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📽️ Can NVIDIA help solve aging? That question became Rentosertib. Not starting from a disease. Starting from aging biology. PandaOmics identified TNIK as a target connecting aging and fibrosis. Generative chemistry designed the molecule. Target to preclinical candidate in 18 months. Phase 1, Phase 2A, now Phase 3. And...

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Insilico Medicine

14,940 subscribers

32,535 Aufrufe • vor 7 Tagen •via X (Twitter)

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3 Kommentare

Profilbild von SignalMed AI
SignalMed AIvor 7 Tagen

Worth keeping in view: the dose with the best FVC was not the dose with the strongest clock shift, which is why the lung and the clocks are still tangled.

Profilbild von Wanderer of the Stars
Wanderer of the Starsvor 7 Tagen

This is where the rubber hits the road for LEV.

Profilbild von Tahoeguym
Tahoeguymvor 7 Tagen

Question: are you or are other companies applying your protocol on measuring aging with other drugs? I wonder about metformin, GLP-1, rapamycin in testing for these biomarkers?

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Aubrey de Grey says defeating age-related diseases ultimately means treating aging itself. - We need to make aging the new COVID. - Mark Zuckerberg said the CCI is going to cure all diseases. - The real challenge is curing the biological damage that causes aging. - Scientific breakthroughs often arrive much faster than expected once the right technologies emerge. - AI is already accelerating biology, from protein structure prediction to drug discovery. - Aging is fundamentally a resource allocation problem. - COVID proved that when governments remove bureaucracy and invest at scale, medical progress can happen in record time. - Aging research has been chronically underfunded. If it became a global priority, progress could accelerate dramatically. Aubrey's message is clear: Don't plan to die from aging. Do everything possible to stay healthy long enough to benefit from future breakthroughs.
3:41

Aubrey de Grey says defeating age-related diseases ultimately means treating aging itself. - We need to make aging the new COVID. - Mark Zuckerberg said the CCI is going to cure all diseases. - The real challenge is curing the biological damage that causes aging. - Scientific breakthroughs often arrive much faster than expected once the right technologies emerge. - AI is already accelerating biology, from protein structure prediction to drug discovery. - Aging is fundamentally a resource allocation problem. - COVID proved that when governments remove bureaucracy and invest at scale, medical progress can happen in record time. - Aging research has been chronically underfunded. If it became a global priority, progress could accelerate dramatically. Aubrey's message is clear: Don't plan to die from aging. Do everything possible to stay healthy long enough to benefit from future breakthroughs.

SciTech Era

17,777 Aufrufe • vor 2 Monaten

🧬 Rentosertib went from an AI-designed molecule to patients and recently showed shifts toward younger predicted biological age across 6 proteomic aging clocks. The first experiment is done. Now you can try our new SOTA+ drug discovery models yourself. InsilicoMMAI-Chem-ADMET achieves SOTA+ performance on 7 drug safety and metabolism prediction tasks. 🚀 It’s a 4B language model trained on 140K+ datapoints in our MMAI Gym for Science. #insilicoSOTAFM
0:23

🧬 Rentosertib went from an AI-designed molecule to patients and recently showed shifts toward younger predicted biological age across 6 proteomic aging clocks. The first experiment is done. Now you can try our new SOTA+ drug discovery models yourself. InsilicoMMAI-Chem-ADMET achieves SOTA+ performance on 7 drug safety and metabolism prediction tasks. 🚀 It’s a 4B language model trained on 140K+ datapoints in our MMAI Gym for Science. #insilicoSOTAFM

Insilico Medicine

18,487 Aufrufe • vor 9 Tagen

Hello, my dear friends, we have some breaking news today! Our rentosertib (novel target that has never been in clinical trials before we picked it using AI, novel molecule designed using true generative AI with the published broadly used AI platform, targeting fibrosis and biology of aging) entered Phase III trial in Idiopathic Pulmonary Fibrosis. This is a major milestone in the life of every drug hunter - the ultimate test. To my knowledge, in our AI drug discovery industry, no other company took the drug for a novel target with a novel molecule into Phase III before so it is a big milestone for the entire industry. Of course, at Insilico we are no longer dependent on this program - we have 13 INDs and many clinical trials are ongoing internally and run by partners. But this program is very special as we also demonstrated the senomorphic properties of this drug and built the entire pipeline of molecules around this target. Please Wish Me Luck! Luck is the most important superpower in everything we do and if we succeed with this program and also demonstrate the antiaging effect - all of us will benefit. Godspeed, my friends and thanks to everyone who helped us along the way!
2:26

Hello, my dear friends, we have some breaking news today! Our rentosertib (novel target that has never been in clinical trials before we picked it using AI, novel molecule designed using true generative AI with the published broadly used AI platform, targeting fibrosis and biology of aging) entered Phase III trial in Idiopathic Pulmonary Fibrosis. This is a major milestone in the life of every drug hunter - the ultimate test. To my knowledge, in our AI drug discovery industry, no other company took the drug for a novel target with a novel molecule into Phase III before so it is a big milestone for the entire industry. Of course, at Insilico we are no longer dependent on this program - we have 13 INDs and many clinical trials are ongoing internally and run by partners. But this program is very special as we also demonstrated the senomorphic properties of this drug and built the entire pipeline of molecules around this target. Please Wish Me Luck! Luck is the most important superpower in everything we do and if we succeed with this program and also demonstrate the antiaging effect - all of us will benefit. Godspeed, my friends and thanks to everyone who helped us along the way!

Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)

49,660 Aufrufe • vor 2 Monaten

I love this take. Elon Musk looks at aging like an engineer, not like a mystic. Exactly the same mindset as Aubrey de Grey. Core ideas that really hit: •Aging is not chaos. The whole body degrades in sync, so there must be a central mechanism. •If everything decays together, there is a biological clock or program behind it. •Programs can be rewritten. Aging is not destiny, it is code. •Other species already solved it. Whales reach 200 years, Greenland sharks up to 500. •That means it is not magic. It is biology and engineering. What I truly hope: •That Elon uses his capital, influence, and engineering culture to seriously push aging research. •If not full lifespan extension, then at least curing age related diseases. •Cancer, neurodegeneration, cardiovascular decay should be optional, not inevitable. If aging is engineered, it can be reverse engineered. That idea alone changes everything.
1:15

I love this take. Elon Musk looks at aging like an engineer, not like a mystic. Exactly the same mindset as Aubrey de Grey. Core ideas that really hit: •Aging is not chaos. The whole body degrades in sync, so there must be a central mechanism. •If everything decays together, there is a biological clock or program behind it. •Programs can be rewritten. Aging is not destiny, it is code. •Other species already solved it. Whales reach 200 years, Greenland sharks up to 500. •That means it is not magic. It is biology and engineering. What I truly hope: •That Elon uses his capital, influence, and engineering culture to seriously push aging research. •If not full lifespan extension, then at least curing age related diseases. •Cancer, neurodegeneration, cardiovascular decay should be optional, not inevitable. If aging is engineered, it can be reverse engineered. That idea alone changes everything.

VraserX e/acc

391,541 Aufrufe • vor 8 Monaten

Elon Musk tells BlackRock CEO Larry Fink at the World Economic Forum that he believes we will be able to slow down and even reverse aging Larry Fink “Can you and I reverse aging in this new history, are we going to see it?” Elon Musk “ It is a very solvable problem — I think when we figure out what causes aging, I think we'll find it's incredibly obvious. It's not a subtle thing. The reason I say it's not a subtle thing is because all the cells in your body pretty much age at the same rate. I've never seen someone with an old left arm and a young right arm ever in my life. So why is that? That means that there must be a clock, a synchronizing clock, that is synchronizing across 35 trillion cells in your body — I think we'll figure out ways to extend life and maybe even reverse aging? I think that's highly likely.” Larry Fink “I'm looking forward to that.”
1:44

Elon Musk tells BlackRock CEO Larry Fink at the World Economic Forum that he believes we will be able to slow down and even reverse aging Larry Fink “Can you and I reverse aging in this new history, are we going to see it?” Elon Musk “ It is a very solvable problem — I think when we figure out what causes aging, I think we'll find it's incredibly obvious. It's not a subtle thing. The reason I say it's not a subtle thing is because all the cells in your body pretty much age at the same rate. I've never seen someone with an old left arm and a young right arm ever in my life. So why is that? That means that there must be a clock, a synchronizing clock, that is synchronizing across 35 trillion cells in your body — I think we'll figure out ways to extend life and maybe even reverse aging? I think that's highly likely.” Larry Fink “I'm looking forward to that.”

Wall Street Apes

489,664 Aufrufe • vor 7 Monaten

My friends, I would like to report a true breakthrough in my life and career - the nomination of our 31st developmental candidate that is very special. Novel Mechanism, Novel Target, Novel Oral Brain-penetrant Multi-parameter Optimized Molecule for... Pain. The target is undisclosed and carries the first letter of my family name - Target Z. This is also our AI Eureka! Moment - the combination of Luck, AI, and curious human experts. I will post the press release and my blog story behind this drug separately but for this special moment, I recorded the video for you. My goal is to solve aging. But if in the process we solve pain - this life was also worth living. The beauty of Target Z is that it is also implicated in aging (and no, it is not our brain-penetrant NLRP3).
8:54

My friends, I would like to report a true breakthrough in my life and career - the nomination of our 31st developmental candidate that is very special. Novel Mechanism, Novel Target, Novel Oral Brain-penetrant Multi-parameter Optimized Molecule for... Pain. The target is undisclosed and carries the first letter of my family name - Target Z. This is also our AI Eureka! Moment - the combination of Luck, AI, and curious human experts. I will post the press release and my blog story behind this drug separately but for this special moment, I recorded the video for you. My goal is to solve aging. But if in the process we solve pain - this life was also worth living. The beauty of Target Z is that it is also implicated in aging (and no, it is not our brain-penetrant NLRP3).

Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)

60,640 Aufrufe • vor 1 Monat

New episode with Dr. Steve Horvath (Prof Steve Horvath), a pioneer in the field of epigenetic aging clocks. Steve developed the original Horvath clock, one of the first tools to show that DNA methylation carries a remarkably reliable signal of aging across human tissues. In this episode, he explains what biological clocks actually measure, why different clocks can disagree, and how to interpret a biological-age result without treating it like a literal lifespan forecast. We talk about chronological age vs. biological age, and we also get into the intervention evidence on exercise and VO2 max, calorie restriction, omega-3s, vitamin D, multivitamins, and weight loss/GLP-1 therapy, among other topics! The big theme is that biological clocks can be useful dashboards, but they are not diagnoses, fortune-telling tools, or proof that one supplement has reversed aging. This was Steve's second appearance on the podcast and he did not disappoint. You won't want to miss this episode. Links to the episode on all platforms in the comments below. Timestamps: 0:00 - Introduction 1:59 - Biological vs. chronological age 7:33 - Why one clock isn't enough 13:16 - PhenoAge vs. GrimAge 15:21 - GrimAge & mortality risk 19:04 - Epigenome as stress memory 23:02 - Can stress be inherited? 25:06 - Why clocks fail in sperm 26:30 - Can lifestyle reverse GrimAge? 28:18 - DunedinPACE as an odometer 32:20 - Judging longevity interventions 34:41 - Clocks as mortality surrogates 38:28 - Most validated interventions 41:25 - 5 years younger in 7 months? 45:43 - Can GrimAge predict death? 47:30 - Translating GrimAge to lifespan 52:16 - Blind spots of aging clocks 58:20 - More than inflammation 1:00:56 - Young blood, transient effects 1:04:46 - Calorie restriction 1:08:54 - GLP-1 drugs & weight loss 1:12:24 - Can a multivitamin slow aging? 1:21:05 - Omega-3, vitamin D, & exercise 1:28:55 - Removing an aging accelerator 1:31:24 - Vegetables vs. exercise 1:36:58 - Does red meat age you? 1:38:38 - Hard training moves the clock 1:45:59 - Heat as an exercise mimetic 1:47:23 - When cold slows the clock 1:49:48 - Does poor sleep speed aging? 1:51:19 - Can friendship slow aging? 1:57:49 - Are consumer tests worth it? 2:02:46 - Choosing a reliable test 2:07:33 - Different clocks, different lenses 2:12:21 - Can AI build better clocks? 2:13:53 - Partial reprogramming 2:17:47 - What reprogramming can't fix 2:22:37 - Do DNA mutations drive aging? 2:24:53 - The silver bullet problem 2:29:23 - Limits of polygenic risk 2:33:32 - Steve's longevity routine 2:38:05 - How stress affects aging
2:39:14

