Загрузка видео...

Не удалось загрузить видео

Возникла проблема при загрузке этого видео. Это может быть связано с временными проблемами сети или видео может быть недоступно.

На главную

.Ditto Bio discovers drugs for autoimmune diseases by harnessing parasite biology. Viruses, ticks, and worms have experimented over millions of years to create proteins that control the human immune system. Ditto Bio is using AI to identify these natural, drug-like proteins and engineer them into next-generation autoimmune therapies. Congrats... show more

Y Combinator

1,642,338 subscribers

29,506 просмотров • 6 месяцев назад •via X (Twitter)

Anya Rossi• Live Now

Private livecam show

Комментарии: 0

Нет доступных комментариев

Здесь появятся комментарии из оригинального поста

Похожие видео

“That is our task, to turn these natural treasures over to the next generation, enhanced, not impaired in value” Senator Adam Schiff on the value of our national parks and the importance of protecting them for the next 250 years

“That is our task, to turn these natural treasures over to the next generation, enhanced, not impaired in value” Senator Adam Schiff on the value of our national parks and the importance of protecting them for the next 250 years

Senate Democrats

21,620 просмотров • 1 месяц назад

Biologist Gary Brecka proposes a provocative theory: the genesis of autoimmune diseases like multiple sclerosis, Hashimoto’s thyroiditis, and Crohn’s disease may lie in hidden environmental and biological culprits—mold mycotoxins, heavy metals, viruses, and parasites. Rather than the immune system inexplicably turning on the body, Brecka suggests it’s often chasing intruders that have infiltrated cells and tissues, disrupting the body’s balance. Consider multiple sclerosis. Brecka cites autopsy studies where helminth larvae—parasitic worms—were found in the myelin sheaths of MS patients. Intriguingly, not all parasites are harmful. In some underdeveloped regions with low MS rates, “healthy” helminths coexist in the gut, potentially regulating immunity. Brecka theorizes that modern sanitation, while beneficial, may disrupt this balance, allowing pathogenic parasites to proliferate and contribute to diseases like MS. The same principle applies to toxins. Heavy metals like mercury and lead, mycotoxins from mold, and viruses don’t just linger outside cells—they invade them. In Hashimoto’s, Brecka notes the thyroid’s affinity for heavy metals, which can accumulate and draw immune attention, leading to antibody production against the gland. Similarly, Crohn’s disease often stems from a compromised gut barrier, where bacteria and pathogens leak into areas they don’t belong, triggering inflammation. Brecka challenges the narrative that autoimmune diseases are purely genetic or idiopathic. While family history is often cited, he points out there’s no direct gene for conditions like Hashimoto’s. Instead, he urges looking at what draws the immune system to attack: toxins and pathogens hiding inside cells. For example, when a virus injects its DNA into a host cell, the immune system must breach the cell to neutralize it, sometimes producing antibodies against the cell itself. His advice? Don’t accept an autoimmune diagnosis without rigorous testing for mold, mycotoxins, heavy metals, viruses, and parasites. “The immune system isn’t the villain—it’s responding to threats we often overlook,” Brecka says. By addressing these root causes, individuals might better understand their conditions and explore targeted interventions.

Biologist Gary Brecka proposes a provocative theory: the genesis of autoimmune diseases like multiple sclerosis, Hashimoto’s thyroiditis, and Crohn’s disease may lie in hidden environmental and biological culprits—mold mycotoxins, heavy metals, viruses, and parasites. Rather than the immune system inexplicably turning on the body, Brecka suggests it’s often chasing intruders that have infiltrated cells and tissues, disrupting the body’s balance. Consider multiple sclerosis. Brecka cites autopsy studies where helminth larvae—parasitic worms—were found in the myelin sheaths of MS patients. Intriguingly, not all parasites are harmful. In some underdeveloped regions with low MS rates, “healthy” helminths coexist in the gut, potentially regulating immunity. Brecka theorizes that modern sanitation, while beneficial, may disrupt this balance, allowing pathogenic parasites to proliferate and contribute to diseases like MS. The same principle applies to toxins. Heavy metals like mercury and lead, mycotoxins from mold, and viruses don’t just linger outside cells—they invade them. In Hashimoto’s, Brecka notes the thyroid’s affinity for heavy metals, which can accumulate and draw immune attention, leading to antibody production against the gland. Similarly, Crohn’s disease often stems from a compromised gut barrier, where bacteria and pathogens leak into areas they don’t belong, triggering inflammation. Brecka challenges the narrative that autoimmune diseases are purely genetic or idiopathic. While family history is often cited, he points out there’s no direct gene for conditions like Hashimoto’s. Instead, he urges looking at what draws the immune system to attack: toxins and pathogens hiding inside cells. For example, when a virus injects its DNA into a host cell, the immune system must breach the cell to neutralize it, sometimes producing antibodies against the cell itself. His advice? Don’t accept an autoimmune diagnosis without rigorous testing for mold, mycotoxins, heavy metals, viruses, and parasites. “The immune system isn’t the villain—it’s responding to threats we often overlook,” Brecka says. By addressing these root causes, individuals might better understand their conditions and explore targeted interventions.

