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If you’re curious what I actually do for longevity, here’s my weekly routine: ~5 hrs/week of exercise (when I'm not traveling). That includes: • CrossFit (~3 hrs/wk) for strength + high-intensity work • "Zone 2" running on recovery days for cardiovascular and brain benefits I also try to sauna...

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Dr. Rhonda Patrick

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331,132 views • 4 months ago •via X (Twitter)

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5 supplements that give you big bang for your buck: • Omega-3 — a high omega-3 index is linked to 5 extra years of life expectancy, 66% lower Alzheimer’s risk, and slower epigenetic aging • Vitamin D — regulates over 5% of your genome, including genes for viral defense, neurotransmitter synthesis, and longevity; correcting deficiency can reverse epigenetic age by ~2 years • Multivitamin — daily use in older adults was linked to 2.1 years less global brain aging, nearly 5 years less episodic memory aging, and modestly slower epigenetic aging • Magnesium — supports 300+ enzymes involved in DNA repair and sleep, and low intake has been linked to higher cancer risk • Creatine monohydrate — one of the most studied supplements for strength and performance, with 10 grams as a baseline for brain benefits
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There is now converging evidence in animals and humans that omega-3 fatty acids are at the least anti-catabolic and, likely, anabolic. They seem to do this by shifting the balance away from breakdown and more towards muscle building, particularly in the context of anabolic resistance. Animal studies show omega-3 fatty acids augment muscle development: Steers fed omega-3s showed improved amino acid efficiency and activated pathways involved in muscle growth. Similarly, pigs given a high omega-3 diet exhibited larger muscles and markers of improved amino acid absorption and use. But more importantly, we have human evidence: • In one study, young women taking 5 grams of omega-3s per day cut their muscle loss almost in half and increased muscle protein synthesis after two weeks of leg immobilization. • In another study, older adults consuming 3.36 grams of omega-3s daily for two months had an increase in muscle protein synthesis in the presence of amino acids and insulin. • Yet another study found that healthy older adults taking 4 grams of omega-3s daily for half a year increased various measures of muscle size and strength. • Still another study, older adults who consumed 4 grams of krill oil daily for six months improved knee strength, grip strength, thigh muscle thickness, and measures of muscle nerve response. There are still open questions. For example, a consistent theme is that many of the studies are high dose at 4 and 5 grams per day - does that imply that these effects in muscle only happen at high dosages? Another question we might ask is, in what context is omega-3 more anabolic - for example, in old age? During immobilization? When protein intake is sub-optimal for muscle building? (It often is for many of us.) Listen to my recent podcast guest Dr. Chris McGlory for more discussion of this fascinating new emerging field. Show notes and transcript for this episode here:
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4 supplements that give you the biggest bang for your buck: • Multivitamin — 3 large RCTs show it reduces brain aging by ~2 years and reverses episodic memory aging by ~5 years in older adults • Omega-3s — a high omega-3 index (8%+) is linked to 5 years of increased life expectancy and 90% lower risk of sudden cardiac death • Magnesium — a cofactor for 300+ biological processes including DNA repair and energy production; 60%+ of the US population is deficient • Vitamin D — regulates over 5% of your genome, including genes for viral defense, neurotransmitter synthesis, and longevity; correcting deficiency can reverse epigenetic age by ~2 years
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Rhonda's top diet & behavioral interventions for optimal health: Diet: • Adequate omega-3s • Adequate vitamin D • Adequate greens & protein Behavioral: • High-intensity exercise • Resistance training • Heat exposure
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Rhonda's top diet & behavioral interventions for optimal health: Diet: • Adequate omega-3s • Adequate vitamin D • Adequate greens & protein Behavioral: • High-intensity exercise • Resistance training • Heat exposure

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Taking around 2 grams of omega-3s per day might be one of the highest-ROI habits for lifespan and cardiovascular protection At that dose, most people can move their omega-3 index from ~4% to ~8%, a range associated in observational studies with about a 5-year increase in life expectancy and ~90% lower risk of sudden cardiac death Omega-3s also support brain function and mood, with clear benefits for depression and cognition Yet nearly 90% of Americans fall short of recommended EPA and DHA intake Few interventions this impactful are this easy
1:02

Taking around 2 grams of omega-3s per day might be one of the highest-ROI habits for lifespan and cardiovascular protection At that dose, most people can move their omega-3 index from ~4% to ~8%, a range associated in observational studies with about a 5-year increase in life expectancy and ~90% lower risk of sudden cardiac death Omega-3s also support brain function and mood, with clear benefits for depression and cognition Yet nearly 90% of Americans fall short of recommended EPA and DHA intake Few interventions this impactful are this easy

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Essential supplements for combating the most common micronutrient deficiencies: • Vitamin D (~4,000 IU/day, but get a blood test to know for certain) • Omega-3s (at least 1.5-2g per day) • Multivitamin (for insurance) • Magnesium (essential for DNA repair enzymes, the salt forms are best: citrate, malate, glycinate, taurate) And if you want to go one step further, add sulforaphane—a potent activator of glutathione, your body’s master antioxidant
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Essential supplements for combating the most common micronutrient deficiencies: • Vitamin D (~4,000 IU/day, but get a blood test to know for certain) • Omega-3s (at least 1.5-2g per day) • Multivitamin (for insurance) • Magnesium (essential for DNA repair enzymes, the salt forms are best: citrate, malate, glycinate, taurate) And if you want to go one step further, add sulforaphane—a potent activator of glutathione, your body’s master antioxidant

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14. Myth: Supplements are a Waste of Money Truth: While a balanced diet is essential, supplements can fill in nutritional gaps, particularly for nutrients that are hard to get from food alone, like omega-3s and vitamin D.
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14. Myth: Supplements are a Waste of Money Truth: While a balanced diet is essential, supplements can fill in nutritional gaps, particularly for nutrients that are hard to get from food alone, like omega-3s and vitamin D.