New episode with Dr. Steve Horvath (Prof Steve Horvath), a pioneer in the field of epigenetic aging clocks. Steve developed the original Horvath clock, one of the first tools to show that DNA methylation carries a remarkably reliable signal of aging across human tissues. In this episode, he explains what biological clocks actually measure, why different clocks can disagree, and how to interpret a biological-age result without treating it like a literal lifespan forecast. We talk about chronological age vs. biological age, and we also get into the intervention evidence on exercise and VO2 max, calorie restriction, omega-3s, vitamin D, multivitamins, and weight loss/GLP-1 therapy, among other topics! The big theme is that biological clocks can be useful dashboards, but they are not diagnoses, fortune-telling tools, or proof that one supplement has reversed aging. This was Steve's second appearance on the podcast and he did not disappoint. You won't want to miss this episode. Links to the episode on all platforms in the comments below. Timestamps: 0:00 - Introduction 1:59 - Biological vs. chronological age 7:33 - Why one clock isn't enough 13:16 - PhenoAge vs. GrimAge 15:21 - GrimAge & mortality risk 19:04 - Epigenome as stress memory 23:02 - Can stress be inherited? 25:06 - Why clocks fail in sperm 26:30 - Can lifestyle reverse GrimAge? 28:18 - DunedinPACE as an odometer 32:20 - Judging longevity interventions 34:41 - Clocks as mortality surrogates 38:28 - Most validated interventions 41:25 - 5 years younger in 7 months? 45:43 - Can GrimAge predict death? 47:30 - Translating GrimAge to lifespan 52:16 - Blind spots of aging clocks 58:20 - More than inflammation 1:00:56 - Young blood, transient effects 1:04:46 - Calorie restriction 1:08:54 - GLP-1 drugs & weight loss 1:12:24 - Can a multivitamin slow aging? 1:21:05 - Omega-3, vitamin D, & exercise 1:28:55 - Removing an aging accelerator 1:31:24 - Vegetables vs. exercise 1:36:58 - Does red meat age you? 1:38:38 - Hard training moves the clock 1:45:59 - Heat as an exercise mimetic 1:47:23 - When cold slows the clock 1:49:48 - Does poor sleep speed aging? 1:51:19 - Can friendship slow aging? 1:57:49 - Are consumer tests worth it? 2:02:46 - Choosing a reliable test 2:07:33 - Different clocks, different lenses 2:12:21 - Can AI build better clocks? 2:13:53 - Partial reprogramming 2:17:47 - What reprogramming can't fix 2:22:37 - Do DNA mutations drive aging? 2:24:53 - The silver bullet problem 2:29:23 - Limits of polygenic risk 2:33:32 - Steve's longevity routine 2:38:05 - How stress affects aging

Dr. Rhonda Patrick

87,613 Aufrufe • vor 3 Monaten

🚨David Sinclair: “The first potential human age-reversal technology is in people right now.” ROGAN: “What is the current state of science as applied to longevity treatments?” SINCLAIR: “We have a human clinical trial.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “My colleagues and I found that aging has a root cause that’s the same in pretty much every cell in the body, and that we could control that.” “In 2020, we had a big publication that showed we could actually safely, for the first time, reverse that process, like reinstalling software in the cell to make it work again.” ---- The treatment is ER-100, an experimental epigenetic reprogramming gene therapy being developed by Life Biosciences, a company co-founded by Harvard geneticist Dr. David Sinclair. In the current FDA clinical trial, the therapy is delivered by injection into the eye. If this works in humans, it could be a major step toward actually reversing aspects of biological aging rather than simply slowing them down. Joe Rogan David Sinclair
3:56

🚨David Sinclair: “The first potential human age-reversal technology is in people right now.” ROGAN: “What is the current state of science as applied to longevity treatments?” SINCLAIR: “We have a human clinical trial.” ROGAN: “If people get old and we understand the mechanism, why couldn’t we reverse it?” SINCLAIR: “My colleagues and I found that aging has a root cause that’s the same in pretty much every cell in the body, and that we could control that.” “In 2020, we had a big publication that showed we could actually safely, for the first time, reverse that process, like reinstalling software in the cell to make it work again.” ---- The treatment is ER-100, an experimental epigenetic reprogramming gene therapy being developed by Life Biosciences, a company co-founded by Harvard geneticist Dr. David Sinclair. In the current FDA clinical trial, the therapy is delivered by injection into the eye. If this works in humans, it could be a major step toward actually reversing aspects of biological aging rather than simply slowing them down. Joe Rogan David Sinclair

KanekoaTheGreat

1,234,890 Aufrufe • vor 1 Monat

ER100 is a new drug and potential gene therapy currently in its first clinical trial with 12 participants. The mechanism is not symptom management and not disease treatment. It targets the biological switch at the cellular level, instructing cells to revert to a different functional state. Conventional medicine has been built around treating disease after it occurs. This approach aims to reverse the biological aging process that underlies disease development. The trial is early and the sample size is small, but if the mechanism holds, the implications for human health and longevity are unlike anything medicine has produced. This conversation is worth following closely.
0:27

ER100 is a new drug and potential gene therapy currently in its first clinical trial with 12 participants. The mechanism is not symptom management and not disease treatment. It targets the biological switch at the cellular level, instructing cells to revert to a different functional state. Conventional medicine has been built around treating disease after it occurs. This approach aims to reverse the biological aging process that underlies disease development. The trial is early and the sample size is small, but if the mechanism holds, the implications for human health and longevity are unlike anything medicine has produced. This conversation is worth following closely.

