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Caffeinated coffee is a powerful protector against neurodegeneration Regular caffeinated coffee drinkers can cut Parkinson’s disease risk by up to 60%, largely via caffeine blocking adenosine A2A receptors in motor circuits and protecting dopamine-producing neurons Even moderate caffeine intake (~2 cups/day) has been linked to noticeably slower cognitive decline...

175,410 Aufrufe • vor 4 Monaten •via X (Twitter)

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Coffee is an important ritual for most people. But it's also a scientifically validated intervention that improves health, longevity, cognitive function, and physical performance. Our latest episode synthesizes extensive research to illuminate how the timing, brewing methods, and additives to coffee influence its health benefits and risks. From biological aging to cardiovascular protection and enhanced brain function, this episode provides comprehensive, actionable insights for integrating coffee optimally into daily life. I also explore: • How coffee reduces the risk of several of the major diseases of aging • The optimal way to prepare your coffee for maximum health benefits • The safety of coffee decaffeination methods • Whether your coffee could be laden with health-harming mycotoxins • The optimal dose of caffeine for mental and physical stimulation Coffee drinkers or not—you need to listen to this episode. It might change the way you think about this widely consumed beverage. Links to YouTube, Apple Podcasts, and Spotify in the comments. Timestamps: 0:00 - Introduction 1:24 - Can coffee really slow biological aging? 4:43 - Is coffee actually protective for your heart? 5:29 - Why morning coffee is healthier than afternoon coffee 8:01 - How coffee improves your metabolic health 9:53 - Does coffee significantly reduce cancer risk? 11:26 - Can coffee actively prevent DNA damage? 13:39 - Does coffee improve your gut microbiome? 16:01 - Can unfiltered coffee raise your cholesterol? 20:14 - Which brewing method maximizes antioxidants? 20:40 - Arabica or robusta—does bean type matter? 23:05 - Dark vs. light roast—what’s richer in antioxidants? 23:28 - Is cold brew as beneficial as hot coffee? 23:51 - Practical tips to maximize antioxidants 24:39 - Filtered vs. French press—what’s best for longevity? 26:49 - Can espresso’s antioxidants offset its cholesterol risk? 27:19 - Instant coffee—an overlooked longevity booster? 27:41 - Why filtered coffee is the clear winner 28:20 - Caffeinated vs. decaf—which is better for your brain? 30:42 - Does decaf coffee still boost cognitive function? 33:38 - How much caffeine optimizes athletic performance? 36:31 - How decaffeination methods affect coffee’s benefits 39:02 - Are mold toxins in coffee really a concern? 41:45 - Is adding dairy a mistake? 43:15 - Does MCT powder boost cognition—or just cholesterol? 44:59 - Does L-theanine effectively reduce caffeine anxiety? 47:04 - A science-backed coffee routine for longevity

