 Summit in France, and later at the European Council Summit and at the NATO Summit in Ankara.

Volodymyr Zelenskyy / Володимир Зеленський

330,640 просмотров • 2 месяцев назад

Very grateful to MEP Lukas Mandl for hosting the event Iran Briefing: A Roadmap to a New Middle East, and for his remarks at the European Parliament. In his speech, MEP Lukas Mandi stated: “Dealing with activities for liberty, for freedom for the Iranian people, I’ve experienced a lot. When I met Mattie Heaven and Vahid Beheshti a few months ago. I pretty quickly understood this is different. These are the people who unite - the ones who are for freedom and liberty. I really to emphasise and outline that in a positive sense it is possible, it is necessary as you have said to unite, to align, and to go in one direct altogether, for the sake of the people of course, not for the sake of this ideology or that ideology or for a political idea, but for liberty and freedom civilisation and dignity itself. This is why I’m honoured that we can hold this conference together with you and I thank you for that.” We are indeed proud to not be associated with any political group or ideology, and are continuing to work towards uniting all opposition groups in order to overthrow the regime of the Islamic Republic, and give the Iranian people their country and national sovereignty.
0:53

Very grateful to MEP Lukas Mandl for hosting the event Iran Briefing: A Roadmap to a New Middle East, and for his remarks at the European Parliament. In his speech, MEP Lukas Mandi stated: “Dealing with activities for liberty, for freedom for the Iranian people, I’ve experienced a lot. When I met Mattie Heaven and Vahid Beheshti a few months ago. I pretty quickly understood this is different. These are the people who unite - the ones who are for freedom and liberty. I really to emphasise and outline that in a positive sense it is possible, it is necessary as you have said to unite, to align, and to go in one direct altogether, for the sake of the people of course, not for the sake of this ideology or that ideology or for a political idea, but for liberty and freedom civilisation and dignity itself. This is why I’m honoured that we can hold this conference together with you and I thank you for that.” We are indeed proud to not be associated with any political group or ideology, and are continuing to work towards uniting all opposition groups in order to overthrow the regime of the Islamic Republic, and give the Iranian people their country and national sovereignty.

Vahid Beheshti وحید بهشتی

89,342 просмотров • 10 месяцев назад

#WATCH | Kolkata | West Bengal BJP President Samik Bhattacharya says, "We thank the people of West Bengal. They have voted fearlessly this time, and have clearly stated that they are voting for change. They have voted against the divisive politics that the TMC practices... In the first phase, people voted for change, and we are seeing the same in the second phase. This is what was going to happen... Those who said they would play DJs, we hope they will play DJs for us after the 4th."
2:52

#WATCH | Kolkata | West Bengal BJP President Samik Bhattacharya says, "We thank the people of West Bengal. They have voted fearlessly this time, and have clearly stated that they are voting for change. They have voted against the divisive politics that the TMC practices... In the first phase, people voted for change, and we are seeing the same in the second phase. This is what was going to happen... Those who said they would play DJs, we hope they will play DJs for us after the 4th."

ANI

19,114 просмотров • 3 месяцев назад

Chinese scientists have developed the world’s first iPSC-derived allogeneic cell therapy for drug-resistant epilepsy to win both China NMPA and US FDA clinical trial approvals. Unlike conventional drugs that mainly suppress symptoms, this therapy directly targets the damaged neurons at the root of seizures, repairs neural circuits, and aims for functional reconstruction. The procedure takes about an hour. Patients can usually leave hospital in 5 to 7 days. And the platform may later extend to Parkinson’s, Alzheimer’s, and other neurological disorders. That is not “Made in China,” but medicine rewritten in China. While some countries are still busy weaponizing supply chains, China is building the future of biomedicine.
1:50

Chinese scientists have developed the world’s first iPSC-derived allogeneic cell therapy for drug-resistant epilepsy to win both China NMPA and US FDA clinical trial approvals. Unlike conventional drugs that mainly suppress symptoms, this therapy directly targets the damaged neurons at the root of seizures, repairs neural circuits, and aims for functional reconstruction. The procedure takes about an hour. Patients can usually leave hospital in 5 to 7 days. And the platform may later extend to Parkinson’s, Alzheimer’s, and other neurological disorders. That is not “Made in China,” but medicine rewritten in China. While some countries are still busy weaponizing supply chains, China is building the future of biomedicine.

𝘊𝘰𝘳𝘳𝘪𝘯𝘦

12,921 просмотров • 4 месяцев назад

We know from our intelligence and our partners that the Russians have readied missiles for a new massive attack on Ukraine. The strike may take place today – we have preliminary information that it could happen within the next 48 hours. Please take care of yourselves and pay attention to air raid alerts. We do expect understanding from our partners – air defense is the first priority where partners can help us. And it is important that more and more is becoming known in our key partner countries about what is really happening in Ukraine, about Russia’s attacks against our people, and about Russia’s efforts to prolong this war. Laura Loomer is in Ukraine these days. She is very close to President Trump. We spoke, and Laura saw a lot in Ukraine, in the capital and beyond – the Lavra, our people, and everything we are going through. I hope that America will continue to stand with Ukraine and that we will be able to end this war with a dignified peace. This is what we need. We are preparing for a meeting with the President of the United States and his team. I thank America. I thank everyone who stands with Ukraine – with our people and our efforts to protect life.
5:00

We know from our intelligence and our partners that the Russians have readied missiles for a new massive attack on Ukraine. The strike may take place today – we have preliminary information that it could happen within the next 48 hours. Please take care of yourselves and pay attention to air raid alerts. We do expect understanding from our partners – air defense is the first priority where partners can help us. And it is important that more and more is becoming known in our key partner countries about what is really happening in Ukraine, about Russia’s attacks against our people, and about Russia’s efforts to prolong this war. Laura Loomer is in Ukraine these days. She is very close to President Trump. We spoke, and Laura saw a lot in Ukraine, in the capital and beyond – the Lavra, our people, and everything we are going through. I hope that America will continue to stand with Ukraine and that we will be able to end this war with a dignified peace. This is what we need. We are preparing for a meeting with the President of the United States and his team. I thank America. I thank everyone who stands with Ukraine – with our people and our efforts to protect life.

Volodymyr Zelenskyy / Володимир Зеленський

334,589 просмотров • 1 месяц назад

Denmark, Finland, and Estonia are countries whose people and governments have supported Ukraine since the very first days of the full-scale war. Today, together we presented state awards to the First Ladies of Finland and Estonia and to the First Gentleman of Denmark – true friends who stand alongside our people. They came to Ukraine for the Fifth Summit of First Ladies and Gentlemen. For us, this is a symbol of genuine partnership and great trust. We are grateful for the attention to our nation and for the support we feel and sincerely value.
0:49

Denmark, Finland, and Estonia are countries whose people and governments have supported Ukraine since the very first days of the full-scale war. Today, together we presented state awards to the First Ladies of Finland and Estonia and to the First Gentleman of Denmark – true friends who stand alongside our people. They came to Ukraine for the Fifth Summit of First Ladies and Gentlemen. For us, this is a symbol of genuine partnership and great trust. We are grateful for the attention to our nation and for the support we feel and sincerely value.

Volodymyr Zelenskyy / Володимир Зеленський

408,609 просмотров • 11 месяцев назад