Dr. Gabrielle Lyon

13,681 Aufrufe • vor 2 Monaten

AGING IS A PROGRAM, NOT YOUR DESTINY - You don’t grow old — you’re taught to. - Your body regenerates every seven years. - Every cell renews itself. - So why do we still age? Because belief becomes biology. - The environment, the jokes, the rituals, the “anti-aging” industry — they’re all emotional contracts with decline. - But you weren’t built to decay. You were built to remember. - You were designed from an eternal life architecture — a 12-strand DNA template that holds the original blueprint of immortality. - When you feed your cells truth instead of fear, they start to remember their divine design. - Aging isn’t natural. It’s learned. - And when you exit the death program, your biology stops obeying it. - Eternal life isn’t a miracle — it’s your original code. - And it’s waiting for you to reactivate it. - I’ve created a rapid 12-strand DNA activation program to help you remember and embody this divine blueprint. ✨🙌🏾💫 © Samuel Lee
2:01

AGING IS A PROGRAM, NOT YOUR DESTINY - You don’t grow old — you’re taught to. - Your body regenerates every seven years. - Every cell renews itself. - So why do we still age? Because belief becomes biology. - The environment, the jokes, the rituals, the “anti-aging” industry — they’re all emotional contracts with decline. - But you weren’t built to decay. You were built to remember. - You were designed from an eternal life architecture — a 12-strand DNA template that holds the original blueprint of immortality. - When you feed your cells truth instead of fear, they start to remember their divine design. - Aging isn’t natural. It’s learned. - And when you exit the death program, your biology stops obeying it. - Eternal life isn’t a miracle — it’s your original code. - And it’s waiting for you to reactivate it. - I’ve created a rapid 12-strand DNA activation program to help you remember and embody this divine blueprint. ✨🙌🏾💫 © Samuel Lee

🧬Maxpein🧬

58,680 Aufrufe • vor 11 Monaten

In 2026, it's quite likely that a pill will hit the market which makes dogs live longer. This is a big deal for many reasons. The pill will come from Loyal and Celine Halioua. And they have more therapies in the pipeline. In this episode, we chat about Celine's life and career and Loyal's unique work in the longevity field. The Core Memory podcast - which makes people smarter - is brought to you by the finance wizards at Brex and the genius investors E1 Ventures 🇺🇸. Enjoy! Timestamps 00:00 – Intro 02:47 – Why Start With Dogs 06:05 – Aging Science Explained 09:12 – Inside FDA Trials 13:18 – Designing a Longevity Drug 17:42 – Metabolism and Aging 22:35 – Lessons From Biotech 26:48 – Building Loyal 31:54 – From Neuroscience to Founder 38:19 – GLP-1 vs Longevity Drugs 43:28 – Ethics of Longer Life 49:44 – What Dog Data Shows 54:59 – Longevity Hype & Peptides 59:47 – Biotech Needs Artists 01:05:20 – Investor Hype vs Reality 01:11:35 – AI in Drug Discovery 01:17:49 – Future of Aging Research 01:23:05 – Dogs and the End of Aging
1:29:44

In 2026, it's quite likely that a pill will hit the market which makes dogs live longer. This is a big deal for many reasons. The pill will come from Loyal and Celine Halioua. And they have more therapies in the pipeline. In this episode, we chat about Celine's life and career and Loyal's unique work in the longevity field. The Core Memory podcast - which makes people smarter - is brought to you by the finance wizards at Brex and the genius investors E1 Ventures 🇺🇸. Enjoy! Timestamps 00:00 – Intro 02:47 – Why Start With Dogs 06:05 – Aging Science Explained 09:12 – Inside FDA Trials 13:18 – Designing a Longevity Drug 17:42 – Metabolism and Aging 22:35 – Lessons From Biotech 26:48 – Building Loyal 31:54 – From Neuroscience to Founder 38:19 – GLP-1 vs Longevity Drugs 43:28 – Ethics of Longer Life 49:44 – What Dog Data Shows 54:59 – Longevity Hype & Peptides 59:47 – Biotech Needs Artists 01:05:20 – Investor Hype vs Reality 01:11:35 – AI in Drug Discovery 01:17:49 – Future of Aging Research 01:23:05 – Dogs and the End of Aging

Ashlee Vance

63,172 Aufrufe • vor 10 Monaten

Vitamin D just got a serious upgrade. A new study found that taking 2,000 IU of vitamin D3 daily for four years significantly slowed telomere shortening — the biological countdown that accelerates aging and age-related diseases. Researchers saw clearer protection in adults 50+ compared to placebo. Omega-3s didn’t show the same effect. It’s not a miracle cure, but it adds real weight to vitamin D’s role in fighting inflammation and supporting healthier aging. Even short daily walks in daylight can help your body produce it naturally. What’s your take — are you already supplementing with vitamin D, or does this make you want to start?
1:28

Vitamin D just got a serious upgrade. A new study found that taking 2,000 IU of vitamin D3 daily for four years significantly slowed telomere shortening — the biological countdown that accelerates aging and age-related diseases. Researchers saw clearer protection in adults 50+ compared to placebo. Omega-3s didn’t show the same effect. It’s not a miracle cure, but it adds real weight to vitamin D’s role in fighting inflammation and supporting healthier aging. Even short daily walks in daylight can help your body produce it naturally. What’s your take — are you already supplementing with vitamin D, or does this make you want to start?