Dr. Rhonda Patrick

316,807 Aufrufe • vor 1 Jahr

Dangers of coffee? Once again, the Sattvic Movement has outdone itself with this utter nonsense of a video that misleads public on coffee. The Sattvic Movement is a pseudo-intellectual, pseudo-scientific, spinal-level thinking nationalistic activism from a scientifically illiterate couple, that is leveraged on peddling anti-science concepts, demonizing scientific progression, misinterpreting evidence, and misrepresenting clinical data all the while promoting ancient and primitive superstition written in the religious texts of Ayurveda which promotes culture-traditional dogmatism in healthcare. Even a grade 4 glioblastoma is not as malignant as Sattvic Movement is to India’s scientific temper. In this video, Lady Sattvic speaks about three “facts” on why coffee is dangerous. 1/ Coffee is just for energizing temporarily and then people who drink coffee become lethargic. 2/ People get physically and psychologically dependent on coffee. 3/ Coffee dehydrates and destroys the lining of the stomach and causes constipation. Her solution: Have warm herbal teas! These statements are proof that mental constipation leads to verbal diarrhea and none of these are true. Coffee does not produce a jerk and flaccid response in the nervous system, but caffeine may. In fact, coffee as a dietary supplement for health/disease is one of the most scientifically studied aspects in clinical medicine. Three cups of black coffee without milk or sugar daily have immense health benefits that you need to know about! The Sattvic Movement is just peddling a whole bunch of lies. Coffee is significantly beneficial for the liver: it reduces fatty liver disease, reduced progression of fatty liver disease, reduces risk of developing cirrhosis and reduces risk of liver cancer development. See here here and here Coffee consumption does not only reduce risk of liver cancer, but also breast and endometrial cancer in women, colorectal and prostate cancers in men, reduces risk of dying from all causes, especially metabolic diseases such as diabetes and heart diseases and reduces risk of developing diabetes type 2 and Parkinson’s disease. See here here here People do not get dependent on coffee, but caffeine. Do you know what else contains caffeine apart from coffee? Tea and chocolates. Yes. Dark chocolate contains 43g of caffeine in 100g, coffee contains 20-40g depending on preparatory methods and tea contains 11g caffeine in 100g. So, is shifting to tea the solution to prevent caffeine dependency? Nope. Avoiding caffeinated products is. What does that mean? It means that decaffeinated coffee is as good as whole coffee, because the “goodness and benefits on health” of coffee is not dependent on caffeine, but polyenol compounds in coffee. See here and here And guess what, coffee and caffeine consumption was also significantly associated with decreased risk of depression. Yes, see here: and hey also this – coffee intake was associated with lower incidence of chronic kidney disease, end-stage kidney disease and protein loss in urine. Damn. Coffee is the superhero we all need! See here - So go ahead and enjoy some raw and real/or decaff that will increase longevity, reduce heart and metabolic diseases, cancers and reduce risk of developing degenerative brain diseases. Ok, so what about herbal teas? It is a bummer. There is absolutely no evidence from clinical studies to showcase that herbal teas are useful for anything other than featuring in misleading, stupid Instagram reels. But wait, there is more on herbal teas. Herbal teas are not all that safe. Herbal teas, especially green tea extract infusions were associated with liver injury, liver failure and death or organ transplantation. The European Union warned and limited the use of green tea extracts in foods fearing liver damage among consumers. See here and here And if you look at benefits of herbal teas versus adverse events of herbal teas in published literature, you will see that adverse events feature more. Herbal teas have caused liver injury, liver failure, multiple organ failure, accelerated hypertension, paralysis, chronic liver injury, heart failure, brain strokes and brain failure and so much more in humans! See this link: Oh, by the way, coffee does not increase blood pressure. In fact, it lowers it. So do not be too miserable on that. In habitual coffee users (3-5 cups a day), coffee had benefits on blood pressure parameters. Do not believe me? See here: and about that destroying stomach lining and causing constipation – that was just bluff from the annoyingly sounding Lady Sattvic. See here But is coffee safe for all? No. Pregnant women, please avoid more than 1-2 cups a day. See here: So, what is this Sattvic Movement all about? It is all about destroying the scientific temperament of the public in India and by misleading the public, they are creating more patients for the modern medicine hospitals to treat. Are they funded by Big Pharma? Hmmm, I wonder. I am going to think that over a hot cup of black coffee. I think you should too! And don’t forget to share this information with your herbal tea lover friends!

