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David Friedberg david friedberg: Anthropic is trying to commoditize everyone's business. Friedberg, a life-sciences CEO and All-In host, sat in on Anthropic's enterprise pitch to biotech: share your proprietary data, get model access. Nearly every company he spoke with reached the same conclusion - sharing the data makes Anthropic's...

51,986 views • 1 month ago •via X (Twitter)

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Big pharma just handed the AI industry one of the most important reality checks of 2026 (Save this). david friedberg revealed that Anthropic approached major life sciences companies with a pitch, share your proprietary data, sign an NDA and we will give you early access to a specialized life sciences model and nearly every company they spoke with said no. Here is what these pharma companies understood that many enterprises still have not. A large pharmaceutical company may have spent decades and tens of billions of dollars generating proprietary datasets, clinical trial results, genomic sequences, drug interaction data, compound libraries. That data is the business and the competitive moat that separates them from every other player in the industry lives in those datasets. Handing it to an AI lab in exchange for early access to a model is essentially handing your most valuable asset to a company whose entire business model depends on combining your data with everyone else's and then selling the output back to you and to your competitors. Palantir CEO Alex Karp made this exact point that enterprise leaders are paying for AI tokens that generate no tangible business value while simultaneously surrendering their most sensitive operational data to external providers. He called this transferring a company's alpha, the unique advantage that secures the business directly to a third-party lab. Microsoft CEO Satya Nadella echoed the same concern independently, warning that entire sectors might find their accumulated knowledge commoditized if they do not build their own data and model ownership layers. The structural problem is not unique to pharma but it applies to every enterprise sector. Every time an employee runs a query through a third-party frontier model, proprietary workflows, customer data, and strategic processes pass through infrastructure the enterprise does not control. The data already shows the market moving, Open-source captured 67% of all AI tokens processed in the first half of 2026, up from a fraction of that just twelve months earlier. The performance gap between proprietary frontier models and open-source alternatives has nearly closed, DeepSeek costs approximately 1/36th of GPT-5 for comparable workloads. What pharma figured out and what enterprises across every sector are starting to realize is that the model is not the moat but the data is. And once you hand your data to a model company, you have permanently surrendered the asset that took you decades and billions of dollars to build.

Milk Road AI

16,317 views • 1 month ago

The most dangerous thing a company can do right now is rent intelligence from the same place as its competitors (Save this). You cannot rent intelligence from the same place that rents it to your competitor as Chamath Palihapitiya points out. If every company in an industry is feeding their workflows into the same frontier model, they are all converging on the same outputs, the same decisions, the same product improvements. The model becomes the equalizer and everyone pays a premium to become more mediocre. This is happening exactly as Chamath predicted, and the evidence is now concrete. Anthropic and OpenAI have established what analysts are now openly calling an emerging model layer duopoly. Anthropic crossed $45 billion ARR in may 2026, more than tripling from $9 billion at the end of 2025, OpenAI was at roughly $24 to $33 billion ARR at the same time. Together, the two companies combined could hit $160 to $240 billion ARR by end of 2026 and Anthropic and OpenAI now control 88% of enterprise LLM spend. That concentration is the structural problem Chamath is pointing at. And Anthropic isn't just winning on merit because it's actively lobbying for regulatory outcomes that would make that duopoly permanent. Dario Amodei has explicitly framed open source models as unsafe, pushing a safety agenda that, if enshrined in regulation, would effectively make it illegal for enterprises to use the cheaper, private, sovereign alternatives locking them into a closed model dependency by government decree rather than by choice. So you have market forces producing a duopoly, and potential regulatory capture moving to enforce it from the top down. This is exactly why the Nvidia Palantir partnership is not just a product announcement but rather a strategic counter to that duopoly. The logic is straightforward from both sides because If you're Palantir, sitting at the application layer, the last thing you want is to be permanently beholden to Anthropic or OpenAI for the intelligence that powers your product. You want competitive model options, sovereignty and be able to tell enterprise customers they can run AI on their own infrastructure with their own data without any of it touching a frontier lab's servers. If you're Nvidia, sitting at the chip layer, an Anthropic-OpenAI duopoly is an existential concentration risk. Right now, Meta, Google, Microsoft, Amazon, and dozens of other companies buy Nvidia's hardware. If the model layer consolidates into two players, both of which are building their own chips Nvidia faces a monopsony where its best customers are building the tools to displace it. A healthy open source ecosystem where thousands of enterprises train, fine tune, and deploy their own models is Nvidia's ideal market structure. More buyers, more diversity, more demand, less pricing leverage from any single customer.