Camus

266,824 Aufrufe • vor 5 Monaten

Twenty years ago, Derya Unutmaz, MD predicted we would reverse aging by 2045. People thought he was crazy. Now, he thinks he was too conservative, and has moved the date up to 2040 because AGI arrived earlier than he expected. I sat down with Derya to ask if such bold predictions are too fatalistic. Is the future guaranteed? Shall we just sit back and wait for AI to save us? Derya disagreed. The golden age for humanity is within our sights, but there is much work to be done. Academia is failing us. If it doesn’t adapt to the pace of progress AI enables, we have no shot at curing aging this century. And we need to invest trillions into collecting the data that superintelligence will need to solve biology. If we pull it off, the future can be brighter than anyone imagines. Watch the full episode below, or look up Free Radicals (Free Radicals) on your favorite podcasting platform. Special thank you to Adam Gries and for hosting us at Vitalist Bay (May 14-17)! Intro AGI arrived early, accelerating the timeline to biosingularity Are we really in the takeoff now? Superintelligence can help us build a world model of biology Aging as the breakdown of biological resilience The case for investing trillions into biological data The economic return on curing aging AI is accelerating science but academics are stuck in the past How AI can liberate humanity from biological constraints Derya’s Human 2.0 dream Testing the latest OpenAI models and rethinking the PhD Agency, jobs, and free will in an AI world Science fiction & Derya’s case for a coming golden age
1:15:51

Twenty years ago, Derya Unutmaz, MD predicted we would reverse aging by 2045. People thought he was crazy. Now, he thinks he was too conservative, and has moved the date up to 2040 because AGI arrived earlier than he expected. I sat down with Derya to ask if such bold predictions are too fatalistic. Is the future guaranteed? Shall we just sit back and wait for AI to save us? Derya disagreed. The golden age for humanity is within our sights, but there is much work to be done. Academia is failing us. If it doesn’t adapt to the pace of progress AI enables, we have no shot at curing aging this century. And we need to invest trillions into collecting the data that superintelligence will need to solve biology. If we pull it off, the future can be brighter than anyone imagines. Watch the full episode below, or look up Free Radicals (Free Radicals) on your favorite podcasting platform. Special thank you to Adam Gries and for hosting us at Vitalist Bay (May 14-17)! Intro AGI arrived early, accelerating the timeline to biosingularity Are we really in the takeoff now? Superintelligence can help us build a world model of biology Aging as the breakdown of biological resilience The case for investing trillions into biological data The economic return on curing aging AI is accelerating science but academics are stuck in the past How AI can liberate humanity from biological constraints Derya’s Human 2.0 dream Testing the latest OpenAI models and rethinking the PhD Agency, jobs, and free will in an AI world Science fiction & Derya’s case for a coming golden age

Daniel Shur

54,731 Aufrufe • vor 1 Monat

If you want to meaningfully impact aging in America, start with obesity—few things erode longevity and quality of life as profoundly, accelerating the biological aging process and fueling nearly every major chronic disease. Obesity alone is linked to 13 types of cancer and cuts life expectancy by 3–10 years, depending on severity. It promotes DNA damage and accelerates our fundamental aging process—often measured by epigenetic age. It’s one of the principal differences between the U.S. and many of the world’s longest-lived nations. We’re overfed but undernourished. 60% of all calories Americans consume come from ultra-processed foods that: • Fail to induce proper satiety, pushing us to overeat. • Remain cheaper than whole foods, economically incentivizing the least healthy choices. • Hijack our dopamine reward pathways, reinforcing addictive eating behaviors. This trifecta—no satiety, low cost, and built-in addictiveness—keeps us in a cycle of poor health outcomes and runaway healthcare costs. But caloric excess is only part of the problem—we are also nutrient-deficient. Low omega-3 levels—affecting 80 to 90% of Americans—carry the same mortality risk as smoking. Vitamin D deficiency—easily corrected—compromises immune function, cognition, and longevity. Nearly half of Americans don't get enough magnesium—impairing DNA repair and increasing the risk of cancer. We are not solving these problems—we are medicating them. The average American over 65 takes five or more prescription drugs daily—stacking interactions that compound in unpredictable ways. We must start treating physical inactivity as a disease. It carries the same mortality risk as smoking, heart disease, and diabetes. Going from a low cardiorespiratory fitness to a low normal adds 2.1 years to life expectancy. By age 50, many Americans have already lost 10% of their peak muscle mass. By 70, many have lost up to 40%. This isn’t just about looking strong. It’s about survival. • Higher muscle mass means improved insulin sensitivity - it means a 30% lower mortality risk. • Grip strength is a stronger predictor of cardiovascular mortality - the number one cause of death in the United States - than high blood pressure. • The strongest middle-aged adults have a 42% lower dementia risk. And yet, we treat resistance training as optional. It is not. It is the most powerful intervention we have against aging including increasing muscle mass, strength and bone density. Hip fractures alone kill 20–60% of older adults within a year. This is a death sentence we can prevent with resistance training - which has been shown to lower fracture risk by 30-40%. The current RDA for protein is too low for older adults. Studies have shown when it's increased by half this reduces frailty by 32%, while doubling it, combined with resistance training, increases muscle mass by 27% and strength by 10% more than training alone. If we want to prevent muscle loss and frailty, we must update our protein recommendations and prioritize strength training. We must foster a culture of American exceptionalism built on daily, effortful exercise. Not as an afterthought. Not as a luxury. But as a non-negotiable foundation for aging, but also clear thinking, resilience, and even leadership. The body and brain are not separate. The consequences of poorly regulated blood sugar, sedentary living, and muscle loss are not just physical—they affect cognition, judgment, and resilience. We cannot medicate our way out of what we have behaved our way into. Grateful for the chance to share my voice at the Senate Aging Committee (Senate Aging Committee). A special thank you to Senator Rick Scott (Rick Scott) for making this opportunity possible.
4:37

