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.Dr. Rhonda Patrick' creatine supplementation regimen: • 5g on lighter workout days (e.g., running) • 10g most days, especially when strength training • 20g (split into two 10g doses) when sleep-deprived for a cognitive boost • Uses Thorne (NSF-certified for purity) • Takes it with coffee (tip: if creatine... show more

FoundMyFitness Clips

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358,748 views • 1 year ago •via X (Twitter)

Health & Wellness Science & Technology Education

Anya Rossi• Live Now

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10 Comments

FoundMyFitness Clips1 year ago

Sign up to become a FoundMyFitness Premium Member Members get access to: • Monthly Q&As with Rhonda • The Aliquot podcast • Our Science Digest email And more Details here:

Kevin Dobrzynski DN1 year ago

@foundmyfitness Creatine is a supplement that almost anyone can benefit from not just gym bros.

burger king1 year ago

@foundmyfitness 20 g make me shit my pants

Rand1 year ago

@foundmyfitness I love to take a scoop of 20 to 30 g every other day

Bigmumbojumbo1 year ago

@foundmyfitness i added ~5-7LBS when taking creatine. feel great but still... has this been anyone else's experience?

Dao Roth1 year ago

@foundmyfitness @bryan_johnson why do you only do 2.5 grams?

MATT MUNSON1 year ago

@foundmyfitness Dr. Patrick, I love your research on creatine. Since beginning it in November, 2024, I have felt immense benefits in workout recovery, physical strength, and ultimately cognitive function. Unfortunately, since supplementation, my liver enzymes have doubled. Could creatine be why?

Centenarius Nutrition1 year ago

@foundmyfitness Make sure to use a Creatine MADE IN GERMANY 🇩🇪 We don’t use any ingredients from China If it’s not made in Germany it’s either made in China 🇨🇳 or India 🇮🇳

Mark gates1 year ago

@foundmyfitness Dr Rhonda dr dr Rhonda. You’re the best.

ben1 year ago

@foundmyfitness Thanks 🙏

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Rhonda Patrick bombshell on Diary of a CEO: 21 hours no sleep? 25–30g creatine erases brain fog—and outperforms well-rested brains. Her personal hack: 10g daily baseline → 20g acute for jet lag or high-stakes days ("Like today"). Creatine = 2025's ultimate cognitive rescue when sleep tanks. Watch this quick 0:35 clip. Travel heavy or sleep-struggling? Tried her protocol? Real stories below.

Rhonda Patrick bombshell on Diary of a CEO: 21 hours no sleep? 25–30g creatine erases brain fog—and outperforms well-rested brains. Her personal hack: 10g daily baseline → 20g acute for jet lag or high-stakes days ("Like today"). Creatine = 2025's ultimate cognitive rescue when sleep tanks. Watch this quick 0:35 clip. Travel heavy or sleep-struggling? Tried her protocol? Real stories below.

Camus

163,522 views • 8 months ago

Creatine gummies are popular, but independent testing reveals a very large percentage contain essentially zero creatine During manufacturing, the heat used to make gummies often destroys active ingredients, making accurate dosing nearly impossible And even if they did contain the right amount, you’d have to eat an unrealistic number of them (along with a ton of sugar) to reach a basic 5–10g dose Stick to pure creatine monohydrate powder (~10g/day, ~25-30g for a cognitive boost when sleep-deprived)

Creatine gummies are popular, but independent testing reveals a very large percentage contain essentially zero creatine During manufacturing, the heat used to make gummies often destroys active ingredients, making accurate dosing nearly impossible And even if they did contain the right amount, you’d have to eat an unrealistic number of them (along with a ton of sugar) to reach a basic 5–10g dose Stick to pure creatine monohydrate powder (~10g/day, ~25-30g for a cognitive boost when sleep-deprived)

FoundMyFitness Clips

80,910 views • 9 months ago

Rhonda Patrick now takes 10 grams of creatine per day — double the standard dose. Why? Once your muscles are saturated at 5g, the extra starts reaching your brain. German research showed 10g meaningfully raises brain creatine levels. Even more striking: 20–30g can completely erase the cognitive damage from 21 hours of sleep deprivation — and in some cases, people performed better than when fully rested. Rhonda uses the higher dose on jet-lagged or high-demand days and says she no longer gets the usual mid-afternoon crash. Many of her vegan friends report more energy and needing less sleep after starting. Creatine is quietly shifting from “muscle supplement” to powerful brain performance tool. Have you tried higher-dose creatine (above 5g)? Did you notice changes in energy, focus, or sleep needs?

Rhonda Patrick now takes 10 grams of creatine per day — double the standard dose. Why? Once your muscles are saturated at 5g, the extra starts reaching your brain. German research showed 10g meaningfully raises brain creatine levels. Even more striking: 20–30g can completely erase the cognitive damage from 21 hours of sleep deprivation — and in some cases, people performed better than when fully rested. Rhonda uses the higher dose on jet-lagged or high-demand days and says she no longer gets the usual mid-afternoon crash. Many of her vegan friends report more energy and needing less sleep after starting. Creatine is quietly shifting from “muscle supplement” to powerful brain performance tool. Have you tried higher-dose creatine (above 5g)? Did you notice changes in energy, focus, or sleep needs?

Camus

282,967 views • 4 months ago

Creatine dose, benefits & safety from Dr. Rhonda Patrick: - Standard muscle dose is 5 g/day of creatine monohydrate - the most well-researched form - but muscles are "very greedy" and consume most of it before it reaches the brain. - Getting creatine into the brain requires higher doses: one German study found that at 10 g/day, MRI scans showed creatine levels rising in key brain regions above what the brain produces on its own. - Creatine shines under brain stress - sleep deprivation, intense cognitive work, travel fatigue. One study gave sleep-deprived subjects 0.35 g per kg bodyweight (roughly 20-25 g) and they performed not just at baseline but above it. - The phosphocreatine system has a frontal bias - the brain areas most associated with strategic planning and working memory rely on it most heavily. "It's one of the most well-studied supplements out there. If it was unsafe, we really would know." Dr. Rhonda Patrick on Andrew D. Huberman, Ph.D.