Camus

102,022 просмотров • 1 год назад

The NIH is now funding human trials for a 'universal programmable vaccine.' This tech is designed entirely by AI. It essentially turns your body into a “super antigen” factory, even for viruses that 'don’t exist yet.' Read that again.. “Viruses that don’t exist yet.” This is Gain of Function on a biological scale. They are using AI to model theoretical threats and then forcing the human immune system to manufacture the 'solution' before the problem ever happens. Why are we trusting AI to predict the future of evolution, and why are we injecting 'antigens' for problems that haven't even emerged? I’m a medic. I’ve seen what happens when we force the body to manufacture spike proteins for threats we don't understand. We aren't lab rats, and the human immune system isn't a software platform for their AI experiments. The machine is writing its own code now. It's time to ask who owns the kill switch. God bless (Link to article in comments) Video below by Cambridge university

The NIH is now funding human trials for a 'universal programmable vaccine.' This tech is designed entirely by AI. It essentially turns your body into a “super antigen” factory, even for viruses that 'don’t exist yet.' Read that again.. “Viruses that don’t exist yet.” This is Gain of Function on a biological scale. They are using AI to model theoretical threats and then forcing the human immune system to manufacture the 'solution' before the problem ever happens. Why are we trusting AI to predict the future of evolution, and why are we injecting 'antigens' for problems that haven't even emerged? I’m a medic. I’ve seen what happens when we force the body to manufacture spike proteins for threats we don't understand. We aren't lab rats, and the human immune system isn't a software platform for their AI experiments. The machine is writing its own code now. It's time to ask who owns the kill switch. God bless (Link to article in comments) Video below by Cambridge university

Harry Fisher

14,751 просмотров • 2 месяцев назад

Del Bigtree on the Autoimmune Crisis: The Vaccine Factor? Del Bigtree warns we're on the brink of losing our species to an immune system in chaos. No other mammal suffers like us—autoimmune diseases are skyrocketing, where our own immune systems attack our bodies, especially our children’s. It's not the fluoride or pesticides—this is about the 72 injections that repeatedly trick our immune system into thinking it’s battling disease. Imagine being injected 72 times with proteins and aluminum, which act as false enemies, confusing the immune system. Aluminum’s role? It stokes the immune response—telling the body, "Every protein you see is the enemy." Now, combine that with everyday foods—eggs, peanuts, cheese—suddenly the body is attacking those too, creating severe allergies and a surge in immune confusion. Allergies are getting worse because of this constant immune provocation and harmful vaccine ingredients. This is not just a theory; it’s an urgent signal we can no longer ignore. The time to rethink injecting aluminum-laden vaccines is now—before the immune system’s confusion claims more lives. Del Bigtree’s call echoes with urgency: It's time to stop this immune attack cycle and protect future generations from this escalating crisis. The truth about vaccines and autoimmune disease demands our attention—because what we’re seeing is a species under siege.

Del Bigtree on the Autoimmune Crisis: The Vaccine Factor? Del Bigtree warns we're on the brink of losing our species to an immune system in chaos. No other mammal suffers like us—autoimmune diseases are skyrocketing, where our own immune systems attack our bodies, especially our children’s. It's not the fluoride or pesticides—this is about the 72 injections that repeatedly trick our immune system into thinking it’s battling disease. Imagine being injected 72 times with proteins and aluminum, which act as false enemies, confusing the immune system. Aluminum’s role? It stokes the immune response—telling the body, "Every protein you see is the enemy." Now, combine that with everyday foods—eggs, peanuts, cheese—suddenly the body is attacking those too, creating severe allergies and a surge in immune confusion. Allergies are getting worse because of this constant immune provocation and harmful vaccine ingredients. This is not just a theory; it’s an urgent signal we can no longer ignore. The time to rethink injecting aluminum-laden vaccines is now—before the immune system’s confusion claims more lives. Del Bigtree’s call echoes with urgency: It's time to stop this immune attack cycle and protect future generations from this escalating crisis. The truth about vaccines and autoimmune disease demands our attention—because what we’re seeing is a species under siege.