If you want to meaningfully impact aging in America, start with obesity—few things erode longevity and quality of life as profoundly, accelerating the biological aging process and fueling nearly every major chronic disease. Obesity alone is linked to 13 types of cancer and cuts life expectancy by 3–10 years, depending on severity. It promotes DNA damage and accelerates our fundamental aging process—often measured by epigenetic age. It’s one of the principal differences between the U.S. and many of the world’s longest-lived nations. We’re overfed but undernourished. 60% of all calories Americans consume come from ultra-processed foods that: • Fail to induce proper satiety, pushing us to overeat. • Remain cheaper than whole foods, economically incentivizing the least healthy choices. • Hijack our dopamine reward pathways, reinforcing addictive eating behaviors. This trifecta—no satiety, low cost, and built-in addictiveness—keeps us in a cycle of poor health outcomes and runaway healthcare costs. But caloric excess is only part of the problem—we are also nutrient-deficient. Low omega-3 levels—affecting 80 to 90% of Americans—carry the same mortality risk as smoking. Vitamin D deficiency—easily corrected—compromises immune function, cognition, and longevity. Nearly half of Americans don't get enough magnesium—impairing DNA repair and increasing the risk of cancer. We are not solving these problems—we are medicating them. The average American over 65 takes five or more prescription drugs daily—stacking interactions that compound in unpredictable ways. We must start treating physical inactivity as a disease. It carries the same mortality risk as smoking, heart disease, and diabetes. Going from a low cardiorespiratory fitness to a low normal adds 2.1 years to life expectancy. By age 50, many Americans have already lost 10% of their peak muscle mass. By 70, many have lost up to 40%. This isn’t just about looking strong. It’s about survival. • Higher muscle mass means improved insulin sensitivity - it means a 30% lower mortality risk. • Grip strength is a stronger predictor of cardiovascular mortality - the number one cause of death in the United States - than high blood pressure. • The strongest middle-aged adults have a 42% lower dementia risk. And yet, we treat resistance training as optional. It is not. It is the most powerful intervention we have against aging including increasing muscle mass, strength and bone density. Hip fractures alone kill 20–60% of older adults within a year. This is a death sentence we can prevent with resistance training - which has been shown to lower fracture risk by 30-40%. The current RDA for protein is too low for older adults. Studies have shown when it's increased by half this reduces frailty by 32%, while doubling it, combined with resistance training, increases muscle mass by 27% and strength by 10% more than training alone. If we want to prevent muscle loss and frailty, we must update our protein recommendations and prioritize strength training. We must foster a culture of American exceptionalism built on daily, effortful exercise. Not as an afterthought. Not as a luxury. But as a non-negotiable foundation for aging, but also clear thinking, resilience, and even leadership. The body and brain are not separate. The consequences of poorly regulated blood sugar, sedentary living, and muscle loss are not just physical—they affect cognition, judgment, and resilience. We cannot medicate our way out of what we have behaved our way into. Grateful for the chance to share my voice at the Senate Aging Committee (Senate Aging Committee). A special thank you to Senator Rick Scott (Rick Scott) for making this opportunity possible.

Dr. Rhonda Patrick

407,681 Aufrufe • vor 1 Jahr

Forget Everything You've Been Told. Dr. Mark Hyman Says It's Possible to Reverse Diabetes, Heart Disease, and Alzheimer's We've been told Alzheimer's is incurable. A life sentence. But what if that's a relic of a broken, outdated medical model? Dr. Hyman reveals that while Big Pharma has spent over $2 billion on 400+ failed drug trials—resulting only in marginally effective, expensive treatments—a different path has proven radically successful. Aggressive lifestyle intervention can not only slow Alzheimer's... it can reverse it. This isn't speculation. It's published data from landmark trials like FINGER and POINTER. Pioneers like Dr. Richard Isaacson are demonstrating that by addressing diet, exercise, stress, sleep, and metabolic health, we can change the course of the disease. The key? Early detection. With new blood tests for Alzheimer's biomarkers, we no longer have to wait for symptoms like forgetting keys. We can see the warning signs and intervene when it matters most. Why isn't this front-page news? Dr. Hyman calls it a "medical paradigm shift." Most of medicine still operates in a "flat world," diagnosing by symptoms. The future is understanding the body as an integrated system. The implications are staggering. This systems-based approach applies to all chronic diseases—diabetes, heart disease, and even aging itself. By targeting the root causes of aging (inflammation, mitochondrial health, microbiome), we're not just adding years to life, but life to years. The system is ossified. But the science is clear. The power to prevent and reverse chronic disease is increasingly in our hands. It's time for medicine to catch up.
4:02

Forget Everything You've Been Told. Dr. Mark Hyman Says It's Possible to Reverse Diabetes, Heart Disease, and Alzheimer's We've been told Alzheimer's is incurable. A life sentence. But what if that's a relic of a broken, outdated medical model? Dr. Hyman reveals that while Big Pharma has spent over $2 billion on 400+ failed drug trials—resulting only in marginally effective, expensive treatments—a different path has proven radically successful. Aggressive lifestyle intervention can not only slow Alzheimer's... it can reverse it. This isn't speculation. It's published data from landmark trials like FINGER and POINTER. Pioneers like Dr. Richard Isaacson are demonstrating that by addressing diet, exercise, stress, sleep, and metabolic health, we can change the course of the disease. The key? Early detection. With new blood tests for Alzheimer's biomarkers, we no longer have to wait for symptoms like forgetting keys. We can see the warning signs and intervene when it matters most. Why isn't this front-page news? Dr. Hyman calls it a "medical paradigm shift." Most of medicine still operates in a "flat world," diagnosing by symptoms. The future is understanding the body as an integrated system. The implications are staggering. This systems-based approach applies to all chronic diseases—diabetes, heart disease, and even aging itself. By targeting the root causes of aging (inflammation, mitochondrial health, microbiome), we're not just adding years to life, but life to years. The system is ossified. But the science is clear. The power to prevent and reverse chronic disease is increasingly in our hands. It's time for medicine to catch up.

Camus

424,275 Aufrufe • vor 11 Monaten

Friedberg: New study shows enzyme reverses skin age from 70+ years to 31 Chamath: That’s a $2T market. Did Scientists Just Discover How to Reverse Skin Aging!? “CML is kind of the predominant molecule that gets formed in this extracellular matrix that's driving aging, and nothing breaks it down. So these scientists set out to try and create an enzyme, an enzyme is a protein that breaks something down, that can break down CML. And so these guys kind of went out and they took the target, which is CML, and tried to figure out, ‘Okay, how do we actually degrade CML, clear that extracellular matrix, and reverse aging?’ They started to test it on the proteins that we would find in our body, casein, collagen, retinal proteins, which are in your eye, hemoglobin, and they were able to get rid of 52 to 97% of the CML, just degrade it away. And then they found several sites where they were able to degrade over 90%. And then they took actual human skin from elderly patients that had donated their skin, and they put this enzyme onto that skin, and they were able to eliminate 55% of the CML on the skin, basically reverse the skin's age down to the age of a 31-year-old, this is from greater than 70-year-old patients, just by putting this enzyme on the skin. And so it's kind of a groundbreaking demonstration of combination of AlphaFold, what's called directed evolution, where you change the order of the DNA that changes the structure of the protein to test different proteins, do high throughput screening, and ultimately make a novel protein that doesn't exist in nature today that can do something pretty profound for human health.” Chamath: “It will be a trillion-dollar market. If you can create a cream…” Friedberg: “I mean, dude, if you could put this enzyme literally on your skin and have it absorb in…” Chamath: “Game over. That alone is $2 trillion.”
1:42