Creatine dose, benefits & safety from Dr. Rhonda Patrick: - Standard muscle dose is 5 g/day of creatine monohydrate - the most well-researched form - but muscles are "very greedy" and consume most of it before it reaches the brain. - Getting creatine into the brain requires higher doses: one German study found that at 10 g/day, MRI scans showed creatine levels rising in key brain regions above what the brain produces on its own. - Creatine shines under brain stress - sleep deprivation, intense cognitive work, travel fatigue. One study gave sleep-deprived subjects 0.35 g per kg bodyweight (roughly 20-25 g) and they performed not just at baseline but above it. - The phosphocreatine system has a frontal bias - the brain areas most associated with strategic planning and working memory rely on it most heavily. "It's one of the most well-studied supplements out there. If it was unsafe, we really would know." Dr. Rhonda Patrick on Andrew D. Huberman, Ph.D.

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15,694 views • 2 months ago

Joe Rogan takes creatine every day, and says it’s one of the few things that can almost completely wipe out the mental effects of sleep deprivation. Gary Brecka backed it up: excellent for cognitive function, especially when sleep is off. If monohydrate causes bloating (common for women), switch to HCL. Pairing it with HMB improves uptake even more. Multiple studies (including a 2024 trial in Scientific Reports) show a high single dose of creatine significantly reduces cognitive decline during sleep deprivation, improving memory, processing speed, and vigilance by supporting brain energy stores. A simple daily supplement that helps protect your brain when life gets in the way of good sleep. What’s your experience with creatine, worth it or overhyped?

Joe Rogan takes creatine every day, and says it’s one of the few things that can almost completely wipe out the mental effects of sleep deprivation. Gary Brecka backed it up: excellent for cognitive function, especially when sleep is off. If monohydrate causes bloating (common for women), switch to HCL. Pairing it with HMB improves uptake even more. Multiple studies (including a 2024 trial in Scientific Reports) show a high single dose of creatine significantly reduces cognitive decline during sleep deprivation, improving memory, processing speed, and vigilance by supporting brain energy stores. A simple daily supplement that helps protect your brain when life gets in the way of good sleep. What’s your experience with creatine, worth it or overhyped?

Camus

79,454 views • 2 months ago

$Creatine isn’t just for athletes. A growing body of scientific evidence now shows creatine helps preserve muscle during aging, maintains bone density, improves cognition (especially during stress), and speeds muscle recovery after intense exercise. To explore the mechanisms, optimal dosing strategies, and practical considerations, and more, I invited a leading creatine researcher Dr. Darren Candow (Darren Candow, PhD, CSEP-CEP, FISSN) onto the podcast. Even if you’re not an athlete—or you’ve dismissed creatine as a muscle supplement—you need to listen to this episode. Links to YouTube, Apple Podcasts, and Spotify in the comments. Timestamps: 0:00 - Introduction 0:56 - What makes creatine effective for exercise performance? 4:23 - The loss of explosive power with aging 5:59 - How creatine speeds up recovery between sets 8:36 - Two ways creatine boosts muscle strength 10:34 - Why creatine might not speed typical weight-training recovery 13:01 - Anti-catabolic effects 13:38 - Why do men and women respond differently? 15:12 - Dietary creatine vs. supplementation 15:59 - Is creatine supplementation necessary—or optional? 17:27 - Why plant-based may benefit most 18:38 - Should creatine dosage change with age? 19:23 - Loading vs. daily dosing 22:20 - Why 5 grams might not be enough—other tissues 24:11 - Can creatine prevent bone loss—even without weight training? 24:32 - How creatine supports osteoblast activity 26:13 - Preventing hip fractures with creatine 28:55 - Creatine vs. bisphosphonates 32:43 - Why creatine isn’t just for weightlifters 35:14 - Why stressed brains benefit most 37:19 - Why brain aging accelerates demand 40:16 - Why 10g per day might be the optimal dose 42:07 - Why creatine counteracts sleep deprivation 45:16 - Before vs. after concussion 47:39 - Should dosage be adjusted by weight? 49:01 - Does creatine improve sleep on training days? 51:56 - Creatine for Alzheimer’s and Parkinson’s 53:29 - Can creatine help with depression and anxiety? 56:46 - Creatine and glutamine for preventing respiratory illness 59:02 - Why creatine may enhance endothelial health and circulation 1:00:26 - Creatine’s role in cardiometabolic health 1:02:07 - When does loading actually make sense? 1:03:12 - Preserving muscle and enhancing recovery after injury 1:06:07 - Is creatine effective without exercise? 1:08:23 - Why creatine might improve male fertility 1:10:19 - Is it safe for children? 1:13:43 - Creatine supplementation during pregnancy 1:15:15 - Could creatine boost motor skills in kids? 1:15:55 - Creatine monohydrate vs. the rest 1:20:37 - How to avoid digestive issues with creatine supplementation 1:23:18 - Does timing matter—and should you cycle it? 1:24:54 - Should you take creatine every day—or only workout days? 1:25:39 - Why caffeine might blunt the effects 1:28:43 - Does creatine increase body fat—or is that a myth? 1:29:30 - Preventing cramps (the hydration myth) 1:30:55 - Why creatine won’t damage your kidneys 1:33:21 - Why creatine is linked (wrongly?) to baldness 1:36:44 - Debunking myths—sleep, cancer, urination 1:40:01 - How creatine affects homocysteine levels 1:42:54 - Creatine and protein—the ideal post-workout pair? 1:45:48 - How to pick the best creatine supplement 1:48:08 - What to know about micronized creatine$