Camus

30,746 просмотров • 9 месяцев назад

We're thrilled to present ESM3 in Science Magazine. ESM3 is a generative language model that reasons over the three fundamental properties of proteins: sequence, structure, and function. Today we're making ESM3 available free to researchers worldwide via the public beta of an API for biological intelligence. Trained with over a trillion teraflops of compute, this is the first time a model of this scale has been trained for biology, pushing the frontier of AI for biological discovery and engineering. ESM3 learns to represent the immense complexity of protein biology, learning from billions of natural proteins. From this training it developed the capability to design proteins, responding to complex prompts combining atomic level details and high level instructions to generate new proteins. ESM3 can explore protein space far beyond natural evolution. We prompted ESM3 to generate a fluorescent protein at a far distance from any known fluorescent proteins, searching an unknown region of protein space, to discover a new fluorescent protein. We estimate this is equivalent to simulating five hundred million years of evolution.

We're thrilled to present ESM3 in Science Magazine. ESM3 is a generative language model that reasons over the three fundamental properties of proteins: sequence, structure, and function. Today we're making ESM3 available free to researchers worldwide via the public beta of an API for biological intelligence. Trained with over a trillion teraflops of compute, this is the first time a model of this scale has been trained for biology, pushing the frontier of AI for biological discovery and engineering. ESM3 learns to represent the immense complexity of protein biology, learning from billions of natural proteins. From this training it developed the capability to design proteins, responding to complex prompts combining atomic level details and high level instructions to generate new proteins. ESM3 can explore protein space far beyond natural evolution. We prompted ESM3 to generate a fluorescent protein at a far distance from any known fluorescent proteins, searching an unknown region of protein space, to discover a new fluorescent protein. We estimate this is equivalent to simulating five hundred million years of evolution.

Alex Rives

227,430 просмотров • 1 год назад

The traditional explanation for autoimmune disease is being fundamentally questioned. The idea that the body suddenly attacks itself for no reason is a flawed narrative. The conditions—Crohn's, Sjogren's, Hashimoto's—are real, but the "autoimmune" label may be a medical dead end. By definition, these are idiopathic diseases, meaning their origin is unknown. If we don't know the cause, how can we be certain of the mechanism? This is not a denial of suffering, but a critique of a label that offers management instead of cure. The fact that people can and do heal from these conditions proves the problem isn't an irreversibly broken immune system. The body isn't attacking itself; it's responding to a root cause we have yet to identify. Fibromyalgia and Chronic Fatigue Syndrome share the same story: "No known cause, no known cure." It's time we applied the same critical thinking to the entire autoimmune category. True healing begins when we stop blaming the body and start looking for the trigger.

The traditional explanation for autoimmune disease is being fundamentally questioned. The idea that the body suddenly attacks itself for no reason is a flawed narrative. The conditions—Crohn's, Sjogren's, Hashimoto's—are real, but the "autoimmune" label may be a medical dead end. By definition, these are idiopathic diseases, meaning their origin is unknown. If we don't know the cause, how can we be certain of the mechanism? This is not a denial of suffering, but a critique of a label that offers management instead of cure. The fact that people can and do heal from these conditions proves the problem isn't an irreversibly broken immune system. The body isn't attacking itself; it's responding to a root cause we have yet to identify. Fibromyalgia and Chronic Fatigue Syndrome share the same story: "No known cause, no known cure." It's time we applied the same critical thinking to the entire autoimmune category. True healing begins when we stop blaming the body and start looking for the trigger.