Friedberg: New study shows enzyme reverses skin age from 70+ years to 31 Chamath: That’s a $2T market. Did Scientists Just Discover How to Reverse Skin Aging!? “CML is kind of the predominant molecule that gets formed in this extracellular matrix that's driving aging, and nothing breaks it down. So these scientists set out to try and create an enzyme, an enzyme is a protein that breaks something down, that can break down CML. And so these guys kind of went out and they took the target, which is CML, and tried to figure out, ‘Okay, how do we actually degrade CML, clear that extracellular matrix, and reverse aging?’ They started to test it on the proteins that we would find in our body, casein, collagen, retinal proteins, which are in your eye, hemoglobin, and they were able to get rid of 52 to 97% of the CML, just degrade it away. And then they found several sites where they were able to degrade over 90%. And then they took actual human skin from elderly patients that had donated their skin, and they put this enzyme onto that skin, and they were able to eliminate 55% of the CML on the skin, basically reverse the skin's age down to the age of a 31-year-old, this is from greater than 70-year-old patients, just by putting this enzyme on the skin. And so it's kind of a groundbreaking demonstration of combination of AlphaFold, what's called directed evolution, where you change the order of the DNA that changes the structure of the protein to test different proteins, do high throughput screening, and ultimately make a novel protein that doesn't exist in nature today that can do something pretty profound for human health.” Chamath: “It will be a trillion-dollar market. If you can create a cream…” Friedberg: “I mean, dude, if you could put this enzyme literally on your skin and have it absorb in…” Chamath: “Game over. That alone is $2 trillion.”

The All-In Podcast

2,983,249 Aufrufe • vor 2 Monaten

David Sinclair says rapamycin had no measurable effect on slowing or reversing epigenetic aging in humans. This was a drug most of the longevity community supported. He was even a believer of it. It was found to extend lifespan in: • Inbred lab animals • Seemingly in dogs And everyone assumed it would translate to humans. Then a study came out about 6 months ago that compared the effect of different interventions on epigenetic age across multiple clinical trials. The results: • Caloric restriction = worked really well • Acarbose = worked really well • Metformin = "looked better than I thought it would" • Rapamycin = no effect on the age of the epigenome Zero. Nothing. Sinclair now takes rapamycin just four times a year while monitoring whether even that makes a difference. The most hyped longevity drug is being deprioritized by the scientist who is actually reversing aging. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.
1:02

David Sinclair says rapamycin had no measurable effect on slowing or reversing epigenetic aging in humans. This was a drug most of the longevity community supported. He was even a believer of it. It was found to extend lifespan in: • Inbred lab animals • Seemingly in dogs And everyone assumed it would translate to humans. Then a study came out about 6 months ago that compared the effect of different interventions on epigenetic age across multiple clinical trials. The results: • Caloric restriction = worked really well • Acarbose = worked really well • Metformin = "looked better than I thought it would" • Rapamycin = no effect on the age of the epigenome Zero. Nothing. Sinclair now takes rapamycin just four times a year while monitoring whether even that makes a difference. The most hyped longevity drug is being deprioritized by the scientist who is actually reversing aging. — David Sinclair (David Sinclair) on Peter Diamandis' (Peter H. Diamandis, MD) Moonshots podcast PS. David Sinclair is speaking at SynBioBeta on May 6th this year, discussing the science of slowing and reversing aging. If longevity is the world you're in, the investors, partners, and scientists shaping this space will be in the room. Grab your ticket in the comments below.

John Cumbers

21,184 Aufrufe • vor 5 Monaten

Today’s guest on the Free Radicals podcast is José Luis Ricón Fernández de la Puente, head of theory Retro Biosciences and blogger Jose is a prolific blogger, covering a wide breadth of topics across economics, philosophy, progress studies, science funding, much more, and of course longevity. His works have been published by a16z, Works in Progress and Adam Smith Institute. Our conversation is wide ranging, spanning a deep dive on Retro’s work to replace and engineer microglia to rejuvenate the brain and how our cells have the ability to turn back the aging clock but choose not to. We also covered the technological stagnation and why biological engineering is the new frontier of progress, as well as philosophical topics like transhumanism and how a future of total biological control might impact our values and way of life. Be sure to follow me and Eric Dai to stay up to date on the latest news in longevity biotech! And Special thank you to NFX & omri_drory for lending us their beautiful podcasting studio! 0:00 Intro 2:49 What is aging & why cells have a tough choice to make 9:02 When cells choose to reverse aging themselves 12:43 Cellular vs Organismal Aging & the magic wand experiment 18:31 What is reprogramming 22:40 How reprogramming plays a role in DNA damage repair 25:42 Do we already know how to cure aging? FOXO3! 28:37 How to cut through the complexity of interconnected biology 32:32 Why transcription factors are so great for intervening 36:49 Does a rejuvenation program exist already in the genome 38:51 Michael Levin: from thinking in terms of genes to morphogenesis 48:14 Tech stagnation and why physics is cooked 55:03 Why doesn't the world look more futuristic 57:26 Transhumanism & asking ourselves what we want out of life 1:05:34 Do we need war for technological progress 1:09:31 Government role in science funding 1:15:06 How Jose became the Head of Theory at Retro 1:24:53 How AI might put software engineers out of a job, and push them towards biotech 1:27:28 What it takes to get a flywheel in biotech 1:29:04 Rejuvenation vs Prevention 1:34:23 Aging is the coolest hardest problem to work on 1:36:09 What does it take to cure aging 1:42:25 Delivery mechanisms for genetic therapies 1:48:53 Retro's work to replace microglia and engineer them outside the body 1:59:10 Consciousness 2:00:39 Jose's Origin Story
2:05:48