Creatine isn’t just for athletes. A growing body of scientific evidence now shows creatine helps preserve muscle during aging, maintains bone density, improves cognition (especially during stress), and speeds muscle recovery after intense exercise. To explore the mechanisms, optimal dosing strategies, and practical considerations, and more, I invited a leading creatine researcher Dr. Darren Candow (Darren Candow, PhD, CSEP-CEP, FISSN) onto the podcast. Even if you’re not an athlete—or you’ve dismissed creatine as a muscle supplement—you need to listen to this episode. Links to YouTube, Apple Podcasts, and Spotify in the comments. Timestamps: 0:00 - Introduction 0:56 - What makes creatine effective for exercise performance? 4:23 - The loss of explosive power with aging 5:59 - How creatine speeds up recovery between sets 8:36 - Two ways creatine boosts muscle strength 10:34 - Why creatine might not speed typical weight-training recovery 13:01 - Anti-catabolic effects 13:38 - Why do men and women respond differently? 15:12 - Dietary creatine vs. supplementation 15:59 - Is creatine supplementation necessary—or optional? 17:27 - Why plant-based may benefit most 18:38 - Should creatine dosage change with age? 19:23 - Loading vs. daily dosing 22:20 - Why 5 grams might not be enough—other tissues 24:11 - Can creatine prevent bone loss—even without weight training? 24:32 - How creatine supports osteoblast activity 26:13 - Preventing hip fractures with creatine 28:55 - Creatine vs. bisphosphonates 32:43 - Why creatine isn’t just for weightlifters 35:14 - Why stressed brains benefit most 37:19 - Why brain aging accelerates demand 40:16 - Why 10g per day might be the optimal dose 42:07 - Why creatine counteracts sleep deprivation 45:16 - Before vs. after concussion 47:39 - Should dosage be adjusted by weight? 49:01 - Does creatine improve sleep on training days? 51:56 - Creatine for Alzheimer’s and Parkinson’s 53:29 - Can creatine help with depression and anxiety? 56:46 - Creatine and glutamine for preventing respiratory illness 59:02 - Why creatine may enhance endothelial health and circulation 1:00:26 - Creatine’s role in cardiometabolic health 1:02:07 - When does loading actually make sense? 1:03:12 - Preserving muscle and enhancing recovery after injury 1:06:07 - Is creatine effective without exercise? 1:08:23 - Why creatine might improve male fertility 1:10:19 - Is it safe for children? 1:13:43 - Creatine supplementation during pregnancy 1:15:15 - Could creatine boost motor skills in kids? 1:15:55 - Creatine monohydrate vs. the rest 1:20:37 - How to avoid digestive issues with creatine supplementation 1:23:18 - Does timing matter—and should you cycle it? 1:24:54 - Should you take creatine every day—or only workout days? 1:25:39 - Why caffeine might blunt the effects 1:28:43 - Does creatine increase body fat—or is that a myth? 1:29:30 - Preventing cramps (the hydration myth) 1:30:55 - Why creatine won’t damage your kidneys 1:33:21 - Why creatine is linked (wrongly?) to baldness 1:36:44 - Debunking myths—sleep, cancer, urination 1:40:01 - How creatine affects homocysteine levels 1:42:54 - Creatine and protein—the ideal post-workout pair? 1:45:48 - How to pick the best creatine supplement 1:48:08 - What to know about micronized creatine

Dr. Rhonda Patrick

463,757 views • 1 year ago

Ever wondered why top biohackers swear by creatine—not for gains, but for brainpower? Dr. Rhonda Patrick spilled the details on Mayim Bialik's "The Breakdown" podcast back on July 8, 2025, and this 3:52 clip is still pure fire for anyone chasing peak mental edge. Rhonda doesn't mess around: She takes 10g daily, bumping to 15-20g on rough days like jet lag or early gigs. Her verdict? "It's like speed without the speed. Caffeine without the caffeine." No jitters, just laser focus and resilience. Breaking it down with science: - Your body makes just 1-2g naturally; vegans get zero from food. - Stress and sleep dips torch your stores—creatine refuels the brain's energy engine. - Hit 5g+ for "spillover" benefits: sharper cognition, mood lift, faster bounce-back from fatigue, even hints at anti-aging for the noggin. - Bonus: It supports methylation (think gene tweaks via folate/choline pathways), freeing up resources when life's chaotic. Rhonda's vegan pal story seals it: Started supplementing, then messaged, "I don't need as much sleep, energy's endless—what's happening?!" Rhonda: "You're finally at baseline. Hulk mode activated. Mayim nails the real-world angle: "So many get SSRIs for low energy, fog, no drive... but what if it's just depleted creatine? Biochemistry we can tweak." Not advice, just two PhD powerhouses unpacking studies. Watch below—it's the convo that upgraded my routine forever. Are you already taking creatine for your brain (or about to start)?