Camus

52,532 просмотров • 9 месяцев назад

NEW EPISODE of HARD DRUGS! AlphaFold, ProteinMPNN and other AI tools are transforming biology and drug design. But how do they work? What can’t they do (yet)? And can we use them to make a vaccine against Strep A for the very first time? In this episode, Jacob and I talk about hacking proteins with AI. 03:21 What makes proteins cool 05:29 Can we make a vaccine against Strep A? 10:12 Proteins in nature aren’t enough, and we can improve them with AI 21:12 ProteinMPNN and AlphaFold are transforming drug design 29:52 A short history of protein structure prediction from physical models to deep learning 34:48 Using AI to design a Strep A vaccine 39:27 Validating an AI-designed Strep A vaccine 43:09 Recent AI protein breakthroughs 49:30 Why we don’t already have a Strep A vaccine and the future of optimizing protein drugs

NEW EPISODE of HARD DRUGS! AlphaFold, ProteinMPNN and other AI tools are transforming biology and drug design. But how do they work? What can’t they do (yet)? And can we use them to make a vaccine against Strep A for the very first time? In this episode, Jacob and I talk about hacking proteins with AI. 03:21 What makes proteins cool 05:29 Can we make a vaccine against Strep A? 10:12 Proteins in nature aren’t enough, and we can improve them with AI 21:12 ProteinMPNN and AlphaFold are transforming drug design 29:52 A short history of protein structure prediction from physical models to deep learning 34:48 Using AI to design a Strep A vaccine 39:27 Validating an AI-designed Strep A vaccine 43:09 Recent AI protein breakthroughs 49:30 Why we don’t already have a Strep A vaccine and the future of optimizing protein drugs

Saloni

72,565 просмотров • 10 месяцев назад

DISTURBING: Yale researchers have found that some COVID jab recipients show signs of a depleted immune system and continue producing spike proteins years after the shot. “This is bad news. Very bad.” What was once called a “conspiracy theory” is now backed by science: vaccine spike proteins can linger in the body for years, potentially causing chronic inflammation and long-term health problems. Even more alarming, some patients experienced Epstein-Barr Virus (EBV) reactivation, while others had dangerously low levels of vital immune cells. The COVID jabs were sold to us as the solution to “end the pandemic.” Instead, it looks like they wrecked the immune system and made things worse. Video via E

DISTURBING: Yale researchers have found that some COVID jab recipients show signs of a depleted immune system and continue producing spike proteins years after the shot. “This is bad news. Very bad.” What was once called a “conspiracy theory” is now backed by science: vaccine spike proteins can linger in the body for years, potentially causing chronic inflammation and long-term health problems. Even more alarming, some patients experienced Epstein-Barr Virus (EBV) reactivation, while others had dangerously low levels of vital immune cells. The COVID jabs were sold to us as the solution to “end the pandemic.” Instead, it looks like they wrecked the immune system and made things worse. Video via E

The Vigilant Fox 🦊

588,884 просмотров • 1 год назад

This is how DNA turns raw data into functional proteins - the building blocks of all your cells. This system requires a minimum of 3 key players working together: DNA: the master blueprint with the instructions RNA Polymerase: reads the DNA and makes a temporary copy called mRNA which carries the instructions to the Ribosome for how to create the Protein Ribosome: the tiny factory that reads the mRNA and strings amino acids together in a specific sequence to create a protein Without all three molecules working together, Proteins cannot be created, cells don't function, and Life ends. Everything needs to fit together, precisely & perfectly, or it all falls apart. In other words: this system cannot evolve, one step at a time. DNA relies other machines made of proteins to create those very proteins - but those proteins can't be made without the information in the DNA. And on top of that, this whole system relies on OTHER systems! You need other things like ATP Synthase that makes energy to power everything, tRNA to carry the amino acids to the Ribosome, other helper proteins, processing enzymes, etc. It's an extremely complex, interdependent network of parts & systems that all rely on each other. The cell is an astounding level of complexity that surpasses anything in human engineering. It's obvious this is intelligently designed. To deny that is absurd.

This is how DNA turns raw data into functional proteins - the building blocks of all your cells. This system requires a minimum of 3 key players working together: DNA: the master blueprint with the instructions RNA Polymerase: reads the DNA and makes a temporary copy called mRNA which carries the instructions to the Ribosome for how to create the Protein Ribosome: the tiny factory that reads the mRNA and strings amino acids together in a specific sequence to create a protein Without all three molecules working together, Proteins cannot be created, cells don't function, and Life ends. Everything needs to fit together, precisely & perfectly, or it all falls apart. In other words: this system cannot evolve, one step at a time. DNA relies other machines made of proteins to create those very proteins - but those proteins can't be made without the information in the DNA. And on top of that, this whole system relies on OTHER systems! You need other things like ATP Synthase that makes energy to power everything, tRNA to carry the amino acids to the Ribosome, other helper proteins, processing enzymes, etc. It's an extremely complex, interdependent network of parts & systems that all rely on each other. The cell is an astounding level of complexity that surpasses anything in human engineering. It's obvious this is intelligently designed. To deny that is absurd.