Today’s guest on the Free Radicals podcast is José Luis Ricón Fernández de la Puente, head of theory Retro Biosciences and blogger Jose is a prolific blogger, covering a wide breadth of topics across economics, philosophy, progress studies, science funding, much more, and of course longevity. His works have been published by a16z, Works in Progress and Adam Smith Institute. Our conversation is wide ranging, spanning a deep dive on Retro’s work to replace and engineer microglia to rejuvenate the brain and how our cells have the ability to turn back the aging clock but choose not to. We also covered the technological stagnation and why biological engineering is the new frontier of progress, as well as philosophical topics like transhumanism and how a future of total biological control might impact our values and way of life. Be sure to follow me and Eric Dai to stay up to date on the latest news in longevity biotech! And Special thank you to NFX & omri_drory for lending us their beautiful podcasting studio! 0:00 Intro 2:49 What is aging & why cells have a tough choice to make 9:02 When cells choose to reverse aging themselves 12:43 Cellular vs Organismal Aging & the magic wand experiment 18:31 What is reprogramming 22:40 How reprogramming plays a role in DNA damage repair 25:42 Do we already know how to cure aging? FOXO3! 28:37 How to cut through the complexity of interconnected biology 32:32 Why transcription factors are so great for intervening 36:49 Does a rejuvenation program exist already in the genome 38:51 Michael Levin: from thinking in terms of genes to morphogenesis 48:14 Tech stagnation and why physics is cooked 55:03 Why doesn't the world look more futuristic 57:26 Transhumanism & asking ourselves what we want out of life 1:05:34 Do we need war for technological progress 1:09:31 Government role in science funding 1:15:06 How Jose became the Head of Theory at Retro 1:24:53 How AI might put software engineers out of a job, and push them towards biotech 1:27:28 What it takes to get a flywheel in biotech 1:29:04 Rejuvenation vs Prevention 1:34:23 Aging is the coolest hardest problem to work on 1:36:09 What does it take to cure aging 1:42:25 Delivery mechanisms for genetic therapies 1:48:53 Retro's work to replace microglia and engineer them outside the body 1:59:10 Consciousness 2:00:39 Jose's Origin Story

Daniel Shur

13,644 Aufrufe • vor 6 Monaten

"We are witnessing a revolution of what it means to be diseased." Zavain Dar believes biotech is entering a new era where conditions once dismissed as behavioral or insignificant are becoming major targets for new drugs. "10 or 15 years ago, pharma and biotech didn't invest in [obesity] because they didn't consider it a disease. They considered a behavioral problem. Today, it's considered a disease and [GLP-1s] are the largest class of drug on the planet." "In areas like aging and longevity, inflammation, and immunology, 20 years ago, no one would touch that because skin related diseases weren't considered serious enough. So we are starting to see a redefinition of the types of areas where biotech and pharma can actually play."
1:20

"We are witnessing a revolution of what it means to be diseased." Zavain Dar believes biotech is entering a new era where conditions once dismissed as behavioral or insignificant are becoming major targets for new drugs. "10 or 15 years ago, pharma and biotech didn't invest in [obesity] because they didn't consider it a disease. They considered a behavioral problem. Today, it's considered a disease and [GLP-1s] are the largest class of drug on the planet." "In areas like aging and longevity, inflammation, and immunology, 20 years ago, no one would touch that because skin related diseases weren't considered serious enough. So we are starting to see a redefinition of the types of areas where biotech and pharma can actually play."

TBPN

42,345 Aufrufe • vor 1 Monat

David Sinclair just announced at the World Government Summit that next month (March 2026), human clinical trials begin — the first in history to test whether we can reverse aging and cure diseases. His core claim: Aging isn't wear-and-tear like a car; it's like scratches on a CD. DNA is the music, but in old age, cells can't read it correctly — leading to confusion, wrong proteins, and disease. The breakthrough? They can "polish the CD" via partial epigenetic reprogramming (using Yamanaka factors like OSK) to restore youthful gene expression without altering DNA itself. Science nugget: In lab and animal studies (published 2020–2025), Sinclair's team reversed epigenetic age by up to 75% in six weeks in mouse optic nerves, restoring vision in blind animals. The approach reactivates youthful gene patterns while avoiding full cellular reprogramming risks like tumors. Current status: The FDA cleared Life Biosciences' Phase 1 trial (ER-100, Sinclair co-founded) in January 2026 for safety in patients with optic neuropathies (e.g., glaucoma, NAION). Enrollment starts soon, with initial results expected by late 2026/early 2027. This targets eye disease first — not whole-body aging — but success could open doors to broader rejuvenation. Sinclair envisions a future where kids with cancer gather under gentle plasma lights that shatter tumors painlessly, one cell at a time. Sci-fi becoming science fact? Are you hopeful this trial delivers — or skeptical it's overhyped?
2:18

David Sinclair just announced at the World Government Summit that next month (March 2026), human clinical trials begin — the first in history to test whether we can reverse aging and cure diseases. His core claim: Aging isn't wear-and-tear like a car; it's like scratches on a CD. DNA is the music, but in old age, cells can't read it correctly — leading to confusion, wrong proteins, and disease. The breakthrough? They can "polish the CD" via partial epigenetic reprogramming (using Yamanaka factors like OSK) to restore youthful gene expression without altering DNA itself. Science nugget: In lab and animal studies (published 2020–2025), Sinclair's team reversed epigenetic age by up to 75% in six weeks in mouse optic nerves, restoring vision in blind animals. The approach reactivates youthful gene patterns while avoiding full cellular reprogramming risks like tumors. Current status: The FDA cleared Life Biosciences' Phase 1 trial (ER-100, Sinclair co-founded) in January 2026 for safety in patients with optic neuropathies (e.g., glaucoma, NAION). Enrollment starts soon, with initial results expected by late 2026/early 2027. This targets eye disease first — not whole-body aging — but success could open doors to broader rejuvenation. Sinclair envisions a future where kids with cancer gather under gentle plasma lights that shatter tumors painlessly, one cell at a time. Sci-fi becoming science fact? Are you hopeful this trial delivers — or skeptical it's overhyped?

Camus

22,434 Aufrufe • vor 6 Monaten