Ever wondered why top biohackers swear by creatine—not for gains, but for brainpower? Dr. Rhonda Patrick spilled the details on Mayim Bialik's "The Breakdown" podcast back on July 8, 2025, and this 3:52 clip is still pure fire for anyone chasing peak mental edge. Rhonda doesn't mess around: She takes 10g daily, bumping to 15-20g on rough days like jet lag or early gigs. Her verdict? "It's like speed without the speed. Caffeine without the caffeine." No jitters, just laser focus and resilience. Breaking it down with science: - Your body makes just 1-2g naturally; vegans get zero from food. - Stress and sleep dips torch your stores—creatine refuels the brain's energy engine. - Hit 5g+ for "spillover" benefits: sharper cognition, mood lift, faster bounce-back from fatigue, even hints at anti-aging for the noggin. - Bonus: It supports methylation (think gene tweaks via folate/choline pathways), freeing up resources when life's chaotic. Rhonda's vegan pal story seals it: Started supplementing, then messaged, "I don't need as much sleep, energy's endless—what's happening?!" Rhonda: "You're finally at baseline. Hulk mode activated. Mayim nails the real-world angle: "So many get SSRIs for low energy, fog, no drive... but what if it's just depleted creatine? Biochemistry we can tweak." Not advice, just two PhD powerhouses unpacking studies. Watch below—it's the convo that upgraded my routine forever. Are you already taking creatine for your brain (or about to start)?

Camus

115,560 views • 8 months ago

Use creatine to protect your brain from head injuries: Repeated head injuries can lead to second-impact syndrome, where a subsequent injury before full recovery causes rapid and potentially permanent brain damage. This is a significant risk for athletes, military, or anyone prone to traumatic brain injury (TBI) or concussions. But here's the good news: research has shown that creatine supplementation can help mitigate the damage caused by second-impact syndrome. In fact, studies have found that creatine depletion prior to additional impacts can worsen the damage to your brain. So, what should you do? If you do experience a head injury, it's essential to replenish your creatine stores as quickly as possible. Creatine monohydrate is a good option, as it's the most researched and widely used form in studies, and it's also one of the most affordable and available options. Creating a regular creatine supplementation routine can be beneficial for overall health and wellness, regardless of your risk level for head injuries. You can obtain creatine through both food sources and supplements. While it is possible to get creatine from food, particularly from meat sources (which contain around 400-600mg of creatine per 100g or 3.5oz serving), it can be challenging to achieve the high dosages needed through diet alone. Most studies on creatine monohydrate for brain injuries have used high dosages of around 20g per day, which is significantly higher than the typical dosages used for performance benefits. As a preventative measure, a daily dose of 5-10g may be sufficient for most people. However, if you know you'll be at risk of exposure to head impacts, you may want to increase your dosage to 20-30g per day for a week, split into multiple doses. Remember, the primary goal should always be to minimize the number of head impacts and injuries in the first place.

Use creatine to protect your brain from head injuries: Repeated head injuries can lead to second-impact syndrome, where a subsequent injury before full recovery causes rapid and potentially permanent brain damage. This is a significant risk for athletes, military, or anyone prone to traumatic brain injury (TBI) or concussions. But here's the good news: research has shown that creatine supplementation can help mitigate the damage caused by second-impact syndrome. In fact, studies have found that creatine depletion prior to additional impacts can worsen the damage to your brain. So, what should you do? If you do experience a head injury, it's essential to replenish your creatine stores as quickly as possible. Creatine monohydrate is a good option, as it's the most researched and widely used form in studies, and it's also one of the most affordable and available options. Creating a regular creatine supplementation routine can be beneficial for overall health and wellness, regardless of your risk level for head injuries. You can obtain creatine through both food sources and supplements. While it is possible to get creatine from food, particularly from meat sources (which contain around 400-600mg of creatine per 100g or 3.5oz serving), it can be challenging to achieve the high dosages needed through diet alone. Most studies on creatine monohydrate for brain injuries have used high dosages of around 20g per day, which is significantly higher than the typical dosages used for performance benefits. As a preventative measure, a daily dose of 5-10g may be sufficient for most people. However, if you know you'll be at risk of exposure to head impacts, you may want to increase your dosage to 20-30g per day for a week, split into multiple doses. Remember, the primary goal should always be to minimize the number of head impacts and injuries in the first place.

Andy Galpin, PhD

137,470 views • 2 years ago

Megyn Kelly and Gary Brecka just shared a simple tool that’s helping a lot of women with poor sleep, especially during menopause. Megyn asked about bounce-back options when sleep isn’t great, even with HRT. Gary’s answer? Creatine. In higher doses (around 20mg daily, split into two 10mg doses), it crosses the blood-brain barrier and can blunt the effects of sleep deprivation, improving cognitive function, focus, and memory. He recommends women over 42–44 start with 5mg and work up to 20mg daily if sleep issues are consistent (or use it as needed for travel/stress). Many women notice a difference in as little as 24 hours. He even has 80–90-year-olds in memory care on it with good results. Practical, low-drama advice that feels actionable. Quick note: Monohydrate has the most research, but some women prefer HCl to minimize bloating. Dissolve it fully in water. What’s one sleep or menopause-related hack that’s actually worked for you?

Megyn Kelly and Gary Brecka just shared a simple tool that’s helping a lot of women with poor sleep, especially during menopause. Megyn asked about bounce-back options when sleep isn’t great, even with HRT. Gary’s answer? Creatine. In higher doses (around 20mg daily, split into two 10mg doses), it crosses the blood-brain barrier and can blunt the effects of sleep deprivation, improving cognitive function, focus, and memory. He recommends women over 42–44 start with 5mg and work up to 20mg daily if sleep issues are consistent (or use it as needed for travel/stress). Many women notice a difference in as little as 24 hours. He even has 80–90-year-olds in memory care on it with good results. Practical, low-drama advice that feels actionable. Quick note: Monohydrate has the most research, but some women prefer HCl to minimize bloating. Dissolve it fully in water. What’s one sleep or menopause-related hack that’s actually worked for you?