Divinely Designed

22,903 просмотров • 7 месяцев назад

DISTURBING: Yale researchers have found that some COVID jab recipients show signs of a depleted immune system and continue producing spike proteins YEARS after the shot. Dr. Robert Malone was right about everything. What was once called a “conspiracy theory” is now backed by science: vaccine spike proteins can linger in the body for years, potentially causing chronic inflammation and long-term health problems. Even more alarming, some patients experienced Epstein-Barr Virus (EBV) reactivation, while others had dangerously low levels of vital immune cells. The COVID jabs were sold to us as the solution to “end the pandemic.” Instead, it looks like they wrecked the immune system and made things worse.

DISTURBING: Yale researchers have found that some COVID jab recipients show signs of a depleted immune system and continue producing spike proteins YEARS after the shot. Dr. Robert Malone was right about everything. What was once called a “conspiracy theory” is now backed by science: vaccine spike proteins can linger in the body for years, potentially causing chronic inflammation and long-term health problems. Even more alarming, some patients experienced Epstein-Barr Virus (EBV) reactivation, while others had dangerously low levels of vital immune cells. The COVID jabs were sold to us as the solution to “end the pandemic.” Instead, it looks like they wrecked the immune system and made things worse.

The Vigilant Fox 🦊

480,764 просмотров • 1 год назад

American Autoimmune Doctor explaining how the medications that are prescribed for autoimmune diseases are not meant to make you better, they’re meant to keep you sick forever This is pure evil “It's interesting, the more that I practice functional medicine, the more I realize that the whole system is really set up against you. And the reason why I say that is that, for example, the most common cause of autoimmune disease is actually an infection. But when you go to the rheumatologist, all you're going to get is Xeljanz, Sulfasalazines, you're going to get Humira, Enbrel, you're going to get those things which actually suppress your immune system. So if the number one root cause, according to authors, right, of autoimmunity is an infectious issue, what's going on here? If you're suppressing your immune system, you're always going to have autoimmunity if your trigger is an infection. So it is the definition of a vicious circle, but it's almost like it was set up so that you will always be on those medications, which by the way, highest profit margin in pharmaceutical science and pharmaceutical sales are these immune modulating medications. So remember, there's no vested interest for you to get better.”

American Autoimmune Doctor explaining how the medications that are prescribed for autoimmune diseases are not meant to make you better, they’re meant to keep you sick forever This is pure evil “It's interesting, the more that I practice functional medicine, the more I realize that the whole system is really set up against you. And the reason why I say that is that, for example, the most common cause of autoimmune disease is actually an infection. But when you go to the rheumatologist, all you're going to get is Xeljanz, Sulfasalazines, you're going to get Humira, Enbrel, you're going to get those things which actually suppress your immune system. So if the number one root cause, according to authors, right, of autoimmunity is an infectious issue, what's going on here? If you're suppressing your immune system, you're always going to have autoimmunity if your trigger is an infection. So it is the definition of a vicious circle, but it's almost like it was set up so that you will always be on those medications, which by the way, highest profit margin in pharmaceutical science and pharmaceutical sales are these immune modulating medications. So remember, there's no vested interest for you to get better.”