Milk Road AI

34,385 views • 1 month ago

Anthropic is running the oldest predatory playbook in Big Tech (Save this). Here is what actually happened. Anthropic's own Chief Product Officer, Mike Krieger, was sitting on Figma's board and he resigned on April 14, 2026. Three days later, Anthropic launched Claude Design, a direct competitor to Figma's core product that allows users to generate prototypes, slide decks, and visual assets through conversation. Figma's stock dropped 7% the day of the launch and the stock has shed approximately 80% from its all-time high, erasing nearly $50 billion in market cap. Anthropic's valuation surged toward $800 billion in the same period. This is not an accident but rather a deliberate, systematic strategy and once you see the pattern, you cannot unsee it. Anthropic watched Cursor build the coding assistant category on top of Claude's models, Cursor became one of Anthropic's biggest customers. Cursor's usage patterns and product insights flowed through Anthropic's infrastructure every single day then Anthropic launched Claude Code, entering the exact category Cursor had created armed with every data point it needed to know the market size, the use cases, and the user behavior. The same pattern has now repeated across Claude Science, Claude Security, Claude Legal, and Claude Financial, every single one a vertical that was previously served by companies building on top of Anthropic's own models. The companies that trusted Anthropic's platform were simultaneously handing Anthropic the product roadmap for what to build next. Every company currently building on top of a closed frontier model is in the same position Figma was in before April 14, 2026. The only question is which category Anthropic targets next. David Sacks

Milk Road AI

69,499 views • 1 month ago

The entire AI industry is racing to build the smartest model. Satya Nadella just admitted that is not where the money is. The model is not the product. The harness is. That is the exact line. And it changes what Microsoft is actually competing on. OpenAI, Anthropic, Google, xAI, Meta every frontier lab is pouring hundreds of billions into training compute, chasing the next capability jump. Each betting that raw model intelligence is the moat. Microsoft is doing the opposite. It is building the harness the orchestration layer that sits above the model, connecting it to tools, data, permissions, sub-agents, and enterprise workflows. And it is letting OpenAI, Anthropic, and MAI compete to plug into it. "You need the model. But the model is not the product. The harness is." So do the math on what a harness actually does. A raw model dropped into an enterprise answers questions. That is a chatbot. A harness turns that same model into an agent that reads the SharePoint, edits the ERP entry, pulls the GitHub PR, updates Salesforce, and files the Excel report with the right permissions, the right audit trail, and the right sub-agent for each sub-task. The model provides the intelligence. The harness converts intelligence into work. Now here's where it gets interesting. "Even the best model in the world will feel broken without a great harness. And an okay model with a great harness can feel like magic." If that is true, the enterprise buyer is not buying model quality. The enterprise buyer is buying the harness. Which means model quality becomes a commodity input over time, and harness quality becomes the sustainable moat. Compare that to the strategy the entire frontier lab industry is executing. Everyone else is chasing the numerator raw intelligence. Almost nobody at scale is racing to build the denominator the orchestration layer that determines whether that intelligence can actually be deployed profitably inside a real company. The frontier model race has a 10 to 20 percent chance of producing a single dominant winner. Nadella just told the industry he does not need to be that winner. If OpenAI wins, Microsoft wins. If Anthropic wins, Microsoft wins. If MAI wins, Microsoft wins. If someone Microsoft has never heard of trains a better model in 2027, Microsoft still wins. Because the compute they train on, the harness they get plugged into, the enterprise contracts they get delivered through, and the products they sit inside are all Microsoft. He is not building the best AI model. He is building the layer that the best AI model has to run on to make anyone money. I wonder which position looks more valuable in ten years.

Vikram M

21,463 views • 1 month ago