Camus

36,303 views • 26 days ago

Rhonda Patrick just leveled up her creatine game—and the reasons will make you rethink that standard 5g scoop. She used to do 5g for workouts... now it's 10g EVERY DAY as baseline. Why? Brain saturation. "Once muscles are full at ~5g, the spillover hits the brain"—boosting cognitive function, potentially shielding against brain aging, and even helping depression via better energy production upstairs. Jet-lagged? Sleepless night? Travel wrecking your rhythm? She cranks to 15–20g (sometimes 20–30g in studies) — calls it "speed without the speed," like caffeine minus the crash/jitters. No addiction, but insanely alert, focused, and resilient. Hits hardest under stress/sleep deprivation (research backs it: single high doses reverse 21+ hour wakefulness cognitive hits and can outperform rested performance). Vegan twist: One friend (no meat = zero dietary creatine) went from dragging to "Bruce Banner → Hulk" mode after starting. Vegans/vegetarians often run low—liver makes only so much. Bonus layer: Extra creatine frees up methylation pathways (homocysteine → methionine), gene expression tweaks, brain-wide perks. 3:13 raw clip of Rhonda spilling the science—perfect if you're biohacking focus, longevity, or just surviving modern life chaos. Are you on creatine? Still at 5g? Gone higher for brain gains? Noticed Hulk-level energy when stressed/sleepless? Vegans—game-changer or nah? Drop your protocol/experience below—this one's sparking real convos!

Rhonda Patrick just leveled up her creatine game—and the reasons will make you rethink that standard 5g scoop. She used to do 5g for workouts... now it's 10g EVERY DAY as baseline. Why? Brain saturation. "Once muscles are full at ~5g, the spillover hits the brain"—boosting cognitive function, potentially shielding against brain aging, and even helping depression via better energy production upstairs. Jet-lagged? Sleepless night? Travel wrecking your rhythm? She cranks to 15–20g (sometimes 20–30g in studies) — calls it "speed without the speed," like caffeine minus the crash/jitters. No addiction, but insanely alert, focused, and resilient. Hits hardest under stress/sleep deprivation (research backs it: single high doses reverse 21+ hour wakefulness cognitive hits and can outperform rested performance). Vegan twist: One friend (no meat = zero dietary creatine) went from dragging to "Bruce Banner → Hulk" mode after starting. Vegans/vegetarians often run low—liver makes only so much. Bonus layer: Extra creatine frees up methylation pathways (homocysteine → methionine), gene expression tweaks, brain-wide perks. 3:13 raw clip of Rhonda spilling the science—perfect if you're biohacking focus, longevity, or just surviving modern life chaos. Are you on creatine? Still at 5g? Gone higher for brain gains? Noticed Hulk-level energy when stressed/sleepless? Vegans—game-changer or nah? Drop your protocol/experience below—this one's sparking real convos!

Camus

233,976 views • 6 months ago

Rhonda Patrick dropped a wild science nugget on Diary of a CEO. It made me rewind twice. After 21 hours with zero sleep, a single high dose of creatine (~25-30g or 0.35 g/kg) didn’t just fix the brain fog. It made people perform better than when fully rested. (Key 2024 study by Gordji-Nejad et al. using brain imaging.) I’ve powered through too many all-nighters on caffeine and stubbornness. This felt like a real cheat code. It makes you wonder what else our biology can do with the right fuel. Would you try a high-dose creatine reset on your roughest sleep-deprived days? Or does 25-30g sound insane?

Rhonda Patrick dropped a wild science nugget on Diary of a CEO. It made me rewind twice. After 21 hours with zero sleep, a single high dose of creatine (~25-30g or 0.35 g/kg) didn’t just fix the brain fog. It made people perform better than when fully rested. (Key 2024 study by Gordji-Nejad et al. using brain imaging.) I’ve powered through too many all-nighters on caffeine and stubbornness. This felt like a real cheat code. It makes you wonder what else our biology can do with the right fuel. Would you try a high-dose creatine reset on your roughest sleep-deprived days? Or does 25-30g sound insane?

Camus

42,722 views • 2 months ago

Creatine is probably not harming our kidneys. Studies using doses up to 11 grams per day for a year have found no harmful effects on kidney, liver, or cardiovascular markers in healthy people. Yet the “creatine ruins your kidneys” myth refuses to die. Even some healthcare professionals still repeat it. Creatine breaks down into creatinine, which shows up on blood tests. If you supplement with creatine, your creatinine levels can go up, but that doesn’t automatically mean your kidneys are failing. It often just means… you’re taking creatine. If you take creatine and your lab work shows elevated creatinine, it’s often a false alarm, not a sign your kidneys are shot. A more reliable marker of kidney function to use when taking creatine is cystatin C. Creatine has plenty of debates around it. But at this point, in healthy people using reasonable doses, “it wrecks your kidneys” shouldn’t be one of them.

Creatine is probably not harming our kidneys. Studies using doses up to 11 grams per day for a year have found no harmful effects on kidney, liver, or cardiovascular markers in healthy people. Yet the “creatine ruins your kidneys” myth refuses to die. Even some healthcare professionals still repeat it. Creatine breaks down into creatinine, which shows up on blood tests. If you supplement with creatine, your creatinine levels can go up, but that doesn’t automatically mean your kidneys are failing. It often just means… you’re taking creatine. If you take creatine and your lab work shows elevated creatinine, it’s often a false alarm, not a sign your kidneys are shot. A more reliable marker of kidney function to use when taking creatine is cystatin C. Creatine has plenty of debates around it. But at this point, in healthy people using reasonable doses, “it wrecks your kidneys” shouldn’t be one of them.