Wall Street Apes

448,544 просмотров • 1 год назад

"[The mRNA platform] is a death technology. It literally is. And it has to end and be exposed...what these big tech bros [don't]...understand is basic immunology. We're tinkering with the basics of human life." Dr. Ryan Cole (), a board certified anatomic and clinical pathologist with 20 years of experience in dermatopathology, describes for Children's Health Defense (Children’s Health Defense) how the entire mRNA-injection platform is "literally" a "death technology" in any of its guises. Cole notes that the technology did not work in the '90s when it was launched and that it still does not work now. "Obviously, many people have been harmed by [these injections]," Cole says. "We have injuries. We have countless deaths. [And] we're not going to see all of it for 5 to 10 years based on the FDA's research with other genetic products." Unpacking this analysis, Cole notes that "four of the chemicals within the lipid nanoparticles [in the mRNA injections]...[are] not for human nor veterinary use." He also notes that there's an issue with so-called "frame shifting," wherein the injections are causing the body to generate "off-target" proteins. Cole refers to these unintended proteins as "Frankenstein proteins" and says they're "inducing autoimmune disease." Referencing the recently announced "Stargate" project, which will attempt to, in part, make "vaccines" for cancer, Cole says, "what these big tech bros...[don't] understand is basic immunology." The physician adds, "We're tinkering with the basics of human life."

"[The mRNA platform] is a death technology. It literally is. And it has to end and be exposed...what these big tech bros [don't]...understand is basic immunology. We're tinkering with the basics of human life." Dr. Ryan Cole (), a board certified anatomic and clinical pathologist with 20 years of experience in dermatopathology, describes for Children's Health Defense (Children’s Health Defense) how the entire mRNA-injection platform is "literally" a "death technology" in any of its guises. Cole notes that the technology did not work in the '90s when it was launched and that it still does not work now. "Obviously, many people have been harmed by [these injections]," Cole says. "We have injuries. We have countless deaths. [And] we're not going to see all of it for 5 to 10 years based on the FDA's research with other genetic products." Unpacking this analysis, Cole notes that "four of the chemicals within the lipid nanoparticles [in the mRNA injections]...[are] not for human nor veterinary use." He also notes that there's an issue with so-called "frame shifting," wherein the injections are causing the body to generate "off-target" proteins. Cole refers to these unintended proteins as "Frankenstein proteins" and says they're "inducing autoimmune disease." Referencing the recently announced "Stargate" project, which will attempt to, in part, make "vaccines" for cancer, Cole says, "what these big tech bros...[don't] understand is basic immunology." The physician adds, "We're tinkering with the basics of human life."

Sense Receptor

26,455 просмотров • 1 год назад

🔥 Dr. Kelly Victory Does a Full 180 on ALL Vaccines: “I Believe We Are Over-Immunizing” “I said [in the past], ‘There’s no credible evidence that vaccines are associated with autism.’ I would do a 180 on that,” professed Kelly Victory MD. “The immune system reacts in ways we don’t necessarily anticipate, and we have been effing with it in a way by continually flogging the immune system with vaccine after vaccine after vaccine,” she continued. “And we are seeing unprecedented rates, not only of autism, Steve Kirsch, but in other things (autoimmune diseases, allergies, eczema, etc.) that I think are likely attributed to or potentially made worse by this assault on the human immune system.”

🔥 Dr. Kelly Victory Does a Full 180 on ALL Vaccines: “I Believe We Are Over-Immunizing” “I said [in the past], ‘There’s no credible evidence that vaccines are associated with autism.’ I would do a 180 on that,” professed Kelly Victory MD. “The immune system reacts in ways we don’t necessarily anticipate, and we have been effing with it in a way by continually flogging the immune system with vaccine after vaccine after vaccine,” she continued. “And we are seeing unprecedented rates, not only of autism, Steve Kirsch, but in other things (autoimmune diseases, allergies, eczema, etc.) that I think are likely attributed to or potentially made worse by this assault on the human immune system.”

The Vigilant Fox 🦊

794,647 просмотров • 3 лет назад

Could cancer become largely curable within the next decade? Cancer is not one disease, but hundreds, and one reason it's so difficult to treat is that cancer cells arise from our own tissues. Destroying them without harming healthy cells requires extraordinary precision. AI may help make that precision possible by integrating genetics, metabolism, immune function, and enormous biological datasets to identify the vulnerabilities unique to each tumor. We are already seeing the beginnings of this with targeted drugs designed around specific mutations and CAR-T therapies that engineer immune cells to recognize and destroy cancer. A provocative (and hopeful) forecast from Derya Unutmaz, MD. From the latest episode of the FoundMyFitness podcast.

Could cancer become largely curable within the next decade? Cancer is not one disease, but hundreds, and one reason it's so difficult to treat is that cancer cells arise from our own tissues. Destroying them without harming healthy cells requires extraordinary precision. AI may help make that precision possible by integrating genetics, metabolism, immune function, and enormous biological datasets to identify the vulnerabilities unique to each tumor. We are already seeing the beginnings of this with targeted drugs designed around specific mutations and CAR-T therapies that engineer immune cells to recognize and destroy cancer. A provocative (and hopeful) forecast from Derya Unutmaz, MD. From the latest episode of the FoundMyFitness podcast.