TheLiverDoc™

359,013 Aufrufe • vor 2 Jahren

One cup of coffee before 4 pm? - total blunder. I do not know why so many people follow this guy on Instagram. Half his content is lame jokes featuring two imaginary people named Saravana Kumar and Arockiasamy and the rest of it is poorly researched, vaguely discussed medical content that misleads & misinforms and in many videos he just randomly throws jargons like "gut health" and "fasting." See this video for instance. Dr. Pal says coffee is not good for the liver because there is no "good evidence" for it. And talks about polysaccharides in coffee that gets converted to short chain fatty acids that improve gut health. He then finally suggests that one cup of coffee before 4PM is good enough and prevents "further adverse effects of coffee." This man is dangerously peddling misinformation on a well studied and documented dietary intervention that spans decades - and in the form of large scale epidemiological studies and metanalysis of such studies, featuring more than 600,000 patients across the world. First, coffee related polysaccharides DOES NOT improve "gut health" - this has been shown in multiple studies from 2007 to 2018. The change of polysaccharides in coffee to short chain fatty acids is negligible and the effect of that on gut bacteria is also not signficant. "The growth of bifidobacteria and lactobacilli (good bacteria) was not stimulated by coffee - "However, caffeine and chlorogenic acid partially improved the disrupted short-chain fatty acid profile in mice, although coffee had no effects." - It is not polysaccharides, but the polyenols in coffee that is beneficial for the liver. This is independent of caffeine content and hence decaff is also healthy option for the liver. See here: In 2016 and 2017 the Institute for Scientific Information on Coffee in association with the British Liver Trust published a report that concluded that: - Regularly drinking moderate amounts of coffee may prevent liver cancer – which was reviewed by WHO and confirmed this reduced risk after reviewing more than 1,000 studies in humans - Coffee also lowers the risk of other liver conditions including fibrosis (scar tissue that builds up within the liver) and cirrhosis - Drinking coffee can slow the progression of liver disease in some patients - Beneficial effects have been found however the coffee is prepared – filtered, instant and espresso See here: In 2021, A large epidemiological study based on data from the UK Biobank in 384,818 people showed that all coffee types decrease the risk of adverse clinical outcomes in chronic liver disease. See here: In 2022, a nationally representative study from the USA showed in 4510 subjects, 20 years and older showed that coffee intake was associated with lower liver stiffness (scarring). See here: In 2023, the Canadian Liver Foundation noted in their release that one cup of black coffee a day could lower the risk of chronic liver disease by 15 per cent. About three to four cups a day can reduce the risk to 71 per cent - so the recommendation is at least 3 cups of black coffee without sugar & milk daily. The experts said that: “The great thing is it doesn’t really matter what way the coffee’s prepared. It can be decaf; it can be caffeinated. It can also be drip, French press, espresso, filtered, (and) instant. All the ways (show) that black coffee is effective for liver health.” See here: The American Liver Foundation advises including coffee in your diet to improve clinical outcomes in patients with fatty liver disease. See here: To avoid reductions in total sleep time, the last cup of coffee (the third cup, ideally 150ml in Indian standard) should be consumed at least 8 hours prior to bedtime. See here: These are just scratching the surface of evidence on benefits of coffee on the liver. And there is lack of evidence? What the mind does not know, the eyes cannot see. One cup of coffee before 4 PM? So lame. What is worse than pseudoscientific garbage like Homeopathy? - Legit doctors without a scientific temperament who misinform consistently. A legit bigger pain in the a** than Ayurveda and Homeopathy. Disclosure: I do not own stocks in any coffee company and have no involvement with the coffee industry and do not receive payments or honorarium from coffee industry stakeholders.

TheLiverDoc™

668,293 Aufrufe • vor 2 Jahren

Vitamin D supplementation was associated with a 40% lower risk of dementia over a decade. After five years, 84% of supplement users were dementia-free compared to just 68% of non-users in a study of over 12,000 people. Vitamin D reduced dementia risk by 33% in adults with mild cognitive impairment or APOE e4, a key genetic risk factor for neurodegenerative diseases. Vitamin D isn’t just a vitamin—it's a steroid hormone regulating over 2,000 genes critical for brain development, neuroplasticity, and inflammation control. Its roles include clearing amyloid beta plaques and tau buildup, boosting neuron survival via neurotrophic factors like BDNF, and enhancing brain connectivity, particularly when paired with exercise. It’s no surprise, then, that higher vitamin D levels are associated with better cognition, larger hippocampal volume, and lower Alzheimer’s risk. Multiple lines of evidence support this. More than 30 large studies have consistently linked low vitamin D levels to a 50–150% increased dementia risk. People genetically prone to low vitamin D—those with genetic variations affecting vitamin D production or metabolism—have a 54% higher dementia risk. Furthermore, supplementing with 800 IU/day of vitamin D improves memory and cognitive function in people with mild cognitive impairment and more serious forms of dementia. To learn more about optimizing vitamin D levels for cognitive health, including underlying brain-protective mechanisms and practical supplementation protocols, see the latest FoundMyFitness video. Link in comments.

Dr. Rhonda Patrick

245,418 Aufrufe • vor 1 Jahr