Dr. Rhonda Patrick

597,371 views • 9 months ago

Why I upped my creatine dose to 10 grams per day. I used to take 5 grams of creatine daily, which provides solid benefits for muscle strength and performance (when combined with resistance training). Recently, I increased my dose to 10 grams, and here’s why I made the switch. Research suggests that 10 grams of creatine per day may offer additional advantages, particularly for brain health. Studies show that this higher dose increases creatine levels in areas like the grey matter, white matter, and thalamus more effectively than lower doses, such as 4 grams, over an 8-week period. This is likely due to a "spillover effect", where excess creatine benefits the brain once muscles are fully saturated. While 5 grams is effective for physical performance, 10 grams seems to provide a broader range of benefits, including potential cognitive support and bone health. If you’re considering creatine supplementation and want to maximize its effects, a 10-gram daily dose could be worth exploring.

Why I upped my creatine dose to 10 grams per day. I used to take 5 grams of creatine daily, which provides solid benefits for muscle strength and performance (when combined with resistance training). Recently, I increased my dose to 10 grams, and here’s why I made the switch. Research suggests that 10 grams of creatine per day may offer additional advantages, particularly for brain health. Studies show that this higher dose increases creatine levels in areas like the grey matter, white matter, and thalamus more effectively than lower doses, such as 4 grams, over an 8-week period. This is likely due to a "spillover effect", where excess creatine benefits the brain once muscles are fully saturated. While 5 grams is effective for physical performance, 10 grams seems to provide a broader range of benefits, including potential cognitive support and bone health. If you’re considering creatine supplementation and want to maximize its effects, a 10-gram daily dose could be worth exploring.

Dr. Rhonda Patrick

331,839 views • 1 year ago

Most people don’t realize how long it actually takes to build real, lasting strength. Your tendons and ligaments need six to nine months to fully adapt to the training you’re doing. That’s not a setback, that’s biology. This week’s conversation dives into what it really takes to prevent osteoporosis, especially for menopausal women dealing with low bone density. The research is clear…the most effective programs combine impact training with strength training. We also get into what most people are getting right versus getting wrong when it comes to nutrition. Because you can fill yourself with food and still be starving your body of what it actually needs. Link in bio for the full episode. Dr. Gabrielle

Most people don’t realize how long it actually takes to build real, lasting strength. Your tendons and ligaments need six to nine months to fully adapt to the training you’re doing. That’s not a setback, that’s biology. This week’s conversation dives into what it really takes to prevent osteoporosis, especially for menopausal women dealing with low bone density. The research is clear…the most effective programs combine impact training with strength training. We also get into what most people are getting right versus getting wrong when it comes to nutrition. Because you can fill yourself with food and still be starving your body of what it actually needs. Link in bio for the full episode. Dr. Gabrielle

Dr. Gabrielle Lyon

164,505 views • 7 months ago

Creatine is SAFE! CASE CLOSED! I have been saying for years that creatine monohydrate (CM) is the most effective & safest supplement on the market for improving lean mass, strength, performance, & now we have data showing it may improve cognition while decreasing symptoms of depression & possibly protect against traumatic brain injury Myths abound about the safety of CM, with claims that it damages the kidneys, liver, heart, causes bloating, damages the gut, & causes water retention A new meta-analysis (PMID: 40198156) attempted to compile all clinical research that reported side effects & analyze whether or not creatine caused side effects vs placebo The meta included over 26,000 total subjects & the characteristics were as follows: Average intake per day: 12.5g Average duration of use: ~9 weeks (longest was 14 years) Average age: 30 (up to 77) There were 49 total side effects reported, including: palpitations, thromboembolic events, GI distress, muscle cramping, kidney issues, liver enzymes, neoplasm, heart issues, & many others There were NO SIGNIFICANT DIFFERENCES for any of these side effects between creatine & placebo, indicating that it is unlikely to cause any side effects Additionally, while CM increases total body water, it does NOT increase extracellular water, which means it doesn’t cause edema (PMID: 12937471) Some people report GI issues from CM & for those people, I recommend dividing it up into smaller doses throughout the day It also does NOT cause hair loss (PMID: 40265319) Do not waste your money on forms of creatine other than monohydrate. It is the most studied form by far & is also the least expensive. All other forms (ethyl ester, hydrochloride, buffered, etc) are more expensive (so supplement companies can justify overcharging you) & none of them are more effective than CM & some are less effective (like ethyl ester). PMIDs: 19228401, 39545789, & 22971354) Get the real deal & don’t get overcharged. That’s why my Recovery product from @outworknutritionofficial contains creatine monohydrate so that you get the most effective, tested, & safe form, without overpaying.

Creatine is SAFE! CASE CLOSED! I have been saying for years that creatine monohydrate (CM) is the most effective & safest supplement on the market for improving lean mass, strength, performance, & now we have data showing it may improve cognition while decreasing symptoms of depression & possibly protect against traumatic brain injury Myths abound about the safety of CM, with claims that it damages the kidneys, liver, heart, causes bloating, damages the gut, & causes water retention A new meta-analysis (PMID: 40198156) attempted to compile all clinical research that reported side effects & analyze whether or not creatine caused side effects vs placebo The meta included over 26,000 total subjects & the characteristics were as follows: Average intake per day: 12.5g Average duration of use: ~9 weeks (longest was 14 years) Average age: 30 (up to 77) There were 49 total side effects reported, including: palpitations, thromboembolic events, GI distress, muscle cramping, kidney issues, liver enzymes, neoplasm, heart issues, & many others There were NO SIGNIFICANT DIFFERENCES for any of these side effects between creatine & placebo, indicating that it is unlikely to cause any side effects Additionally, while CM increases total body water, it does NOT increase extracellular water, which means it doesn’t cause edema (PMID: 12937471) Some people report GI issues from CM & for those people, I recommend dividing it up into smaller doses throughout the day It also does NOT cause hair loss (PMID: 40265319) Do not waste your money on forms of creatine other than monohydrate. It is the most studied form by far & is also the least expensive. All other forms (ethyl ester, hydrochloride, buffered, etc) are more expensive (so supplement companies can justify overcharging you) & none of them are more effective than CM & some are less effective (like ethyl ester). PMIDs: 19228401, 39545789, & 22971354) Get the real deal & don’t get overcharged. That’s why my Recovery product from @outworknutritionofficial contains creatine monohydrate so that you get the most effective, tested, & safe form, without overpaying.