Dr. Rhonda Patrick

161,466 просмотров • 27 дней назад

NVIDIA CEO Jensen Huang just gave us a glimpse into the future of AI, and it's far bigger than text and images. He asked: "If you can understand worlds, is it possible that you understand proteins and chemicals that have structure?” This is the quiet revolution happening in AI right now. We're moving from an AI that understands human language to an AI that understands the language of nature itself. The "letters" are atoms. The "words" are molecules. The "sentences" are the complex structures of life, networks, and reality. The same foundational models that generate video are now being used to: *Decode proteins to fight disease *Design new materials at the atomic level *Simulate complex systems in quantum computing These were once the domain of supercomputers and Nobel laureates. Now, they're becoming solvable problems for a new generation of startups. AI is transitioning from a tool for communication to a tool for creation and discovery in the physical world. This is where the next wave of generational companies will be built. The "hard-to-solve" problems are now within reach.

NVIDIA CEO Jensen Huang just gave us a glimpse into the future of AI, and it's far bigger than text and images. He asked: "If you can understand worlds, is it possible that you understand proteins and chemicals that have structure?” This is the quiet revolution happening in AI right now. We're moving from an AI that understands human language to an AI that understands the language of nature itself. The "letters" are atoms. The "words" are molecules. The "sentences" are the complex structures of life, networks, and reality. The same foundational models that generate video are now being used to: Decode proteins to fight disease Design new materials at the atomic level *Simulate complex systems in quantum computing These were once the domain of supercomputers and Nobel laureates. Now, they're becoming solvable problems for a new generation of startups. AI is transitioning from a tool for communication to a tool for creation and discovery in the physical world. This is where the next wave of generational companies will be built. The "hard-to-solve" problems are now within reach.

Konstantine Buhler

13,014 просмотров • 10 месяцев назад

Long COVID: The Immune & Lymphatic System Long COVID is associated with persistent immune dysregulation. Studies document chronic inflammation, abnormal immune activation, altered T- and B-cell signaling, and the presence of autoantibodies. This immune dysregulation can create a state of vulnerability in the body, which can increase susceptibility to infections, reactivation of latent-viruses as seen with EBV, CMV, HSV... and contribute to the emergence or unmasking of secondary conditions, including autoimmune diseases such as Lupus, neurologic disorders such as multiple sclerosis (MS), and even certain can also impact how your body responds to other infections and illnesses, impact vaccine efficacy and antibody response, and more. Long COVID can reflect a destabilized immune system with systemic consequences that vary by person, severity, and time since infection. We are all #OneInfectionAway Learn more about #LongCOVID and visit our #LongCOVIDAwareness Month page to take action, get involved, and spread the word! Access the video here:

Long COVID: The Immune & Lymphatic System Long COVID is associated with persistent immune dysregulation. Studies document chronic inflammation, abnormal immune activation, altered T- and B-cell signaling, and the presence of autoantibodies. This immune dysregulation can create a state of vulnerability in the body, which can increase susceptibility to infections, reactivation of latent-viruses as seen with EBV, CMV, HSV... and contribute to the emergence or unmasking of secondary conditions, including autoimmune diseases such as Lupus, neurologic disorders such as multiple sclerosis (MS), and even certain can also impact how your body responds to other infections and illnesses, impact vaccine efficacy and antibody response, and more. Long COVID can reflect a destabilized immune system with systemic consequences that vary by person, severity, and time since infection. We are all #OneInfectionAway Learn more about #LongCOVID and visit our #LongCOVIDAwareness Month page to take action, get involved, and spread the word! Access the video here:

COVID-19 Longhauler Advocacy Project

10,571 просмотров • 5 месяцев назад

Mike Yeadon, Former Pfizer chief scientist, saw early on the spike protein which the mRNA gets your cells to produce is very similar to a protein important for female fertility. And if the immune system spills over and gets "tricked" into accidentally targeting proteins important for fertility, that could be why we have seen birth rates plummet globally a short time period after the mRNA rollout began.