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Rhonda's current supplement routine: • Omega-3s • Vitamin D • Multivitamin • Magnesium glycinate • Magnesi-Om • Alpha-lipoic acid • Benfotiamine • Lutein & zeaxanthin • CoQ10 • Sulforaphane • Glutamine • Creatine
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Rhonda's current supplement routine: • Omega-3s • Vitamin D • Multivitamin • Magnesium glycinate • Magnesi-Om • Alpha-lipoic acid • Benfotiamine • Lutein & zeaxanthin • CoQ10 • Sulforaphane • Glutamine • Creatine

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Exercise is more than a tool for physical transformation—it's a cornerstone of longevity, metabolic resilience, and neurocognitive vitality This is Rhonda Patrick's weekly routine: • CrossFit (2 Days/Week): ~1 hour total, including strength training and HIIT (e.g., rowing, biking, jumping rope, and bodyweight exercises) • Aerobic and Resistance Combo (1 Day/Week): ~1 hour of combined hypertrophy training and aerobic exercises like rowing or biking • Zone 2–3 Training (2 Days/Week): Moderate-intensity running with sprints at the end • Recovery Hike (1 Day/Week): A 1.5–2-hour hike, including walking uphill and occasional sprints
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Exercise is more than a tool for physical transformation—it's a cornerstone of longevity, metabolic resilience, and neurocognitive vitality This is Rhonda Patrick's weekly routine: • CrossFit (2 Days/Week): ~1 hour total, including strength training and HIIT (e.g., rowing, biking, jumping rope, and bodyweight exercises) • Aerobic and Resistance Combo (1 Day/Week): ~1 hour of combined hypertrophy training and aerobic exercises like rowing or biking • Zone 2–3 Training (2 Days/Week): Moderate-intensity running with sprints at the end • Recovery Hike (1 Day/Week): A 1.5–2-hour hike, including walking uphill and occasional sprints

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Rhonda Patrick just gave a super practical breakfast recommendation on Chris Williamson’s podcast. She recommends eggs (4–5 depending on your size) scrambled, paired with bacon, steak, or smoked salmon for omega-3s. She prefers pasture-raised eggs because the chickens eat grass and greens, boosting choline (key for brain function) and lutein. Simple, high-protein, nutrient-dense, and no processed junk. Studies confirm egg yolk choline improves verbal memory and cognitive function, while pasture-raised eggs contain significantly more lutein, omega-3s, and better nutrient profiles than conventional ones. High-protein breakfasts also stabilize energy and focus throughout the day. Most breakfast advice is either overly complicated or loaded with sugar. This feels sustainable and actually nourishing. I’ve been leaning into higher-protein mornings lately and the difference in steady energy is noticeable. Rhonda’s approach feels refreshingly straightforward. What’s your go-to high-protein breakfast that actually keeps you full and sharp?
1:31

Rhonda Patrick just gave a super practical breakfast recommendation on Chris Williamson’s podcast. She recommends eggs (4–5 depending on your size) scrambled, paired with bacon, steak, or smoked salmon for omega-3s. She prefers pasture-raised eggs because the chickens eat grass and greens, boosting choline (key for brain function) and lutein. Simple, high-protein, nutrient-dense, and no processed junk. Studies confirm egg yolk choline improves verbal memory and cognitive function, while pasture-raised eggs contain significantly more lutein, omega-3s, and better nutrient profiles than conventional ones. High-protein breakfasts also stabilize energy and focus throughout the day. Most breakfast advice is either overly complicated or loaded with sugar. This feels sustainable and actually nourishing. I’ve been leaning into higher-protein mornings lately and the difference in steady energy is noticeable. Rhonda’s approach feels refreshingly straightforward. What’s your go-to high-protein breakfast that actually keeps you full and sharp?

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“I switched to steak and eggs for breakfast and found that it’s like a power up.” Rogan and Musk talk about creatine and the carnivore diet.
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“I switched to steak and eggs for breakfast and found that it’s like a power up.” Rogan and Musk talk about creatine and the carnivore diet.

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Taking ~2 grams/day of omega-3s may be one of the simplest high-ROI habits for lifespan and cardiovascular health At that dose, most people can move their omega-3 index from ~4% to ~8%, a range linked in observational studies to a ~5-year increase in life expectancy and ~90% lower risk of sudden cardiac death To put that in perspective, a low omega-3 index has been associated with a life expectancy gap similar to smoking Yet the vast majority of Americans fall short on EPA and DHA Few interventions this impactful are this easy All you have to do is take a fish oil supplement
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Taking ~2 grams/day of omega-3s may be one of the simplest high-ROI habits for lifespan and cardiovascular health At that dose, most people can move their omega-3 index from ~4% to ~8%, a range linked in observational studies to a ~5-year increase in life expectancy and ~90% lower risk of sudden cardiac death To put that in perspective, a low omega-3 index has been associated with a life expectancy gap similar to smoking Yet the vast majority of Americans fall short on EPA and DHA Few interventions this impactful are this easy All you have to do is take a fish oil supplement

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