Layne Norton, PhD

43,972 views • 1 year ago

If you’re curious what I actually do for longevity, here’s my weekly routine: ~5 hrs/week of exercise (when I'm not traveling). That includes: • CrossFit (~3 hrs/wk) for strength + high-intensity work • "Zone 2" running on recovery days for cardiovascular and brain benefits I also try to sauna 5x/week at night for heat acclimation and supporting sleep quality. A simple, whole-food diet: • ~1.6 g protein/kg/day • Eggs + smoothie for breakfast, turkey burger for lunch, and vegetables/salad + meat for dinner Last is supplements: • In the morning, I take creatine (10 grams), a multivitamin, cocoa polyphenols, sulforaphane, and omega-3s • In the evening, I take magnesium, omega-3s, vitamin D + K2, PQQ, and nicotinamide riboside (NR) This is what I’ve found to be sustainable and aligns with the latest evidence.

If you’re curious what I actually do for longevity, here’s my weekly routine: ~5 hrs/week of exercise (when I'm not traveling). That includes: • CrossFit (~3 hrs/wk) for strength + high-intensity work • "Zone 2" running on recovery days for cardiovascular and brain benefits I also try to sauna 5x/week at night for heat acclimation and supporting sleep quality. A simple, whole-food diet: • ~1.6 g protein/kg/day • Eggs + smoothie for breakfast, turkey burger for lunch, and vegetables/salad + meat for dinner Last is supplements: • In the morning, I take creatine (10 grams), a multivitamin, cocoa polyphenols, sulforaphane, and omega-3s • In the evening, I take magnesium, omega-3s, vitamin D + K2, PQQ, and nicotinamide riboside (NR) This is what I’ve found to be sustainable and aligns with the latest evidence.

Dr. Rhonda Patrick

332,486 views • 6 months ago

Eating protein before bed may improve muscle mass and aid recovery — if you lift weights. In the evening, especially in the hours before bed, our bodies are at their least insulin-sensitive. As melatonin levels rise, it interacts with receptors in the pancreas, signaling a reduction in insulin secretion. However, for the purposes of maximizing our adaptive response to resistance training, sleep is a period of long unbroken fasting. Evidence shows that during exercise training, consuming 30 grams of protein before enhances gains in muscle mass and strength. There’s two ways to look at this: One way is through the lens of time-restricted eating and the other is through the lens of actively optimizing for muscle protein synthesis on training days. Pre-sleep protein is just one way to increase total daily protein intake. A low-calorie protein shake on training days can support muscle growth by enhancing protein synthesis. However, keep in mind the natural drop in insulin sensitivity near bedtime, especially on non-training days when exercise isn’t boosting insulin sensitivity. Learn more by tuning into the Science of Protein podcast, available now on all major platforms. Show notes:

Eating protein before bed may improve muscle mass and aid recovery — if you lift weights. In the evening, especially in the hours before bed, our bodies are at their least insulin-sensitive. As melatonin levels rise, it interacts with receptors in the pancreas, signaling a reduction in insulin secretion. However, for the purposes of maximizing our adaptive response to resistance training, sleep is a period of long unbroken fasting. Evidence shows that during exercise training, consuming 30 grams of protein before enhances gains in muscle mass and strength. There’s two ways to look at this: One way is through the lens of time-restricted eating and the other is through the lens of actively optimizing for muscle protein synthesis on training days. Pre-sleep protein is just one way to increase total daily protein intake. A low-calorie protein shake on training days can support muscle growth by enhancing protein synthesis. However, keep in mind the natural drop in insulin sensitivity near bedtime, especially on non-training days when exercise isn’t boosting insulin sensitivity. Learn more by tuning into the Science of Protein podcast, available now on all major platforms. Show notes:

Dr. Rhonda Patrick

92,595 views • 1 year ago

I've included two videos of the car running into me... one inside the car and one outside. With the FSD 14 light reversing issues I was curious if it would stop for a person m, especially a child so I ran a couple tests. When I was standing straight up, the car, wouldn't continue to move backwards, but when I crouch down so I was the height of a kid or a pet it ran into me. I even tried walking at first and then crouching down and when I was walking it showed red on the screen so it knew I was there, but then the red went away when I stopped and crouched down. I was thinking if it saw me walking, there would be object permanence and it would stop.

I've included two videos of the car running into me... one inside the car and one outside. With the FSD 14 light reversing issues I was curious if it would stop for a person m, especially a child so I ran a couple tests. When I was standing straight up, the car, wouldn't continue to move backwards, but when I crouch down so I was the height of a kid or a pet it ran into me. I even tried walking at first and then crouching down and when I was walking it showed red on the screen so it knew I was there, but then the red went away when I stopped and crouched down. I was thinking if it saw me walking, there would be object permanence and it would stop.