Mike Yeadon, Former Pfizer chief scientist, saw early on the spike protein which the mRNA gets your cells to produce is very similar to a protein important for female fertility. And if the immune system spills over and gets "tricked" into accidentally targeting proteins important for fertility, that could be why we have seen birth rates plummet globally a short time period after the mRNA rollout began.

Humanspective

24,739 просмотров • 1 год назад

🚨David Sinclair: “AI helped us do 160 years of biology work in two months.” ROGAN: “What?!” SINCLAIR: “We’re looking for molecules, a single molecule that can replace this cocktail... You need a molecule to do three or four activities in the cell. Finding one activity is what pharmaceutical companies do. It takes hundreds of millions, if not billions, to make a drug.” “My little lab of 20 people and students are trying to make one drug do three or four different things. That’s beyond the reach of pharmaceutical experience, at least five years ago.” “This funnel is full of a trillion molecules, and we have to come down to one. We don’t look for a trillion molecules at the bench. That would take 160 or thousands of years... so we do it inside the computer.” “We just use a lot of compute, and we dock each of these molecules against the enzymes that we now know how they work, thanks to Google DeepMind solving the problem of how all our proteins look, 20,000 of them.” 1 trillion candidate molecules. Filtered to 200. Two months. “Next week, we’re testing these 200 against human cells, and we’ve also got AI helping us tell if the human cells go from 92 years old back to 20. We can tell that just by looking at them, thanks to AI.” Dr. David Sinclair is a Harvard geneticist and one of the world's leading longevity researchers. Fascinating to hear how he's using AI to compress 160 years of biology work into two months. What other decades of work is about to become two months? Joe Rogan David Sinclair

🚨David Sinclair: “AI helped us do 160 years of biology work in two months.” ROGAN: “What?!” SINCLAIR: “We’re looking for molecules, a single molecule that can replace this cocktail... You need a molecule to do three or four activities in the cell. Finding one activity is what pharmaceutical companies do. It takes hundreds of millions, if not billions, to make a drug.” “My little lab of 20 people and students are trying to make one drug do three or four different things. That’s beyond the reach of pharmaceutical experience, at least five years ago.” “This funnel is full of a trillion molecules, and we have to come down to one. We don’t look for a trillion molecules at the bench. That would take 160 or thousands of years... so we do it inside the computer.” “We just use a lot of compute, and we dock each of these molecules against the enzymes that we now know how they work, thanks to Google DeepMind solving the problem of how all our proteins look, 20,000 of them.” 1 trillion candidate molecules. Filtered to 200. Two months. “Next week, we’re testing these 200 against human cells, and we’ve also got AI helping us tell if the human cells go from 92 years old back to 20. We can tell that just by looking at them, thanks to AI.” Dr. David Sinclair is a Harvard geneticist and one of the world's leading longevity researchers. Fascinating to hear how he's using AI to compress 160 years of biology work into two months. What other decades of work is about to become two months? Joe Rogan David Sinclair

KanekoaTheGreat

499,244 просмотров • 17 дней назад

.Polymath is training world generation models to automate the creation of RL environments. Traditionally, RL environment generation has been bottlenecked by human data. Superintelligence will never be achieved by human data alone. Polymath is building the core technology to enable automated environment generation using far less human effort than traditionally required, and eventually none. This allows for more complex and realistic worlds, and higher quality, scale, and diversity of tasks. This will be essential to unlock RL scaling. The end goal is to create large-scale, long-horizon environments from a text description alone. This will enable the creation of worlds of arbitrary complexity and scale, which is foundational for training & evaluating autonomous, superintelligent AI agents. Congrats on the launch, Dylan Ma and Naren Yenuganti!

.Polymath is training world generation models to automate the creation of RL environments. Traditionally, RL environment generation has been bottlenecked by human data. Superintelligence will never be achieved by human data alone. Polymath is building the core technology to enable automated environment generation using far less human effort than traditionally required, and eventually none. This allows for more complex and realistic worlds, and higher quality, scale, and diversity of tasks. This will be essential to unlock RL scaling. The end goal is to create large-scale, long-horizon environments from a text description alone. This will enable the creation of worlds of arbitrary complexity and scale, which is foundational for training & evaluating autonomous, superintelligent AI agents. Congrats on the launch, Dylan Ma and Naren Yenuganti!

Y Combinator

44,192 просмотров • 5 месяцев назад