Lincoln

19,183 views • 25 days ago

Creatine Monohydrate is STILL KING Creatine monohydrate (CrM) is the most effective supplement on the market & has decades of data & thousands of studies to back up its use. It is also the least expensive form of creatine on the market. If CrM is so effective why do companies keep trying to reinvent the wheel? I’ll let you in on a dirty little supplement industry secret, companies can’t make much money on CrM because it is so widely available that it drives down the price. So companies make ‘new & improved’ forms of creatine to justify charging you 2-4x more money. There’s only one problem… these forms are either less effective or only equally effective but cost WAY more One of the new forms of creatine that has generated a lot of buzz is creatine hydrochloride (CrHCl). CrHCl is more soluble in water & so the claim has been made that it gets absorbed better & you don’t need to take as much to get equal results. A recent study (PMID: 39545789) aimed to test these claims directly. The researchers split the participants into 4 groups who resistance trained (RT): RT + placebo RT + CrM at 0.03g/kg BW RT + CrHCl at 0.03g/kg BW RT + CrM at a loading dose of 0.3g/kg BW followed by a maintenance dose of 0.03g/kg BW At the end of the study all the creatine groups had better results than the placebo group, but NONE of the creatine groups had any significant differences from each other. Sorry CrHCl, you’re just another overpriced reinvention of the wheel to try to get people to spend more money so that supplement companies can pocket more Some people do get GI distress with rCM, in this case you can try splitting the normal 5g/day dose up into 2-3 smaller doses throughout the day & that will help Stick with tried & true CrM. It is inexpensive & very effective. That is why we use CrM in my Recovery product from @outworknutritionofficial (link in bio) because why would we charge you more for a less effective, more expensive product? We wouldn’t, because we don’t roll like that

Creatine Monohydrate is STILL KING Creatine monohydrate (CrM) is the most effective supplement on the market & has decades of data & thousands of studies to back up its use. It is also the least expensive form of creatine on the market. If CrM is so effective why do companies keep trying to reinvent the wheel? I’ll let you in on a dirty little supplement industry secret, companies can’t make much money on CrM because it is so widely available that it drives down the price. So companies make ‘new & improved’ forms of creatine to justify charging you 2-4x more money. There’s only one problem… these forms are either less effective or only equally effective but cost WAY more One of the new forms of creatine that has generated a lot of buzz is creatine hydrochloride (CrHCl). CrHCl is more soluble in water & so the claim has been made that it gets absorbed better & you don’t need to take as much to get equal results. A recent study (PMID: 39545789) aimed to test these claims directly. The researchers split the participants into 4 groups who resistance trained (RT): RT + placebo RT + CrM at 0.03g/kg BW RT + CrHCl at 0.03g/kg BW RT + CrM at a loading dose of 0.3g/kg BW followed by a maintenance dose of 0.03g/kg BW At the end of the study all the creatine groups had better results than the placebo group, but NONE of the creatine groups had any significant differences from each other. Sorry CrHCl, you’re just another overpriced reinvention of the wheel to try to get people to spend more money so that supplement companies can pocket more Some people do get GI distress with rCM, in this case you can try splitting the normal 5g/day dose up into 2-3 smaller doses throughout the day & that will help Stick with tried & true CrM. It is inexpensive & very effective. That is why we use CrM in my Recovery product from @outworknutritionofficial (link in bio) because why would we charge you more for a less effective, more expensive product? We wouldn’t, because we don’t roll like that

Layne Norton, PhD

28,197 views • 1 year ago

Tim Robbins reveals he went 14 straight days without a single bite of food, lost 25 pounds, and unlocked total mental clarity "I just did a cleanse... one of those master cleanses. I just did 14 days on where you don't eat a thing for 14 days, and it's amazing how great you feel at the end of it." "14 whole days. No food at all?" "No food at all. No... It's lemon juice, cayenne pepper, and maple syrup, and that'll get you through the day. And then every morning you're doing a purge, right? So you're cleaning all the poisons out." "14 days is a long time with no food." "It is." "What was the first thing you ate when it was over?" "You got to ease your way back in. Like clear broth first, then soups, then vegetables... about a week re-entry." "Do you experience mental clarity when you do that?" "Total mental clarity. First three days are tough, but once you get past the third day, your energy level is constant throughout the day and you can work. I play sports with it..." "How do you decide when to do it?" "Usually when you've been a little indulgent and you're not feeling too good... and you put on a little weight." "You must lose a ton of weight doing that. How much have you lost doing 14 days?" "25 pounds. About two a day." "And then your body's running completely on ketones, right? Because your body's running on fat... your mental clarity is just so much better. Everything just runs smooth. Flat energy throughout the day, no crashing after a big meal." "And you sleep less, too. You need less sleep for some reason." "Also, I think it's probably good to give your digestive system a little break, too. Just let it relax."

Tim Robbins reveals he went 14 straight days without a single bite of food, lost 25 pounds, and unlocked total mental clarity "I just did a cleanse... one of those master cleanses. I just did 14 days on where you don't eat a thing for 14 days, and it's amazing how great you feel at the end of it." "14 whole days. No food at all?" "No food at all. No... It's lemon juice, cayenne pepper, and maple syrup, and that'll get you through the day. And then every morning you're doing a purge, right? So you're cleaning all the poisons out." "14 days is a long time with no food." "It is." "What was the first thing you ate when it was over?" "You got to ease your way back in. Like clear broth first, then soups, then vegetables... about a week re-entry." "Do you experience mental clarity when you do that?" "Total mental clarity. First three days are tough, but once you get past the third day, your energy level is constant throughout the day and you can work. I play sports with it..." "How do you decide when to do it?" "Usually when you've been a little indulgent and you're not feeling too good... and you put on a little weight." "You must lose a ton of weight doing that. How much have you lost doing 14 days?" "25 pounds. About two a day." "And then your body's running completely on ketones, right? Because your body's running on fat... your mental clarity is just so much better. Everything just runs smooth. Flat energy throughout the day, no crashing after a big meal." "And you sleep less, too. You need less sleep for some reason." "Also, I think it's probably good to give your digestive system a little break, too. Just let it relax."

Nichole

2,663,232 views • 19 days ago